Université catholique de Louvain (UCL-Bruxelles)
Louvain Drug Research Institute (Department of Pharmaceutical Sciences)
Cellular and Molecular Pharmacology Unit

Viruses of Microbes 2023
Tbilisi, Georgia (3-7 July 2023)

• Inhibition of bacteriophages as a result of serum supplementation to the media
  Steven De Soir, Maya Merabishvili, Daniel. De Vos, Jean-Paul Pirnay, Françoise Van Bambeke
  poster
  
  
• Exploiting Synergistic Effects of Bacteriophages and Antibiotics on Dual-Species Biofilms in the setting of Cystic Fibrosis
  Steven De Soir, Zhifen Wang, Maya Merabishvili, Daniel. De Vos, Jean-Paul Pirnay, Françoise Van Bambeke
  poster

33th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)
Copenhagen, Denmark (15-18 April 2023)

• Setting up a bi-fluorescent model to follow intracellular replication of Pseudomonas aeruginosa in the presence of antibiotics
  Audrey Comein, Françoise Van Bambeke
  Oral presentation - session Intracellular bacterial infections and persistence
  
  
• Vancomycin pharmacokinetics and activity in a novel in vivo model of biofilm-related infection of tissue cages in guinea pigs: comparison with in vitro data
  Randy Buzisa Mbuku, Hervé. Poilvache, Alix Mangin, Olivier Cornu, Françoise Van Bambeke.
  Poster P1026- Session Preclinical biofilm studies
  
  
• Can S. aureus and P. aeruginosa cohabit in dual species biofilms? Comparison of reference strains and clinical isolates from patients with cystic fibrosis
  Zhifen Wang, Christiane Knoop, and Françoise Van Bambeke
  Poster P1023- Session Preclinical biofilm studies
  
  
• Linezolid toxicity in clinical practice: towards a better detection of at-risk patients? Interim analysis of a prospective multicentric study
  Hélène Thirot, David Fage, Jean-Cyr Yombi, Olivier Cornu, Caroline Briquet, Philippe Clevenbergh, Tatiana Besse, Frédéric Cotton, Anne Spinewine, Françoise Van Bambeke.
  Oral presentation - Session Safety, hypersensitivity and adverse effects of treatment
  
  
• Impact of ABCB1 and its polymorphism on fluoroquinolone transport in eukaryotic cells
  Gwenaëlle Mahieu, Françoise Van Bambeke, Laure Elens
  Poster P2228 - Session Pharmacokinetics/pharmacodynamics of antibacterial drugs & therapeutic drug monitoring
  
  
• Population pharmacokinetics and dosing simulation of the beta-lactam temocillin in liver transplanted paediatric patients
  Perrin Ngougni Pokem, Xavier Stéphenne, Dimitri Van der Linden, Marie-Laura Godet, Gert-Jan Wijnant, Olga Chatzis, Laurent Houtekie, Astrid Haenecour, Pierre Wallemacq, Paul M. Tulkens, Etienne Sokal, Laure Elens, Françoise Van Bambeke
  ePoster flash session - PK/PD: from bench to bedside and back

BVIKM/SBIMC-NVMM-NVII joined meeting
Bruges, Belgium (7-8 November 2022)

• Occurrence and Risk Factors of Linezolid Toxicity in Clinical Practice: Interim Analysis of a Prospective Multicentric Study
  Hélène Thirot, David Fage, Jean-Cyr Yombi, Olivier Cornu, Caroline Briquet, Philippe Clevenbergh, Tatiana Besse, Frédéric Cotton, Anne Spinewine, Françoise Van Bambeke.
  Poster
  
  
• Pharmacokinetics and PK/PD of temocillin in non-ICU urinary tract infection patients with various stages of renal insufficiency
  Gert-Jan Wijnant, Perrin Ngougni-Pokem, Marie Coessens, Eleorora Cottone, Lieven Goeman, Steven Vervaeke, Françoise Van Bambeke
  Poster

21th Annual Meeting of the International Society for Pharmacovigilance (ISOP)
Verona, Italy (20-23 September 2022)

• Occurrence and Characteristics of Linezolid Toxicity in Clinical Practice: Interim Analysis of a Prospective Multicentric Study.
  H. Thirot *, D. Fage**, JC Yombi***, O. Cornu***, C. Briquet***, P. Clevenbergh****, T. Besse****, F. Cotton**, A. Spinewine*, F. Van Bambeke*
  *Université catholique de Louvain (Louvain Drug Research Institute); **Laboratoire Hospitalier Universitaire de Bruxelles; ***Cliniques universitaires St-Luc; ****Centre Hospitalier Universitaire Brugmann, Brussels; ;Belgium

Viruses of Microbes (VoM) meeting
Guimaraes, Portugal (18-22 July 2022)

• Phage-Antibiotic Synergy for the Treatment of Biofilm-related Infections on Orthopedic Implants
  S. De Soir*,**, H. Parée*, N. Kumarudin***, J.Wagemans****, M. Merabishvili**, D. De Vos**, JP. Pirnay**, F. Van Bambeke*
  *Université Catholique de Louvain, Louvain Drug Research Institute; **2.Lab for Cellular & Molecular Technology, Queen Astrid Military Hospital; ***Department of Materials Engineering, Biomaterials and Tissue Engineering Research Group, KU Leuven; ****Laboratory of Gene Technology, KU Leuven, Belgium

32th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)
Lisbon, Portugal (22-25 April 2022)

• In-vitro study of dual species biofilms formed by clinical isolates of S. aureus and different phenotypes of P. aeruginosa collected as pairs from patients with cystic fibrosis (CF)
  Zhifen Wang*, Albert Ruiz Sorribas*, Christiane Knoop**, and Françoise Van Bambeke*
  * Université catholique de Louvain, Brussels, Belgium; ** Université libre de Bruxelles,Belgium;
  Poster P1867- Session Preclinical biofilm studies
  
  
• Development of a thermo-responsive hydrogel as a carrier for biofilm targeting enzymes and antimicrobials for the treatment of orthopaedic device-related infections
  Hervé Poilvache*,**, Ambre Freyberg*, Olivier Cornu**, Françoise Van Bambeke*
  * Pharmacologie cellulaire et moléculaire, LDRI, Université catholique de Louvain, Brussels;** Neuromusculoskeletal Laboratory, IREC, Université catholique de Louvain, Brussels;*** Orthopaedic Surgery Department, Cliniques Universitaires Saint-Luc, Brussels
  Mini-oral Flash Session - Enhancing antibiotic therapy against biofilms with combined treatments
  
  
• Pharmacokinetics and PK/PD of temocillin in non-ICU urinary tract infection patients with various stages of renal insufficiency
  Gert-Jan Wijnant*, Perrin Ngougni Pokem*, Marie Coessens**, Eleonora Cottone**, Lieven Goeman***, Steven Vervaeke**, Françoise Van Bambeke*
  * Pharmacologie cellulaire et moléculaire, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium, ** Department of Laboratory Medicine, AZ Delta Hospital, Roeselare, Belgium, ***Department of Urology, AZ Delta Hospital, Roeselare, Belgium
  Oral Session - Clinical PK/PD studies and TDM to improve dosing of anti-infectives
  presentation selected for a travel grant to the presenting author
  
  
• The polyamino-isoprenic potentiator NV716 revives the disused antibiotic rifampin against biofilm infection by Gram-negative ESKAPE pathogens
  Gang Wang*, Jean-Michel Brunel**, Negar Mozaheb*, Jean-Michel Bolla**, Françoise Van Bambeke*
  * Université catholique de Louvain, Brussels, Belgium; ** Aix-Marseille Université, Marseille, France;
  Mini-oral Flash Session - Enhancing antibiotic therapy against biofilms with combined treatments

31th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)
         Online meeting, 9-12 July 2021
 This meeeting, originally scheduled in Vienna, Asutria, will be held as a on-line meeting due to the corona virus pandemia and foreseable travel uncertainties.

Links to posters and/or presentations will be activated after the meeting

• The polyamino-isoprenic potentiator NV716 revives disused antibiotics against intracellular forms of infection by Escherichia coli, Klebsiella pneumoniae, and Acinetobacter baumannii
  Gang Wang*, Jean-Michel Brunel**, Jean-Michel Bolla**, Françoise Van Bambeke*
  * Université catholique de Louvain, Brussels, Belgium; ** Aix-Marseille Université, Marseille, France;
  Session type: 1,5-hour Oral Session
  Session name: Combination of drugs for a synergistic antibacterial effect
  
  
• Analysis of reimbursement data of antibiotics prescribed in the community in Belgium: no negligible impact of public campaigns and of global price decreases but major effect of changes in reimbursement conditions
  Paul M. Tulkens
  Session type: 1-hour Oral Session
  Session name: New modalities for improving antimicrobial stewardship
  
  
• Antibiotic-antifungal combinatory pharmacodynamics against an in-vitro inter-kingdom three-species biofilm model in the context of orthopaedic devices infection
  Albert Ruiz Sorribas, Françoise Van Bambeke
  Session type: 1-hour Mini Oral Flash
  Session name: Current developments in antimicrobial strategies
  
  
Inter- and intra-species variations in the in vitro efficacy of a tri-enzymatic cocktail to prevent and disperse biofilms from bacteria responsible for prosthetic joint infection
Aline Lardinois*, Hussein Chalhoub*, Michel Delmee*, Youri Glupczynski*, Hervé Poilvache**,***,****, Françoise van Bambeke**, Laetitia Fontaine*
* OneLife sa, Louvain-la-Neuve; ** Pharmacologie cellulaire et moléculaire, LDRI, Université catholique de Louvain, Brussels; *** Neuromusculoskeletal Laboratory, IREC, Université catholique de Louvain, Brussels; *** Orthopaedic Surgery Department, Cliniques Universitaires Saint-Luc, Brussels.
Session type: ePoster Session
Session category: 9. Experimental microbiology, microbial pathogenesis & biofilm


• A novel in-vivo model of Prosthetic Joint Infection: application to the evaluation of treatment efficacy and of antibiotic pharmacokinetics
  Hervé Poilvache*,**,***, Françoise Van Bambeke*, Olivier Cornu**,***
  * Pharmacologie cellulaire et moléculaire, LDRI, Université catholique de Louvain, Brussels;** Neuromusculoskeletal Laboratory, IREC, Université catholique de Louvain, Brussels;*** Orthopaedic Surgery Department, Cliniques Universitaires Saint-Luc, Brussels
  Session type: ePoster Session
  Session category: 9. Experimental microbiology, microbial pathogenesis & biofilm
  
  
• The polyamino-isoprenyl compound NV716 re-sensitizes old disused antibiotics against Pseudomonas aeruginosa by inhibiting efflux and disturbing outer membrane permeability.
  Gang Wang*, Jean-Michel Brunel**, Jean-Michel Bolla**, Françoise Van Bambeke*
  * Université catholique de Louvain, Brussels, Belgium; ** Aix-Marseille Université, Marseille, France
  Session type: ePoster Session
  Session category: 5. New antibacterial agents, PK/PD & Stewardship

• Setting up of a model for the study of antibiotic protein binding and prediction of interferences by other drugs: application with temocillin
  Perrin Ngougni Pokem, Françoise Van Bambeke, Paul M. Tulkens
  Session type: ePoster Session
  Session category: 5. New antibacterial agents, PK/PD & Stewardship

World Wide Microbe Fourm 2021 (American Society of Microbiology [ASM] and Federation of the European Microbiological Societies [FEMS])
20-24 June 2021
An world online meeting

Links to posters will be activated after the meeting.

• Setting up an in-vitro dual species biofilm model in the context of cystic fibrosis airway infections
  Zhifen Wang and Françoise Van Bambeke
  e-posterSession MBP07 Biofilms, Motility and other Collective Behaviors
  
  
• Combination of enzymes and antimicrobials against an inter-kingdom biofilm model
  Albert Ruiz Sorribas, Françoise Van Bambeke
  e-poster
  FEMS: Infection Biology and Pathogens
  
  

ASM Microbe 2020 (American Society of Microbiology [ASM])
Chicago, IL (USA), 18-22 June 2020
The physical meeting has been cancelled

• Mechanism of thrombocytopenia induced by oxazolidinone antibiotics (linezolid, tedizolid): demonstration of impairment of megakaryocyte differentiation from human hematopoietic stem cells associated with mitochondrial toxicity
  T.V. Milosevic, G. Vertenoeil*,**, W. Vainchenker***, P.M. Tulkens, S.N. Constantinescu*,**, F. Van Bambeke
  * Signal Transduction and Molecular Hematology, Ludwig Institute for Cancer Research, Brussels Branch, Brussels, Belgium; ** de Duve Institute, Université catholique de Louvain (UCLouvain), Brussels, Belgium and Walloon Excellence in Life Science and Biotechnology, Brussels, Belgium; *** UMR 1170, Institut National de la Santé et de la Recherche Médicale, Université de Paris-Sud & Institut Gustave Roussy, Villejuif, France
  Poster
  
  
• Analysis of antibiotic consumption by community patients in a defined small-size market (Belgium) shows a lack of impact of public campaigns and of price decreases but a major effect of narrowing the applicable prescription rules
  P.M. Tulkens
  Poster

30th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)
         Paris, France (EU), 18-21 April 2020
         The meeting has been cancelled

• Linezolid thrombocytopenia: any factor that influences the time of onset? A retrospective study in 4 Belgian hospital centres
  H. Thirot, C. Briquet*, F. Frippiat**, F. Jacobs***, X. Holemans****, S. Henrard, P.M. Tulkens, A. Spinewine, F. Van Bambeke
  * Cliniques universitaires Saint Luc, Groupe de gestion de l'antibiothérapie, Brussels, Belgium; ** Centre hospitalier universitaire de Liège, Infectiologie, Liège, Belgium; *** Cliniques universitaires Erasme, Infectiologie, Brussels, Belgium; **** Grand hôpital de Charleroi, Infectiologie, Charleroi, Belgium
  18-4-2020 - 15:30-16:30 - Poster number: P0034 - Session title: Adverse effects of antibiotics: data from clinical trials - Session number: PS002
  
  
• Synergistic effect of an enzymatic solution with multiple classes of antibiotics against methicillin-resistant Staphylococcus aureus biofilms in an in vitro model relevant of prosthetic joint infections
  H. Poilvache, A. Ruiz-Sorribas, O. Cornu*^,**, Françoise Van Bambeke
  * Neuromusculoskelettal Laboratory, Institut de Recherche Experimentale et Clinique, Université catholique de Louvain, Brussels, Belgium; ** Orthopaedic Surgery Department, Cliniques Universitaires Saint-Luc, Brussels, Belgium
  18-4-2020 - 15:30-16:30 - Poster number: P0066 - Session title: Antibiofilm strategies - Session number: PS004
  
  
• Evaluation of total and free temocillin penetration into cerebrospinal fluid in critically ill patients suspected of cerebral ventriculitis using a validated HPLC/MS-MS method: a pilot study
  P. Ngougni Pokem, X. Wittebole*, A. Verroken**, Arnaud Capron***, S. Asta***, P.M. Tulkens, P. Wallemacq***, F. Vn Bambeke, P.F. Laterre*
  * Department of Critical Care Medicine, Cliniques Universitaires St. Luc, Université catholique de Louvain, Brussels, Belgium; ** Department of Microbiology, Cliniques Universitaires Saint-Luc - Université Catholique de Louvain, Brussels, Belgium; *** Clinical Chemistry Department, Cliniques Universitaires St. Luc, Université catholique de Louvain, Brussels, Belgium
  19-4-2020 -13:30-14:30 - Arena 4 - Session type: Mini-oral ePoster Session - Session name: Is your drug where it should be? Target-site pharmacokinetics
  
  
• Administration of ceftazidime to patients undergoing haemodialysis: are trough levels consistently above the EUCAST breakpoints for Enterobacterales and Pseudomonas ?
  A. Tamigniau*, D. Govaerts*, B. Guillaume*, S. Treille*, S. Cherifi*, C. Lelubre*, I.K. Delattre, P.M. Tulkens, R. Demeester*
  * University Hospital of Charleroi, Lodelinsart, Belgium
  20-4-2020 - 11:00-12:00 - Arena 4 - Session type: Mini-oral ePoster Session - Session name: From new TDM technology to optimised dosing
  
  
• The polyamino-isoprenyl compound NV716 re-sensitises old disused antibiotics against Pseudomonas aeruginosa by inhibiting efflux and disturbing outer membrane permeability
  G. Wang, Jean-Michel Brunel*, Paul M. Tulkens, Jean-Michel Bolla*, F. Van Bambeke
  * Aix-Marseille Université, Marseille, France
  21-4-2020 - 12:30-13:30 - Poster number: P4230 - Session title: Overcoming infections caused by non-fermenters - Session number: PS162
  
  
• Pharmacodynamics of common antibiotics against uropathogenic Escherichia coli revealed significant antibiotic tolerance and persistence of intracellular bacteria
  I. Kerkez*, M. Putrins*, P.M. Tulkens, T. Tenson*, Françoise Van Bambeke
  * Institute of Technology, University of Tartu, Tartu, Estonia.
  21-4-2020 - 12:30-13:30 - Poster number: P3467 - Session title: PK/PD studies and applications - Session number: PS164
  
  
• Undescribed target mutations conferring high level resistance to ciprofloxacin in Achromobacter xylosoxidans collected from patients with cystic fibrosis
  H. Chalhoub, S. Kampmeier*, H. Rodriguez-Villalobos**, P.M. Tulkens, B.C. Kahl*, F. Van Bambeke
  * Münster University Hospital and Clemenshospital, Münster, Germany; ** Cliniques Universitaires Saint-Luc, Brussels, Belgium.
  21-4-2020 - 12:30-13:30 - Poster number: P4351 - Session title: Resistance issues in special circumstances - Session number: PS166
  
  
• Undescribed resistance mechanisms to azithromycin in Achromobacter xylosoxidans collected from patients with cystic fibrosis
  H. Chalhoub, S. Kampmeier*, B.C. Kahl*, H. Rodriguez-Villalobos**, P.M. Tulkens, F. Van Bambeke
  * Münster University Hospital and Clemenshospital, Münster, Germany; ** Cliniques Universitaires Saint-Luc, Brussels, Belgium.
  21-4-2020 - 12:30-13:30 - Poster number: P4350 - Session title: Resistance issues in special circumstances - Session number: PS166

ASM Microbe 2019 (American Society of Microbiology [ASM])
San Francisco, CA (USA), 20-24 June 2019

• Combination of polymyxin B and rifampicin is synergistic against intracellular P. aeruginosa
  V. Varik, E. Drouot, G. Wang, P. M. Tulkens, F. Van Bambeke
  Poster FRIDAY- AAR810- Session Title: AAR08: New Antimicrobial Agents (pre-Phase2) and Novel Membrane Disruptors
  Presentation Date/Time: Friday, June 21, 2019: 11 am - 12 pm and 4 pm - 5 pm
  
  
• Do public campaigns and changes in antibiotic pricing affect antibiotic consumption in the community ? An example from Belgium
  P.M. Tulkens
  Poster SATURDAY-AAR667 (with Press Release) - Session Title: AAR05 - Antimicrobial Stewardship 2
  Presentation Date/Time: Saturday, June 22, 2019: 11 am - 12 pm and 4 pm - 5 pm

European Knee Society (EKS Arthroplasty Conference 2019)
         Valencia, Spain (EU), 2-3 May 2019

• Study of the effect of pulsed washing on antibiotic susceptibility of Staphylococcus aureus biofilms
  H. Poilvache, A. Ruiz-Sorribas, H. Rodriguez-Villalobos*, G. Sakoulas**, O. Cornu***, F. Van Bambeke F
  * Microbiology Department, Cliniques Universitaires Saint-Luc, Brussels, Belgium, EU; ** University of California at San Diego, School of Medicine, San Diego, CA, USA; *** Neuromusculoskeletal Laboratory, Université catholique de Louvain and Orthopaedic Surgery Department, Cliniques Universitaires Saint-Luc, Brussels, Belgium, EU.
  e-Poster

29th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)
         Amsterdam, The Netherlands (EU), 13-16 April 2019

• Study of the effect of pulsed washing on antibiotic susceptibility of Staphylococcus aureus biofilms
  H. Poilvache, A. Ruiz Sorribas, H. Rodriguez-Villalobos*, G. Sakoulas**, O. Cornu***, F. Van Bambeke
  * Microbiology Department, Cliniques Universitaires Saint-Luc, Brussels, Belgium, EU; ** Uiversity of California at San Diego School of Medicine, San Diego, CA, USA; *** Neuromusculoskeletal Laboratory, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain and Orthopaedic Surgery and Traumatology Department, Cliniques Universitaires Saint-Luc, Brussels, Belgium, EU.
  Poster P0568 - Session "Biofilm susceptibility" - 13/04/2019 - 15:30h - 16:30h - Paper Poster Area

• Role of efflux pumps on the antimicrobial activity of representative penicillins, aminoglycosides and macrolides against laboratory strains of Achromobacter insuavis and clinical isolates of Achromobacter xylosoxidans from patients with cystic fibrosis
  H. Chalhoub, B.C. Kahl*, P.M. Tulkens, F. Van Bambeke
  * University Hospital Munster, Germany, EU
  Poster P0897 - Session "Infection due to Pseudomonas aeruginosa and other non-fermenters - many challenges" - 14/04/2019 - 12:30h - 13:30h - Paper Poster Area
  
  
• Activity of finafloxacin, ciprofloxacin, and imipenem against intracellular Burkholderia thailandensis, Yersinia pseudotuberculosis, and Francisella philomirargia in media at neutral and acidic pH
  H. Chalhoub, Sarah V. Harding*, P.M. Tulkens, F. Van Bambeke
  * CBR Division, Defence Science and Technology Laboratory, Porton Down, Salisbury, United Kingdom
  Poster P1987 - Session "Evaluation of diverse antimicrobials in in vitro and experimental models" - 15/04/2019 - 13:30h - 14:30h - Paper Poster Area
  
  
• Population pharmacokinetics of unbound temocillin in paediatric patients requiring antibiotic prophylaxis following hepatic transplantation
  P. Ngougni Pokem, I.K. Delattre, X. Stéphenne*, D. Van der Linden*, C. Mark, A. Capron*, P.M. Tulkens, P. Wallemacq*, E. Sokal*, F. Van Bambeke
  * Cliniques Universitaires St. Luc, Université catholique de Louvain, Brussels, Belgium, EU.
  Poster P1957 - Session "Current issues in clinical pharmacokinetics" - 15/04/2019 - 13:30h - 14:30h - Paper Poster Area
  
  
• The polyamino-isoprenic efflux inhibitor NV716 revives old disused antibiotics against intracellular forms of infection by Pseudomonas aeruginosa
  G. Wang, J.-M. Brunel*, P.M. Tulkens, J.-M. Bolla*, F. Van Bambeke
  * Aix-Marseille Université, Marseille, France, EU
  Poster P1988 - Session "Evaluation of diverse antimicrobials in in vitro and experimental models" - 15/04/2019 - 13:30h - 14:30h - Paper Poster Area
  
  
• Determination of optimal loading and maintenance doses for continuous infusion of vancomycin in critically ill patients: population pharmacokinetic modelling and simulation
  D.H. Vu*, D.A. Tran*, I.K. Delattre, T.T. Ho*, T.H.G. Do**, H.N. Pham**, X.C. Dao**, N.T. Tran**, G.B. Nguyen**, F. Van Bambeke, P.M. Tulkens, H.A. Nguyen*
  * Hanoi University of Pharmacy, Hanoi, Vietnam; ** Bach Mai Hospital, Hanoi, Vietnam
  Oral presentation O1160 - Session "PK/PD to guide dosing in special populations" - 16/04/2019 - 13:30h - 13:40h - Hall L
  
  
• Biofilm removal by enzymatic or non-enzymatic cleaners in an in vitro model mimicking biofilms formed on dry clinical surfaces
  W. Siala*, F. Van Bambeke, T. Vanzieleghem*
  *OneLIFE SA, Louvain-la-Neuve, Belgium, EU
  Oral presentation - Session "Strategies for testing and destroying biofilm" - 16/04/2019 - 15:18h - 15:28h - Hall I
  
  

See also the Invited Lectures given during this meeting:

• Activity of Drug Combinations against Staphylococcal Biofilms (14 April 2019; Symposium "Thinking out of the box to beat biofilms")
• Epidemiology, Risk Factors, and Comorbidities Associated With MRSA Infections (15 April 2019; MSD Integrated Symposium Walking a fine line to meet the clinical realities")

49th International Detergency Conference (IDC)
Dusseldorf, Germany (EU), 9-11 April 2019

• Simulated reprocessing model for flexible endoscopes: assessment of routine cleaning to prevent accumulation of build-up biofilm
  W. Siala, M. Delmée*, F. Van Bambeke
  * Institut de Recherche Experimentale et Clinique, UCLouvain
  Oral presentation - 9th Colloquium “Medical Instruments” - Session "Reprocessing of thermo-labile endoscopes" - 10/04/2019

ISoP 2018 (International Society of Pharmacovigilance 18th Annual Meeting)
Geneva, Switzerland, 11-14 November 2018

• Is the risk of linezolid to cause serotonin syndrome real in routine clinical practice ?
  H. Thirot, X. Holemans¹, F. Jacobs², C. Briquet³, F. Frippiat⁴, A. Spinewine, F. Van Bambeke, P.M. Tulkens
  1 Grand hôpital de Charleroi, Infectiologie, Charleroi, Belgium; 2 Cliniques universitaires de Bruxelles (Hôpital Erasme), Infectiologie, Brussels, Belgium; 3 Cliniques universitaires Saint Luc, Groupe de gestion de l'antibiothérapie, Brussels, Belgium; 4 Centre hospitalier universitaire de Liège, Infectiologie, Liège, Belgium
  Poster présentation: Monday, November 12, 2018
  Poster board Number: 17

IDweek 2018 (Infectious Diseases Society of America [ISA])
San Francisco, CA (USA), 3-7 October 2018

• Review of linezolid use and onset of toxicity in 4 Belgian hospital centers: a retrospective study
  H. Thirot, C. Briquet¹, F. Frippiat², F. Jacobs³, X. Holemans⁴, P.M. Tulkens, A. Spinewine, F. Van Bambeke
  1 Cliniques universitaires Saint Luc, Groupe de gestion de l'antibiothérapie, Brussels, Belgium; 2 Centre hospitalier universitaire de Liège, Infectiologie, Liège, Belgium; 3 Cliniques universitaires Erasme, Infectiologie, Brussels, Belgium; 4 Grand hôpital de Charleroi, Infectiologie, Charleroi, Belgium
  Poster presentation: Saturday, October 6, 2018 12:30 PM - 1:45 PM - Session: Treatment of AMR Infections
  Poster board Number: 2434

ASM Microbe 2018 (American Society of Microbiology [ASM])
Atlanta, GA (USA), 7-11 June 2018

• Activity of moxifloxacin against Staphylococcus aureus in models of persistent infections (intracellular survival, biofilms)
  T.K. Nguyen, N.H. Pham*, H.A. Nguyen**, P.M. Tulkens, F. Van Bambeke
  *Department of Microbiology, Bach Mai Hospital, Ha Noi, Viet Nam; **National Drug Information and Adverse Drug Reaction Monitoring Center, Hanoi University of Pharmacy, Ha Noi, Viet Nam
  Poster Presentation: Saturday Jun 8, 2018 11:00 AM - 1:00 PM
  Poster board Number 507

BIOFILMS 8
Aarhus, Denmark (EU), 27-29 May 2018

• Correlation between biofilm removal and bacterial killing in a model mimicking disinfection of contaminated endoscopes
  W. Siala*, M. Weickmans*, G. Heynen*, F. Van Bambeke, Thomas Vanzieleghem*
  * OneLIFE SA, Louvain-la-Neuve (Belgium)
  Poster P88
  
  
• Activity of combinations of an enzymatic cocktail with tobramycin, amikacin, ciprofloxacin, moxifloxacin, vancomycin or linezolid against biofilms of clinical isolates from different ESKAPE pathogens
  W. Siala*, A. Hoche*, F. Van Bambeke, T. Vanzieleghem*
  * OneLIFE SA, Louvain-la-Neuve (Belgium)
  Poster P125

Polymyxins 2018 (3rd International Conference on Polymyxins)
Madrid, Spain (EU), 24-26 April 2018

• Requirement of very high doses of colistin in a critically-ill patient with augmented renal clearance
  D. Fage*,A. Herpain*, G. Deprez*, F. Wolff*, M. Hites*, F. Van Bambeke, F. Cotton*, F. Jacobs*
  * CUB Erasme Hospital, Université libre de Bruxelles, Brussels, Belgium
  Poster

28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)
         Madrid, Spain (EU), 21-24 April 2018

By order of date and time of presentation

• Activity of combinations of an enzymatic cocktail with tobramycin, amikacin, ciprofloxacin, moxifloxacin, vancomycin, or linezolid against biofilms of clinical isolates from different ESKAPE pathogens
  W. Siala*, A. Hoche*, F. Van Bambeke, T. Vanzieleghem*
  *OneLIFE SA, Louvain-la-Neuve, Belgium
  Oral presentation O0081 - Session: Biofilm-associated infections - treatment made easy? - 21/04/2018 - Sesion time: 11:00 - 13:00 - Presentation: 11:58 - 12:08 - Place: Hall H
  
  
• Mitochondrial metabolism impairment induced by oxazolidinones at clinically-relevant concentrations: studies with two human megakaryocytic cell lines (UT7-WT and UT7-MPL)
  T. Milosevic, P. Thomas, V.L. Payen*, G. Vertenoeil**, P. Sonveaux*, P.M. Tulkens, S. Constantinescu**, F. Van Bambeke
  *Institute of experimental and clinical research, Université catholique de Louvain, Brussels, Belgium; **Ludwig Institute for Cancer Research, Brussels Branch, Brussels, Belgium
  Poster P0146 - Session: Antibiotic toxicity: from mechanisms to clinical data - 21/04/2018
  
  
• Cellular pharmacokinetics (accumulation, subcellular distribution, efflux) of the FabI inhibitor Debio 1452 in J774 mouse macrophages
  A. Van Wessem, F. Peyrusson, G. Dieppois*, F. Van Bambeke, P.M. Tulkens
  * Debiopharm International SA, Lausanne, Switzerland
  Poster P1523 - Session: Exploring antibacterial activity with the help of pharmacology - 23/04/2018
  
  
• The putative de-N-acetylase DnpA increases intracellular and biofilm-associated persistence upon fluoroquinolone exposure in Pseudomonas aeruginosa
  S. Khandekar, V. Liebens*, M. Fauvart*, P.M. Tulkens, J. Michiels, F. Van Bambeke
  *Centre of Microbial and Plant Genetics, KULeuven, Leuven, Belgium
  Poster P1525 - Session: Exploring antibacterial activity with the help of pharmacology - 23/04/2018
  
  
• Activity of fluoroquinolones (finafloxacin, levofloxacin, ciprofloxacin) vs that of imipemen against the extracellular and intracellular forms of infections by Burkholderia thailandensis
  H. Chalhoub, S.V. Harding*, P.M. Tulkens, F. Van Bambeke
  *CBR Division, Defence Science and Technology Laboratory, Porton Down, Salisbury, United Kingdom
  Poster P1526 - Session: Exploring antibacterial activity with the help of pharmacology - 23/04/2018
  
  
• Influence of chromosomal mutations in genes encoding MtrCDE efflux, PorB1b porin, and PBP1 on susceptibility towards multiple antibiotic classes in clinical isolates of Neisseria gonorrhoeae
  C. Mark, T. Crucitti*, F. Van Bambeke
  *Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium
  Poster P1849 - Session: Resistance in Neisseria - 23/04/2018
  
  
• Protein binding of temocillin is lower in plasma from patients in intensive care units compared to healthy subjects: in vitro and in vivo studies
  P. Ngougni Pokem, P. Matzneller*, A. Capron**, P.M. Tulkens, P. Wallemacq**, M. Zeitlinger**, P.-F. Laterre***, J.W. Mouton****, F. Van Bambeke
  *Department of Clinical Pharmacology, Medical University of Vienna, Austria; **Clinical Chemistry Department, Cliniques Universitaires St. Luc, Université catholique de Louvain, Brussels, Belgium; ***Department of Critical Care Medicine, Cliniques Universitaires St. Luc, Université catholique de Louvain, Brussels, Belgium; ****Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, Rotterdam, The Netherlands
  Poster 2219 - Session: Clinical Pharmacokinetics - 24/04/2018
  
  
• Population pharmacokinetic modelling of total and unbound temocillin in the plasma of healthy volunteers after intravenous administration
  P. Ngougni Pokem, P. Matzneller*, B. Wulkersdorfer*, A. Capron**, L. Elens***, P.M. Tulkens, P. Wallemacq**, M. Zeitlinger*, F. Van Bambeke
  * Department of Clinical Pharmacology, Medical University of Vienna, Austria; **Clinical Chemistry Department, Cliniques Universitaires St. Luc, Université catholique de Louvain, Brussels, Belgium; ***Integrated PharmacoMetrics, PharmacoGenomics and PhamacoKinetics, Université catholique de Louvain, Brussels, Belgium
  Poster P2220 - Session: Clinical Pharmacokinetics - 24/04/2018
  
  
• Temocillin susceptibility testing with Vitek 2 and E-test: are these methods reliable to determine temocillin MIC ?
  J. Descy*, C. Visée**, F. Frippiat**, C. Meex*, N. Layios***, F. Van Bambeke, P. Melin*
  *Clinical Microbiology, **Infectious Diseases and ***Intensive Care, CHU of Liège, Liège, Belgium
  e-poster E0002 - Session: Antibacterial susceptibility and resistance - 21 to 24/04/2018

See also the Invited Lectures (Integrated Industry-suported Symposia) given during this meeting:
  - A new approach to the treatment of Severe Bacterial Skin Infections: Various treatments and pre-clinical profiles (21 April 2018) 
   - Contribution of new antibiotics to current and future challenges of main Gram positive infections (23 April 2018)

37ème Réunion interdisciplinaire de chimiothérapie anti-infectieuse (RICAI)
         Paris, France (EU), 18-19 décembre 2015

• Resistance and persistence in Staphylococcus aureus clinical isolates from Vietnam
  T.K. Nguyen, N.H. Pham*, H.A. Nguyen**, M.A. Argudin***, P.M. Tulkens, F. Van Bambeke
  *Microbiology Laboratory, Bach Mai Hospital, Hanoi, Vietnam; **Hanoi University of Pharmacy, Hanoi, Vietnam; ***Centre national de référence des staphylocoques, Hôpital Erasme, Université libre de Bruxelles, Brussels, Belgium
  Poster no. P-010

30th International Congress of Chemotherapy and Infection (ICC)
         Taipei, Taiwan, 24-27 November 2017

• Pharmacodynamic comparison of antibiotic activity against Pseudomonas aeruginosa in models of persistent infection (intracellular infection, biofilm)
  S. Khandekar, P.M. Tulkens, F. Van Bambeke
  Oral presentation OS-7-1 - Oral session #7
  
  
• Variations in dissolution time, coloring, and stability in concentrated solutions of original and generics of meropenem
  I.K. Delattre, F. Van Bambeke, P.M. Tulkens
  Poster no. 040
  
  
• Activity of moxifloxacin in a model of intracellular infection by Staphylococcus aureus clinical isolates from patients suffering from persistent infections in Vietnam
  T.K. Nguyen, N.H. Pham*, H.A. Nguyen**, P.M. Tulkens, F. Van Bambeke
  * Microbiology Laboratory, Bach Mai Hospital, Hanoi, Vietnam; ** Hanoi University of Pharmacy, Hanoi, Vietnam
  Poster no. 310

See also the Invited Lecture given during this conference:
- New agents for MRSA: recently released or in the pipeline (Symposium #2 MRSA: global epidemiology and treatment; 25 Nov 2017)

Eurobiofilms 2017 (5th European Congress on Microbial Biofilms; organized by the ESCMID Study Group for Biofilms)
        Amsterdam, The Netherlands (EU), 19-22 September 2017

• Activity of antibiotics against P. aeruginosa and S. aureus biofilms
  Y. Diaz Iglesias, P.M. Tulkens, F. Van Bambeke
  Poster

Euromit 2017 (10th International Meeting on Mitochondrial Pathology)
        Cologne, Germany (EU), 11-15 June 2017

• Mitochondrial alterations induced by oxazolidinone antibiotics in human cultured cells
  T. Milosevic, V.L. Payen*, P. Sonveaux*, G.G. Muccioli**, P.M. Tulkens, F. Van Bambeke
  * Institute of Experimental and Clinical Research, Université catholique de Louvain, Brussels, Belgium; ** Bioanalysis and Pharmacology of Bioactive Lipids, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium
  Poster no. 1669

ASM Microbe 2017 (American Society for Microbiology [ASM])
         New Orleans, LA (USA), 1-5 June 2017

• Comparative instabilities and release of colored products from original and generics of meropenem when prepared in concentrated solutions for prolonged infusion to patients
  I.K. Delattre, F. Van Bambeke, P.M. Tulkens
  Poster Presentation: Saturday Jun 3, 2017 12:15 PM - 2:15 PM
  Poster Board Number: 1133
  
  
• Mitochondrial metabolism impairment and ultrastructural alterations induced by linezolid and tedizolid at clinically-relevant concentrations: studies with human HL-60 promyelocytes and THP-1 monocytes
  T. Milosevic, V. Payen*, P. Sonveaux*, G. G. Muccioli**, F. Van Bambeke, P. M. Tulkens
  * Pharmacology & Therapeutics, Institute of Experimental and Clinical Research, Université catholique de Louvain, Brussels, Belgium,
  ** Bioanalysis and Pharmacology of Bioactive Lipids, Louvain Drug Reserach Institute, Université catholique de Louvain, Brussels, Belgium
  Poster Presentation: Saturday Jun 3, 2017 12:15 PM - 2:15 PM
  Poster Board Number: 1161
  
  
• Phospholipidosis and its reversal induced by solithromycin and its main animal metabolites (N-acetyl-solithromycin and des-aminophenyltriazol-hydroxy-solithromycin [CEM-214]): studies with cultured rat fibroblasts
  T.K. Nguyen, D. Das, F. Van Bambeke, P.M. Tulkens
  Poster Presentation: Sunday Jun 4, 2017 12:15 PM - 2:15 PM
  Poster Board Number: 2122

See also the Invited Lectures given during this meeting:
- The general Concepts of Pharmacokinetics (Workshop)
- Modulating Intracellular Antimicrobial Activity (Symposium: Pharmacodynamics in the intracellular space)

27th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)
         Vienna, Austria (EU), 22-25 April 2017

• Are Vitek2 system and E-test relevant and reliable for determining susceptibility to temocillin?
  C. Visée*, F. Frippiat*, J. Descy*, C. Meex*, P. Melin*, V. Mistretta*, F. Van Bambeke, N. Layios*
  * Centre hsopitalo-universitaire & Univesrité de Liège, Liège, Belgium.
  Poster P0169 (paper) - Session: MIC and disc diffusion methods revisited - 22/04/2017 -15:30 - 16:30
  
  
• Evaluation of the activity of 4 neglected and disused antibiotics towards intracellular Pseudomonas aeruginosa using a pharmacodynamic model of infected human THP-1 monocytes
  E. Drouot, P.M. Tulkens, F. Van Bambeke
  Oral presentation OS0469 - Session: A patchwork of innovative approaches in PK/PD - 23/04/2017 - 14:30 - 15:30
  
  
• Salicydene acylhydrazides and hydroxyquinolines decrease type three secretion system-dependent cytotoxicity induced by Pseudomonas aeruginosa clinical isolates
  A. Anantharajah, C. Sundin*, M.P. Mingeot-Leclercq, P.M. Tulkens, F. Van Bambeke
  * Creative Antibiotics, Umeå, Sweden
  Poster no. P0541 (paper) - Session: Microbial pathogenesis and virulence - 23/04/2017 - 12:30 - 13:30
  
  
• Analysis of the changes in antibiotic use in the community in Belgium between 2004 and 2012: comparison between defined daily doses (DDDs) and prescription numbers, position of the fluoroquinolones, and impact of public campaigns
  G. Moreau*, Michel Boutsen**, P.M. Tulkens
  * Ecole de Santé Publique, Université libre de Bruxelles, Bruxelles, Belgium; ** Service d'études, Mutualités socialistes (Solidaris), Bruxelles, Belgium
  Poster no. P1140 (paper) - Session: Outpatient antibiotic prescription measurement and surveys - 24/04/2017 - 12:30 - 13:30
  
  
• Temocillin pharmacokinetics in healthy volunteers after intravenous and subcutaneous administration
  P. Matzneller*, P. Ngougni Pokem, A. Capron**, F. Van Bambeke, M. Zeitlinger*
  *Department of Clinical Pharmacology, Medical University of Vienna, Austria; **Clinical Chemistry Department, Cliniques Universitaires St. Luc, Université catholique de Louvain, Brussels, Belgium
  Poster no. P1187 (paper) - Session PK/PD studies in humans - 24/04/2017 - 12:30 - 13:30
  
  
• Comparison of biofilm dispersion by commercially available cleaning solutions recommended for the manual cleaning of endoscopes
  W. Siala, F. Van Bambeke, T. Vanzieleghem*
  * OneLIFE S.A., Louvain-la-Neuve, Belgium
  Poster no. P1484 (paper) - Session: Disinfection and biocides - 24/04/2017 - 13:30 - 14:30

• Epithelial lining fluid penetration of temocillin administered by continuous infusion in critically ill patients with nosocomial pneumonia
  C. Visée*, N. Layios*, V. Mistretta*, N. Maes*, F. Van Bambeke, F. Frippiat*
  * Centre hsopitalo-universitaire & Université de Liège, Liège, Belgium.
  Poster EP0353 (electronic) - Oral presentation: 23/04/2017 - 13:00 - 13:05 (Session: Tissue penetration and optimized dosing in special patient populations)
  
  
• Avibactam is a substrate for Mex-AB-OprM in Pseudomonas aeruginosa
  H. Chalhoub, P.M. Tulkens, F. Van Bambeke
  Poster EP0469 (electronic) - displayed during the whole meeting
  
  
• Phenotypic and genetic characterization of successive Pseudomonas aeruginosa isolates obtained from the same cystic fibrosis patient
  C. Lozano*, J.M. Azcona-Gutiérrez**, F. Van Bambeke, Y. Saénz*
  * Area de Microbiología Molecular, Centro de Investigación Biomédica de La Rioja (CIBIR), Logroño, Spain; ** Departamento de Diagnóstico Biomédico, Laboratorio de Microbiología, Hospital San Pedro, Logroño, Spain.
  Poster EV0460 (electronic) - displayed during the whole meeting

See also the Invited Lectures given during this meeting:
  - New antibiotics: action on intracellular targets (24 April 2017)
  - Novel therapies and the role of early switch and early discharge protocols for management of MRSA infections (24 April 2017; Integrated Industry supported sympoisum)

Keystone Symposium "Mitochondria Communication"
        Taos, NM (USA), 14-18 January 2017

• Oxazolidinone antibiotics reversibly inhibit mitochondrial metabolism in human cell lines
  T. Milosevic, V.L. Payen*, P. Sonveaux*, P.M. Tulkens, F. Van Bambeke
  *Institute of Experimental and Clinical Research, Université catholique de Louvain, Brussels, Belgium
  Poster no. 2030

2016 ESCMID Conference on Antimicrobial resistance in microbial biofilms and options for treatment
        Ghent, Belgium (EU), 5-7 October 2016 (corganized by the European Study Group for Biofilms [ESGB] and the European PK/PD of Anti-Infectives Study Group [EPASG])

• A small molecule candidate for antibiotic co-therapy in the fight against persistence
  V. Defraine*, V. Liebens*, T. Swings*, R. Corbau**, A. Marchant**, P. Chaltin**^,***, F. van Bambeke, A. Anantharajah, M. Fauvart*^,**** and J. Michiels*
  * Centre of Microbial and Plant Genetics, KU Leuven, Heverlee, Belgium; ** CISTIM Leuven, Leuven, Belgium; *** Centre for Drug Design and Discovery, KU Leuven, Leuven, Belgium; **** Smart Systems and Emerging Technologies Unit, Department of Life Science Technologies, IMEC, Leuven, Belgium.
  
  
• Setting-up an in-vitro model of mature biofilm of Pseudomonas aeruginosa to evaluate the activity of antibiotics used to treat chronic lung infection in Cystic Fibrosis patients
  Y. Diaz Iglesias, M.H. Mustafa, P.M. Tulkens, F. Van Bambeke
  
  
• Activity of antibiotics in combination with clarithromycin in an in vitro model of Pseudomonas aeruginosa mature biofilm in the context of lung infection in Cystic Fibrosis patients
  M.H. Mustafa, H. Traore*, F. Vanderbist*, P.M. Tulkens, F. Van Bambeke
  * SMB laboratories, Brussels, Belgium
  
  
• Comparative study of biofilm formation, pigment production, elastase activity, motility and antimicrobial resistance among Pseudomonas aeruginosa isolates recovered from different origins
  Y. Sáenz*, E. Bassères, H. Chalhoub, A. Anantharajah, C. Casado1**, V. Estepa**, B. Rojo-Bezares*, F. Van Bambeke.
  * Área de Microbiología Molecular, Centro de Investigación Biomédica de La Rioja (CIBIR), Logroño, Spain; ** Área de Bioquímica y Biología Molecular, Universidad de La Rioja, Logroño, Spain.
  
  
• Fusidic acid combined with daptomycin is effective against Staphylococcus aureus biofilms in an in vitro dynamic model mimicking human exposure
  W. Siala, P. Fernandes*, P.M. Tulkens, F. Van Bambeke
  * Cempra Pharmaceuticals, Chapel Hill, NC, USA

3rd International Conference Pathophysiology of Staphylococci
        Tübingen, Germany (EU), 15-17 September 2016

• Comparison of the intracellular and extracellular activities of approved and novel antistaphylococcal antibiotics using a pharmacodynamic model exploring full drug concentration-responses
  F. Peyrusson, P.M. Tulkens, F. Van Bambeke
  Poster no. AR-P02 (15 June 2016)

ASM Microbe 2016 (American Society for Microbiology [ASM])
         Boston, Mass.(USA), 16-20 June 2016

• Do public campaigns decrease antibiotic prescription in the community ? Evidence from a 12-years reimbursement data survey in Belgium
  P.M. Tulkens
  Oral presentation - Session Title: Antimicrobial Stewardship I - June 17, 2016 (8:15-10:45)
  
  
• Limited maximal activity without marked loss of potency of antibiotics against intracellular forms of Staphylococcus aureus and Pseudomonas aeruginosa: an analysis with 13 bactericidal antibiotics from 7 different pharmacological classes in a pharmacodynamic model of human THP-1 infected monocytes
  F. Van Bambeke, P.M. Tulkens
  Poster SATURDAY-571 - Session 188: Microbial Adherence, Invasion and Colonization I - June 18, 2016 (12:45 - 14:45)

PAGE (Population Approach Group in Europe) 2016 (American Society for Microbiology)
         Lisbon, Portugal (EU), 7-10 June 2016

• Using modeling and simulation to design and evaluate dosing strategies for temocillin in haemodialysis patients
  AC Miranda Bastos*, SJ Vandecasteele**, A Capron***, PM Tulkens*, A Spinewine*, F Van Bambeke*
  * these authosr are also part of the Clinical Pharmacy Research Group of the Louvain Drug Research Institute
  ** Department of Nephrology and Infectious Diseases, AZ Sint-Jan Brugge-Oostende AV, Bruges, Belgium,; *** Department of Clinical Chemistry, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium
  Poster II-1

• Achieving pharmacokinetic/pharmacodynamic targets of beta-lactams in critically ill patients at first dose: can we do it with standard dosing ?
  I.K. Delattre, F.S. Taccone ¹, F. Jacobs ², T. Dugernier ³, H. Spapen ⁴, P.F. Laterre ⁵, P.E. Wallemacq ⁶, V.H. Tam ⁷, F. Van Bambeke, P.M. Tulkens
  1 Hôpital universitaire Erasme, Service des soins intensifs, Brussels, Belgium; 2 Hôpital universitaire Erasme, Service des maladies infectieuses, Brussels, Belgium; 3 Clinique St-Pierre, Service des soins intensifs, Ottignies, Belgium; 4 Universitair Ziekenhuis Brussel, Intensieve Zorgen, Brussels, Belgium; 5 Cliniques Universitaires St-Luc, Service des soins intensifs, Brussels, Belgium; 6 Université catholique de Louvain, Institut de recherche expérimentale et clinique, Brussels, Belgium; 7 University of Houston, College of Pharmacy, Houston, United States
  Oral session: PK/PD-based optimized broad-spectrum beta-lactam therapy (Sunday 10 April, 11:30 [Hall I]).
  
  
• Cooperation between active efflux and porin alteration is sufficient to confer high-level resistance to meropenem in Pseudomonas aeruginosa clinical isolates
  H. Chalhoub, Y. Sáenz*, H. Rodriguez-Villalobos**, O. Denis***, B. Kahl****, P.M. Tulkens, F. Van Bambeke
  * Centro de Investigación Biomédica de La Rioja (CIBIR), Logrono, Spain; ** Cliniques Universitaires Saint-Luc, Brussels, Belgium; *** Hôpital Erasme, Brussels, Belgium; ***University Hospital Münster, Münster, Germany
  Poster session: The complexity of antibacterial resistance mechanisms (Sunday 10 April, 13:30)
  
  
• Activity of the novel Fabl inhibitor Debio 1452 against intracellular forms of susceptible and resistant S. aureus: comparison with linezolid, vancomycin and daptomycin
  F. Peyrusson, F. Van Bambeke, P.M. Tulkens
  Poster session: New agents in clinical development against gram-positive bacteria (Monday 11 April, 13:30:00)
  
  
• Cellular pharmacokinetics of gepotidacin (GSK2140944) in human monocytes (THP-1) and murine macrophages (J774)
  F. Peyrusson, F. Van Bambeke, P.M. Tulkens
  e-Poster. Category; Mechanisms of action, preclinical data and pharmacology of antibacterial agents (displayed on all 4 congress days on ePoster stations).

• Mutations in 23S rRNA among Pseudomonas aeruginosa isolates from Cystic Fibrosis patients confer higher resistance to macrolides.
  M.H. Mustafa, S. Khandekar1, H. Traore*, F. Vanderbist*, P.M. Tulkens, F. Van Bambeke
  * SMB laboratories, Brussels, Belgium
  Poster P35

35e Réunion interdisciplinaire de chimiothérapie anti-infectieuse (RICAI)
         Paris, France (EU), 14-15 décembre 2015

• Molecular surveillance of rising fluoroquinolone resistance in non-invasive Streptococcus pneumoniae isolates in Belgium (1995-2014).
  P-J. Ceyssens*, F. Van Bambeke, S. Bertrand*, S. Damée*, S. De Craeye*, F. Fux*, W. Mattheus*, H-J. Nyssen*, E. Van Bossuyt*, Jan Verhaegen**, The Belgian S. pneumoniae Study Group*, P.M. Tulkens, R. Vanhoof*.
  *Scientific Institute of Public Health (Unit of Bacterial Diseases), Brussels, Belgium; **Laboratory of Clinical Microbiology, KULeuven, Leuven, Belgium

15th Annual meeting of the International Society of Pharmacovigilance (ISoP)
        "Cubism in Pharmacovigilance"
         Prague, Czech Republic (EU), 27th-30th October 2015

• Use and toxicities of linezolid in severely-ill patients in two teaching hospitals: a retrospective pilot study revealing a large incidence of side effects
  P. Papachristoforou, C. Briquet*, F. Jacobs**, C. Yombi***, F. Van Bambeke, P.M. Tulkens
  *Groupe de Gestion de l’Antibiothérapie, Cliniques universitaires St-Luc, Université catholique de Louvain Brussels, Belgium; **Service des maladies infectieuses, Cliniques universitaires de Bruxelles Erasme, Bruxelles, Belgium; ***Service de médecine interne, Cliniques Universitaires St-Luc, Université catholique de Louvain, Brussels, Belgium
  Poster no. 166

55th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) &
       25th International Congress of Chemotherapy (ICC)
        San Diego, CA (USA), 17-21 September 2015

• Activity of the novel bacterial type II topoisomerase inhibitor GSK2140944 against extracellular and intracellular forms of susceptible and resistant Staphyloccus aureus: comparison with moxifloxacin, ciprofloxacin, linezolid, clarithromycin and daptomycin
  F. Peyrusson, P. M. Tulkens, F. Van Bambeke
  Poster no. A029
  Poster Session Title: Pharmacokinetics/Pharmacodynamics of New Drugs in Development
  Session Day & Time: 18 Sep 2015 12:00 PM - 2:00:00 PM
  
  
• Activity of fusidic acid alone or incCombination with daptomycin,vancomycin and linezolid (compared with each of these antibiotics alone) in an in vitro dynamic model of Staphylococcus aureusbBiofilm
  W. Siala, P. Fernandes*, PM. Tulkens, F. Van Bambeke
  * Cempra Pharmaceuticals, Chapel Hill, NC, USA
  Poster no. A492
  Poster Session Title: Pharmacokinetics/Pharmacodynamics of Agents Against Gram-Positive Bacteria
  Session Day & Time: 19 Sep 2015 11:00AM - 1:00 PM
  
  
• Determining beta-lactam exposure threshold to suppress resistance development in Gram-negative bacteria
  V.H. Tam*, K.T. Chang*, J. Zhou*, K.R. Ledesma*, K. Phe*, F. Van Bambeke, A. Sánchez**, R. Cantón**
  * College of Pharmacy, University of Houston, Houston, TX, USA; ** Hospital Universitario Ramón y Cajal, Madrid, Spain
  Poster no.1170
  Poster Session Title: Pharmacokinetics/Pharmacodynamics of Agents Against Gram-Negative Bacteria
  Session Day & Time: 19 Sep 2015 11:00 AM - 1:00 PM
  
  
• Tedizolid inhibits mitochondrial metabolism and reversibly impairs Cytochrome c-oxidase expression in cultured human cells: impact of a discontinuous exposure
  T. Milosevic, V. Payen*, L. Brisson*, P. Sonveaux*, F. Van Bambeke, P. M. Tulkens
  * Pharmacology & Therapeutics, Institute of Experimental and Clinical Research, Université catholique de Louvain, Brussels, Belgium
  Poster no. A574
  Poster Session Title: Pharmacology and Toxicology of Antimicrobials
  Session Day & Time:20 Sep 2015 11:00 AM - 1:00 PM

ASM Conference on Pseudomonas 2015
      Washington, DC (USA), September 8-12, 2015

• DnpA, a putative de-N-acetylase, increases intracellular persistence upon fluoroquinolone exposure in Pseudomonas aeruginosa
  S. Khandekar, V. Liebens*, M. Fauvart*, P. M. Tulkens, J. Michiels*, F. Van Bambeke
  *Centre of Microbial and Plant Genetics, KU Leuven, Leuven, Belgium

Gordon Research Conference: Microbial Adhesion & Signal Transduction
(The Forefront of Microbial Communication, Colonization and Pathogenesis Research)
        Newport, RI (USA), July 26-31, 2015

• The virulence inhibitor INP1855 impairs pathogenicity of Pseudomonas aeruginosa and inflammasome activation in vitro and in vivo
  A. Anantharajah1, E. Faure*, J.M. Buyck, C. Sundin**, T. Lindmark**, P.M.Tulkens, M.P. Mingeot-Leclercq, B. Guery*, F. Van Bambeke
  * EA7366, Host-Pathogen Translational Research Group, Université Droit et Santé de Lille, Faculté de Médecine, CHRU Lille, France; ** Creative Antibiotics, Umea, Sweden

40th Congress of the Federation of European Biochemical Societies (FEBS)
The biochemical basis of life
        Berlin, Germany (EU), 4-9 July, 2015

• Effect of 3’,6-diNonylneamine, an amphiphilic aminoglycoside derivative, on Pseudomonas aeruginosa shape and membrane integrity
  El Khoury M. Van der Smissen P.*, Collet J.-F.** Zimmermann L.***, Décout J.-L.***, Mingeot-Leclercq M.-P.
  * Cellular Biology, de Duve Institute, Université catholique de Louvain, Brussels, Belgium; ** Biochemistry and Metabolic Research, de Duve Institute, Université catholique de Louvain, Brussels, Belgium; *** Département de Pharmacochimie Moléculaire [ICMG FR 2607] and I/CNRS, UMR 5063, Université de Grenoble, Grenoble, France
  

4th European Congress on Microbial Biofilms – Basic and Clinical Aspects
        Brno, Czech Republic (EU), 23-26 June, 2015

• The antifungal caspofungin increases moxifloxacin activity against Staphylococcus aureus biofilms in vitro or in a mice subcutaneous model
  W Siala, S Kucharíková*, PM Tulkens, P Van Dijck*, F Van Bambeke
  * Vlaamse Instituut voor Biotechnologie (VIB) and KULeuven, Leuven, Belgium

24th Meeting of the Population Approach Group Europe (PAGE)
         Hersonissos, Crete, Greece (EU) - 2-5 June 2015

• A joint population pharmacokinetic model of total and unbound temocillin serum concentrations in haemodialysis patients
  AC Miranda Bastos*, SJ Vandecasteele**, A Capron***, PM Tulkens*, A Spinewine*, F Van Bambeke*
  * see also Center for Clinical Pharmacy and Clinical Pharmacy group; ** Department of Nephrology and Infectious Diseases, AZ Sint-Jan Brugge-Oostende AV, Bruges, Belgium; *** Department of Clinical Chemistry, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium
  

25th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)
         Copenhagen, Denmark (EU), 25-28 April 2015

• Temocillin is not substrate for OprD2 porin from Pseudomonas aeruginosa
  H. Chalhoub, M. Winterhalter*, D. Pletzer*, Y. Braun*, H. Weingart*, P.M. Tulkens, F. Van Bambeke
  * Biophysics, School of Engineering and Science, Jacobs University Bremen, Germany.
  Poster P0306 - Sunday, 26 April 2015 - Session: P16 Focus: Acinetobacter, Pseudomonas and other nonfermenters
  
  
• DnpA, a putative de-N-acetylase involved in Pseudomonas aeruginosa persistence, reduces ciprofloxacin activity in an in vitro model of intracellular infection.
  S. Khandekar, V. Liebens*, M. Fauvart*, P.M. Tulkens, Jan Michiels*, F. Van Bambeke
  *Centre of Microbial and Plant Genetics, KULeuven, Leuven; Belgium
  Poster P0317 - Sunday, 26 April 2015 - Session: P16 Focus: Acinetobacter, Pseudomonas and other nonfermenters
  
  
• Mutations in 23S rRNA among Pseudomonas aeruginosa isolates from Cystic Fibrosis patients confer higher resistance to macrolides
  M-H. Mustafa, J. Buyck, S. Khandekar, H. Traore*, F. Vanderbist*, P.M. Tulkens, F. Van Bambeke1
  * SMB laboratories, Brussels, Belgium
  Poster P0313 - Sunday, 26 April 2015 - Session: P16 Focus: Acinetobacter, Pseudomonas and other nonfermenters
  
  
• Activity of fusidic acid alone or in combination with daptomycin, vancomycin, or linezolid in an in vitromodel of Staphylococcus aureus biofilm
  W. Siala, H. Rodriguez-Villalobos*, P. Fernandes**, P.M. Tulkens, F. Van Bambeke
  * Laboratoire de microbiologie, Cliniques Universitaires Saint Luc, Université Catholique de Louvain, Brussels, Belgium; ** Cempra Pharmaceuticals, Chapel Hill, NC, USA
  e-poster EV0056 - Session: EV02 Antimicrobials: antimicrobial PK/PD, pharmacogenomics, pharmacoeconomics and general pharmacology, drug interaction studies
  
  
• In vitro susceptibility of S. pneumoniae to solithromycin in collections with an elevated proportion of isolates resistant to levofloxacin and moxifloxacin
  P.M. Tulkens, F. Van Bambeke, N. Vandevelde, R. Vanhoof *, M. van der Linden**
  * Scientific Institute of Public Health, Brussels, Belgium; * German Reference Centre for Streptococci, Institute of Medical Microbiology, University Hospital RWTH Aachen, Germany.
  e-poster EV0153 - Session: EV04 Antimicrobials: in vitro antibacterial susceptibility
  
  
• Therapeutic beta-lactam Antibiotics Monitoring for Stratified Treatment of Hospital-acquired Pneumonia, Improved Dose-dependent Efficacy, Decreased Treatment Duration, and Prevention of Emergence of Resistance
  European Network Corner (presented during the whole meeting)
  

See also the Lecture given during this meeting (Drug pipeline for Gram-positive bacteria)

2015 JMP Discovery Summit: Exploring Data - Inspiring Innovation
        Brussles, Belgium (EU), 23-25 March 2015

• Use of contour interval analysis in antimicrobial susceptibility studies (this poster has 2 pages; you need to scroll down to see them both)
  H. Chalhoub, F. Van Bambeke, P.M. Tulkens
  E-poster (presented during the whole meeting)
  

ESCMID (European Society of Clinical Microbiology and Infectious Diseases) conference on reviving old antibiotics
         Vienna, Austria, 22-24 October 2014

• Clinical pharmacokinetics of temocillin in patients with end stage renal disease undergoing haemodialysis
  A.C. Miranda Bastos, A. Capron*, P.M. Tulkens, A. Spinewine**, F. Van Bambeke, S.J. Vandecasteele***
  *Department of Clinical Chemistry, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium;
  **Clinical Pharmacy Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium;
  ***Department of Nephrology and Infectious Diseases, AZ Sint-Jan Brugge-Oostende AV, Bruges, Belgium
  
  
• Comparative in vitro activity of temocillin and other beta-lactams against Pseudomonas aeruginosa isolated from cystic fibrosis patients
  H. Chalhoub, J.M. Buyck, M. Tunney(1), J.S. Elborn(1), A. Vergison(2), O. Denis(3), P. Plésiat(4), B.C. Kahl(5), P.M. Tulkens & F. Van Bambeke
  (1)Cystic Fibrosis & airways Microbiology Research Group, Queen’s University Belfast, Belfast, United Kingdom;
  (2)Unité des maladies infectieuses, Hôpital Universitaire des Enfants Reine Fabiola, Brussels, Belgium;
  (3)Laboratoire de microbiologie, Hôpital Erasme, Brussels, Belgium;
  (4)Laboratoire de bactériologie, Hôpital Jean Minjoz, Besançon, France;
  (5)Medical Microbiology, University Hospital Münster, Münster, Germany.
  

See also the plenary lecture given during this conference (F. Van Bambeke): Optimisation of therapy in Gram-negative infections: TEMOCILLIN

ESCMID (European Society of Clinical Microbiology and Infectious Diseases) Study Group for Biofilms:
Biofilm-based health associated infections: from microbiology to clinics
         Rome, Italy, 9-10 October 2014

• Detection of a matrix disassembly phenomenon improving the antibiotic killing activity towards very mature S. pneumoniae in vitro biofilms.
  Y. Diaz Iglesias, F. Van Bambeke and N. M. Vandevelde
  Poster P24
  

54th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
        Washington, DC, 5-9 September 2014

• Targeting Type Three Secretion System (T3SS) in P. aeruginosa with the inhibitor INP1855 reduces toxin and inflammasome-dependent virulence in vitro and in vivo
  A. Anantharajah, E. Faure*, J. M. Buyck, Y. Glupczynski, C. Sundin**, T. Lindmark***, P. M. Tulkens, M-P. Mingeot-Leclercq, B. Guery*, F. Van Bambeke
  *Université de Lille-2, Lille, France; **Umea University, Umea, Sweden; ***Swedenbio, Stockholm, Sweden
  Session: Gram-Negative and Unusual Organisms, Biofilms and Toxins - Poster B-059
  Saturday, Sep 06 2014, 12:00 PM - 2:00 PM
  
  
• Antibiotic activity against Pseudomonas aeruginosa with normal or mucoid phenotypes in an artificial sputum medium in vitro biofilm model
  E. Bassères, P. M. Tulkens, F. Van Bambeke
  Session: Pharmacokinetics/Pharmacodynamics of Anti-Infective Agents - Poster A-052
  Saturday, Sep 06, 2014, 12:00 PM - 2:00 PM
  
  
• Caspofungin, colistin and polymyxin B enhance moxifloxacin activity against Staphylococcus aureus biofilms by disturbing matrix exopolysaccharides
  W. Siala, M-P. Mingeot-Leclercq, P.M. Tulkens, F. Van Bambeke
  Session: Pharmacokinetics/Pharmacodynamics of Anti-Infective Agents - Poster A-053
  Saturday, Sep 06, 2014, 12:00 PM - 2:00 PM
  
  
• Accumulation, release, and subcellular distribution of the peptide deformylase inhibitor GSK1322322 in murine macrophages (J774) and human monocytes (THP-1)
  F. Peyrusson, G. Huys, F. Van Bambeke, D. Butler*, P. M. Tulkens
  *GSK, Collegeville, PA
  Session: Clinical Pharmacology of Anti-Infective Agents in Clinical Development - Poster A-686
  Sunday, Sep 07, 2014, 11:00 AM - 1:00 PM
  

• Activity and resistance to temocillin in Pseudomonas aeruginosa isolated from cystic fibrosis patients
  H Chalhoub, M Winterhalter*, PM Tulkens, F Van Bambeke
  * Biophysics, School of Engineering and Science, Jacobs University, Bremen, Germany.
  

Drug Analysis 2014 - 10th International Symposium on Drug Analysis & 25th International Symposium on Pharmaceutical and Biomedical Analysis
       Liege, Belgium - June 22-25, 20144

• Temocillin quantification in human serum using a high performance liquid chromatography-tandem mass spectrometry
  P. Ngougni Pokem, A.C. Miranda Bastos*, P.M. Tulkens, F. Van Bambeke, A. Capron**
  * also member of the Clinical Pharmacy Research Group; ** Department of Clinical Chemistry, Cliniques universitaires St-Luc, Brussels, Belgium
  
  
• Development and validation of a HPLC assay for the determination of temocillin in serum of haemodialysis patients
  AC Miranda.Bastos*, S.Vandecasteele**, P.M.Tulkens, A. Spinewine*, F. Van Bambeke
  * also member of the Clinical Pharmacy Research Group; ** Department Nephrology and Infectious Diseases, AZ Sint-Jan Brugge-Oostende a.v., Bruges, Belgium
  

23d meeting of the Population Approach Group in Europe (PAGE)
        Alicante, Spain, 10-13 June 2014

• Modeling and simulation of temocillin in patients with end stage renal disease undergoing haemodialysis
  AC Miranda Bastos, SJ Vandecasteele *, A Capron **, PM Tulkens, A Spinewine, F Van Bambeke
  * AZ Sint-Jan Brugge-Oostende AV, Bruges, Belgium; * Department of Clinical Chemistry, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium.
  Poster no. 3184 - Ana Miranda Bastos has received a received a "Pharsight Student sponsorship" grant (see Special events

24th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)
         Barcelona, Spain, 10-13 May 2014

• Cytotoxicity is correlated with Type Three Secretion System expression and inflammasome activation but not with motility in clinical isolates of Pseudomonas aeruginosa from acute infections
  A. Anantharajah, J.M. Buyck, Y. Glupczynski*, M.P. Mingeot-Leclercq, P.M. Tulkens, F. Van Bambeke
  * Laboratoire de microbiologie, CHU Mont-Godinne Dinant, Yvoir, Belgium
  Poster P0174 (10 May 2014 - 15:30- 16:30 PM) - session: Basic science: pathogenesis of Gram-negative bacteria
  

• Can efflux confer high level resistance to meropenem in Pseudomonas aeruginosa clinical isolates ?
  H. Chalhoub, H. Rodriguez-Villalobos ⁽¹⁾, A. Vergison ⁽²⁾, O. Denis ⁽³⁾, B. Kahl ⁽⁴⁾, P.M. Tulkens, F. Van Bambeke.
  (1) Laboratoire de microbiologie, Cliniques universitaires St-Luc, Bruxelles, Belgium; (2) Hôpital Erasme, Université libre de Bruxelles, Bruxelles, Belgium; (3) Laboratoire de microbiologie, Hôpital Erasme, Bruxelles, Belgium; (4) Medical Microbiology, University Hospital Münster, Münster, Germany.
  Poster P1122 (12 May 2014 - 12:30-13:30) - session: Pseudomonas sp. and Burkholderia sp.: knowing the mechanics of resistance

• Antibiotic resistance in a collection of Pseudomonas aeruginosa isolated from Cystic Fibrosis patients through Europe (Belgium, France, Germany and United Kingdom)
  M-H. Mustafa, H. Chalhoub, M. Tunney ⁽¹⁾, S. Elborn ⁽¹⁾, A. Vergison ⁽²⁾, O. Denis ⁽²⁾, P. Plésiat ⁽³⁾, B. C. Kahl (4), H. Traore ⁽⁵⁾, F. Vanderbist ⁽⁵⁾, J.M. Buyck, P.M. Tulkens, F. Van Bambeke
  (1) The Queen's University of Belfast, UK; (2) Hôpital Erasme, Brussels, Belgium; (3) Hôpital Jean Minjoz, Besançon, France; (4) University Hospital Münster, Münster, Germany; (5) SMB laboratories, Brussels, Belgium
  Poster P1077 (12 May 2014 - 12:30-13:30) - session: Resistance surveillance in Gram-negatives.
  

• Comparative in vitro activity of ceftazidime and ceftazidime-avibactam in a european collection of Pseudomonas aeruginosa from cystic fibrosis patients
  H. Chalhoub, M. Tunney ⁽¹⁾, S. Elborn ⁽¹⁾, A. Vergison ⁽²⁾, O. Denis ⁽³⁾, P. Plésiat ⁽⁴⁾, B.C. Kahl ⁽⁵⁾, F. Van Bambeke, P.M. Tulkens.
  (1) CF & airways Microbiology Research Group, Queen's University Belfast, Belfast, United Kingdom; (2) Unité des maladies infectieuses, Hôpital Universitaire des Enfants Reine Fabiola, Bruxelles, Belgium; (3) Laboratoire de microbiologie, Hôpital Erasme, Bruxelles, Belgium; (4) Laboratoire de bactériologie, Hôpital Jean Minjoz, Besançon, France; (5) Medical Microbiology, University Hospital Münster, Mûnster, Germany
  e-poster eP440

• Activity of the peptide deformylase inhibitor GSK1322322 against intracellular forms of susceptible and resistant S. aureus: comparison with azithromycin, clindamycin, linezolid, vancomycin, daptomycin, and moxifloxacin
  F. Peyrusson, P.M. Tulkens, F. Van Bambeke
  e-poster eP185 (oral presentaation: 12 May 12014)

• Setting up a NADH oxidase-based assay to quantify antibiotic activity in pneumococcal planktonic cultures and biofilms
  N.M. Vandevelde, Y. Diaz Iglesias, P.M. Tulkens and F. Van Bambeke
  e-poster eP288
  

• New approaches to antibiotic therapy in Gram-positive infections (P.M. Tulkens) - Session: Perspectives on the evolution and dissemination of MRSA: a global challenge (10 May 2014 - 13:30-15:30)
• In vitro models for the study of antibiotic PK/PD in biofilms (F. Van Bambeke) - Session: Exploring and treating biofilms (11 May 2014 - 09:00-11:00)
• Susceptibility trends in pneumonia pathogens and current prescribing (P.M. Tulkens) - Session: Optimising diagnosis and appropriate antibiotic prescribing in pneumonia (12 May 2014 - 9:00- 11:00)

1st meeting of the Belgian Interdisciplinary Biofilm Research Group
        Louvain-la-Neuve, Belgium 20 December 2013   

• Activity of tobramycin in combination with clarithromycin against Pseudomonas aeruginosa biofilms in an artificial sputum medium (ASM) model.
  E. Bassères, J.M. Buyck, H. Traore,* P.M. Tulkens, F.Vanderbist,* and F.Van Bambeke.
  * SMB Laboratories; Brussels, Belgium
  (this poster was alerady presented at the 14th International Conference on Pseudomonas [Lausanne, Switzerland, 7-11 September 2013])
  
  
• Does nicotine influence the kinetics of biofilm development in reference and clinical strains of Streptococcus pneumoniae ?
  Y. Diaz Iglesias, F. Van Bambeke, N.M. Vandevelde
  
  
• Revealing moxifloxacin activity against biofilms of S. aureus isolated from persistent infections by means of polycationic and amphiphilic substances.
  W. Siala, M.P. Mingeot-Leclercq, P.M. Tulkens, and F. Van Bambeke
  (this poster was alerady presented at the 3rd European Congress on Microbial Biofilms [ Ghent, Belgium, 9-12 September 2013])
  
  
• Activity of antibiotics in models of naïve and induced biofilms of Streptococcus pneumoniae
  N.M. Vandevelde, P.M. Tulkens, F. Van Bambeke
  (oral presentation)
  

See also Conferences (2013) for a Lecture "In vitro pharmacodynamics models for the study of antibiotic activity against bacterial biofilms" (F. Van Bambeke) given during this meeting.

42nd European Society of Clinical Microbiology (ESCP) Symposium on Clinical Pharmacy
        Prague, Czech Republic, 16-18 October 2013   

• Effect of a clinical pharmacist intervention on unintentional medication discrepancies after discharge: a prospective cohort study
  C. Claeys *, C. Senterre *, J. Nève *, P.M. Tulkens **, P. Debusschere ***, A. Spinewine **
  * Faculty of Pharmacy and School of Public Health, Université Libre de Bruxelles, Brussels; ** Louvain Drug Research Institute & CHU Mont-Godinne Dinant, Université catholique de Louvain, Brussels; *** Faculté de Médecine et de Pharmacie, Université de Mons, Mons; Belgium
  
  
• Chronic obstructive pulmonary disease (COPD): severity risk factors and evaluation of medication use
  N. M. Vandevelde *, P. M. Tulkens *, I. Philippart **, N. Coppens **, H. Rodriguez-Villalobos **, J. Cadrobbi **, G. Liistro **, J.-P. d’Odemont **, A. Boel **, P. Jordens **, Y. Valcke **, H. Francart **, F. Van Bambeke *
  * Louvain Drug Research Institute, Université catholique de Louvain, Brussels and ** the follwing clinical centers: CHR Mons-Warquignies, Mons; Clinique Ste Elisabeth, Namur; Cliniques universitaires St Luc, Bruxelles; OLV Ziekenhuis, Aalst; AZ Nikolaas, St Niklaas; Belgium
  

53d Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
        Denver, C0, 10-13 September 2013

• Activity of solithromycin against S. pneumoniae clinical strains with nonsusceptibility and resistance [EUCAST interpretative criteria] to penicillin G, amoxicillin, ceftriaxone, moxifloxacin, levofloxacin and ceftaroline
  PM Tulkens, M van der Linden*, F Van Bambeke, R Vanhoof**
  * National Reference Centre for Streptococci, Aachen, Germany; ** Scientific Institute of Public Health, Brussels, Belgium
  Poster C2-201 - Session Title: Surveillance of resistance: focus on Gram-positives
  Session Day & Time: 10 Sep 2013 12:00:00 PM - 2:00:00 PM
  
  
• Activity and pharmacodynamic evaluation of avibactam-ceftazidime against extracellular and intracellular forms of ceftazidime-susceptible and ceftazidime-resistant Pseudomonas aeruginosa.
  JM Buyck, C Luyckx, F Van Bambeke, K M Krause*, WW Nichols**, PM Tulkens
  * Cerexa Inc., Oakland, CA, ** AstraZeneca Pharmaecuticals, Waltham, MA.
  Poster A1021 - Session: Beta-lactam and beta-lactamase inhibitor combinations pharmacology
  Session Day & Time: 12 Sep 2013 11:00:00 AM - 1:00:00 PM
  
  
• RX-P873, a novel protein synthesis inhibitor, accumulates in human THP-1 monocytes and is active against extracellular and intracellular Pseudomonas aeruginosa
  J M Buyck, PM Tulkens and F Van Bambeke
  Poster F638 - Session Title: Inhibition of bacterial protein synthesis
  Session Day & Time: 11 Sep 2013 11:00:00 AM - 1:00:00 PM
  
  
• Relationships between antibiotic susceptibility to beta-lactams, macrolides, and fluoroquinolones of Streptococcus pneumoniae isolated from COPD patients and their ability to produce biofilm in a chronic in vitro model
  NM Vandevelde1, Y Diaz Iglesias, PM Tulkens, H Rodriguez-Villalobos*, G Liistro*, A Boel**, K Van Vaerenbergh**, P. Jordens**, I. Philippart***, JP d’Odemont***, J Cadrobbi****, N Coppens****, F Van Bambeke
  * Cliniques universitaires St Luc, Brussels, Belgium; ** O.L.V. Ziekenhuis, Aalst, Belgium, *** CHR Mons Warquignies, Mons, Belgium, ****Clinique Ste Elisabeth, Namur, Belgium
  Poster C2-539 - Session Title: Streptococcus pneumonia: effect of vaccinations
  Session day & time: 11 Sep 2013 11:00 AM - 1:00 PM
  
  
• Activity of antibiotic combinations towards intracellular Pseudomonas aeruginosa strains with different resistance phenotypes in a model of THP-1 monocytes
  JM Buyck, PM Tulkens and F Van Bambeke
  Poster A1049 - Session Title: Pharmacokinetics/Pharmacodynamics for optmization antin-infective therapy
  Session Day & Time: 12 Sep 2013 11:00:00 AM - 1:00:00 PM
  
  
• Co-medications improve moxifloxacin ativity in models of pneumococcal naïve and induced biofilms
  NM Vandevelde, M Van Obbergh, PM Tulkens, J Verhaegen*, F Van Bambeke
  * KU-Leuven, Leuven, Belgium
  Poster A1047 - Session Title: Pharmacokinetics/pharmacodynamics for optimization of anti-Infective therapy
  Session Day & Time: 12 Sep 2013 11:00 AM - 1:00 PM

3rd European Congress on Microbial Biofilms
       Ghent, Belgium, 9-12 September 2013

• Revealing moxifloxacin activity against biofilms of S. aureus isolated from persistent infections by means of polycationic and amphiphilic substances.
  W. Siala, M.P. Mingeot-Leclercq, P.M. Tulkens, and F. Van Bambeke
  

14th International Conference on Pseudomonas
        Lausanne, Switzerland, 7-11 September 2013

• The 8-hydroxyquinoline INP1855 reduces Type Three secretion system (T3SS)-dependent virulence of Pseudomonas aeruginosa in vitro and in vivo
  A. Anantharajah, E. Faure*, J.M. Buyck, C. Sundin**, T. Lindmark**, PM.Tulkens, M.P. Mingeot-Leclercq, B. Guery* and F. Van Bambeke
  * Lille-2 University Hospital & Host-Pathogen Translational Research Group Pseudomonas aeruginosa, Lille, France; ** Creative Antibiotics, Umea, Sweden
  Poster ID 182
  
  
• Type Three Secretion System (T3SS)-mediated internalisation and cytotoxicity of Pseudomonas aeruginosa by epithelial and phagocytic cells : does inflammasome make the difference?
  A. Anantharajah, E. Faure*, J.M. Buyck, PM.Tulkens, M.P. Mingeot-Leclercq, B. Guery* and F. Van Bambeke
  * Lille-2 University Hospital & Host-Pathogen Translational Research Group Pseudomonas aeruginosa, Lille, France
  Poster ID 214
  
  
• Activity of tobramycin in combination with clarithromycin against Pseudomonas aeruginosa biofilms in an artificial sputum medium (ASM) model.
  E. Bassères, J.M. Buyck, H. Traore,* P.M. Tulkens, F.Vanderbist,* and F.Van Bambeke.
  * SMB Laboratories; Brussels, Belgium.
  Poster ID 218
  

28th International Congress on Chemotherapy and Infection (ICC)
        Yokoama, Japan, 5-8 June 2013

• Vancomycin administered by continuous infusion should be dosed according to clearance and not as patient's body weight
  This poster was also presented orally (PDF)
  P. M. Tulkens, P. Wallemacq *, H. Derendorf **
  *Institute of Experimental and Clinical Research, Université catholique de Louvain, Bruxelles, Belgium, **Department of Pharmaceutics, University of Florida, Gainesville, United States
  Poster 29 - Session: Antimicrobial pharmacokinetics, pharmacodynamics, pharmacogenomics, pharmacoeconomics and general pharmacology - Thursday 6 June 2013, 1:10 pm - 2:00 pm
  
  
• Activity of solithromycin against clinical isolates of S. pneumoniae with variable susceptibilities to conventional antibiotics
  S. Lemaire, M. van der Linden *, P. M. Tulkens
  *Institute of Medical Microbiology, University Hospital RWTH Aachen, Aachen, Germany
  Poster 105 - Session: In vitro antibacterial susceptibility and drug interaction studies - Thursday 6 June 2013, 1:10 pm - 2:00 pm
  
  
• Comparing susceptibility profiles of antibiotics by contour interval analysis: ceftaroline and Belgian S. pneumoniae and MRSA isolates
  P. M. Tulkens, S. Lemaire
  Poster 106 - Session: In vitro antibacterial susceptibility and drug interaction studies - Thursday 6 June 2013, 1:10 pm - 2:00 pm
  
  
• Cell safety and subcellular distribution of the oxazolidinone tedizolid in murine J774 and human THP-1 macrophages
  D. Das, A. Lambert, P. M. Tulkens, G. G. Muccioli, F. Van Bambeke
  Poster 114 - Session: New antimicrobials - Thursday 6 June 2013, 1:10 pm - 2:00 pm
  This poster was also presented at the 17th Annual MAD-ID (Making a Difference in Infectious Diseases Pharmacotherapy) Meeting
  held in Orlando, Florida, May 29-31, 2014.(see updated PDF)
  

23d European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)
        Berlin, Germany, 27-30 April 2013

• Catalase activity in Staphylococcus aureus is associated with increased susceptibility to hydrogen peroxide killing and to decreased intracellular growth.
  S. Lemaire, R. Leclercq*, B. Kahl**, F. Van Bambeke, PM. Tulkens
  * Service de Microbiologie, Université de Caen Basse-Normandie, Caen, France; ** Institüt fur Medizinische Mikrobiologie, Universitaetsklinikum Münster, Münster, Germany.
  Oral presentation O175 - Session " Virulence and pathogenesis of Staphylococcus aureus infections - Saturday, 27 April 2013, 16:30, Hall A
  .
• Dissociation of minimum inhibitory concentration distributions of ceftaroline and amoxicillin in a clinical collection of Streptococcus pneumoniae from respiratory tract infection isolates with reduced susceptibility to amoxicillin
  S. Lemaire, M. van der Linden*, P.M. Tulkens
  * National Reference Centre for Streptococci, Institute of Medical Microbiology, University Hospital, Aachen, Germany.
  Poster P1614 - Session "Susceptibility testing and breakpoints of new drugs" - Sunday, 28 April 2013, 13:30-14:30.
  
  
• Activities of amoxicillin, clarithromycin and moxifloxacin towards intracellular forms of Streptococcus pneumoniae with increasing minimum inhibitory concentrations (MICs): attempt at defining an intracellular susceptibility breakpoint
  S. Lemaire, M. van der Linden*, F. Van Bambeke, P.M. Tulkens
  * National Reference Centre for Streptococci, Institute of Medical Microbiology, University Hospital, Aachen, Germany.
  Oral presentation O608 - Session "Need to attain the target – dosing regimen in special situations" - Tuesday, 30 April 2013, 11:30, Hall 7.

Réunion annuelle de l'Association francophone des pharmaciens hospitaliers de Belgique (AFPHB)
        La Hulpe, Belgium, 2 March 2013

• Assessment of the suitability and usefulness of a new antibiotic in Belgium in the absence of local clinical data using pharmacokinetics/ pharmacocodynamics: an example with ceftaroline
  S. Lemaire, PM Tulkens
  Poster presentation
  .
• Stability and compatibility of vancomycin for administration by continuous infusion
  V. Raverdt, E. Ampe, JD Hecq, P.M. Tulkens
  Poster presentation
  
  
• Vancomycin administered by continuous infusion should be dosed according to clearance and not according to patient's body weight
  E. Ampe, P.M.. Tulkens, P. Wallemacq*, H. Derendorf**
  * Institute of Experimental and Clinical Research, Université catholique de Louvain, Bruxelles, Belgium; ** Department of Pharmaceutics, University of Florida, Gainesville, FL.
  Poster presentation
  

2d International Conference on Antimicrobial Research      
        Lisbon, Portugal, 21-23 November 2012

• INPs (inhibitors of the type III secretion system) reduce virulence of Pseudomonas aeruginosa towards A549 alveolar epithelial cells
  A. Anantharajah, J.M Buyck, E. Faure; G. de Laminne de Bex; M.P. Mingeot-Leclercq; PM.Tulkens; B. Guery; F. Van Bambeke
  abstract 564 - session "Susceptibility and resistance - mechanisms of action - new targets"
  

• Pharmacological effects of tobramycin/macrolides combination on extracellular and intracellular infection by Pseudomonas aeruginosa
  J.M. Buyck; H. Traore; F. Vanderbist; P.M. Tulkens; F. Van Bambeke
  abstract 565 - session "Susceptibility and resistance - mechanisms of action - new targets"

12th Annual meeting of the International Society of Pharmacovigilance (ISoP): "New Landscapes for Pharmacovigilance"
         Cancun, Mexico, 30 October - 2 November 2012 

• Communicating Comprehensive Safety Data Gained from Clinical Trials to the Scientific Community: Opportunities and Difficulties from an Example with Moxifloxacin
  P.M. Tulkens, P. Arvis*, F. Kruesmann**
  * Bayer Santé SAS, Loo, France; ** Bayer Pharma AG, Wuppertal, Germany
  Abstract no. 231 - Oral presentation

• Activity of macrolides and fluoroquinolones in models of naive and induced biofilms of Streptococcus pneumoniae.
  N. Vandevelde, P. M. Tulkens, F. Van Bambeke
  Poster
  
  
• Quantitative and qualitative assessment of antibiotic activity against Staphylococcus aureus biofilm.
  W. Siala, M. P. Mingeot-Leclercq, P. M. Tulkens, F. Van Bambeke
  Poster

52d Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
        San Francisco, CA, 9-12 September 2012

See also conferences (2012) for Lectures given during this meeting:

• Plenary lecture: Hepatic toxicity of antibiotics [P.M. Tulkens]
• Meet the expertpresentation: Intra- and extracellular activity of antibiotics [F. Van Bambeke]

• Menadione-dependent Small-colony Variants of MRSA Are Hypersusceptible to beta-lactams Intracellularly Due to Cooperation Between Vacuolar Acidic pH and Oxidant Species
  L.G. Garcia, S. Lemaire, B. C. Kahl*, K. Becker*, R.A. Proctor**, P.M. Tulkens, F. Van Bambeke
  * Univ. Clinics Muenster, Muenster, Germany; ** Univ. Wisconsin Med. School, Madison, WI
  Poster A-596 - Session Title: Glycopeptides and Lipopeptides: What's New in PK/PD and Safety
  Session Day & Time: 10 September /2012 11:15:00 AM - 1:15:00 PM
  
  
• Activity of Antibiotics against a Normal Phenotype MRSA and its menD and hemB Mutants on Models of Bronchial Epithelial Cells Expressing Wild-Type, F508del or no CFTR
  L.G. Garcia, B. C. Kahl*, K. Becker*, R.A. Proctor**, O. Denis***, P.M. Tulkens, F. Van Bambeke
  * Univ. Clinics Muenster, Muenster, Germany; **Univ. Wisconsin Med. School, Madison, WI; *** Univ. libre de Bruxelles, Brussels, Belgium
  Poster A-597 - Session Title: Glycopeptides and Lipopeptides: What's New in PK/PD and Safety
  Session Day & Time: 10 September /2012 11:15:00 AM - 1:15:00 PM
  
  

• Activity of Anti-Staphylococcal Antibiotics in an in-vitro Model of Biofilm Using Clinical Isolates of S. aureus
  J. Bauer, M. Hallin*, O. Denis*, P.M. Tulkens, F. Van Bambeke
  * Université libre de Bruxelles, Brussels, Belgium
  Poster A-598 - Session Title: Glycopeptides and Lipopeptides: What's New in PK/PD and Safety
  Session Day & Time: 10 September 2012 11:15:00 AM - 1:15:00 PM

• Influence of Oxidant Stress on the Activity of Antibiotics against the Extracellular and Intracellular (THP-1 cells) Forms of S. aureus and its Small Colony Variants (SCV) Mutants
  L.G. Garcia, S. Lemaire, B. C. Kahl*, K. Becker*, R.A. Proctor**, P.M. Tulkens, F. Van Bambeke
  * Univ. Clinics Muenster, Muenster, Germany; **Univ. Wisconsin Med. School, Madison,WI
  Poster A-599 - Session Title: Glycopeptides and Lipopeptides: What's New in PK/PD and Safety
  Session Day & Time: 10 September 2012 11:15:00 AM - 1:15:00 PM
  

• Study of the Cellular Uptake and Subcellular Distribution of the Oxazolidinone Tedizolid (TZD) in Murine J774 Macrophages: Lack of Association with Mitochondria
  D. Das, A. Lambert, P.M.. Tulkens, G.G. Muccioli*, F. Van Bambeke
  * Bioanalysis and Pharmacology of Bioactive Lipids, Université catholique de Louvain, Brussels, Belgium
  Poster A-1291 - Session Title: Pharmacokinetics/Pharmacodynamics of New and Old Oxazolidinones
  Session Day & Time: 11 September 2012 11:15:00 AM - 1:15 PM

• The Monoclonal Antibody Panobacumab (KBPA101) Improves Pseudomonas aeruginosa Opsonophagocytosis by THP1 Monocytes
  H. Jacqmin, J.M. Buyck, P.M. Tulkens, F. Van Bambeke
  Poster A-1278 - Session Title: Clinical Pharmacology of Novel Anti-Infective Agents
  Session Day & Time: 11 September 2012 11:15:00 AM - 1:15 PM

• In vitro Activity and Pharmacodynamic evaluation of Dual Targeting Inhibitors of Bacterial DNA Gyrase and Topoisomerase IV (DTIs) against Extracellular and Intracellular Forms of ciprofloxacin-susceptible and ciprofloxacin-resistant Pseudomonas aeruginosa and Staphylococcus aureus
  J. M. Buyck, S. Lemaire, D. Pierard*, F. Van Bambeke, P. M. Tulkens
  * Vrije Universiteit Brussel, Brussels, Belgium
  Poster F-2029 - Session Title: Novel Inhibitors of Bacterial GyrB/ParE Topoisomerase Subunits
  Session Day & Time: 12 September 2012 9:15:00 AM - 11:15:00 AM

22d European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)
        London, UK, 31 March - 2 April 2012

• Fluoroquinolone recognition by prokaryotic S. aureus NorA and eukaryotic murine Mrp4 efflux transporters: a combined experimental and structural study
  J. Dupont,* C. Vallet, P.M. Tulkens, M. Prévost,* F. Van Bambeke
  * Structure et Fonction des Membranes biologiques, Université libre de Bruxelles, Brussels, Belgium
  Poster presentation P-1279 - Session "Epidemiology and molecular resistance of Staphylococcus sp. and Enterococcus sp."
  Sunday, April 01, 2012 - 12:30 - 13:30
  
  
• Pharmacodynamic analysis of the susceptibility of intracellular methicillin-susceptible, methicillin-resistant and linezolid-resistant Staphylococcus aureus to ceftaroline
  A. Melard, S Lemaire, P.M. Tulkens, F. Van Bambeke
  Poster presentation P-1602 - "Session Pharmacodynamic analyses and antibiotic combinations: S.aureus, MDR-Klebsiella and others"
  Sunday, April 01, 2012 - 13:30 - 14:30
  
  
• Comparison of anti-MRSA antibiotics (vancomycin, linezolid, daptomycin, rifampin) and anti Gram-positive fluoroquinolones (moxifloxacin, delafloxacin) against MSSA and MRSA in models of young and mature biofilms
  J. Bauer, P.M. Tulkens, F. Van Bambeke
  Poster presentation P-2057 - Session "Experimental treatment (animal model) of progeria bacterial infections"
  Monday, April 02, 2012 - 13:30-14:30
  
  
• Activity of macrolides, ketolides, and fluoroquinolones against S. pneumoniae in an in vitro pharmacodynamic model of biofilm
  N.M. Vandevelde, J. Bauer, P.M. Tulkens, F. Van Bambeke
  Poster presentation P-2176 - Session " Pathogenesis of Gram-positive bacteria"
  Tuesday, April 03, 2012 - 12:30-13:30
  
  
• Clinical safety of moxifloxacin: an analysis of "Valid for Safety" data from controlled phase II to phase IV studies performed between 1996 and 2010
  P.M. Tulkens, P. Arvis,* F. Kruesmann**
  * Bayer Santé SAS, Loos, France; ** Bayer Pharma AG, Wuppertal, Germany.
  Poster presentation P-2210 - Session "Clinical experience with antibiotics"
  Tuesday, April 03, 2012 - 12:30-13:30

25th North American Cystic Fibrosis Conference
        Anaheim, CA, 3-5 November 2011    

• Pharmacodynamic evaluation of antibiotics and combinations against Pseudomonas aeruginosa in broth and in human THP-1 monocytes
  J. Buyck, L. Garcia, P.M. Tulkens, F. Van Bambeke
  
  
• Pharmacodynamic evaluation of the intracellular activity of antibiotics against hemin and menadione-dependant Small-Colony Variant (SCV) mutants of Staphylococcus aureus in a model of activated or not THP-1 cells
  L. Garcia, B. C. Kahl,* K. Becker,*, R.A. Proctor,** P.M. Tulkens, F. Van Bambeke
  * Univ. Clinics Muenster, Muenster, Germany; ** Univ. Winconsin Med. School, Madison
  
  
• Characterization of the internalization and intracellular persistence of menadione and hemin-dependant Small-Colony Variants (SCV) of Staphylococcus aureus in a model of THP-1 cells and of the human airway epithelial cell Line , CFBE41o-
  L. Garcia, B. C. Kahl,* K. Becker,* R.A. Proctor,** O. Denis,*** S. Lemaire, P.M. Tulkens, F. Van Bambeke
  * Univ. Clinics Muenster, Muenster, Germany; ** Univ. Winconsin Med. School, Madison; *** Département de Microbiologie & Laboratoire de référence MRSA-Staphylocoques, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
  

• Lysosomal membrane permeabilization, a key event for apoptosis induced by aminoglycoside antibiotics
  S. Denamur, D. Tyteca,* J. Marchand-Brynaert,** F. Van Bambeke, P. M. Tulkens, P. J. Courtoy,* M.-P. Mingeot-Leclercq
  * Laboratory of Cell Biology, de Duve Institute, UCL; ** Laboratory of Solids, Molecules and Reactivity, Institute of Condensed Matter and Nanosciences, UCL
  
  
• Bacterial membrane bilayer as drug target
  M. Ouberai M., F. El Garch, A. Bussiere,* M. Riou, D. Alsteens,** L. Lins,*** I. Baussanne,* Y.F. Dufrêne,** R. Brasseur,*** J.L. Decout,* M.-P. Mingeot-Leclercq
  *Pharmacochimie Moléculaire, Université de Grenoble; ** Chimie des Interfaces, Institute of Condensed Matter and Nanosciences, UCL; ***Centre de Biophysique Moléculaire Numérique, ULg Agro-BioTech Gembloux
  

51th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
        Chicago, IL, 17-20 September 2011

• Inhibitors of Type Three Secretion System (TTSS) protect against Pseudomonas aeruginosa cellular toxicity by inhibiting the transcription of TTSS
  J. Buyck, G. de Laminne de Bex, P.M. Tulkens, F. Van Bambeke
  Poster A2-057 - Session "Pharmacokinetic/Pharmacodynamic (PK/PD) of New Antibacterial Agents"9/17 - /2011 11:30:00 AM
  
  
• Increased susceptibility of Pseudomonas aeruginosa to macrolides in biologically-relevant media by modulation of outer membrane permeability and of efflux pump expression
  J. Buyck, P.M. Tulkens, F. Van Bambeke
  Poster E-139 - Session "Miscellaneous" - 9/17/2011 11:30:00 AM
  
  
• Comparative assessment of antibacterial and cytotoxic effects of colistin, colistin methanesulfonate and polymyxin B using Pseudomonas aeruginosa, macrophages and renal cells, and liposomes
  D. Das, J. Buyck, F. Van Bambeke, J. Lorent, M.-P. Mingeot-Leclercq, P. Gobin,* W. Couet,* P.M. Tulkens
  * INSERM - ERI 23, Poitiers, France
  Poster Number F2-170 - Session "Innovative Drug Discovery and Drug Development Technologies" - 9/17/2011 11:30:00 AM
  
  
• Novel polymyxin derivatives are less cytotoxic than polymyxin B in a model of LLC-PK1 renal cell line
  M.-P. Mingeot-Leclercq, P.M. Tulkens, T. Vaara,* M. Vaara*,**
  * Northern Antibiotics Ltd, Helsinki, Finland; ** Helsinki University Hospital, Helsinki, Finland
  Poster F1-748 - Session "New Peptides, Lipopeptides and Peptidomimetics" - 9/18/2011 11:15:00 AM
  
  
• Role of MexAB-OprM in intrinsic resistance of Pseudomonas aeruginosa to temocillin
  J. Buyck1, P. Plésiat,* P.M. Tulkens, F. Van Bambeke
  * Laboratoire de Bactériologie, Hôpital Jean Minjoz, Besançon, France
  Poster C1-618 - Session "Mechanisms of Action and Mechanisms of Resistance in Gram-Negatives" - 9/18/2011 11:15:00 AM
  
  
• A maturing and mature staphylococcal biofilm model for screening of antibiotic activity
  J. Bauer, P.M. Tulkens, F. Van Bambeke
  Poster E-134 - Session "Staphylococcus" - 9/19/2011 11:15:00 AM
  
  
• Interferon-gamma potentiates the intracellular activity of rifampin towards intracellular Staphylococcus aureus in human THP-1 macrophages
  S. Lemaire, P. M. Tulkens, F. Van Bambeke
  Poster A1-1750 - Session "Penetration of Anti-Infective Agents and PK/PD Modeling Issues" - 9/20/2011 9:00:00 AM
  
  
• Influence of phorbol myristate acetate on cellular accumulation and intracellular activity of antibiotics against against hemin- and menadione-dependent small-colony variants of Staphylococcus aureus in human THP-1 cells
  L. Garcia, B. C. Kahl,* K. Becker,* R.A. Proctor,** S. Lemaire, P.M. Tulkens, F. Van Bambeke
  * University Clinics Muenster, Muenster, Germany; ** University of Winconsin Medical School, Madison, WI
  Poster A1-1751 - Session "Penetration of Anti-Infective Agents and PK/PD Modeling Issues" - 9/20/2011 9:00:00 AM
  
  
• Effect of menadione supplementation on the intracellular growth of a menadione-dependent small-colony variant of S. aureus in a model of THP-1 macrophages: consequences for antibiotic intracellular activity
  L. Garcia, B. C. Kahl,* K. Becker,* R.A. Proctor,** S. Lemaire, P.M. Tulkens, F. Van Bambeke
  * University Clinics Muenster, Muenster, Germany; ** University of Winconsin Medical School, Madison, WI
  Poster A1-1752 - Session "Penetration of Anti-Infective Agents and PK/PD Modeling Issues" - 9/20/2011 9:00:00 AM
  
  
• Activity of antibiotic combinations towards intracellular Pseudomonas aeruginosa in a model of THP-1 macrophages
  J. Buyck, P.M. Tulkens, F. Van Bambeke
  Poster A1-1753 - Session "Penetration of Anti-Infective Agents and PK/PD Modeling Issues" - 9/20/2011 9:00:00 AM

2d Conference "How dead is dead? - The ins and outs of bacterial dormancy"
        (organized by the German Association for General and Applied Microbiology (VAAM) study groups “Water and Waste Water” and “Pathogenicity”;
        supported by the German Society of Hygiene and Microbiology (DGHM)).
        Tübingen, Germany, 16-17 June 2011.

• Establishment of a maturing and mature staphylococcal biofilm model suitable for screening of antibiotic activity
  J. Bauer, P.M. Tulkens, F. Van Bambeke  

21th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)
        & 27th International Congress of Chemotherapy (ICC)
         Milan, Italy, 7-10 May 2011

See also conferences (2011) for a Plenary lecture given during this meeting (Improving usage by guidelines: a critical view [P. Tulkens])

• Comparative analysis of the potential of polymyxin B and gentamicin to cause apoptosis and necrosis in cultured renal LLC-PK1 cells: concentration-dependent studies with incubated and electroporated cells
  M-P. Mingeot-Leclercq, P.M. Tulkens
  Oral presentation O78 (Session: "Antimicrobial pharmacology: from bench to bedside" -- Saturday, 7 May 2011)
  
  
• Exposure of Pseudomonas aeruginosa to sub-MIC concentrations of chlorhexidine leads to increased resistance, marked phenotypic changes, overexpression of MexG, and cross-resistance to antipseudomonal antibiotics
  Q. Tan, T. Nguyen, F. Bilocq, D. De Vos*,**, J. Pirnay**, P. Cornelis,* F. Van Bambeke, P.M. Tulkens
  * Bio-ingenieur Wetenschappen, Vrije Universiteit Brussel & Vlaamse Instituut voor Biotechnologie, Brussels, Belgium; ** Queen Astrid Military Hospital, Brussels, Belgium
  Oral presentation O291 (Session: Clinical and microbiological update on antibiotic-resistant P. aeruginosa; Monday, 9 May 2011)
  
  
• Comparison of chromogenic and selective media for the detection of Staphylococcus aureus and Pseudomonas aeruginosa in respiratory samples from cystic fibrosis patients
  A. Nobre Machado*, C. Nonhoff*, S. Roisin*, A. Vergison*, F. Van Bambeke, N. Legros*, G. Hay*, P. Buidin* C. Thiroux*, O. Denis*
  * Université libre de Bruxelles, Brussels, Belgium
  Oral presentation 0297(Session: Clinical and microbiological update on antibiotic-resistant P. aeruginosa; Monday, 9 May 2011)
  
  
• Differential recognition of quinolones by efflux pumps in Gram-positive (Staphylococcus aureus, Streptococcus pneumoniae) and Gram-negative (Pseudomonas aeruginosa) bacteria
  C. Vallet, J. Buyck, F. El Garch,* P.M. Tulkens, F. Van Bambeke
  * Laboratoire de microbiologie, Cliniques universitaire UCL de Mont-Godinne, Yvoir, Belgium
  Poster P725 (Session: "Porins and efflux pumps are good friends" -- Saturday, 7 May 2011)
  
  
• Intracellular activity of fusidic acid against clinical isolates of Staphylococcus aureus of increasing MIC
  S. Lemaire, D. Piérard,* F. Van Bambeke, P.M. Tulkens
  * Universitair Ziekenhuis Brussel & Vrije Universiteit Brussel, Brussels, Belgium
  Poster P780 (Session: "Antimicrobial pharmacodynamics" -- Saturday, 7 May 2011)
  
  
• Activity of 9 antibiotics against intracellular forms of S. pneumoniae
  S. Lemaire, P.M. Tulkens, F. Van Bambeke
  Poster P781 (Session "Antimicrobial pharmacodynamics" -- Saturday, 7 May 2011)
  
  
• Population pharmacokinetics of temocillin in Intensive Care patients and Monte Carlo simulations to evaluate resistance breakpoints.
  A.E. Muller,* P.F. Laterre,* T. Dugernier,** X. Wittebole,** N. Couwenbergh, P.M. Tulkens, S. Carryn, J.W.Mouton***
  * Cliniques universitaires St-Luc, Brussels, Belgium; ** Clinique St Pierre, Ottignies, Belgium, *** Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
  Poster P807 (Session "Antimicrobial pharmacokinetics" -- Saturday, 7 May 2011)
  
  
• Activity of finafloxacin, a fluroquinolone with enhanced activity at acid pH, against intracellular Legionella pneumophila: comparison with azithromycin, clarithromycin, telithromycin, ciprofloxacin and moxifloxacin
  S. Lemaire, P.M. Tulkens, F. Van Bambeke
  Poster P1139 (Session: "New antimicrobials in vitro activity" -- Sunday 8 May 2011

8th International Symposium on Antimicrobial Agents and Resistance (ISAAR 2011)
        Seoul, Korea, 6-8 April 2011

• In vitro selection of resistance to temocillin in Enterobacter aerogenes
  T. T. H. Nguyen, Jean-Marie Pages,* Y. Glupczynski,** F. Van Bambeke, P.M. Tulkens
  * Université de la Méditerrané, Marseille, France; ** Clinique universitaire UCL de Mont-Godinne, Yvoir, Belgium
  Poster P3-43 - April 8, 2011

BioWin Day - Science for Business : Open innovation, the new model to innovate in health
Louvain-La-Neuve, Belgium, December 8, 2010

• Setting-up a model of intracellular infection by Pseudomonas aeruginosa for the pharmacodynamic evaluation of antibiotic activity.
  J. Buyck, O. Jolois*, P.M. Tulkens and F. Van Bambeke
  * laboratoire d'histologie humaine, Université de Liège, Liège, Belgium

50th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
         Boston, MA. September 12-15, 2010

• Cellular Accumulation is not Predictive of Intracellular Activity for Fluoroquinolones against S. aureus: Comparison of Gemifloxacin with Moxifloxacin and Ciprofloxacin
  poster A1-676 (session PK/PD of novel fluoroquinolones and fluoroketolides)
  E. Ngabirano, C. Vallet, S. Lemaire, B. Marquez, P.M. Tulkens, F. Van Bambeke
  Session Day / Time: 9/13/2010 11:15:00 AM
  
  
• Solithromycin (CEM-101), a Novel Fluoroketolide with Exceptional Cellular Accumulation, Localizes in Lysosomes and Induces Phospholipidosis but not Apoptosis and no Change in Reactive Oxygen Species (ROS) Production in Cultured Cells. Comparison with Azithromycin and Gentamicin.
  poster A1-686 (session PK/PD of novel fluoroquinolones and fluoroketolides)
  D. Das, F. Van Bambeke, P.M. Tulkens
  Session Day / Time: 9/13/2010 11:15:00 AM
  
  
• Pharmacodynamic Evaluation of the Intracellular Activity of Antibiotics against Hemin and Menadione-Dependent Small-Colony Variants of
  Staphylococcus aureus in a Model of THP-1 Macrophages
  poster A1-678 (session PK/PD of novel fluoroquinolones and fluoroketolides)
  L. Garcia, B. C. Kahl,* K. Becker,* R.A. Proctor,**, S. Lemaire, P.M. Tulkens, F. Van Bambeke
  * Med. Microbiology, University Clinics Muenster, Muenster, Germany; **University of Winconsin Med. School, Madison, WI
  Session Day / Time: 9/13/2010 11:15:00 AM
  
  
• Contrasting Effect of Acidic pH on the Extracellular and Intracellular Activities of Delafloxacin vs Moxifloxacin towards S. aureus
  poster A1-677 (session PK/PD of novel fluoroquinolones and fluoroketolides)
  S. Lemaire, P.M. Tulkens, F. Van Bambeke
  Session Day / Time: 9/13/2010 11:15:00 AM
  
  
• Increased Susceptibility of Pseudomonas aeruginosa to Macrolides and Ketolides in Eukaryotic Cell Culture Media by modulation of Outer Membrane Permeability
  poster D-751 (session Conventional methods for detection of resistance in Gram-negative organisms)
  J. Buyck, P.M. Tulkens and F. Van Bambeke
  Session Day / Time: 9/13/2010 11:15:00 AM
  
  
• Pharmacodynamic Evaluation of 11 Antibiotics against Pseudomonas aeruginosa (PAO1) in Broth and in Human THP-1 Monocytes
  poster A1-1395 (session PK/PD of beta-lactams agents)
  J. Buyck, P.M. Tulkens and F. Van Bambeke
  Session Day / Time: 9/14/2010 11:15:00 AM
  
  
• Influence of Oritavancin on Phagocytosis, Generation of Reactive Oxygen Species and Killing of Intracellular S. aureus in Murine and Human Macrophages and Comparison with Azithromycin and Vancomycin
  poster A1-1360 (seession Glyco- and lipopeptides PK/PD : improving dosage)
  S. Lemaire, P. de Galard, J. Buyck, P.M. Tulkens, M.P. Mingeot-Leclercq, F. Van Bambeke
  Session Day / Time: 9/14/2010 11:15:00 AM

ISSSI-2010 - International Symposium on Staphylococci and Staphylococcal Infections
         Bath, United Kingdom, 6-9 September 2010

• Characterization of the Intracellular Growth of Menadione and Hemin-dependent Small-Colony Variants (SCV) of Staphylococcus aureus in a Model of THP-1 Macrophages: Consequences for Antibiotic Intracellular Activity
  poster
  L. Garcia, B. C. Kahl,* K. Becker,* R.A. Proctor,**, S. Lemaire, P.M. Tulkens, F. Van Bambeke
  * Med. Microbiology, University Clinics Muenster, Muenster, Germany; **University of Winconsin Med. School, Madison, WI

• Comparative Study of the Phagocytosis and Intracellular Susceptibility to Antibiotics of a Pig-related ST-398 Methicillin-Resistant S. aureus (A-MRSA) vs Hospital-Acquired MRSA in a Model of THP-1 Macrophages
  poster
  S. Lemaire, L. Garcia, F. Van Bambeke Y. Glupczynski*, P.M. Tulkens
  * Clinique universitaire UCL de Mont-Godinne, Yvoir, Belgium

16th International Social Pharmacy Workshop (ISPW)
         Lisbon, Portugal, 23-26 August 2010

• Development and effectiveness of the delivery of a written transmission at hospital discharge to community pharmacy in Belgium
  Oral Communication (Com 208)
  C Claeys,* Jean Neve,* P.M. Tulkens, A. Spinewine
  * Institut de Pharmacie, Université libre de Bruxelles, Brussesl, Belgium
  

FEBS Workshop: "Microbial Lipids: from genomics to lipidomics"
        Vienna, Austria 12-16 May 2010

• Identification and quantification of ceramide and glucosylceramide in Murine J774 macrophages cells wild type and Ciprofloxacin resistant cells (CIPR) by liquid chromatography­electrospray ionization tandem mass spectrometry
  Poster
  H. Bensikaddour, M. Fillet*, Paul. M Tulkens, F. Van Bambeke, M.-P. Mingeot-Leclercq
  * Department of Analytical Pharmaceutical Chemistry, Institute of Pharmacy, University of Liege, Liege, Belgium
  
  
• Physical chemical properties of lipids extracted from J774 macrophages cells wild type and ciprofloxacin resistant cells: Fluidity and membrane potential
  Poster
  H. Bensikaddour, P.M. Tulkens, F. Van Bambeke, M.P. Mingeot-Leclercq
  
  
• Fluorescence Anisotropy, ATR-FTIR and 31P NMR spectroscopies and conformational analysis: Interactions of Ciprofloxacin with DPPC and DPPG
  H. Bensikaddour
  Oral communication - Session Structural Properties of Lipids (Biomembranes)

20th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)
         Vienna, Austria, 10-13 April 2010

• Influence of antibiotic treatments on gene expression of RND efflux pumps in successive isolates of Pseudomonas aeruginosa collected from patients with nosocomial pneumonia hospitalized in intensive care units from Belgian teaching hospitals
  Poster P 780 (Session: Pseudomonas)
  M. Riou, L. Avrain, F. El Garch, Y. Glupczynski,* J.P. Pirnay,** D. De Vos,** P.M. Tulkens, F. Van Bambeke
  *Laboratoire de microbiologie, Clinique universitaire UCL de Mont-Godinne, Yvoir, Belgium ; ** Vrije Universiteit Brussel & Queen Astrid Military Hospital, Brussels, Belgium.
  
  
• Respective contribution of PatA/PatB and PmrA in fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae
  Poster P 922 (Session: New resistance mechanisms)
  A. Lismond, M.I. Garvey,* F. El Garch, S. Delvigne, P.M. Tulkens, L.J. Piddock,* F. Van Bambeke
  * Antimicrobial Agents Research Group, University of Birmingham, Birmingham, UK.
  
  
• Phagocytic activity and production of reactive oxygen species in J774 mouse macrophages exposed to increasing concentrations of oritavancin: comparison with vancomycin and azithromycin
  Poster P 1585 (Session: Clinical and experimental studies)
  S. Lemaire, P. de Galard, P.M. Tulkens, M.P. Mingeot-Leclercq, F. Van Bambeke
  
  
• Pharmacodynamic evaluation of the intracellular activity of tobramycin, doripenem, levofloxacin, and colistin towards Pseudomonas aeruginosa after phagocytosis by human THP-1 macrophages
  Oral presentation O 518 (Session: PK/PD approaches in Gram-negative infections
  J. Buyck, P.M. Tulkens, F. Van Bambeke

3d FEBS Special Meeting - ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases
         Innsbruck, Austria, February 27 - March 5, 2010

• Influence of two ABC transporters, ABCC4 and ABCG2, on ciprofloxacin accumulation in teh context of cystic fibrosis
  L. Garcia, B. Marquez, J. Buyck, M.P. Mingeot-Leclercq, P.M. Tukens, F. Van Bambeke
  poster
  
  
• Expression and functionality of ABC transporters in J774 macrophages selected by chronic exposure to ciprofloxacin or moxifloxacin, two fluoroquinolone antibiotics
  C. Vallet, B. Marquez, N. Nhiri,* M-P Mingeot-Leclercq, P.M. Tulkens, E. Jacquet,* F. Van Bambeke
  * Institut de chimie des substances naturelles, Gif sur Yvette, France
  poster
  This poster has obtained the FEBS Youth Travel Fund grant

29ème Réunion Interdisciplinaire de Chimiothérapie Anti-infectieuse
       Paris, France, 3-4 décembre 2009

Links to posters or oral presentations will be activated after the meeting
Visit http://www.facm.ucl.ac.be/facm-conferences-fr.htm for the Plenary Lecture given at this meeting

• Etude de l'activité d'antibiotiques vis-à-vis des formes intracellulaires de Staphylococcus aureus et Legionella pneumophila.
  S. Lemaire, F. Van Bambeke, P.M. Tulkens
  présentation orale - session "Antibiotiques et infections expérimentales"
  
  
• Sensibilité d'isolats récents de S. aureus résistant à la méthicilline (SARM) vis-à-vis de la vancomycine (VAN), de la quinupristin/dalfopristin (Q-D), et du ceftobiprole (BPR) dans un centre hospitalo-universitaire belge
  S. Lemaire, F. Van Bambeke, P.M. Tulkens, D. Piérard*
  * Universitair Ziekenhuis Brussel, Bruxelles, Belgique
  Affiche n° 327 - session "Staphylocoque et épidémiologie de la résistance des bactéries Gram positif"
  
  
• Etude comparative de la sensibilité au doripénème, à l'imipénème et au méropénème de souches de Pseudomonas aeruginosa collectées chez des patients souffrants de pneumonie nosocomiale dans 5 hôpitaux belges (2004 - 2008).
  M. Riou, F. Van Bambeke, P.M. Tulkens, J. Broughal*
  * Janssen-Cilag Ltd, High Wycombe, Royaume-Uni
  Affiche n° 348 - session: "Activité anti-bactérienne et mécanisme de résistance"
  
  
• Impact du traitement antibiotique sur le niveau de résistance des souches de Pseudomonas aeruginosa collectées par paires sur des patients souffrant d'une pneumonie nosocomiale dans cinq hôpitaux belges.
  M. Riou, Y. Glupczynski 1, S. Carbonelle, L. Avrain 2, J. Pirnay 3 , D. De Vos 3,4, A. Simon 5, D. Pierard 6, F. Jacobs 7, A. Dediste 8, F. Van Bambeke, P.M. Tulkens
  1 Laboratoire de microbiologie, Clinique universitaire UCL de Mont-Godinne, Yvoir; 2 Coris Bioconcept s.a., Gembloux; 3 Queen Astrid Military Hospital, Bruxelles, 4 Vrije Universiteit Brussel, Bruxelles; 5 Cliniques universitaires St-Luc, Bruxelles; 6 Universitaire Ziekenhuis Brussel, Bruxelles; 7 Hôpital Erasme, Bruxelles; 8 Centre hospitalo-universitaire St-Pierre, Bruxelles.
  Affiche n° 427 - Session " Infections associées aux soins (Epidémiologie, politique antibiothérapie, prévention)"

9th Annual meeting of the International Society of Pharmacovigilance (ISoP):
       "From Pharmacovigilance to Risk Management"
         Reims, France, October 7th-9th, 2009

• Critical Analysis of the Risk/Benefit Ratio of First Line Antibiotics Included in Guidelines for the Treatment of Community-Acquired Pneumonia
  S. Carbonnelle, F. Van Bambeke, P.M. Tulkens
  Poster no. 375 (This poster has obtained the 3d prize of the "best posters" contest)
  
  
• Adverse neurological events of antiretroviral therapy in Mali
  A.A. Oumar,* S. Dao,* N. Djibril,** Y. Kone,** S. Traore,*** A. Diallo,**** P.M. Tulkens
  * Faculty of Medicine, Pharmacy and Odontostomatology, Bamako-Mali, ** Pharmacological Unit, Faculté des sciences de santé Cotonou, Bénin, *** Service de Neurologie, Hôpital du point G, Bamako, Mali, **** Rectorat, Université de Bamako, Mali
  Poster no. 152

“Signal Transduction and Disease” (a joint meeting of the Biochemical societies of Belgium, the Netherlands and Germany).
           Aachen, Germany, 27-30 September 2009

• Changes in the expression of MDR transporters in J774 mouse macrophages selected by chronic exposure to ciprofloxacin or moxifloxacin, two fluoroquinolone antibiotics.
  C. Vallet, B. Marquez, N. Nhiri,* E. Jacquet,* M-P. Mingeot-Leclercq, P.M. Tulkens, F. Van Bambeke
  * Institut de chimie des substances naturelles, CNRS, Gif sur Yvette, France
  

49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
         San Francisco, CA, September 12-15, 2009

See also conferences (2009) for a Plenary lecture given during this meeting (Administration of beta-lactams by continuous infusion: when, how, and for which molecules ? [P. Tulkens])

• Susceptibility of Pseudomonas aeruginosa to biocides among clinical isolates collected from Intensive Care units patients with nosocomial
  pneumonia in 5 Belgian teaching hospitals during the 2004-2008 period.
  M. Riou, S. Carbonnelle, D. De Vos,* A. Simon, F. Van Bambeke, P. M. Tulkens
  *Vrije Universiteit Brussel & Queen Astrid Military Hospital, Brussels, Belgium.
  Poster Session 072 (Acinetobacter and Pseudomonas: Two Friends) - Presentation Number: C2-628 - Session Day / Time: 9/13/2009 11:15:00 AM
  
  
• Oritavancin kills S. aureus by increasing membrane permeability without causing extensive cell lysis: comparative studies with vancomycin, daptomycin, and lysostaphin
  P. Baudoux, H. A. Nguyen, O. Domenech, M. P. Mingeot-Leclercq, F. Van Bambeke, P. M. Tulkens
  Poster Session 155 (Antibiotic Resistance in Staphylococcus aureus) - Presentation Number: C1-1354 - Session Day / Time: 9/14/2009 11:15:00 AM
  
  
• Contrasting effect of acidic pH on the bactericidal activities of CEM-102 (fusidic acid) vs. linezolid and clindamycin towards Staphylococcus aureus
  S. Lemaire, F. Van Bambeke, P.M. Tulkens
  Poster Session 226 (PK/PD Investigational Antibacterials) - Presentation Number: A1-1928 - Session Day / Time: 9/15/2009 9:00:00 AM
  
  
• Torezolid (TR-700), a novel methyltetrazolyl-oxazolidinone, accumulates markedly within human THP-1 macrophages and shows activity towards intraphagocytic Legionella pneumophila: comparison with linezolid
  S. Lemaire, F. Van Bambeke, P.M. Tulkens
  Poster Session 226 (PK/PD Investigational Antibacterials) - Presentation Number: A1-1934 - Session Day / Time: 9/15/2009 9:00:00 AM
  
  
• Accumulation and intracellular activity of radezolid, a new oxazolidinone, in non-phagocytic cells
  S. Lemaire, K. Kosowska-Shick,* P.C. Appelbaum,* J. Pirnay,** G. Verween,** G. Verbeken,** D. De Vos,** P.M. Tulkens, F. Van Bambeke
  * Hersey Medical Center, Hershey, PA; ** Queen Astrid Military Hospital, Brussels, Belgium.
  Poster Session 226 (PK/PD Investigational Antibacterials) - Presentation Number: A1-1936 - Session Day / Time: 9/15/2009 9:00:00 AM
  
  
• Radezolid, a new oxazolidinone, is active against intraphagocytic Staphylococcus aureus with various resistance phenotypes in a model of THP-1 human macrophages
  S. Lemaire, K. Kosowska-Shick,* P.C. Appelbaum,* P.M. Tulkens, F. Van Bambeke
  * Hershey Medical Center, Hershey, PA.
  Poster Session 226 (PK/PD Investigational Antibacterials) - Presentation Number: A1-1937 - Session Day / Time: 9/15/2009 9:00:00 AM
  
  
• Cellular accumulation and intracellular activity of finafloxacin (FNX), a novel fluoroquinolone (FQ) with enhanced activity at acid pH, against S. aureus and L. pneumophila: comparison with ciprofloxacin and moxifloxacin
  S. Lemaire, F. Van Bambeke, P.M. Tulkens
  Poster Session 226 (PK/PD Investigational Antibacterials) - Presentation Number: A1-1940 - Session Day / Time: 9/15/2009 9:00:00 AM

34th Federation of the European Societies of Biochemistry (FEBS) meeting - Life's molecular interactions
         Prague, Czech Republic, July 4th - 9th, 2009

• Phenotypic, genotypic and proteomic characterization of J774 macrophages upon chronic exposure to fluoroquinolone antibiotics
  B. Marquez, N. E. Caceres, M. Aerts,* C. Vallet, M-P. Mingeot-Leclercq, P.M. Tulkens, B. Devreese,* F. Van Bambeke
  * Laboratory for Protein Biochemistry & Biomolecular Engineering, Ghent University, Ghent, Belgium
  Poster 4-84 (Sunday July 5-Monday July 6). .

26th International Conference on Chemotherapy
         Toronto, Ont., 18-21 June 2009

See also conferences (2009) for a Plenary lecture given during this meeting (Collateral effects of antibiotics:adverse effects and drug interactions [F. Van Bambeke])

• Pharmacodynamic evaluation of the Intracellular activity of CEM-101, a novel ketolide, towards Staphylococcus aureus, Listeria monocytogenes, and Legionella pneumophila in human THP-1 macrophages.
  S. Lemaire, F. Van Bambeke, P.M. Tulkens
  Poster (Friday June 19th - P-70)
  
  
• Antibiotic resistance of clinical isolates of Pseudomonas aeruginosa (PA) collected from Intensive Care Units (ICU) patients with nosocomial pneumonia in 5 Belgian hospitals during the 2004-2008 period using EUCAST breakpoints.
  M. Riou, S. Carbonnelle, L. Avrain (1), J.P. Pirnay (2), D. De Vos (2), A. Simon (3), D. Pierard (4), F. Jacobs (5), Anne Dediste (6), F. Van Bambeke, P.M. Tulkens
  1 Coris Bioconcept, Gembloux; 2 Queen Astrid Military Hospital, Brussels, 3 Universitair Ziekenhuis Brussel, Brussels, 4 Hôpital Erasme, Brussels , 5 Centre hospitalo-universitaire St-Pierre, Brussels; Belgium
  Poster (Friday June 19th - P-113)
  
  
• Radezolid (RX-1741), a novel oxazolidinone, accumulates extensively within human macrophages and PMNs and shows activity towards
  intracellular linezolid-sensitive and linezolid-resistant Staphylococcus aureus
  S. Lemaire, P.M. Tulkens, F. Van Bambeke
  Oral presentation (Saturday June 20th - 10:15 - Abstract symposium: Antimicrobials)
  
  
• Motivations for antibiotic prescription by General Practitioners (GPs) for patients with respiratory tract infection (RTI) in a country with large antibiotic consumption (Belgium). A questionnaire study.
  Feron JM*, Legrand D*, Pestiaux D*, Tulkens PM
  * Centre académique de médecine générale, Université catholique de Louvai, Brussels, Belgium
  Poster (Saturday June 20th - P-313)
  
  
• Analysis of guidelines for treatment of Community acquired pneumonia (CAP) in outpatients.
  S. Carbonnelle, A. Lismond, F. Van Bambeke, P.M. Tulkens
  Poster (Saturday June 20th - P-315)

19th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)
         Helsinki, Finland, 16-19 May 2009

Note: for the plenary lectures given at this Conference, visit http://www.facm.ucl.ac.be/facm-conferences.htm

• Competition between ciprofloxacin and antiviral agents (adefovir, saquinavir, ritonavir) for efflux transporters in J774 macrophages
  L. Garcia, B. Marquez, S. Carryn, M.P. Mingeot-Leclercq, P.M. Tulkens, F. Van Bambeke
  oral presentation (Pharmacokinetics/pharmacodynamics: clinical relevance - 023)
  
  
• Determination of pharmacokinetic/pharmacodynamic index for patients treated with high-dose vancomycin by continuous infusion
  E. Ampe, P.M. Tulkens, B. Delaere,*J.D. Hecq,* Y. Glupczynski*
  oral presentation (Pharmacokinetics/pharmacodynamics: clinical relevance - 026)
  * Clinique universitaire UCL de Mont-Godinne, Yvoir, Belgium
  
  

• The novel oxazolidinone radezolid (RX-1741) accumulates in THP-1 macrophages: comparative studies with linezolid and azithromycin
  S. Lemaire, P.M. Tulkens, F. van Bambeke
  oral presentation (Pharmacokinetics/pharmacodynamics: clinical relevance - 029)
  

• Radezolid (RX-1741), a novel oxazolidinone, is active against intracellular S. aureus, L. monocytogenes and L. pneumophila phagocytosed by human THP-1 macrophages
  S. Lemaire, PM. Tulkens, F. Van Bambeke
  oral presentation (Pharmacokinetics/pharmacodynamics: clinical relevance - 030)

• Inducibility of PatA/PatB efflux pumps by fluoroquinolones in Streptococcus pneumoniae
  F. El Garch, A. Lismond, F. Van Bambeke, P.M. Tulkens
  oral presentation (Streptococci: mechanisms of resistance and epidemiology - 0495)
  
  

• Role of rsbU and staphyloxanthin in intracellular growth of Staphylococcus aureus in human phagocytic cells (THP-1 macrophages)
  A. Olivier, S. Lemaire, F. Van Bambeke, P.M. Tulkens, E. Oldfield*
  poster (Pathogenesis of infections caused by Gram-positive bacteria - P735)
  * Department of Chemistry and Center for Biophysics and Computational Biology, University of Illinois, Urbana, IL
  

• MIC distribution and efflux of 4 respiratory fluoroquinolones (gemifloxacin, garenoxacin, moxifloxacin, levofloxacin) towards S. pneumoniae isolated from patients with confirmed CAP in a country with large fluoroquinolone use (Belgium)
  A. Lismond, S. Carbonnelle, F. Van Bambeke, P.M. Tulkens
  poster (Antimicrobial resistance in Gram-positive bacteria - P1068
  
  

• TR-700, a novel methyltetrazolyl-oxazolidinone, accumulates extensively within human macrophages cells and shows activity towards intraphagocytic linezolid-sensitive and linezolid-resistant S. aureus
  S. Lemaire, K. Kosowska-Shick,* P. Appelbaum,* F. Van Bambeke, P.M. Tulkens
  poster (New antimicrobials against Gram-positives - P1092)
  * Hershey Medical Center, Hershey, PA

• Comparative activities of the novel ketolide CEM-101 and telithromycin towards towards Streptococcus pneumoniae resistant to macrolides from patients with confirmed community-acquired pneumonia
  A. Lismond, F. Van Bambeke, P.M. Tulkens
  poster (New antimicrobials against Gram-positives - P1099)
  
  
• Prevalence and epidemiology of antibiotic resistance in Pseudomonas aeruginosa isolated from low respiratory tract of patients hospitalized in intensive care units from 5 Belgian hospitals, 2004-2008
  M. Riou, S. Carbonnelle, L. Avrain, Y. Glupczynski,1 D. Devos,2 J.-P. Pirnay,2 A. Simon,3 D. Pierard,4 F. Jacobs,5 A. Dediste,6 F. Van Bambeke, P.M. Tulkens
  poster (Resistance in Pseudomonas spp - P1502)
  1Laboratoire de microbiologie, Clinique universitaire UCL de Mont-Godinne, Yvoir, Belgium; 2 Queen Astrid Military Hospital, Brussels, Belgium; 3 Cliniques universitaires St-Luc, Brussels, Belgium; 4 Universitair Zikenhuis Brussel, Brussels, Belgium; 5 Hôpital Erasme, Brussels, Belgium; 6 Centre hospitalo-universitaire St-Pierre, Brussels, Belgium
  
  

• Quantitative comparison of aminoglycoside nephrotoxicity in rats for effective screening and evaluation of new derivatives, and dosing rationales that minimise toxicity
  C.F. Kostrub,* R. Diokno,* J.B. Aggen,* G.H. Miller,* J.K. Judice,* P.M. Tulkens
  poster (Pharmacokinetics & pharmacodynamics of aminoglycosides & lipoglycopeptides) Tuesday , 19 May 2009 12:30-13:30
  * Achaogen, South San Francisco, CA

53d Annual Meeting of the Biophysical Society
         Boston, Mass., February 28th - March 4th, 2009

• Lipid membrane composition of J774 macrophages cells surexpressing MRP protein (resistant to ciprofloxacin) as compared to wild type
  H. Bensikaddour, P.M. Tulkens, F. Van Bambeke, M.P. Mingeot-Leclercq
  Poster B-655.

31th Symposium of the Belgian Society for Infectiology and Cinical Microbiology
         6 November 2008, Dolce Conference Centre, La Hulpe, Belgium

Note: for the plenary lectures given at this Conference, visit http://www.facm.ucl.ac.be/facm-conferences.htm

• SCV and antibiotic activity (oral presentation of poster presented at ICAAC 2008)
  H.A Nguyen, T.D Huang,* P.M. Tulkens, F. Van Bambeke, and Y. Glupczynski*
  * Cliniques universitaires St-Luc, Brussels; ** Cliniques universitaires UCL de Mont-Godinne, Yvoir, Belgium
  
• S. pneumoniae epidemiology in CAP (oral presentation of a poster presented at ECCMID 2008)
  A. Lismond, F. Van Bambeke, S. Carbonnelle, F. Jacobs,1 M.J. Struelens,2 J. Gigi,3 A. Simon,3 Y. Van Laethem,4 A. Dediste,4 D. Pierard,5 A. De Bel,5 P.M. Tulkens
  1Service des maladies infectieuses et 2Laboratoire de microbiologie, Hôpital Erasme, Bruxelles; 3Laboratoire de microbiologie, Cliniques universitaires Saint-Luc, Bruxelles; 4Service des maladies infectieuses et 5Laboratoire de microbiologie, CHU St-Pierre, Bruxelles; 6Laboratorium voor microbiologie, Universitair Zikenhuis Brussel, Brussel; Belgique

 48th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) &
 46th Annual meeting of the Infectious Diseases Society of America (IDSA)
         Washington, DC, October 25-28, 2008

Note: for the plenary lectures given at this Conference, visit http://www.facm.ucl.ac.be/facm-conferences.htm

• Identification of the efflux transporter of ciprofloxacin in murine macrophages: studies with ciprofloxacin-resistant cells.
  B. Marquez, N. E. Caceres, M. P. Mingeot-Leclercq, P. M. Tulkens, F. Van Bambeke
  Poster no. A-045
  
• SCV phenotype and reduced intracellular activity of antibiotics: a cause for persistent staphylococcal infection ?
  H. A. Nguyen, T. D. Huang,* P. M. Tulkens, F. Van Bambeke, Y. Glupczynski**
  * Cliniques universitaires St-Luc, Brussels; ** Cliniques universitaires UCL de Mont-Godinne, Yvoir, Belgium
  Poster no. A-970
• Intracellular activity of oritavancin against MSSA, MRSA and VISA strains in a model of human macrophages
  P. Baudoux, P. M. Tulkens, F. Van Bambeke
  Poster no. A-971
• Subcellular localisation of S. aureus Small Colony Variant (SCV) versus its normal phenotype counterpart in a model of Calu-3 airway epithelial cells: impact on the intracellular activity of oritavancin, gentamicin, oxacillin and moxifloxacin
  H.A. Nguyen, O. Denis,* A. Vergison,** P.M. Tulkens, M.J. Struelens,* F. Van Bambeke
  * Université libre de Bruxelles (Hôpital Erasme), Brussels, Belgium; ** Université libre de Bruxelles (Hôpital universitaire des enfants Reine Fabiola), Brussels, Belgium
  Poster no. A-972
• CEM-101, a novel macrolide/ketolide, shows improved intracellular activity against phagocytized S. aureus in comparison with azithromycin, clarithromycin, or telithromycin
  S. Lemaire, P. M. Tulkens, F. Van Bambeke
  Poster no. A-995
• Influence of inhibitors of P-glycoprotein (P-gp) and Multidrug Resistance-associated Protein (MRP) on the accumulation and intracellular activity of CEM-101, a novel macrolide/ketolide, in human THP-1 macrophages: comparison with azithromycin
  S. Lemaire, P. M. Tulkens, F. Van Bambeke
  Poster no. A-996
• Assay of free and total vancomycin serum concentrations with E-test-based determination of MICs in patients treated by continuous infusion for severe staphylococcal and enterococcal infections.
  E. Ampe,* K. Berthoin, B. Delaere,* S. Noirhomme,* P. M. Tulkens, J. Hecq,* S. Carryn, Y. Glupczynski*
  * Cliniques universitaires UCL de Mont-Godinne, Yvoir, Belgium
  Poster no. A-1882
• Comparative study of membrane permabilization induced by oritavancin vs. vancomycin in liposomes: importance of the acidic character of the membrane
  O. Domenech, F. Van Bambeke, P. M. Tulkens, M. P. Mingeot-Leclercq
  Poster no. C1-199

Colloque ABC Franco-Belge
French-Belgian ABC meeting

6ème édition du Colloque ABC franco-belge / 6th edition of the French-Belgian ABC meeting
            Paris, France, 14 October 2008

• Active transport of ciprofloxacin in murine macrophages
  B. Marquez, N.E. Caceres, M.-P. Mingeot-Leclercq, P.M. Tulkens, F. Van Bambeke
  Oral presentation       

5ème Congrès de Lipidomique - Les lipides du futur: des agroressources à la santé humaine
         (organisé par le "Groupe d'Etude et de Recherche en Lipidomique [GERLI])
         Compiègne, France, 21-23 octobre 2008

• Interactions between Fluoroquinolones and lipids: Biophysical studies
  H. Bensikaddour
  Oral presentation

2d World Conference on Magic Bullets (Ehrlich II)
         Nuremberg, Germany, 3-5 October 2008

Note: for the plenary lectures given at this Conference, visit http://www.facm.ucl.ac.be/facm-conferences.htm

• Magic activity of beta-lactams against intracellular Methicillin-Resistant S. aureus: role of acidic pH
  S. Lemaire, F. Van Bambeke, PM Tulkens
  Oral presentation
  
• In vitro pharmacodynamic evaluation of intracellular activity of antibiotics alone or in combination against a small colony variant (SCV) of Staphylococcus aureus
  H.A. Nguyen, O. Denis,* A. Vergison,** P.M Tulkens, M. Struelens,* F. Van Bambeke
  * Département de microbiologie, **Département de maladies infectieuses pédiatriques; Université libre de Bruxelles, Brussels, Belgium
  Oral presentation
  
• Can we make eucaryotic cells resistant to antibiotics ? Correlation between Multidrug Resistance-associated Protein (Mrp) efflux pump expression and fluoroquinolones accumulation in J774 macrophages
  B. Marquez, P.M. Tukens, F. Van Bambeke

Membrane trafficking in global cellular responses (The 2008 Golgi meeting)
         Pavia, Italy, 4-9 September 2008

• Determination of the lipid membrane composition of J774 macrophages cells surexpressing MRP proteins (resistant to ciprofloxacin)
  H. Bensikaddour, P.M. Tulkens, F. Van Bambeke, and M.-P. Mingeot-Leclercq
  Poster no. 4H

8th Sienna Meeting- From genome to proteome: integration and proteome completion
        Sienna, Italy, 31 August- 4 September 2008

• Proteomic analysis of ciprofloxacin-resistant murine macrophages
  M. Aerts,* N. Caceres, J. Van Beeumen,* P.M. Tulkens, F. Van Bambeke and B. Devreese*
  * L-ProBE, Ghent University, Ghent, Belgiuum

18th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)
         Barcelona, Spain, 19-22 April 2008

Note: for the plenary lectures given at this Conference, visit http://www.facm.ucl.ac.be/facm-conferences.htm

• Presence of extended-spectrum beta-lactamase-producing Enterobacteriaceae in the faecal flora of patients from general practice
  C. Meex,* P. Melin,* J.D. Docquier,* T. Kabasele,* P. Huynen,* P.M. Tulkens, D. Giet,* P. De Mol*
  * Université de Liège (Laboratoire de microbiologie et Département de médecine générale), Liège, Belgium)
  Poster 631 - Saturday, April 19, 2008, 15:30 - 16:30
• Intracellular activity of antibiotics against Staphylococcus aureus internalised human skin keratinocytes: comparison with THP-1 macrophages
  S. Lemaire, F. Van Bambeke, J.P. Pirnay,* G. Verween,* P. De Corte,* D. De Vos,* P.M. Tulkens
  * Queen Astrid Military Hospital, Brussels, Belgium
  Oral session O143 Sunday, April 20, 09:00 - 09:12 (Lecture Hall 116)
• Temocillin protein binding is concentration-dependent and not restricted to albumin
  S. Carryn, J.W. Mouton,* N. Couwenbergh, P.M. Tulkens
  * Casinius Wilhelmina Ziekenhuis, Nijmegen, The Netherlands
  Oral session O146 Sunday, April 20, 9:36 - 09:48 (Lecture Hall 116)
• MDR1 (P-glycoprotein) and MRP1 (multidrug resistance-related protein 1) eukaryotic efflux transporters do not affect the cellular accumulation and intracellular activity of tigecycline towards intraphagocytic Staphylococcus aureus
  S. Lemaire, F. Van Bambeke, M.P. Mingeot-Leclercq, P.M. Tulkens
  Oral session O147 Sunday, April 20, 09:48 - 10:00 (Lecture Hall 116)
• Temocillin 6g daily in critically ill patients: continuous infusion vs. conventional administration
  P.F. Laterre,* T. Dugernier,** X. Wittebole,* N. Couwenbergh, P.M. Tulkens, S. Carryn
  * Cliniques universitaires Saint-Luc, Brussels; ** Clinique Saint-Pierre, Ottignies; Belgium
  Oral session O150, Sunday, April 20, 10:24 - 10:36(Lecture Hall 116)
• Activity of antibiotic combinations towards intracellular small colony variants of Staphylococcus aureus in a model of THP-1 macrophages
  H.A. Nguyen, O. Denis,* A. Vergison,** P.M. Tulkens, M.J. Struelens,* F. Van Bambeke
  * Département de microbiologie, **Département de maladies infectieuses pédiatriques; Université libre de Bruxelles, Brussels, Belgium
  Poster session P1059, Sunday, April 20
• Identification of a Staphylococcus aureus strain with increased intracellular growth and reduced intracellular susceptibility to gentamicin
  A. Olivier, F. Van Bambeke, M.P. Mingeot-Leclercq, P.M. Tulkens
  Poster session P1060, Sunday, April 20
• Intracellular activity of antibiotics against a stable small colony variant of Staphylococcus aureus isolated from a CF patient in model Calu-3 human airway epithelial cells
  H.A. Nguyen, O. Denis,* A. Vergison,** P.M. Tulkens, M.J. Struelens, F. Van Bambeke
  * Département de microbiologie, **Département de maladies infectieuses pédiatriques; Université libre de Bruxelles, Brussels, Belgium
  Poster session P1058, Sunday April 20
• Guidelines observance by general practitioners for respiratory tract infections: a quantitative study using the "Small Samples Approach" for in-depth, case-based analysis in French-speaking Belgium
  J.M. Feron,* D. Legrand,* P.M. Tulkens
  * Centre académique de médecine générale, Université catholique de Louvain, Brussels, Belgium
  Oral session O249, Sunday, April 20, 16:36 - 16:48 (Lecture Hall 115)
• Epidemiological survey of resistance to beta-lactams (AMX, CFX, CRO), macrolides (CLR, TEL), and fluoroquinolones (LVX, MXF) in a Belgian collection of community-acquired pneumonia isolates of Streptococcus pneumoniae
  A. Lismond, F. Van Bambeke, S. Carbonnelle, F. Jacobs,1 M.J. Struelens,2 J. Gigi,3 A. Simon,3 Y. Van Laethem,4 A. Dediste,4 D. Pierard,5 A. De Bel,5 P.M. Tulkens
  1Service des maladies infectieuses et 2Laboratoire de microbiologie, Hôpital Erasme, Bruxelles; 3Laboratoire de microbiologie, Cliniques universitaires Saint-Luc, Bruxelles; 4Service des maladies infectieuses et 5Laboratoire de microbiologie, CHU St-Pierre, Bruxelles; 6Laboratorium voor microbiologie, Universitair Zikenhuis Brussel, Brussel; Belgique
  Poster session P1747, Monday, April 21

52d Meeting of the Biophysical Society and 16th International Biophysics Congress
         Long Beach, CA, 2-6 February, 2008

• Probing Ciprofloxacin - Lipid Interaction by ATR-FTIR and 31P NMR Spectroscopy
  Hayet Bensikaddour, Marie-Paule Mingeot-Leclercq, Karim Snoussi,* and Erik Goormaghtigh**
  * Université catholique de Louvain, Faculty of Sciences, Unité de chimie structurale et des mécanismes réactionnels, Place L. Pasteur, 1, B-1348 Louvain-la-Neuve, Belgium 
  ** Université libre de Bruxelles, Faculty of Sciences, Unité de structure et fonction des membranes biologiques, CP206/02, Boulevard du Triomphe, B-1050 Bruxelles, Belgium
  Poster no. B-193

27ème Réunion Interdisciplinaire de Chimiothérapie Anti-Infectieuse (RICAI)
Paris, France, 6-7 décembre 2007

• Evaluation de l'usage des antibiotiques en médecine générale en Belgique francophone: détermination des raisons de la surprescription apparente et de la non-observance des recommandations de bonne pratique
  (Présentation orale; no. 235)
  J.M. Feron,* D. Legrand,* N. Kacenelenbogen,** A. Freyens,*** P.M. Tulkens
  * Centre académique de médecine générale, Université catholique de Louvain; * Département universitaire de médecine générale, Université libre de Bruxelles, Bruxelles; * Département universitaire de médecine générale, Université de Liège, Liège; Belgique
  
  
• Comparative intracellular activity of 11 antistaphylococcal antibiotics against a stable, thymidine-dependent small colony variant (SCV) and a normal phenotype isolate from a cystic fibrosis patient
  H.A. Nguyen, O. Denis,* A. Vergison,**, P.M. Tulkens, M. Struelens,*, F. Van Bambeke
  Poster no. 325 - This poster has received the AORIC (Association pour l'Organisation des Réunions Interdisciplinaires de Chimiothérapie anti-infectieuse) prize
  * Département de microbiologie, **Département de maladies infectieuses pédiatriques; Université libre de Bruxelles, Bruxelles, Belgique
  
  
• Intracellular activity of moxifloxacin against European, American and Asian clinical isolates of community-acquired methicillin-resistant S. aureus (CA-MRSA)
  S. Lemaire, F. Van Bambeke, Y. Glupczynski,* P.M. Tulkens
  Poster no. 487
  *Laboratoire de microbiologie, Clinique universitaire UCL de Mont-Godinne, Yvoir, Belgique
  
  
• Synthesis and evaluation of vancomycin target analogues as potential biosensors for on-line therapeutic monitoring
  I. Delattre, O. Hernout, J. Marchand-Brynaert,* K. Berthoin, P.M. Tulkens, S. Carryn**
  Poster no. 502
  *Unité de chimie organique et médicinale, Université catholique de Louvain, Louvain-La-Neuve; **Eumedica sa, Manage; Belgique
  
  
• Apoptosis induced by aminoglycosides in cultured cells: comparison between gentamicin and amikacin using incubated and electroporated cells
  Poster no. 503
  S. Denamur, F. Van Bambeke, M.P. Mingeot-Leclercq, P.M. Tulkens
  
  
• Epidemiological survey of antibiotic resistance in a Belgian collection of CAP isolates of Streptococcus pneumoniae
  Poster no. 557
  A. Lismond, F. Van Bambeke, S. Carbonelle, F. Jacobs,1 M. Struelens,2 J. Gigi,3 A. Simon,3 Y. Van Laethem,4 A. Dediste,5 D. Pierard,6 P.M. Tulkens
  1Service des maladies infectieuses et 2Laboratoire de microbiologie, Hôpital Erasme, Bruxelles; 3Laboratoire de microbiologie, Cliniques universitaires Saint-Luc, Bruxelles; 4Service des maladies infectieuses et 5Laboratoire de microbiologie, CHU St-Pierre, Bruxelles; 6Laboratorium voor microbiologie, Universitair Zikenhuis Brussel, Brussel; Belgique

Colloque ABC Franco-Belge
French-Belgian ABC meeting

5ème édition du Colloque ABC franco-belge / 5th edition of the French-Belgian ABC meeting
            Paris, France, 9 October 2007

• Antibiotic efflux in eucaryotic cells:implications of ABC transportersand pharmacokinetic and pharmacodynamic consequences
  F. Van Bambeke
  Oral presentation       

36th European Symposium on Clinical Pharmacy
            Istanbul, Turkey, 25–27 October 2007

• Antibiotic drug monitoring quality assessed by a clinical pharmacist: observational study
  Poster PK102
  E. Ampe, A. Spinewine,* Y. Glupczynski,* B. Delaere,* J.D. Hecq,* P.M. Tulkens
  * Cliniques universitaires de Mont-Godinne, Yvoir, Belgium
• Antibiotic drug Monitoring quality assessed by a Clinical Pharmacist: qualitative study
  Poster PT104 and Poster Discussion Forum
  E. Ampe, A. Spinewine,* Y. Glupczynski,* B. Delaere,* J.M. Feron,** J. Pierart,*** C. Bouland,**** J.D. Hecq,* P.M. Tulkens
  * Cliniques universitaires de Mont-Godinne, Yvoir, Belgium; ** Centre académique de Médecine générale, Université catholique de Louvain, Brussels, Belgium; *** Unité d'anthropologie et de sociologie, Université catholique de Louvain, Louvain-la-Neuve, Belgium; **** Institut Bruxellois de Gestion de l'Environnement, Brussels, Belgium

47th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
           Chicago, Ill., September 17-20, 2007

• Ciprofloxacin selects for PatA/PatB over-expression in a wild-type and PmrA-overproducer S. pneumoniae exposed to half-MIC concentrations -- (Poster C1/110)
  L. Avrain, M. Garvey,* Y. Glupczynski,** N. Mesaros, M. P. Mingeot-Leclercq, L. J. V. Piddock,* P. M. Tulkens, R. Vanhoof,*** F. Van Bambeke
  *University of Birmingham, Birmingham, United Kingdom; ** Cliniques universitaires de Mont-Godinne, Yvoir, Belgium; *** Institut Pasteur, Brussels, Belgium
• Competition between ciprofloxacin and non-steroidal anti-inflammatory drugs for efflux transporters in J774 macrophages -- (Poster A1141)
  F. Huyghe, M.P. Mingeot-Leclercq, B. Marquez-Garrido, P. M. Tulkens, F. Van Bambeke
• Insufficient activity of most common antistaphylococcal antibiotics towards intraphagocytic forms of S. aureus isolates from a patient with persistent bactereriemia: a cause for treatment failure ? -- (Poster A1439)
  S. Lemaire, L. M. Koeth, H. Labischinski,** K. Kosowska-Shick,*** F. Van Bambeke, P. M. Tulkens, P. Appelbaum***
  * Laboratory Specialists, Westlake, OH, ** Combinature Biopharm AG, Berlin, Germany, ***Hershey Med. Ctr., Hershey, PA.
• Intraphagocytic activities of ceftobiprole vs. conventional cephalosporins against methicillin-sensitive (MSSA) and methicillin-eesistant S. aureus (MRSA) -- (Poster A1438)
  S. Lemaire, F. Van Bambeke, Y. Glupczynski,* P. M. Tulkens
  * Cliniques universitaires de Mont-Godinne, Yvoir, Belgium.
  
• Comparative intracellular activity of ten antistaphylococcal antibiotics against a stable Small Colony Variant (SCV) of S. aureus in a model of human THP-1 macrophages -- (Poster A1437)
  H. A. Nguyen, O. Denis,* A. Vergison,** P. M. Tulkens, M. Struelens,* F. Van Bambeke
  * Université libre de Bruxelles (Hôpital Erasme), Brussels, Belgium; ** Université libre de Bruxelles (Hôpital universitaire des enfants Reine Fabiola), Brussels, Belgium
• Phoenix is overcalling the resistance of Enterobacteriaceae to temocillin -- (Poster D24)
  A. Simon (1), K. Camps (2), H. De Beenhouwer (3), B. Glibert (4), F. Meunier (5), A. Trouve (6), V. Vael (7), P.M. Tulkens, S. Carryn (8)
  (1) Cliniques universitaires St-Luc, Brussels; (2) ZNA Stuyvenberg, Antwerp; (3) OLVZ Aalst, Aalst; (4) AZ Zusters van Barmhartigheid, Ronse; (5) CH de Jolimont, La Louvière; (6) WZVGO Knokke-Heist; (7) ZNA J. Palfijn, Antwerp; (8) Belpharma SA, Brussels and Université catholique de Louvain, Brussels

6th European Biophysics Congress (EBC)
London, UK, July 14-18, 2007

• Interactions of fluoroquinolone antibiotics with phospholipids: modification of their physicochemical properties
  H. Bensikaddour, E. Goormaghtigh,* M.P. Mingeot-Leclercq - Poster P54
  * Unité de Structure et Fonction des Membranes biologiques, Université Libre de Bruxelles, Brussels, Belgium

32d Federation of the European Biochemical Societies (FEBS)
Vienna, Austria, July 7-12, 2007

• Evaluation of Macrophage Cell Membrane Preparation for Proteomics Analysis (Poster E-11)
  N. E. Caceres, M. Aerts,* M. P.Mingeot-Leclercq, R. Wattiez,** P.M. Tulkens, B.Devreese,** and F. Van Bambeke
  *Laboratory for Protein Biochemistry & Engineering, Ghent University. Ghent, Belgium; ** Laboratory of Biological Chemistry, University of Mons-Hainaut. Mons, Belgium.

Joint meeting of the Belgian FNRS contact group "Proteomics" and the Belgian Society of Biochemistry and Molecular Biology
"Organelle sub-proteomics and post-translationals modifications"
Brussels, May 15, 2007

• Modeling of a transmembrane multidrug resistance protein, P-glycoprotein
  G. Depret,* J.-P. Becker,* P.M. Tulkens, F. Van Bambeke, and M. Prévost*
  * Structure et Fonction des Membranes Biologiques, Université Libre de Bruxelles, Brussels, Belgium
  

17th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) & 27th International Congress of Chemotherapy
Munich, Germany, 31 March - 3 April 2007

• Extracellular and intracellular activities of Quinupristin-Dalfopristin (Synercid) against S. aureus, with different resistant phenotypes (MSSA, MRSA, VISA).
  P. Baudoux, Y. Glupczynski,* P.M.Tulkens, F. Van Bambeke. - Tuesday, April 03, 2007 - Poster 2058
  * Laboratoire de microbiologie, Cliniques universitaires de Mont-Godinne, Yvoir
  
• Ciprofloxacin and doxorubicin are substrates of different Multidrug Resistance-related Proteins efflux transporters in J774 macrophages
  F. Clesse, M.-P. Mingeot-Leclercq, P.M. Tulkens, F. Van Bambeke - Tuesday, April 03, 2007 - Poster 2067
• Intracellular activity of daptomycin against methicillin-sensitive, methicillin-resistant, and vancomycin-intermediate S. aureus
  S. Lemaire, F. Van Bambeke, and P.M. Tulkens - Sunday, April 01, 2007 - Poster 829
• Inhibitors and activator of the P-glycoprotein efflux pump modulate the accumulation of daptomycin in THP-1 macrophages and its intracellular activity towards S. aureus.
  S. Lemaire, F. Van Bambeke, and P.M. Tulkens - Tuesday, April 03, 2007 10:18-10:30 (oral session) presentation O429
• Comparative activity of moxifloxacin, linezolid, cloxacillin, clindamycin, trimethoprim-sulfamethoxazole, and ciprofloxacin against intracellular Methicillin-sensitive and Community-Acquired Methicillin-Resistant S. aureus.
  S. Lemaire, F. Van Bambeke, P.M. Tulkens and Y. Glupczynski.* - Sunday, April 01, 2007 - Poster 703
  * Laboratoire de microbiologie, Cliniques universitaires de Mont-Godinne, Yvoir
  
• Prevalence of Mex-mediated resistance in P. eruginosa isolates from patients with ventilator-associated pneumonia in 4 Belgian hospitals.
  N. Mesaros, Y. Glupczynski,* D. Pierard,** A. Dediste,*** Y. Van Laethem,*** F. Jacobs,**** M. Struelens,**** D. De Vos,***** J.-P. Pirnay,***** F. Van Bambeke, P.M. Tulkens - Monday, April 02, 2007 - Poster 1358
  * Laboratoire de microbiologie, Cliniques universitaires de Mont-Godinne, Yvoir ; ** Dients voor MIcrobologie, AZ-VUB, Brussels; *** CHU St-Pierre, Brussels; **** Erasme Hospital, Brussels; **** Queen Astrid Military Hospital, Brussels
• Aminoglycoside-induced apoptosis in cultured renal (LLC-PK1) and non-renal (J774 macrophages) cells: comparison between gentamicin and amikacin
  S. Denamur, F. Van Bambeke, M.-P. Mingeot-Leclercq, P.M. Tulkens - Tuesday, April 03, 2007 10:06-10:18 (oral session) presentation O428

26ème Réunion Interdisciplinaire de Chimiothérapie Anti-Infectieuse (RICAI)
Paris, France, December 7-8th, 2006

• Evolution of fluoroquinolone-resistance in clinical isolates of Streptoccus pneumoniae isolated in Belgium from 1995 to 2005.
  R. Vanhoof,* S. Damée,* S. De Craeye,* E. Van Bossuyt,* L.Avrain, P.M. Tulkens, J. Van Eldere,** J. Verhaegen** and the Belgian SP Study Group.
  * Pasteur Instituut, Brussels; ** University Hospital Gasthuisberg, Louvain.

FEBS Special Meeting - European Lipidomics Initiative: New concepts in lipidology: from lipidomics to disease
Noordwijkerhout, The Netherlands, October 21 - 25, 2006

• Characterization at nanometric scale of the interactions between fluoroquinolones (ciprofloxacin) and membrane lipids
  H. Bensikaddour, N. Fa, M. Deleu,* A. Schanck,** Y. Dufrene,*** M.-P. Mingeot-Leclercq
  * Unité de chimie biologique industrielle, Faculté universitaire des Sciences agronomiques de Gembloux, Gembloux, Belgium; ** Unité de chimie structurale et des mécanismes réactionnels, Université catholique de Louvain, Louvain-La-Neuve, Belgium; *** Unité de chimie des interfaces, Université catholique de Louvain, Louvain-la-Neuve, Belgium

46th Interscience Conference on Antimicrobial Agents and Chemotherapy
San Francisco, CA, September 27-30, 2006

Note: for the plenary lectures given at this Conference, visit http://www.facm.ucl.ac.be/facm-conferences.htm

• Mechanisms of resistance in S. pneumoniae exposed to half MICs of ciprofloxacin and moxifloxacin.
  L. Avrain, N. Mesaros, Y. Glupczynski*, F. Van Bambeke, R. Vanhoof**, and P.M. Tulkens
  * Laboratoire de Microbiologie, Cliniques universitaires Mont-Godinne, Yvoir, Belgium; ** Eenheid voor antibiotica onderzoek, Pasteur Instituut, Brussels, Belgium
  Poster C1-0041
  
  
• Telavancin is more bactericidal than vancomycin against both extracellular and intracellular (THP-1 macrophages) Staphylococcus aureus with different resistance phenotypes.
  M. Barcia-Macay, S. Lemaire, M.-P. Mingeot-Leclercq, P.M. Tulkens, and F. Van Bambeke
  Poster A-0642
  
  
• Bactericidal activity of ceragenin CSA-13 against intracellular MSSA, hospital-acquired (HA) and Community-acquired (CA) MRSA, and VISA in THP-1 macrophages: relation to cellular toxicity ?
  S. Lemaire, T. Bogdanovitch,* S. Chavez-Bueno,** P.D. Savage,*** F. Van Bambeke, P. Appelbaum,* and P.M. Tulkens
  * Hershey Medical Center, Hershey, PA; ** University of Texas Southwestern Medical Center, Dallas, TX; ***Brigham Young University, Provo, UT
  Poster A-0633
  
  
• Intracellular MRSA, VISA and VRSA are sensitive to cloxacillin and meropenem.
  S. Lemaire, F. Van Bambeke, Y. Glupczynski,* P. C. Appelbaum,** and P.M. Tulkens
  * Laboratoire de Microbiologie, Cliniques universitaires de Mont-Godinne, Yvoir, Belgium; ** Hershey Medical Center, Hershey, PA
  Poster A-0634
  
  
• Synergy between bacterial Lde and macrophage MRP efflux pumps markedly reduces the activity of ciprofloxacin but not that of moxifloxacin against intracellular Listeria monocytogenes.
  A. Lismond, P. Courvalin,* M.-P. Mingeot-Leclercq, P.M. Tulkens, F. Van Bambeke
  * Unité des Agents Antibactériens, Institut Pasteur, Paris, France
  Poster A-1108

• Contrasting effect of acid pH on the extracellular and intracellular activities of gentamicin and oxacillin against Staphylococcus aureus.
  P. Baudoux, N. Bles, S. Lemaire, M.-P. Mingeot-Leclercq, P. M. Tulkens, F. Van Bambeke
  Poster no. P-002
  
  
• Intracellular activity of antibiotics against methicillin-sensitive, hospital-acquired methicillin-resistant, and vancomycin-intermediate Staphylococcus aureus (MSSA, HA-MRSA, and VISA) in human macrophages (THP-1.
  S. Lemaire, P. Baudoux, M. Barcia-Macay, F. Van Bambeke, Y. Glupczynski,* P.M. Tulkens
  * Laboratoire de Microbiologie, Cliniques universitaires de Mont-Godinne, Yvoir, Belgium
  Poster no. P-004
  
  
• Intracellular infection of THP-1 human macrophages by Staphylococcus aureus and role of haemolysins.
  A. Olivier, S. Lemaire, M.P. Mingeot-Leclercq, F. Van Bambeke, P.M. Tulkens.
  Poster no. P-021

International Burkholderia cepacia Working Group
Ghent, Belgium, April 20-23, 2006

• Comparative in vitro activity of Temocillin, Meropenem, Ceftazidime, and Piperacillin/Tazobactam against panel strains and clinical isolates of Burkholderia cepacia complex from 9 different genomovars
  S. Carryn, P.M. Tulkens, and P. Vandamme*
  oral presentation
  * Universiteit Gent, Ghent, Belgium

16th European Congress of Clinical Microbiology and Infectious Diseases
Nice, France, April 1-4th, 2006

• Pharmacokinetics of Temocillin in Intensive Care Patients and Monte Carlo Simulations to Evaluate Breakpoints
  J.W. Mouton *, R. DeJongh **, V. Basma, P.M. Tulkens, S. Carryn
  Poster P-1515
  * Casinius Whilhelmina Ziekenhuis, Nijmegen, The Netherlands; ** Zuid-Oost-Limburg Ziekenhuis, Genk, Belgium
  
  
• Pharmacodynamic evaluation of the bactericidal activity of telavancin (TLV) against extracellular and intracellular MSSA and MRSA
  M. Barcia-Macay, M.P. Mingeot-Leclercq, P.M. Tulkens, F. Van Bambeke
  oral presentation O356
  
  
• Meropenem and cloxacillin are active against MRSA clinical isolates (including VISA)in acidic broth and in THP-1 macrophages.
  S. Lemaire, F. Van Bambeke, P.M. Tulkens, M.P. Mingeot-Leclercq, J. Coyette,* Y. Glupczynski**
  Poster P1534
  * Université de Liège, Liége, Belgium; ** Cliniques universitaires de Mont-Godinne, Yvoir, Belgium
  
  
• Detection of mexA and mexX efflux genes in P. aeruginosa: correlation between QC-RT-PCR and Real-Time PCR.
  N. Mesaros, Y. Glupczynski,* D. Pierard,** A. Dediste,*** Y. Van Laethem,*** P.M. Tulkens, M.P. Mingeot-Leclercq, F. Van Bambeke
  Poster P1751
  * Cliniques universitaires de Mont-Godinne, Yvoir, Belgium; ** AZ-Vrije Universiteit Brussel, Brussels, Belgium; *** CHU Saint-Pierre, Brussels, Belgium

45th Interscience Conference on Antimicrobial Agents and Chemotherapy
Washington, DC, December 16-19th, 2005

Note: for the plenary lectures given at this Conference, visit http://www.facm.ucl.ac.be/facm-conferences.htm

• Telavancin accumulates in cultured macrophages and is active against intracellular S. aureus
  M. Barcia-Macay, M.P. Mingeot-Leclercq, P.M. Tulkens, and F. Van Bambeke
  Poster A-1831
  
  
• Carbapenems are Active against Intracellular MRSA
  S. Lemaire, F. Van Bambeke, M.-P. Mingeot-Leclercq, Y. Glupczynski,* and P.M. Tulkens
  * Laboratoire de microbiologie, Cliniques universitaires de Mont-Godinne, Yvoir, Belgium
  Poster A-1832
  
  
• Genotypic method is more reliable than phenotypic characterization to detect Mex efflux pumps in clinical Isolates of Pseudomonas aeruginosa
  N. Mesaros, N. Caceres, F. Van Bambeke, Y. Glupczynski,* M.P. Mingeot-Leclercq, and P.M. Tulkens
  * Laboratoire de microbiologie, Cliniques universitaires de Mont-Godinne, Yvoir, Belgium
  Poster D-1699
  
  
• Gentamicin causes apoptosis at low concentrations in LLC-PK1 cells subjected to electroporation.
  H. Servais, Y. Jossin,* F. Van Bambeke, M.P. Mingeot-Leclercq, and P.M. Tulkens
  * Unité de neurobiologie du développement, Université catholique de Louvain, Brussels, Belgium
  Poster A-1836

7th European Congress of Chemotherapy and Infectious Diseases
Florence, Italy, October 19-22, 2005

• Comparative in vitro activity of temocillin, meropenem, ceftazidime and piperacillin/tazobactam against panel strains and clinical isolates of Burkholderia cepacia complex from 9 different genomovars.
  S. Carryn, PM Tulkens and P. Vandamme*
  *Laboratorium voor Microbiologie, Universiteit Gent, Ghent, Belgium
  Poster PS10-271 - Journal of Chemotherapy (2005), 17 (suppl. 3) : 94.
  
  
• Induction of fluoroquinolone efflux in Streptococcus pneumoniae by subinhibitory ciprofloxacin concentrations
  L. Avrain, N. Mesaros, R. Vanhoof,* F. Van Bambeke, and P.M. Tulkens.
  * Antibiotica resistentie en nosocomiale infecties, Instituut Pasteur, Brussels, Belgium
  Poster PS2-071 - Journal of Chemotherapy (2005), 17 (suppl. 3) : 3

Lipids, Liposomes, and Biomembranes 2005
Vancouver, BC, Canada, July 27-30th, 2005

• Probing fluoroquinolone-biomembrane interactions on the nanoscale
  Nathalie Fa, Ingrid Burton,* Magali Deleu,** Robert Brasseur,*** Yves Dufrêne,* Marie-Paule Mingeot-Leclercq
  * Unité de chimie des interfaces, Université catholique de Louvain, Louvain-la-Neuve; ** Unité de Chimie Biologique Industrielle, Faculté Universitaire des Sciences Agronomiques de Gembloux, Gembloux; *** Centre de Biophysique Moléculaire Numérique, Faculté Universitaire des Sciences Agronomiques de Gembloux, Gembloux.
  Poster

• Pharmacological comparison of the activity of antibiotics against intracellular S. aureus
  M. Barcia-Macay, M.P. Mingeot-Leclercq, P.M. Tulkens, F. Van Bambeke
  Oral communication O120 - Clinical Microbiology and Infection (2005): 11 Suppl. 2, 28-29.

• Learning appropriate use of antibiotics (PK/PD and guidelines :a CD-rom course for healthcare professionals and students
  E. Ampe, Y. Glupczynski*, P.M. Tulkens, and F. Van Bambeke
  * Laboratoire de Microbiologie, Cliniques universitaires UCL, Mont-Godinne
  Poster P878 - Clinical Microbiology and Infection (2005): 11 Suppl. 2, 295.
  Note: Persons interested in obtaining a copy of the course may send an E-mail to tulkens@facm.ucl.ac.be
  
  
• Ciprofloxacin (CIP) accumulation and intracellular activity against L. monocytogenes are reduced in ciprofloxacin-resistant macrophages due to increased efflux
  M. Heremans, M.P. Mingeot-Leclercq, P.M. Tulkens, and F. Van Bambeke
  Poster P1100 - Clinical Microbiology and Infection (2005): 11 Suppl. 2, 344.
  
  
• Phenotypic and genotypic detection of Mex efflux pumps in P. aeruginosa
  N. Mesaros, N. Caceres, F. Van Bambeke, M.P. Mingeot-Leclercq and P.M. Tulkens
  Poster P1731- Clinical Microbiology and Infection (2005): 11 Suppl. 2, 568-569.

• Development of a Protocol for extraction and Preparation of Macrophage Integral Membrane Proteins for Proteomics Analysis by the Conventional 2DE-MS Approach
  N.E. Caceres, M.P.Mingeot-Leclercq, P.M. Tulkens, R. Wattiez* and F. Van Bambeke
  * Service de Chimie Biologique, Université de Mons/Hainaut, Mons, Belgium
  Poster P139-S
  

• Interaction of the macrolide anitbiotic azithromycin with model of membranes
  N.Fa, A.Berquand*, Y.F. Dufrêne*, M.-P. Mingeot-Leclercq
  * Unité de chimie des interfaces, Université catholique de Louvain, Louvain-la-Neuve
  

• Intracellular models of infection to evaluate antibiotic activity
  M. Barcia-Macay, S. Carryn, S. Lemaire, C. Seral, M.P. Mingeot-Leclercq, P.M. Tulkens, F. Van Bambeke
  Oral communication
  

• A versatile method to quantify the expression level of  mexAB-oprM AND mexXY-oprM genes in P. aeruginosa
  N. Mesaros, N. Caceres, F. Van Bambeke, M.P. Mingeot-Leclercq, and P.M. Tulkens
  Poster 564/91P
  
  
• Continuous versus intermittent infusion of temocillin in Intensive Care patients
  V. Basma, R. de Jongh*, F. Van Bambeke, M.P. Mingeot-Leclercq, and P.M. Tulkens
  * Zuid Oost-Limburg Ziekenhuis, Genk, Belgium
  Poster 660/96P

• Ciprofloxacin-resistant J774 mouse macrophages show a reduction in the accumulation of quinolones through increased activity of an MRP-like transporter
  M. Heremans, J.M. Michot, M.P. Mingeot-Leclercq, P.M. Tulkens, F. Van Bambeke
  Oral presentation (abstract no. 1304)
  
  
• Beta-lactams are bactericidal against intracellular forms of S. aureus in  a 24-h human macrophages model (THP-1 cells)
  Maritza Barcia-Macay, Cristina Seral, Marie-Paule Mingeot-Leclercq, Paul M. Tulkens, Françoise Van Bambeke.
  Poster A1488
  
  
• Synthesis and activity of penicillin G hydroxamic acid derivatives against S. aureus, S. pneumoniae, and intraphagocytic L. monocytogenes.
  Leah Efron, Françoise Van Bambeke, Catherine Berhin, Youri Glupczynski*, Paul M. Tulkens, and Etienne Sonveaux**.
  (* Laboratoire de microbiologie, Clinique Universitaire de l'UCL à Mont-Godinne, Yvoir; ** Unité de Chimie Pharmaceutiques)
  Poster F333
  
  
• Contrasting effects of ertapenem (ETP) against intracellular L. monocytogenes and S. aureus in a model of THP-1 macrophages
  S. Lemaire, F. Van Bambeke, M.P. Mingeot-Leclercq, P.M. Tulkens.
  Poster A1487
  
  
• Involvement of mitochondrial pathway and Bax in gentamicin-induced apoptosis in renal LLC-PK1 cells.
  H. Servais, E. Delbecq, G. Van der Essen, G. Thirion, F. Van Bambeke, P.M. Tulkens and M.P. Mingeot-Leclercq
  Poster A 1491

• Interaction of azithromycin, an antibiotic, with model membranes
  N.Fa, A.Schanck, A.Berquand, M.-P. Mingeot-Leclercq
  (oral communication)
  
  

• Effet de l’azithromycine, un antibiotique de la classe des macrolides, sur des membranes modèle
  N.Fa, A.Schanck, A.Berquand, M.-P. Mingeot-Leclercq
  (oral communication)
  
  

• Increased susceptibility of intracellular Listeria monocytogenes to ampicillin: studies with Caco-2 cells and THP-1 macrophages.
  S. Vandevelde S. Carryn, F. Van Bambeke, M-P. Mingeot-Leclercq and P. M. Tulkens
  Poster no. 123
  
  
• PMA activation increases accumulation and activity against intracellular Listeria monocytogenes in THP-1 cells of ciprofloxacin and moxifloxacin but not of levofloxacin and garenoxacin
  S. Van de Velde, S.

• Dosing the magic bullets against intracellular bacteria: lessons from a comparison between beta-lactams and quinolones againts L. monocytogenes and S. aureus
  M. Barcia-Macay, S. Lemaire, S. Carryn,  M.P. Mingeot-Leclercq, P.M. Tulkens, and F. Van Bambeke
  
  
• Cellular pharmacokinetics of quinolones revisited: role of MDR efflux pumps expressed in macrophages
  J.M. Michot, M. Heremans, F. Van Bambeke, M.P. Mingeot-Leclercq, and P.M. Tulkens
  
  

• Antibiotic activity of new penams (6-APA) and cephems (7-ACA) with bulky T-shaped side-chains.
  L. Efron, Th. Happaerts, E. Sonveaux,  H. Chanteux, C. Berhin,Y. Glupczynski, F. Van Bambeke, P.M. Tulkens.
  Poster P544
  
  
• Comparison of ertapenem, ampicillin, and meropenem against the intracellular forms of Listeria monocytogenes in human THP-1 macrophages.
  S. Lemaire, S. Van de Velde, S. Carryn,  F. Van Bambeke, M.-P. Mingeot-Leclercq, P.M. Tulkens.
  Poster P1045
  
  
• In-vitro antifungal activity, cytotoxicity and cellular accumulation of new water-soluble amphotericin B (AMB) ­ polyvinylpyrrolidone (PVP) formulations.
  E. Charvalos, M.N. Tzatzarakis, F. Van Bambeke, P.M. Tulkens, A.M. Tsatsakis, M.-P. Mingeot-Leclercq
  Poster P1785

• Oritavancin accumulates to high levels in the lysosomes of macrophages by endocytosis
  F. Van Bambeke, H. Chanteux, D. Tyteca,  M.P. Mingeot-Leclercq, P.M. Tulkens
  Poster 1169 A
  
  
• Comparative Activity of 12 Antibiotics Used at Clinically-meaningful Extracellular Concentration Against Staphylococcus aureus in Broth and in Human THP-1 Macrophages
  M. Barcia-Macay, C. Seral, M.P. Mingeot-Leclercq, P.M. Tulkens, F. Van Bambeke
  Poster 1174 A
  
  
• Influence of Inhibitors of Efflux Pumps on the Accumulationof Quinolones in a model of Calu-3 Human Airway Epithelial Cells
  C. Seral, E. Viaene, F. Van Bambeke, M.P. Mingeot-Leclercq and P.M. Tulkens
  Poster 1175 A
  

• Activity of Garenoxacin (BMS284756) and Levofloxacin Against IntracellularStaphylococcus aureus or Listeria monocytogenes in J774 Macrophages
  C. Seral, P.M. Tulkens and  F. Van Bambeke
  Poster 1176 A
  
  
• Two Years of National Public Campaigns to Promote Appropriate Use of Antibiotics in the Community In BelgiumI. Bauraind, H. Goossens, E. Hendrickx, F. Yane, B. Seys, J.-L. Marchal, P.M. Tulkens, L. Verbist, J.-M. Lopez-Lozano, A. Beyaert.
  Poster 1362A