Université catholique de Louvain (UCL-Bruxelles)
Louvain Drug Research Institute
(Department of Pharmaceutical Sciences)
Cellular and Molecular Pharmacology

Conferences and Public adresses
(selection since 1998)

 Conférences en français -  Voordrachten in het Nederlands

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2012 | 2011 | 20102009 | 2008 20072006 | 20052004 | 2003 | 2002 | 2001 2000 | before 2000

2012 (by reverse chronological order)

  • EUCAST breakpoints
    13th Congress of the Lebanese Society for Infectious Diseases and Clinical Microbiology, Beirut, Lebanon, 2-4 February 2012
    PDF

  • Guidelines in infectious diseases: from diversity to logics (a study about CAP guidelines)
    13th Congress of the Lebanese Society for Infectious Diseases and Clinical Microbiology, Beirut, Lebanon, 2-4 February 2012
    PDF


2011 (by reverse chronological order)

  • Moxifloxacin safety data review
    8th Forschungswerkstatt Moxifloxacin 2011, Leverkusen, Germany, 18 November 2011
    PDF


  • But where does the Pharmaceutical Industry go ... and Universities in all that business ?
    A3P Symposium Belgium, Spa, Belgium, 16 November 2011
    PDF


  • Discovery of new antibiotics: Why and some approaches (with a short presentation of Belgium and of the Université catholique de Louvain)
    International University, Vietnam National University, Ho Chi Minh City, Vietnam, 10 October 2011

    PDF

  • Colistin: from structure to clinical use via microbiology, PK/PD, and toxicology
    Bach Mai Hospital, Hanoi, Vietnam (within the context of a cooperative programme between Wallonie-Bruxelles International and the University of Pharmacy, Hanoi, Vietnam), 6 October 2011
    PDF


  • Optimising treatment based on PK/PD principles
    Evolving Antibacterial Therapy - 30 years of clinical experience, 24-25 September, Istanbul, Turkey
    PDF

  • Towards clinical Applications of PK-PD in specific situations
    51th Interscience Conference onf Antimicrobial Agents and Chemotherapy (ICAAC), Chicago, IL. - ICAAC/ISAP Workshop - 16 September 2010

    PDF


  • Guidelines in lower respiratory tract infections: from diversity to logics
    Latin-America consensus meeting on Respiratory Tract Infections ( "Inspiration" ), Rio-de-Janeiro, Brazil, 28-30 July 2011
    PDF


  • Antibiotic resistance: are we heading for failures ?
    36th Annual Meeting of the International Urogynecological Association, Lisbon, Portugal, 29 June 2011
    Symposium "The guidelines offer more than antibiotics to manage recurrent urinary tract infections"

    PDF

  • Towards rational international antibiotic breakpoints: Actions from the European Committee on Antimicrobial Susceptibility Testing (EUCAST)
    1st International & 12th Iranian Congress of Microbiology, Kermanshah, Iran, 23-26 May 2011
    PDF

  • Hunting intracellular bacteria with antibiotics
    1st International & 12th Iranian Congress of Microbiology, Kermanshah, Iran, 23-26 May 2011
    PDF


  • Improving usage by guidelines: a critical view
    21st European Congress of Chemotherapy and Infectious Diseases & 27th International Congress of Chemotherapy, Milan, Italy, 7-10 May 2011
    Symposium: Bridging the gap of innovation – what we all could do ?
    PDF


  • Strategies to combat resistance: Focus on pharmacokinetics/ pharmacodynamics with applications to beta-lactams and a few words on colistin
    - Academy for Infection Management, India -- Mumbai (12-02) -- Chennai (13-02) -- Bangalore (14-02) -- Kolkata (15-02) -- Delhi (16-02) -- calculator (beta-lactams "concentration vs time" after IV bolus) (available soon)
    - International Critical care Congress 2001(CRITICARE 2001), Delhi 18 February 2011 - PDF (this set of slides contains also data on vancomycin)

2010 (by reverse chronological order)

  • Respiratory fluoroquinolones: Benefit-Risk profiles
    Belgische Vereniging voor Pneumologie – Société belge de pneumologie, Antwerp, 27 November 2010
    PDF

  • Towards clinical Applications of PK-PD in specific situations
    50th Interscience Conference onf Antimicrobial Agents and Chemotherapy (ICAAC), Boston, Mass. - ICAAC/ISAP Workshop - 11 September 2010
    PDF

  • Hunting intracellular bacteria with antibiotics
    Invited Lecture - Department of Chemistry and Biochemistry, University of Notre-Dame, Notre Dame, Indiana, 9 September 2010
    PDF

  • How do antibiotics play with multidrug transporters in eucaryotic cells ?
    462nd W.E. Heraeus Seminar, Jacobs University, Bremen, Germany, 9 July 2010
    PDF

  • Antibiotic transporters in Pseudomonas aeruginosa and Streptococcus pneumoniae: impact on resistance and clinical significance
    (Introductory comment: why do we need but will have difficulties in getting new antibiotics)
    462nd W.E. Heraeus Seminar, Jacobs University, Bremen, Germany, 9 July 2010
    PDF


  • Antibiotic efflux in procaryotic and eucaryotic cells: from molecular mechanisms to pharmacological consequences
    Institut National de la Recherche Agronomique, Toulouse, France, 21 May 2010
    PDF


  • Impact of the antibiotic treatment on resistance of Pseudomonas aeruginosa in nosocomial pneumonia, or "Pseudomonas in Brussels in 2010"
    Séminaire de microbiologie et maladies infectieuses, Hôpital Erasme, Université libre de Bruxelles, Brussels, Belgium, 24 March 2010
    PDF

  • Intracellular Killing: Where’s the Bug? Where’s the Drug?
    Gordon Research Conference "New Antibacterial Discovery & Development", Galveston, TX, 18 March 2010
    PDF


  • Update on new antibiotics in Belgium
    Seminar for Clinical pharmacists, Université catholique de Louvain & Cliniques universitaires St-Luc, Brussels, Belgium, 25 January 2010
    PDF

2009 (by reverse chronological order)

  • Aminoglycosides: What have we learned about toxicity ?
    Infectious Diseases Society of America (IDSA) 47th Annual Meeting, Philadelphia, PA, 29 November 2009
    (Symposium # 153: Back to the Future: The Aminoglycosides are Here Again)
    PDF


  • ABC transporters: from survival to resistance (or vice-versa)
    Colloque ABC franco-belge / ABC French-Belgian Colloquium, Paris, France, 14 October 2009
    PDF

  • Iron metabolism and medical needs: a view from Academia
    Iron Therapy Master Class, Zürich, Switzerland, 13-15 October 2009
    PDF

  • Efflux pump inhibitors to restore antibiotic efficacy
    ESCMID/FEMS Conference: "From Microbial Pathogenesis to the Discovery of Antivirulence Drugs", Les Diablerets, Switzerland, 4-8 October 2009
    PDF


  • Administration of beta-lactams by continuous infusion: when, how, and for which molecules ?
    49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Francisco, CA (Meet-the-Experts – session 202. Optimization of Beta-Lactams: Continuous and Prolonged Infusions versus Standard Regimens) - 14 September 2009
    PDF


  • Updates on treatment of Staphylococcus aureus / MRSA
    26th Annual Meeting of the Scandinavian Society of Antimicrobial Chemotherapy, Tromsoe, Norway, 5 September 2009
    PDF

  • Safety of antibiotics used in respiratory tract infections: benefit-risk profile of moxifloxacin
    2009 Annual Meeting of the Finnish Society for Infectious Diseases (satellite symposium), Helsinki, Finland, 25 August 2009
    PDF

  • Intracellular infection and activity of antibiotics: concepts and examples with Staphylococcus aureus and Listeria monocytogenes
    Lecture given at The Turku Center for Immunology, National Public Health Institute, Turku, Finland, 24 August 2009
    PDF


  • Antibiotic selection in community-acquired pneumonia (CAP): appropriate benefit-risk profiles
    7th Forschungswerkstatt Moxifloxacin 2011, Leverkusen, Germany, 26 June 2011
    PDF


  • Collateral effects of antibiotics: adverse effects and drug interactions
    26th International Congress of Chemotherapy and Infection (Meet the Experts session ME-41), Toronto, Ont., 20th June 2009
    PDF

  • New antimicrobials
    27th Annual meeting of the European Society for Paediatric Infectious Diseases (ESPID), Brussels, Belgium, 12 June 2009
    PDF


  • Adopting EUCAST breakpoints in countries currently on CLSI breakpoints and some personal thinking…
    19th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Helsinki, Finland, 18 May 2009
    PDF

  • Colistin pharmacokinetics/pharmacodynamics with an introduction and comments about reasonable uses
    19th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Helsinki, Finland, 17 May 2009
    PDF

  • Antibiotic transporters: Clinical Implications
    Gordon Reserach Conference "Efflux Transporters", Galveston, TX, 26 March 2009
    PDF


  • Antibiotics for Community-acquired pneumonia (CAP): appropriate benefit-risk profiles
    - 5th Forum on Respiratory Tract Infections, Sitges (Barcelona), Spain, 5 February 2009  PDF
    - Italian medical educational meeting, Leverkusen, Germany, 6 March 2009  PDF
    - 7 Forschungswerkstatt Moxifloxacin, Leverkusen, Germany, 26 June 2009 PDF

  • Doripenem vs meropenem: a summary of international and Belgian published data
    Brussels, Belgium, 2 February 2009
    PDF

  • Deciphering the activity of antibiotics against intracellular Staphylococcus aureus with the help of PK/PD (pharmacokinetics/pharmacodynamics)
    Seminar held at the Institut für Medizinische Mikrobiologie, Universitätsklinikum Münster, Germany, 15 January 2009
    PDF

2008 (by reverse chronological order)

  • Safety of moxifloxacin with special reference to the recent labelling change and benefit-risk ratio
    Lecture for Italian Infectious Diseases and Pulmonologists, Leverkusen, Germany, 2 december 2008
    PDF


  • New developments in anti-Gram positive treatments
    Société belge d'infectiologie et de microbiologie clinique/Belgische Vereniging voor Infectiologie en Klnische Microbiologie, La Hulpe, 6 November 2008
    PDF

  • Pharmacodynamics of antibiotics in cerebrospinal fluid (CSF): Principles and Consequences (factors predictive of efficacy)
    17ème Conférence de consensus en maladies infectieuses - Prise en charge des méningites bactériennes aiguës, Paris, 19 novembre 2008
    PDF (English version - pour une version française: cliquez ici)


  • Toxicodynamics
    Symposium in honor of Prof. W.A. Craig, University of Madison, School of Medicine and Public Health, Madison, WI, October 29, 2008
    PDF

  • How to target intracellular pathogens
    48th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) / Infectious Diseases Society of America(Symposium Pharmacokinetic/Pharmacodynamic - Factors in Treating Infection in Special Sites and/or Special Pathogens - session 53), Washington, DC, October 25, 2008
    PDF


  • Aminoglycoside nephrotoxicity: a paradigm in toxicodynamic research
    48th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) / Infectious Diseases Society of America (Symposium Toxicodynamics - session 72), Washington, DC, October 26, 2008
    PDF

  • Towards clinical Applications of PK-PD
    48th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) / Infectious Diseases Society of America (Workshop), Washington, DC, October 24, 2008
    PDF

  • Safety of moxifloxacin and its benefit-risk ratio in community setting
    Educational symposium at the occasion of the 2008 Annual Meeting of the European Respiratory Society, Berlin, Germany, October 6, 2008
    PDF


  • From erythromycin to telithromycin: two bullets for one target ... what makes the difference ?
    2nd World Conference on Magic Bullets (Ehrlich II), Nürnberg, Germany, October 3 - 5, 2008
    PDF

  • Chemotherapy and PK/PD of intracellular infections
    2nd World Conference on Magic Bullets (Ehrlich II), Nürnberg, Germany, October 3 - 5, 2008
    PDF

  • Aminoglycoside nephrotoxicity: a paradigm in toxicodynamic research
    2nd World Conference on Magic Bullets (Ehrlich II), Nürnberg, Germany, October 3 - 5, 2008
    PDF

  • Antibiotic transporters: from Discovery to Clinical Implications
    PhD's Day, Académie Bruxelles-Wallonie, Brussels, 20 May 2008
    PDF


  • Activity of antibiotics against intracellular S. aureus
    European Congress of Clinical Microbiology and Infection (ECCMID), Barcelona, Spain - 21 April 2008
    PDF

2007 (by reverse chronological order)

  • Towards Rational International Antibiotic Breakpoints: Actions from the European Committee on Antimicrobial Susceptibility Testing (EUCAST)
    Academy of Infection Management, Athens, Greece – 16 November 2007
    PDF


  • Towards clinical Applications of PK-PD
    47th Interscience Conference on Antimicrobial Agents and Chemotherapy (Workshops), Chicago, IL, September 16th, 2007
    PDF

  • Efflux as new challenge in antibacterial chemotherapy
    Transport across membranes: Multiple drug resistance, mechanisms and new tools. Summer School Jacobs University Bremen, July 8-14th, 2007
    PDF

  • Inhibitors of efflux pumps: the long journey from procaryotes to eukaryotes
    Transport across membranes: Multiple drug resistance, mechanisms and new tools. Summer School Jacobs University Bremen, July 8-14th, 2007
    PDF

  • Molecular bases for antibiotic resistance through efflux
    Transport across membranes: Multiple drug resistance, mechanisms and new tools. Summer School Jacobs University Bremen, July 8-14th, 2007
    PDF

  • Towards Rational International Antibiotic Breakpoints: Actions from the European Committee on Antimicrobial Susceptibility Testing (EUCAST) and some personal thinking…
    Hospital Vesale, Montigny-le-Tilleul, Belgium - May 22d, 2007
    PDF
    version française (Le Roeulx [9/11] et Liège [11/11 ])
    Nederlandse versie (Hasselt [4/6], Antwerpen [11/6], Destelgem [18/6])


  • Examining the interaction of drugs and membranes to improve selectivity
    Ehancing Screening Strategies with Cell-Based Assays, Informa-Life Sciences (Informa plc, London, UK), Munich, Germany - February 5-8th, 2007
    PDF

  • Towards Rational International Antibiotic Breakpoints: Actions from the European Committee on Antimicrobial Susceptibility Testing (EUCAST) and some personal thinking…
    Seminar for AstraZeneca, Destelbergen, Belgium, January 15, 2007
    PDF

  • The bad and good uses of fluoroquinolones in urology
    Groupe local d'étude de la médecine (GLEM), Cliniques universitaires St-Luc, Brussels, Belgium - January 9, 2007
    PDF

2006 (by reverse chronological order)

  • Are intracellular drug concentrations relevant for efficacy ? A discussion about accumulation, efflux and activity …
    2006 Joint Fall Meeting of the Nederlandse Vereniging voor Medische Microbiologie & Vereniging voor Infectie Ziekten, Amsterdam, The Netherlands, November 16, 2006
    PDF

  • Towards Rational International Antibiotic Breakpoints: Actions from the European Committee on Antimicrobial Susceptibility Testing (EUCAST) and some personal thinking…
    "Les midis de l'Infectiologie", Centre hospitalo-universitaire, Université de Liège, Belgium, November 14, 2006
    PDF

  • Quinolones, macrolides, beta-lactams, glycopeptides ... and a few others against resistant S. aureus
    3d International Symposium on Gram-positive Infections, Niagara-on-the Lake, Ontario, October 9-11th, 2006
    PDF

  • Pharmacokinetics of Old and New Glycopeptides
    46th Interscience Conference on Antimicrobial Agents and Chemotherapy, American Society of Microbiology, San Francisco, CA, September 27, 2006
    PDF

  • Pharmacodynamics of antibiotics as a means to improve and curb the emergence of resistance
    2d International Symposium of the Jordanian Society of Pathology, Amman, Jordania, August 31, 2006
    PDF

  • New antistaphylococcal agents: hopes and limitations
    2d International Symposium of the Jordanian Society of Pathology, Amman, Jordania, August 31, 2006
    PDF

  • Antibiotic restriction policies: are they applicable (and desirable) outside the western world ?
    2d International Symposium of the Jordanian Society of Pathology, Amman, Jordania, August 31, 2006
    PDF

  • Pharmacodynamics of antibiotics … From what you already knew about " optimizing activity " ... to what you didn't dare to ask about emergence of resistance...
    Joint Spanish-Belgian Intensive Care meeting, Barcelona, Spain, April 22, 2006
    PDF

  • Pharmacodynamics of antibiotics: Correlation between kinetics and activity
    4th Arab Symposium for Antimicrobial Agents / 16th National Tunisian Congress of Infectiology, Tunis, Tunisia, April 18th, 2006
    PDF

  • Aminoglycosides: a new look at old but probably faithfull antibiotics
    Research Lecture for Pfizer Central Laboratories, Groton, Conn., April 12, 2006
    PDF

  • Antibiotic combinations vs. monotherapy in critical care
    AB-Biodisk Educational Workshop, Stockhom, April 5-6, 2003
    PDF

  • PK/PD modeling of antibiotics: Clinical Implications
    AB-Biodisk Educational Workshop, Stockhom, April 5-6, 2003
    PDF

  • Pharmacodynamic indices in targeting therapy of critical infections
    AB-Biodisk Educational Workshop, Stockhom, April 5-6, 2003
    PDF


  • PK/PD of antibiotics: from theory to applications in the real world...
    Joint Italian-Belgian Intensive Care meeting, Milan, Italy, March 18, 2006
    PDF

  • Use of cell lines to study specific aspects related to bacterial infections and antibiotic transport
    International Worshop on Cellular Models in Drug Development, London, UK, February 15, 2006
    PDF

  • Relationship between resistance, antibiotic policies, and clinical guidelines in the community: Government interventions on Antibiotic Policy in Belgium
    Libra Initiative European Summit, Brussels, Belgium, January 18, 2006
    PDF


2005
  • Models of antibiotic intracellular transport
    45th Interscience Conference on Antimicrobial Agents and Chemotherapy, American Society of Microbiology, Washington, DC, December 19th, 2005

    PDF

  • How to choose an antibiotic for respiratory tract infections in 2005
    Barcelona, Spain, November 24th, 2005
    PDF

  • Antibiotic efflux pumps in eucaryotic cells: consequences for activity against intracellular bacteria
    Journée d'animation scientifique IFR 136 "Agents transmissibles et infectiologie - Mécanismes d’efflux et résistances aux agents thérapeutiques", Institut National de la Recherche Agronomique (INRA), Tours-Nouzilly, France, June 8th, 2005
    Web presentation - PDF
  • The pharmacological and microbiological basis of PK/PD: Why did we have to invent PK/PD in the first place ?
    24th International Congress of Chemotherapy, Manila, Philippines, June 5, 2005
    Web presentation - PDF

  • Towards Rational International Antibiotic Breakpoints: Actions from the European Committee on Antimicrobial Susceptibility Testing (EUCAST) - A report to the Interntaional Scociety of Chemotherapy (ICC)
    24th International Congress of Chemotherapy, Manila, Philippines, June 4, 2005
    PDF

  • Azalides revisited: why the single dose ?  The pharmacologist's answer
    24th International Congress of Chemotherapy, Manila, Philippines, June 4, 2005
    Web presentation - PDF



2004
  • Glycopeptides: how can a structural modification bring to a new life an old family of antibiotics ?
    Séminaire et Conférences du Département des Sciences Pharmaceutiques, Université catholique de Louvain, Brussels, Belgium, December 13th, 2004
    Web presentation - PDF

  • Collaborations on antibiotics with the Rega Institute
    Rega Institute 50th Anniversary, Katholieke Universiteit Leuven, Louvain, Belgium, October 9th, 2004
    Web presentation - PDF

  • Belgian Antibiotic campaigns (2000-2002)
    European Workshop on Antibiotic Campaigns, Brussels, Belgium, September 23-24, 2004
    Web presentation - PDF

  • Intracellular antibiotics
    World Conference on Magic Bullets - Celebrating Paul Ehrlich's 150th birthday, Nuremberg, Germany, September 9-11th, 2004
    Web presentation - PDF

  • Antibiotic efflux pumps in eucaryotic cells: consequences for activity against intracellular bacteria
    Cost B16 meeting (European Commission), Ghent, Belgium, May 28th, 2004
    Web presentation - PDF file

  • Setting-up of a 24 h model to evaluate the activity of antibiotics against intracellular forms of S. aureus infection
    King Pharmaceuticals Workshop, Prague,Czech Republic, May 4th, 2004
    Web presentation - PDF file

  • Vancomycin by continuous infusion ... Why and how ?
    GSK-Belgium satellite meeting - 14th European Congress of Chemotherapy, Prague, Czech Republic, May 3d, 2004
    Web presentation - PDF file

  • MRSA treatments: does the future shine ?
    GSK-Belgium satellite meeting - 14th European Congress of Chemotherapy, Prague, Czech Republic, May 3d, 2004
    Web presentation - PDF file

  • Nephrotoxicity of Aminoglycosides and Comparisons with Cis-Platinum
    American Association for Research in Otolaryngology, Annual Meeting - Presidential Symposium (Daytona Beach, FL),
    February 22, 2004
    Web presentation - PDF file



2003

2001


2000


before 2000

  • Fluoroquinolones: structure versus activity and toxicity. 
    Société Belge d’Infectiologie et de Microbiologie Clinique/Belgische Vereniging voor Infectiologie en Klinische Microbiologie, St.-Niklaas, Belgium, December 11, 1999

  • Fluoroquinolones : from structure to activity, 
    Internal training and education seminar for Bristol-Myers/Squibb, Brussels, Belgium, October 25, 1999

  •  Aminoglycoside nephrotoxicity: from molecular pharmacology and pathology to some clinical applications (only part of ythe slides shown are available), 
    University of Cincinnati Medical Center (Division of Nephrology & Hypertension), Cincinnati, Ohio, October 9, 1999

  • Intracellular infection : a journey from biology to therapy, 
    University of Cincinnati Medical Center (College of Pharmacy), Cincinnati, Ohio, October 8, 1999

  • In vitro toxicodynamic models to accelerate drug selection and safety assessment,
    9th Symposium of the International Society for Anti-infective Pharmacology, Birmingham, United Kingdom, July 3, 1999

  • Antibiotic use : is it time for a change ? My personal view, 
    Joint EMEA (European Agency for the Evaluation of Medicinal Products) / ISAP (International Society of Antiinfective Pharmacology), Uppsala, Sweden, June 10, 1999

  • Can computer modelling predict the intracellular activity of antibiotics, 
    Symposium “Computer modelling of antibiotic response”, 9th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Berlin, Germany, March 24, 1999

  • Intracellular anti-infectives: is it important for efficacy and do we need to care for toxicity?  
    1st workshop of the International Society of Antiinfective Pharmacology, Berlin, Germany, March 21,1999

  • Pharmacokinetics and Pharmacodynamics in action : a view from the patient, 
    1st workshop of the International Society of Antiinfective Pharmacology, Berlin, Germany, March 21,1999

  • Pharmacokinetic/ Pharmacodynamics in Drug Development and Evaluation 
    FDA / ISAP Workshop “Pharmacodynamics and the impact on antiinfective drug development”, Rockville, MD, March 1, 1999
    (Presidential address on behalf of the International Society of Antiinfective Pharmacology)

  • Problems arising from the use of modern antibiotics  
    Opening lecture at the Annual Meeting of the Portuguese Society for Microbiology and Infectious Diseases, Coimbra, Portugal, February 25, 1999

  • Antibiotic uptake in cells: do liposomes help ? 
    Symposium “"Pharmacological issues for antimicrobial Therapy using liposomes"
    38th Interscience Conference on Antimicrobial Agents and Chemotherapy, American Society of Microbiology, San Diego, CA, September 25, 1998

  • Cultured cells models for the prospective assessment of anti-infective toxicity 
    Pharmacodynamics of Antiinfective Drugs as a Way to accelerate Drug Pre-clinical and Clinical Development, International Society of Antiinfective Pharmacology, San Diego, CA, September 23, 1998

  • Defining the requirements for an intracellular antibiotic, 
    Pharmacodynamics of Antiinfective Drugs as a Way to accelerate Drug Pre-clinical and Clinical Development, International Society of Antiinfective Pharmacology, San Diego, CA, September 23, 1998

  • Antibiotic distribution and activity in cells, 
    Chlamydia pneumoniae Consensus Conference, Carefree, AZ, June 13, 1998

  • Can we define breakpoints for intracellular infections ? 
    Pharmacokinetic/pharmacodynamic Interactions : concepts, controversies and challenges, International Society of Antiinfective Pharmacology/Paul Ehrlich Gesellschaft/2d European Congress of Chemotherapy, Hamburg, Germany, May 10, 1998