Publications of Cellular and Molecular Pharmacology at UCL

	Université catholique de Louvain Louvain Drug Research Institute > Cellular and Molecular Pharmacology
	*Scientific publications*

"Was auch als Wahrheit oder Fabel
In tausend Büchern dir erscheint,
Das alles ist ein Turm zu Babel,
Wenn es die Liebe nicht vereint."
J.W. von Goethe

View of the private library of J.W. von Goethe, Goethe's House, Weimar, Germany

Photograph:
Toma Babovic,
LZW 3,
Edition Media dell'arte
(with permission)

In press | 2024 | 2023| 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | before 2000

Key: Latest addition in the corresponding section | en français ... | in het Nederlands... | clinical pharmacy (see also Centre for Clinical Pharmacy)

In press or Advance Access (E-pub)
(by reverse chronological order of acceptance

Wang Z, Vanbever R, Lorent JH, Solis J, Knoop C, Van Bambeke F.
Repurposing DNase I and alginate lyase to degrade the biofilm matrix of dual-species biofilms of Staphylococcus aureus and Pseudomonas aeruginosa grown in artificial sputum medium: In-vitro assessment of their activity in combination with broad-spectrum antibiotics.
Journal of Cystic Fibrosis 2024 Feb 23:S1569-1993(24)00027-4. doi: 10.1016/j.jcf.2024.02.012
Original paper - Journal impact factor (in 2023): 5.527
Link to PubMed (US National Library of Medicine): PMID=38402083
Link to original document at publisher's site through DOI: 10.1016/j.jcf.2024.02.012

Published papers and chapters of books
(by year and alphabetical order)

2024

Anantharajah A, Goormaghtigh F, Nguvuyla Mantu E, Güler B, Bearzatto B, Momal A, Werion A, Hantson P, Kabamba-Mukadi B, Van Bambeke F, Rodriguez-Villalobos H, Verroken A
Long-term intensive care unit outbreak of carbapenemase-producing organisms associated with contaminated sink drains.
Journal of Hospital Infection. 2024;143:38-47.
Original paper - Journal impact factor (in 2023): 6.9
Reprint (PDF) (with Supplementary Material)
Link to original document at publisher's site through DOI:10.1016/j.jhin.2023
De Soir S, Parée H, Kamarudin NHN, Wagemans J, Lavigne R, Braem A, Merabishvili M, De Vos D, Pirnay J-P, Van Bambeke F.
Exploiting phage-antibiotic synergies to disrupt Pseudomonas aeruginosa PAO1 biofilms in the context of orthopedic infections.
Microbiology Spectrum 2024;12:e0321923.
Original paper - Journal impact factor (in 2023): 3.70
Link to PubMed (US National Library of Medicine):PMID=38084971
Reprint (PDF) (with Supplementary Material)
Link to original document at publisher's site through DOI: 10.1128/spectrum.03219-23.
Goormaghtigh F, Van Bambeke F.
Understanding Staphylococcus aureus internalisation and induction of antimicrobial tolerance.
Expert Review inAnti Infective Therapy. 2024 Jan-Jun;22(1-3):87-101.
Review paper - Journal impact factor (in 2023): 5.40
Link to PubMed (US National Library of Medicine): PMID=38180805
Reprint (PDF)
Link to original document at publisher's site through DOI: 10.1080/14787210.2024.2303018.
Ngougni Pokem P, Liu X, Parker SL, Verroken A, Collienne C, Finet P, Wijnant GJ, Laterre PF, Roberts JA, Van Bambeke F, Wittebole X.
Population pharmacokinetics and dosing simulations of total and unbound temocillin in the plasma and CSF of neurocritically ill patients with external ventricular drain-related cerebral ventriculitis.
Journal of Antimicrobial Chemotherapy. 2024 Feb 1;79(2):429-442
Original paper - Journal impact factor (in 2023): 5.2
Link to PubMed (US National Library of Medicine):PMID=38153240
Reprint (PDF) (with Supplementary Material)
Link to original document at publisher's site through DOI. 10.1093/jac/dkad398
Thirot H, Fage D, Leonhardt A, Clevenbergh P, Besse-Hammer T, Yombi JC, Cornu O, Briquet C, Hites M, Jacobs F, Wijnant GJ, Wicha SG, Cotton F, Tulkens PM, Spinewine A, Van Bambeke F.
Towards a better detection of patients at-risk of linezolid toxicity in clinical practice: a prospective study in three Belgian hospital centers.
Frontiers inPharmacology 2024 Jan 19;15:1310309. doi: 10.3389/fphar.2024
Link to PubMed (US National Library of Medicine):PMID=38313312
Original paper - Journal impact factor (in 2023): 5.60
Reprint (PDF) (with Supplementary Material)
.Link to original document at publisher's site through DOI. 10.3389/fphar.2024.1310309

2023

Catteau L, Diaz Iglesias Y, Tsunemoto H, Pogliano J, Van Bambeke F, Nizet V, Sakoulas G.
Nafcillin Augmentation of Daptomycin and Cathelicidin LL-37 Killing of Methicillin-resistant Staphylococcus epidermidis: Foundations of Successful Therapy of Endocarditis
Interrnational Journal of Antimicrobial Agents. 2023; 61:106758.
Original paper - Journal impact factor (in 2022): 13.90
Abstract
Link to PubMed (US National Library of Medicine):PMID=36775256
Reprint (PDF) (with Supplementary Material)
Link to original document at publisher's site through DOI:10.1016/j.ijantimicag.2023.106758
Hughes K, Le TB, Van Der Smissen P, Tyteca D, Mingeot-Leclercq MP, Quetin-Leclercq J.
The Antileishmanial Activity of Eugenol Associated with Lipid Storage Reduction Rather Than Membrane Properties Alterations.
Molecules. 2023; 28:3871.
Original paper - Journal impact factor (in 2022): 4.927
Abstract
Link to PubMed (US National Library of Medicine):PMID=37175277
Reprint (PDF) (with Supplementary Material)
Link to original document at publisher's site through DOI:10.3390/molecules28093871
Kaur M, Buyck JM, Goormaghtigh F, Decout JL, Mozaheb N, Mingeot-Leclercq MP.
Deficient Pseudomonas aeruginosa in MlaA/VacJ outer membrane lipoprotein shows decrease in rhamnolipids secretion, motility, and biofilm formation, and increase in fluoroquinolones susceptibility and innate immune response.
Res Microbiol. 2023 Nov-Dec;174(8):104132. doi: 10.1016/j.resmic.2023.104132
Mozaheb N, Rasouli P, Kaur M, Van Der Smissen P, Larrouy-Maumus G, Mingeot-Leclercq MP
A Mildly Acidic Environment Alters Pseudomonas aeruginosa Virulence and Causes Remodeling of the Bacterial Surface.
Microbiology Spectrum 2023; Jun 6:e0483222.
Original paper - Journal impact factor (in 2022): 9.043
Abstract
Link to PubMed (US National Library of Medicine):PMID=37278652
Reprint (PDF) (with Supplementary Material)
Link to original document at publisher's site through DOI:10.1128/spectrum.04832-22 .
Vanderroost J, Parpaite T, Avalosse N, Henriet P, Pierreux CE, Lorent JH, Gailly P, Tyteca D.
Piezo1 Is Required for Myoblast Migration and Involves Polarized Clustering in Association with Cholesterol and GM1 Ganglioside.
Cells. 2023;12(24):2784.
Original paper - Journal impact factor (in 2022): 6.0
Link to PubMed (US National Library of Medicine):PMID=38132106
Reprint (PDF) (with Supplementary Material)
Link to original document at publisher's site through DOI:10.3390/cells12242784 .
Verhaegen M, Bergot T, Liebana E, Stancanelli G, Streissl F, Mingeot-Leclercq MP, Mahillon J, Bragard C.
On the use of antibiotics to control plant pathogenic bacteria: a genetic and genomic perspective.
Front Microbiol. 2023; 14:1221478.
Review- Journal impact factor (in 2022): 5.40
Abstract
Link to PubMed (US National Library of Medicine):PMID=37440885
Reprint (PDF) (with Supplementary Material)
Link to original document at publisher's site through DOI: 10.3389/fmicb.2023.1221478 .

2022

Chalhoub H, Kampmeier S, Kahl BC, Van Bambeke F.
Role of efflux in antibiotic resistance of Achromobacter xylosoxidans and A. insuavis isolates from patients with cystic fibrosis.
Frontiers in Microbiology 2022; 13:762307
Original paper - Journal impact factor (in 2021): 5.640
Abstract
Link to PubMed (US National Library of Medicine):PMID=35418957
Reprint (PDF) (with Supplementary Material)
Link to original document at publisher's site through DOI:10.3389/fmicb.2022.762307
De Bels D, Maillart E, Van Bambeke F, Redant S, Honoré PM.
Existing and emerging therapies for the treatment of invasive candidiasis and candidemia.
Expert Opinion Emerging Drugs. 2022; 27(4):405-416.
Review paper - Journal impact factor (in 2021): 5.640
Link to PubMed (US National Library of Medicine):PMID=36317695
Reprint (PDF): PMID=36317695
Link to original document at publisher's site through DOI:10.1080/14728214.2022.2142207
Dohou AM, Buda VO, Yemoa LA, Anagonou S, Van Bambeke F, Van Hees T, Dossou FM, Dalleur O.
Antibiotic Usage in Patients Having Undergone Caesarean Section: A Three-Level Study in Benin
Antibiotics 2022; 11(5):617.
Original paper - Journal impact factor (in 2022): 5.222
Abstract
Link to PubMed (US National Library of Medicine): PMID=35196815
Reprint (PDF) (with Supplementary Material)
Link to original document at publisher's site through DOI: 10.3390/antibiotics11050617
Dohou AM, Buda VO, Yemoa LA, Anagonou S, Van Bambeke F, Van Hees T, Dossou FM, Dalleur O.
Healthcare Professionals' Knowledge and Beliefs on Antibiotic Prophylaxis in Cesarean Section: A Mixed-Methods Study in Benin
Antibiotics 2022; 11(7):872.
Original paper - Journal impact factor (in 2022): 5.222
Abstract
Link to PubMed (US National Library of Medicine): PMID=35884126
Reprint (PDF) (with Supplementary Material)
Link to original document at publisher's site through DOI: 10.3390/antibiotics11070872
Maja M, Mohammed D, Dumitru AC, Verstraeten S, Lingurski M, Mingeot-Leclercq MP, Alsteens D, Tyteca D.
Surface cholesterol-enriched domains specifically promote invasion of breast cancer cell lines by controlling invadopodia and extracellular matrix degradation
Cellular and Molecular Life Sciences 2022;79(8):417.
Original paper - Journal impact factor (in 2022): 9.261
Abstract
Link to PubMed (US National Library of Medicine): PMID=35819726
Reprint (PDF) (with Supplementary Material)
Link to original document at publisher's site through DOI: 10.1007/s00018-022-04426-8
Meléndez-Carmona MÁ, Mancheño-Losa M, Ruiz-Sorribas A, Muñoz-Gallego I, Viedma E, Chaves F, Van Bambeke F, Lora-Tamayo J
Strain-to-strain variability among Staphylococcus aureus causing prosthetic joint infection drives heterogeneity in response to levofloxacin and rifampicin
J Antimicrob Chemother 2022; 77(12):3265-3269
Original paper - Journal impact factor (in 2022): 5.758
Link to PubMed (US National Library of Medicine): PMID=36124848
Reprint (PDF) (with Supplementary Material)
Link to original document at publisher's site through DOI: 10.1093/jac/dkac311
Mozaheb N, Van Der Smissen P, Opsomer T, Mignolet E, Terrasi R, Paquot A, Larondelle Y, Dehaen W, Muccioli GG, Mingeot-Leclercq MP
Contribution of Membrane Vesicle to Reprogramming of Bacterial Membrane Fluidity in Pseudomonas aeruginosa
Msphere 2022; 7(3):e0018722
Original paper - Journal impact factor (in 2021): 4.389
Abstract
Link to PubMed (US National Library of Medicine): PMID=35603537
Reprint (PDF) (with Supplementary Material)
Link to original document at publisher's site through DOIi: 10.1128/msphere.00187-22.
Ngougni Pokem P, Wittebole X, Collienne C, Rodriguez-Villalobos H, Tulkens PM, Elens L, Van Bambeke F, Laterre PF.
Population Pharmacokinetics of Temocillin Administered by Continuous Infusion in Patients with Septic Shock Associated with Intra-Abdominal Infection and Ascitic Fluid Effusion
Antibiotics 2022 5;11(7):898
Original paper - Journal impact factor (in 2022): 5.222
Abstract
Link to PubMed (US National Library of Medicine): PMID=35884152
Reprint (PDF) (with Supplementary Material)
Link to original document at publisher's site through DOI: 10.3390/antibiotics11070898
Ngougni Pokem P, Matzneller P, Vervaeke S, Wittebole X, Goeman L, Coessens M, Cottone E, Capron A, Wulkersdorfer B, Wallemacq P, Mouton JW, Muller AE, Zeitlinger M, Laterre PF, Tulkens PM, Van Bambeke F.
Binding of temocillin to plasma proteins in vitro and in vivo: the importance of plasma protein levels in different populations and of co-medications
J Antimicrob Chemother 2022; 77(10):2742-2753
Original paper - Journal impact factor (in 2022): 5.758
Link to PubMed (US National Library of Medicine): PMID=36018077
Reprint (PDF) (with Supplementary Material)
Link to original document at publisher's site through DOI: 10.1093/jac/dkac286
Peyrusson F, Nguyen TK, Najdovski T, Van Bambeke F.
Host cell oxidative stress induces dormant Staphylococcus aureus persisters
Microbiology Spectrum 2022; 10(1):e0231321
Original paper - Journal impact factor (in 2021): 7.171
Abstract
Link to PubMed (US National Library of Medicine): PMID=35625261
Reprint (PDF) (with Supplementary Material)
Link to original document at publisher's site through DOI: 10.1128/spectrum.02313-21
Poilvache H, Van Bambeke F, Cornu O
Development of an innovative in vivo model of PJI treated with DAIR.
Front Med (Lausanne). 2022; 9:984814.
Original paper - Journal impact factor (in 2022): 5.091
Link to PubMed (US National Library of Medicine): PMID=36314026
Reprint (PDF) (with Supplementary Material) doi:
Link to original document at publisher's site through DOI:10.3389/fmed.2022.984814
Ruiz-Sorribas A, Poilvache H, Van Bambeke F
Pharmacodynamics of moxifloxacin, meropenem, caspofungin and their combinations against in vitro polymicrobial inter-kingdom biofilms
Antimicrobial Agents and Chemotherapy 2022; 6(2):e02149-21.
Original paper - Journal impact factor (in 2021): 5.191
Abstract
Link to PubMed (US National Library of Medicine):PMID=34930026
Reprint (PDF) (with Supplementary Material)
Link to original document at publisher's site through DOI: 10.1128/AAC.02149-21 (may require a subscription)
Ruiz-Sorribas A, Poilvache H, Kamarudin NHN, Braem A, Van Bambeke F
Hydrolytic enzymes as potentiators of antimicrobials against an inter-kingdom biofilm model
Microbiology Spectrum 2022; 10(1):e0258921
Original paper - Journal impact factor (in 2021): 7.171
Abstract
Link to PubMed (US National Library of Medicine):PMID=35196793
Reprint (PDF) (with Supplementary Material) // Erratum
Link to original document at publisher's site through DOI: 10.1128/spectrum.02589-21
Wang G, Brunel JM, Preusse M, Mozaheb N, Willger SD, Larrouy-Maumus G, Baatsen P, Häussler S, Bolla JM, Van Bambeke F.
The membrane-active polyaminoisoprenyl compound NV716 re-sensitizes Pseudomonas aeruginosa to antibiotics and reduces bacterial virulence
Communications Biology 2022; 5(1):871.
Original paper - Journal impact factor (in 2021): 6.548
Abstract
Link to PubMed (US National Library of Medicine):PMID=36008485
Reprint (PDF) (with Supplementary Material)
Link to original document at publisher's site through DOI: 10.1038/s42003-022-03836-5
Wang G, Brunel JM, Rodriguez-Villalobos H, Bolla JM, Van Bambeke F
The polyamino-isoprenyl potentiator NV716 revives disused antibiotics against Gram-negative bacteria in broth, infected monocytes, or biofilms, by disturbing the barrier effect of their outer membrane
European Journal of Medicinal Chemistry 2022; 238:114496.
Original paper - Journal impact factor (in 2022): 6.82
Abstract
Link to PubMed (US National Library of Medicine):PMID=35691172
Reprint (PDF) (with Supplementary Material)
Link to original document at publisher's site through DOI: 10.1016/j.ejmech.2022.114496
.

2021

Guagliardo R, Herman L, Penders J, Zamborlin A, De Keersmaecker H, Van de Vyver T, Verstraeten S, Merckx P, Mingeot-Leclercq MP, Echaide M, Pérez-Gil J, Stevens MM, De Smedt SC, Raemdonck K
Surfactant Protein B Promotes Cytosolic SiRNA Delivery by Adopting a Virus-like Mechanism of Action.
ACS Nano. 2021;15(5):8095-8109.
Original paper - Journal impact factor (in 2020): 15.881
Abstract
Link to PubMed (US National Library of Medicine):PMID=33724778
Reprint (PDF) (with Supplementary Material)
Link to original document at publisher's site through DOI: 10.1021/acsnano.0c04489
Kerkez I, Tulkens PM, Tenson T, Van Bambeke F, Putrinš M.
Uropathogenic Escherichia coli shows antibiotic tolerance and growth heterogeneity in an in-vitro model of intracellular infection.
Antimicrob Agents Chemother. 2021; 65(12):e0146821.
Original paper - Journal impact factor (in 2021): 5.191
Abstract
Link to PubMed (US National Library of Medicine):PMID=34570646
Reprint (PDF) (with Supplementary Material)
Link to original document at publisher's site through DOI:10.1128/AAC.01468-21 (may require a subscription)
Nguyen TK, Peyrusson F, Siala, W., Pham NH, Nguyen HA, Tulkens PM, Van Bambeke F.
Activity of moxifloxacin against biofilms formed by clinical isolates of Staphylococcus aureus differing by their resistant or persister character to fluoroquinolones
Frontiers in Microbiology 2021; 12:785573
Original paper - Journal impact factor (in 2021): 5.64
Abstract
Reprint (PDF) (with Supplementary Material)
Link to original document at publisher's site through DOI: 10.3389/fmicb.2021.785573
Nguyen TM, Ngo TH, Truong AQ, Vu DH, Le DC, Vu NB, Can TN, Nguyen HA, Phan TP, Van Bambeke F, Vidaillac C, Ngo QC
Population Pharmacokinetics and Dose Optimization of Ceftazidime and Imipenem in Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease
Pharmaceutics. 2021;13(4):456
Original paper - Journal impact factor (in 2020): 6.321
Abstract
Link to PubMed (US National Library of Medicine):PMID=33801657
Reprint (PDF) (with Supplementary Material)
Link to original document at publisher's site through DOI:10.3390/pharmaceutics13040456
Peyrusson F, Nguyen TK, Buyck JM, Lemaire S, Wang G, Seral S, Tulkens PM, Van Bambeke F
In Vitro Models for the Study of the Intracellular Activity of Antibiotics
In Bacterial Persistence: Methods and Protocols (Second edition)
Book chapter
ISBN 978-1-0716-1620-8 ISBN 978-1-0716-1621-5 (eBook)
Verstraeten N and Michiels J, Eds.
Link to PubMed (US National Library of Medicine): PMID=34590263
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document at publisher's site through DOI: 10.1007/978-1-0716-1621-5_16 (may require a subscription)
Peyrusson F, Whelan AO, Hartley MG, Norville IH, Harding SV, Van Bambeke F
Intracellular activity of antibiotics against Coxiella burnetii in a model of activated human THP-1 cells.
Antimicrob Agents Chemother. 2021; 65(12):e0106121.
Original paper - Journal impact factor (in 2021): 5.191
Abstract
Link to PubMed (US National Library of Medicine): PMID=34543094
Reprint (PDF) (with Supplementary Material) - UCL only - Copyright owned by the publisher
Link to original document at publisher's site through DOI:10.1128/AAC.01061-21 (may require a subscription)
Poilvache H, Ruiz-Sorribas A, Cornu O, Van Bambeke F
In-vitro study of the synergistic effect of an enzyme cocktail and antibiotics against biofilms in a prosthetic joint infection model
Antimicrobial Agents and Chemotherapy 2021; 65(4):e01699-20
Original paper - Journal impact factor (in 2021): 5.191
Abstract
Link to PubMed (US National Library of Medicine): PMID=33468484
Reprint (PDF) (with Supplementary Material) - UCL only - Copyright owned by the publisher
Link to original document at publisher's site through DOI: 10.1128/AAC.01699-20 (may require a subscription)
Ruiz-Sorribas A, Poilvache H, Kamarudin NHN, Braem A, Van Bambeke F.
In vitro polymicrobial inter-kingdom three-species biofilm model: influence of hyphae on biofilm formation and bacterial physiology.
Biofouling 2021; 37(5):481-493
Original paper - Journal impact factor (in 2020): 3.209
Abstract
Link to PubMed (US National Library of Medicine):PMID=34225500
Reprint (PDF) (with Supplementary Material) - UCL only - Copyright owned by the publisher
Link to original document at publisher's site through DOI:10.1080/08927014.2021.1919301 (may require a suscription)
Sounouvou HT, Toukourou H, Catteau L, Toukourou F, Evrard B, Van Bambeke F, Gbaguidi, F. Quetin-Leclercq J.
Antimicrobial potentials of essential oils extracted from West African aromatic plants on common skin infections
Scientific African 2021; 11:e00706
Original paper
Abstract
Reprint (PDF)
Link to original document and updates through DOI: 10.1016/j.sciaf.2021.e00706 (may require a suscription)
Swain J, Dezanet C, Chalhoub H, Auquière M, Kempf J, Décout JL, Mingeot-Leclercq MP.
Interest of Homodialkyl Neamine Derivatives against Resistant P. aeruginosa, E. coli, and ß-Lactamases-Producing Bacteria-Effect of Alkyl Chain Length on the Interaction with LPS.
Int J Mol Sci. 2021 Aug 13;22(16):8707.
Original paper - Journal impact factor (in 2020): 5.923
Abstract
Link to PubMed (US National Library of Medicine):PMID=34445410
Reprint (PDF) (with Supplementary Material) - UCL only - Copyright owned by the publisher
Link to original document and updates through DOI: 10.3390/ijms22168707.(may require a suscription)
Thirot H, Briquet C, Frippiat F, Jacobs F, Holemans X, Henrard S, Tulkens PM, Spinewine A, Van Bambeke F.
Clinical Use and Adverse Drug Reactions of Linezolid: A Retrospective Study in Four Belgian Hospital Centers.
Antibiotics (Basel) 2021; 10(5):530.
Original paper - Journal impact factor (in 2020): 4.639
Abstract
Link to PubMed (US National Library of Medicine): PMID=34064418
Reprint (PDF)
Link to original document and updates through DOI: 10.3390/antibiotics10050530
Wang G, Brunel JM, Bolla JM, Van Bambeke F
The polyaminoisoprenyl potentiator NV716 revives old disused antibiotics against intracellular forms of infection by Pseudomonas aeruginosa
Antimicrobial Agents and Chemotherapy 2021; 65(3):e02028-20.
Original paper - Journal impact factor in 2019: 4.921
Link to PubMed (US National Library of Medicine): PMID=33318000
Reprint (PDF) (with Supplementary Material) - UCL only - Copyright owned by the publisher
Link to original document and updates through DOI: 10.1128/AAC.02028-20 (may require a suscription)
Yehouenou C, Bogaerts B, Vanneste K, Roosens NHC, De Keersmaecker SCJ, Marchal K, Affolabi D, Soleimani R, Rodriguez-Villalobos H, Van Bambeke F, Dalleur O, Simon A.
First detection of a plasmid-encoded New-Delhi metallo-beta-lactamase-1 (NDM-1) producing Acinetobacter baumannii using whole genome sequencing, isolated in a clinical setting in Benin
Ann Clin Microbiol Antimicrob. 2021; Jan 6;20(1):5.
Original paper - Journal impact factor in 2019: 2.924
Abstract
Link to PubMed (US National Library of Medicine): PMID= 33407536
Reprint (PDF)
Link to original document and updates through DOI: 10.1186/s12941-020-00411-w

2020

Ameryckx A, Pochet L, Wang G, Yildiz E, Saadi BE, Wouters J, Van Bambeke F, Frédérick R.
Pharmacomodulations of the benzoyl-thiosemicarbazide scaffold reveal antimicrobial agents targeting d-alanyl-d-alanine ligase in bacterio
European Journal of Medicinal Chemistry (2020) 200:112444 (9 printed pages)
Original paper - Journal impact factor (in 2019): 5.572.
Abstract
Link to PubMed (US National Library of Medicine): PMID=32497961
Reprint (PDF) (with Supplementary Material) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1016/j.ejmech.2020.112444 (may require a subscription)
Bayiha JC, Evrard B, Cataldo D, De Tullio P, Mingeot-Leclercq MP.
The budesonide-hydroxypropyl-ß-cyclodextrin complex attenuates ROS generation, IL-8 release and cell death induced by oxidant and inflammatory stress. Study on A549 and A-THP-1 cells.
Molecules. (2020) 25:4882 (21 printed pages)
Original paper - Journal impact factor (in 2019): 3.297
Abstract
Link to PubMed (US National Library of Medicine): PMID=33105741
Link to full text at PubMed Central (US National Library of Medicine): PMCID=PMC7660049.
Repint (PDF) (with Supplementary Material) - UCL only - Copyright owned by the publisher
Link to original document at publisher's site through DOI: 10.3390/molecules25214882 (may require a subscription)
Chalhoub H, Harding S, Tulkens PM, Van Bambeke F
Influence of pH on the activity of finafloxacin against extracellular and intracellular Burkholderia thailandensis, Yersinia pseudotuberculosis, and Francisella philomiragia and on its cellular pharmacokinetics in THP-1 monocytes
Clinical Microbiology and Infection (2020) 26: 1254.e1-1254.e8
Original paper - Journal impact factor (in 2019): 7.117
Abstract
Link to PubMed (US National Library of Medicine): PMID=31404671
Reprint (PDF) (with Suplementary Material) - UCL only - Copyright owned by the publisher - free access for members through through
Link to original document at publisher's site through DOI: 10.1016/j.cmi.2019.07.028 (may require a subscription)
da Cruz RMD, Zelli R, Benshain S, da Cruz RMD, Siqueira-Júnior JP, Décout JL, Mingeot-Leclercq MP, Mendonça-Junior FJB.
Synthesis and evaluation of 2-aminothiophene derivatives as Staphylococcus aureus efflux pump inhibitors.
ChemMedChem. (2020) 15:716-725
Original paper - Journal impact factor (in 2019): 3.124
Abtstract
Link to PubMed (US National Library of Medicine): PMID= 32073756
Repint (PDF) - UCL only - Copyright owned by the publisher
Link to original document at publisher's site through DOI: 10.1002/cmdc.201900688 (may require a subscription)
Delattre IK, Briquet C, Wallemacq P, Tulkens PM, Van Bambeke F
Comparative in vitro antimicrobial potency, stability, colouration, and dissolution time of generics vs. innovator of meropenem in Europe
International Journal of Antimicrobial Agents (2020) 55:105825 (5 printed pages)
Original paper - Journal impact factor (in 2019): 4.615
Abstract
Link to PubMed (US National Library of Medicine): PMID=31634551
Reprint (PDF) (with Suppementary Material) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1016/j.ijantimicag.2019.10.006 (may require a subscription)
Dezanet C, Kempf J, Mingeot-Leclercq MP, Décout JL.
Amphiphilic aminoglycosides as medicinal agents.
International Journal of Molecular Science (2020) 21:7411 (37 printed pages)
Review paper - Journal impact factor (in 2019): 4.556
Abstract
Link to PubMed (US National Library of Medicine): PMID=33049963
Link to full text at PubMed Central (US National Library of Medicine): PMCID=7583001.
Repint (PDF) - UCL only - Copyright owned by the publisher
Link to original document at publisher's site through DOI: 10.3390/ijms21197411 (may require a subscription)
Diaz Iglesias Y, Van Bambeke F
Activity of antibiotics against Pseudomonas aeruginosa in an in vitro model of biofilms in the context of cystic fibrosis: influence of the culture medium
Antimicrobial Agents and Chemotherapy (2020) 64:e02204-19 (14 printed pages)
Original paper - Journal impact factor (in 2019): 4.715
Abstract
Link to PubMed (US National Library of Medicine): PMID=32015047
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Link to original document through DOI: 10.1128/AAC.02204-19 (may require a subscription)
Dumitru AC, MohammedD, Maja M, Yang J, Verstraeten S, del Campo A, Mingeot-Leclercq MP, Tyteca D, Alsteens D
Label-free imaging of cholesterol assemblies reveals hidden nanomechanics of breast cancer cells
Advanced Science (2020) 7:2002643 (13 printed pages)
Original paper - Journal impact factor (in 2019): 15.84
Abstract (from the publisher)
Link to PubMed (US National Library of Medicine): PMID=33240781
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Link to original document and pudates through DOI: 10.1002/advs.202002643.
Kapepula PM, Kabengele JK,1 Kingombe M, Van Bambeke F, Tulkens PM, Kishabongo AS, Decloedt E, Zumla A, Tiberi S, Suleman F, Tshilolo L, Muyembe-TamFum J-J, Zumla A, Nachega JB
Artemisia Spp. derivatives for COVID-19 treatment: anecdotal use, political hype, treatment potential, challenges, and road map to randomized clinical trials
American Journal of Tropical Medicine and Hygiene (2020) 103:960-964
Perspective paper - Journal impact factor (in 2020): 2.250
Abstract
Link to PubMed (US National Library of Medicine): PMID=32705976
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Link to original document through DOI: 10.4269/ajtmh.20-0820
Matzneller P, Ngougni Pokem P, Capron A, Lackner E, Wulkersdorfer B, Nussbaumer-Pröll A, Österreicher Z, Duchek M, Van de Velde S, Wallemacq PE, Mouton JW, Van Bambeke F, Zeitlinger M.
Single-dose pharmacokinetics of temocillin in plasma and soft tissues of healthy volunteers after intravenous and subcutaneous administration: a randomized crossover microdialysis trial
J Antimicrob Chemother. (2020) 75(9):2650-2656
Original paper - Journal impact factor (in 2019): 5.217
Abstract
Link to PubMed (US National Library of Medicine): PMID=32433753
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Link to original document through DOI: 10.1093/jac/dkaa176 (may require a subscription)
Meerwein M, Tarnutzer A, Böni M, Van Bambeke F, Hombach M, Zinkernagel AS.
Increased azithromycin susceptibility of multidrug-resistant Gram-negative bacteria on RPMI-1640 agar assessed by disk diffusion testing
Antibiotics (Basel). (2020) 9(5):218
Original paper - Journal impact factor (in 2019): 3.893.
Abstract
Link to PubMed (US National Library of Medicine): PMID=32365460
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Link to original document through DOI: 10.3390/antibiotics9050218
Mozaheb N, Mingeot-Leclercq MP.
Membrane vesicle production as a bacterial defense against stress
Frontiers in Microbiology (2020) 11:600221 (21 printed pages)
Review paper - Journal impact factor (in 2019): 4;235
Abstract
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Link to original document and updates through DOI: 10.3389/fmicb.2020.600221
Nguyen TK, Argudin MA, Deplano A, Pham NH, Nguyen HA, Tulkens PM, Dodemont M, Van Bambeke F
Antibiotic resistance, biofilm formation, and intracellular survival as possible determinants of persistent or recurrent infections by Staphylococcus aureus in a Vietnamese tertiary hospital. Focus on bacterial response to moxifloxacin.
Microbial Drug Resistance (2020) 26(6):537-544
Original paper - Journal impact factor (in 2019): 2.397
Abstract
Link to PubMed (US National Library of Medicine): PMID=31825276
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Link to original document through DOI: 10.1089/mdr.2019.0282 (may require a subscription)
Nguyen TK, Peyrusson F, Dodémont M, Pham NH, Nguyen HA, Tulkens PM, Van Bambeke F.
The persister character of clinical isolates of Staphylococcus aureus contributes to faster evolution to resistance and higher survival in THP-1 monocytes: a study with moxifloxacin.
Frontiers in Microbiology (2020) 11:587364 (12 printed pages)
Original paper - Journal impact factor (in 2019): 4.235
Abstract
Link to PubMed (US National Library of Medicine): PMID=33329458
Link to free full text at PubMed Central (US National Library of Medicine): PMCID=PMC7719683
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Link to original document at publisher's site through DOI: 10.3389/fmicb.2020.587364
Peyrusson F, Van Wessem A, Dieppois G, Van Bambeke F, Tulkens PM
Cellular pharmacokinetics and intracellular activity of the bacterial fatty acid synthesis inhibitor afabicin desphosphono against different resistance phenotypes of Staphylococcus aureus in models of cultured phagocytic cells
International Journal of Antimicrobial Agents (2020) 55:105848 (9 printed pages)
Original paper - Journal impact factor (in 2019): 4.615
Abstract
Link to PubMed (US National Library of Medicine): PMID=31770623
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Link to original document through DOI: 10.1016/j.ijantimicag.2019.11.005 (may require a subscription)
Peyrusson F, Varet H, Nguyen TK, Legendre R, Sismeiro O, Coppée JY, Wolz C, Tenson T, Van Bambeke F.
Intracellular Staphylococcus aureus persisters upon antibiotic exposure.
Nature Communications (2020) 11:2200 (14 printed pages)
Original paper - Journal impact factor (in 2019): 12.121.
Abstract
Link to PubMed (US National Library of Medicine): PMID=32366839
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Link to original document through DOI: 10.1038/s41467-020-15966-7 (may require a subscription)
Poilvache H, Ruiz-Sorribas A, Sakoulas G, Rodriguez-Villalobos H, Cornu O, Van Bambeke F.
Synergistic effects of pulsed lavage and antimicrobial therapy against Staphylococcus aureus biofilms in an in-vitro model
Frontiers in Medicine (2020) 7:527 (9 printed pages)
Original paper - Journal impact factor (in 2019): 3.421.
Abstract
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Link to PubMed (US National Library of Medicine): PMID=33043028
Link to free full text at PubMed Central (US National Library of Medicine): PMCID=7527469
Link to original document through DOI: 10.3389/fmed.2020.00527
Poilvache H, , Van Bambeke F.
Dangerous Slimes: How Bacterial Biofilms Make You Sick and How to Combat Them
Frontiers for Young Minds (2020) 8:62
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Link to original docuemnt thogh DOI: 10.3389/frym.2020.00062
Theuretzbacher U, Barbee L, Connolly K, Drusano G, Fernandes P, Hook E, Jerse A, O'Donnell J, Unemo M, Van Bambeke F, VanScoy B, Warn P, Werth BJ, Franceschi F, Alirol E.
Pharmacokinetic/pharmacodynamic considerations for new and current therapeutic drugs for uncomplicated gonorrhoea - challenges and opportunities.
Clinical Microbiology and Infection (2020) 26:1630-1635
Commentary - Journal impact factor (in 2019): 7.117
Abstract
Link to PubMed (US National Library of Medicine): PMID=32798687
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Link to original document through DOI: 10.1016/j.cmi.2020.08.006 (may require a subsciption)
Toukourou H, Sounouvou H, Catteau L, Toukourou F, Van Bambeke F, Gbaguidi F, Quetin-Leclercq J
Cymbopogon giganteus Chiov. Essential oil: Direct effects or activity in combination with antibiotics against multi-drug resistant bacteria
Original paper (Short communication)
Journal of Applied Biology and Biotechnology (2020) 8:84-89
Abstract (from the publihser)
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Link to original document through DOI: 10.7324/JABB.2020.80114 (Open access)
Tulkens PM
Phosphocholine may allow for listeriolysin-mediated escape of phagocytized Listeria from vacuolar compartments into the host cytosol while protecting against overt destruction of the infected cell.
Journal of Infectious Diseases (2020) 222:1425-1427
Editorial - Journal impact factor (in 2019): 5.045
No abstract available
Link to PubMed (US National Library of Medicine): PMID=31965180
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Link to original document through DOI: 10.1093/infdis/jiaa023 (may require a subscription)
Verstraeten SL, Lorent JH, Mingeot-Leclercq MP.
Lipid membranes as key targets for the pharmacological actions of ginsenosides.
Frontiers in Pharmacology (2020) 11:576887
Review paper - Journal impact factor (in 2019): 3.860
Abstract
Link to PubMed (US National Library of Medicine): PMID=33041822
Link to full text at PubMed Central (US National Library of Medicine): PMCID=PMC7518029.
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Link to original document at publisher's site through DOI: 10.3389/fphar.2020.576887 (may require a subscription)
Yehouenou CL, Kpangon AA, Affolabi D, Rodriguez-Villalobos H, Van Bambeke F, Dalleur O, Simon A.
Antimicrobial resistance in hospitalized surgical patients: a silently emerging public health concern in Benin.
Annals of Clinical Microbiology and Antimicrobials (2020) 19:54 (to be completed)
Original paper - Journal impact factor (in 2019): 2.967
Abstract
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Link to PubMed (US National Library of Medicine): PMID=33239061
Link to free full text at PubMed Central (US National Library of Medicine): PMCID=7687776
Link to original document through DOI: 10.1186/s12941-020-00398-4

2019

Diaz Iglesias Y, Wilms T, Vanbever R, Van Bambeke F.
Activity of antibiotics against Staphylococcus aureus in an in vitro model of biofilms in the context of cystic fibrosis: influence of the culture medium
Antimicrobial Agents and Chemotherapy (2019) 63:e00602-19 (14 printed pages)
Original paper - Journal impact factor (in 2019): 4.715
Abstract
Link to PubMed (US National Library of Medicine): PMID=31036685
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Link to original document through DOI: 10.1128/AAC.00602-19 (may require a subscription)
Fage D, Deprez G, Wolff F, Hites M, Jacobs F, Van Bambeke F, Cotton F
Investigation of unbound colistin A and B in clinical samples using a mass spectrometry method
International Journal of Antimicrobial Agents (2019) 53:330-336
Original paper - Journal impact factor (in 2018): 4.615
Abstract
Link to PubMed (US National Library of Medicine): PMID=30391382
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Link to original document through DOI: 10.1016/j.ijantimicag.2018.10.017 (may require a subscription)
Le TB, Beaufay C, Nghiem DT, Pham TA, Mingeot-Leclercq MP, Quetin-Leclercq J
Evaluation of the anti-trypanosomal activity of Vietnamese essential oils, with emphasis on Curcuma longa L. and its components
Molecules (2019) 24:pii: E1158 (13 pinted pages)
Original paper - Journal impact factor (in 2019): 3.060
Abstract
Link to PubMed (US National Library of Medicine): PMID=30909559
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Link to original document through DOI: 10.3390/molecules24061158 (may require a subscription)
Milosevic TV, Vertenoeil G, Payen VL, Sonveaux P, Tulkens PM, Constantinescu SN, Van Bambeke F
Prolonged inhibition and incomplete recovery of mitochondrial function in oxazolidinone-treated megakaryoblastic cell lines
International Journal of Antimicrobial Agents (2019) 54:661–667
Original paper - Journal impact factor (in 2019): 4.615
Abstract
Link to PubMed (US National Library of Medicine): PMID=31374333
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Link to original document through DOI: 10.1016/j.ijantimicag.2019.07.021 (may require a subscription)
Ngougni-Pokem P, Capron A, Wallemacq P, Tulkens PM, Van Bambeke F, Laterre PF
Temocillin plasma and pancreatic tissue concentrations in a critically-ill patient with septic shock.
Journal of Antimicrobial Chemotherapy (2019) 74:1459–1461
Letter - Journal impact factor (in 2018): 5.113
No abstract
Link to PubMed (US National Library of Medicine): PMID=30649374
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Link to original document through DOI: 10.1093/jac/dky565 (may require a subscription)
Oumar AA, Ruelle J, Katile D, Sidibe Y, Guindo I, Dao S, Tulkens P, Kabamba-Mukadi B.
Valeur diagnostique de deux tests rapides utilisés dans le diagnostic du VIH-2 au Mali
(Diagnosis value of two HIV-2 rapid diagnostic tests used in Mali)
Annales Africaines de Médecine (2019) 12:e334-e339
Original paper
Abstract (in English and in French)
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Oumar AA, Dakouo M, Tchibozo A, Maiga M, Landouré G, Abdi-Bogoreh R, Tulkens PM, Sao S, Yomb JC
Antiretroviral-induced adverse drug reactions in HIV-infected patients in Mali: a resource-limited setting experience
International Journal of Basic & Clinical Pharmacology (2019) 8:831-836
Original paper
Abstract
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Link to original document through DOI: 10.18203/2319-2003.ijbcp20191565 (may require a subscription)
Tulkens PM, Van Bambeke F, Zinner SH
Profile of a novel anionic fluoroquinolone — Delafloxacin
Clinical Infectious Diseases (2019) 68 (Supplement 3):S213-S222
Position paper - Journal impact factor (in 2018): 9.055
Abstract
Link to PubMed (US National Library of Medicine): PMID=30957164
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Link to original document through DOI: 10.1093/cid/ciy1079
Swain J, El Khoury M, Flament A, Dezanet C, Briée F, Van Der Smissen P, Décout JL, Mingeot-Leclercq MP
Antimicrobial activity of amphiphilic neamine derivatives: Understanding the mechanism of action on Gram-positive bacteria.
Biochimica Biophysica Acta (Biomembranes) (2019) 1861:182998 (10 printed pages)
Original papee - Journal impact factor (in 2019): 3.790
Abstract
Link to PubMed (US National Library of Medicine): PMID=31153908
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Link to original document through DOI: 10.1016/j.bbamem.2019.05.020 (may require a subscription)
Verstraeten SL, Deleu M, Janikowska-Sagan M, Claereboudt EJS, Lins L, Tyteca D, Mingeot-Leclercq MP
The activity of the saponin ginsenoside Rh2 is enhanced by the interaction with membrane sphingomyelin but depressed by cholesterol
Scientific Reports (2019) 9:7285 (14 printed pages)
Original paper - Journal impact factor (in 2018): 4.525
Abstract
Link to PubMed (US National Library of Medicine): PMID=31086211
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Link to original document through DOI: 10.1038/srep40208
Vu DH, Nguyen DA, Delattre IK, Hoa TT, Doc HG, Pham HN, Dao XC, Tran NT, Nguyen GB, Van Bambeke F, Tulkens PM, Nguyen HA
Determination of optimal loading and maintenance doses for continuous infusion of vancomycin in critically ill patients: population pharmacokinetic modelling and simulations for improved dosing schemes
International Journal of Antimicrobial Agents (2019) 54:702–708
Original paper - Journal impact factor (in 2019): 4.615
Abstract
Link to PubMed (US National Library of Medicine): PMID=31600554
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Link to original document through DOI: 10.1016/j.ijantimicag.2019.09.018 (may require a subscription)

2018

Ameryckx A, Thabault L, Pochet L, Leimanis S, Poupaert JH, Wouters J, Joris B, Van Bambeke F, Frédérick R.
1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio.
European Journal of Medicinal Chemistry (2018) 159:324-338
Original paper - Journal impact factor (in 2017-2018): 4.816
Abstract
Link to PubMed (US National Library of Medicine): PMID=30300845
Reprint (PDF) - Supporting Information (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1016/j.ejmech.2018.09.067 (may require a subscription)
Carradori D, Dos Santos AG, Masquelier J, Paquot A, Saulnier P, Eyer J, Préat V, Muccioli GG, Mingeot-Leclercq MP, des Rieux A
The origin of neural stem cells impacts their interactions with targeted-lipid nanocapsules: Potential role of plasma membrane lipid composition and fluidity
Journal of Control Release (2018) 292:248-255
Original paper - Journal impact factor (in 2017-2018): 7.877
Abstract
Link to PubMed (US National Library of Medicine): PMID=30408552
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Link to original document through DOI: 10.1016/j.jconrel.2018.11.005 (may require a subscription)
Chalhoub H, Sáenz Y, Nichols WW, Tulkens PM, Van Bambeke F
Loss of activity of ceftazidime-avibactam due to Mex-AB-OprM efflux and overproduction of AmpC cephalosporinase in Pseudomonas aeruginosa isolated from patients suffering from cystic fibrosis.
International Journal of Antimicrobial Agents (2018) 52:697-701
Short Communication - Journal impact factor (in 2017-2018): 4.253
Abstract
Link to PubMed (US National Library of Medicine): PMID=30081137
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Link to original document through DOI: 10.1016/j.ijantimicag.2018.07.027 (may require a subscription)
Coenye T, Goeres D, Van Bambeke F, Bjarnsholt T
Should standardized susceptibility testing for microbial biofilms be introduced in clinical practice?
Clinical Microbiology and Infection (2018) 24:570-572
Commentary - Journal impact factor (in 2016-2017): 5.292
No abstract
Link to PubMed (US National Library of Medicine): PMID=29337253
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Link to original document through DOI: 10.1016/j.cmi.2018.01.003 (may require a subscription)
Khandekar S, Liebens V, Fauvart M, Tulkens PM, Michiels J, Van Bambeke F
The putative de-N-acetylase DnpA contributes to intracellular and biofilm-associated persistence of Pseudomonas aeruginosa exposed to fluoroquinolones
Frontiers in Microbiology (2018) 9:1455 (12 printed pages)
Original paper - Journal impact factor (in 2017): 4.019
Abstract
Link to PubMed (US National Library of Medicine): PMID=30042739
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Link to original document through DOI: 10.3389/fmicb.2018.01455
Le TB, Beaufay C, Bonneau N, Mingeot-Leclercq MP, Quetin-Leclercq J
Anti-protozoal activity of essential oils and their constituents against Leishmania, Plasmodium and Trypanosoma
Phytochemistry (2018) 18:1 (33 printed pages)
Review
Abstract
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Leonard C, Pollet H, Vermylen C, Gov N, Tyteca D, Mingeot-Leclercq MP.
Tuning of differential lipid order between submicrometric domains and surrounding membrane upon erythrocyte reshaping
Cellular Physiology and Biochemistry (2018) 48: 2563-2582
Original paper - Journal impact factor (in 2017): 5.104
Abstract
Link to PubMed (US National Library of Medicine): PMID=30121671
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Link to original document through DOI: 10.1159/000492700
Lozano C, Azcona-Gutiérrez JM, Van Bambeke F, Sáenz Y
Great phenotypic and genetic variation among successive chronic Pseudomonas aeruginosa from a cystic fibrosis patient.
PLoS Public Library of Science) One (2018) 13:e0204167 (15 printed pages)
Original paper - Journal impact factor (in 2017): 2.766
Abstract
Link to PubMed (US National Library of Medicine): PMID=30212579
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Link to original document through DOI: 10.1371/journal.pone.0204167
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Milosevic TV, Payen VL, Sonveaux P, Muccioli GG, Tulkens PM, Van Bambeke F
Mitochondrial alterations (inhibition of mitochondrial protein expression, oxidative metabolism and ultrastructure) induced by linezolid and tedizolid at clinically-relevant concentrations in cultured human HL-60 promyelocytes and THP-1 monocytes
Antimicrobial Agents and Chemotherapy (2018) 23;62:e01599-17 (17 printed pages)
Original paper - Journal impact factor (in 2016-2017): 4.302
Abstract
Link to PubMed (US National Library of Medicine): PMID=29263063
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Link to original document through DOI: 10.1128/AAC.01599-17 (may require a subscription)
Miranda Bastos AC, Vandecasteele SJ, Spinewine A, Tulkens PM, Van Bambeke F
Temocillin dosing in haemodialysis patients based on population pharmacokinetics of total and unbound concentrations and Monte Carlo simulations
Journal of Antimicrobial Chemotherapy (2018) 73:1630-1638
Original paper - Journal impact factor (in 2016-2017): 5.071
Abstract
Link to PubMed (US National Library of Medicine): PMID=29579214
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Link to original document through DOI: 10.1093/jac/dky078 (may require a subscription)
Peyrusson F, Tulkens PM, Van Bambeke F
Cellular pharmacokinetics and intracellular activity of gepotidacin against Staphylococcus aureus with different resistance phenotypes in models of cultured phagocytic cells
Antimicrobial Agents and Chemotherapy (2018) 27;62:e02245-17 (14 printed pages).
Original paper - Journal impact factor (in 2016-2017): 4.302
Abstract
Link to PubMed (US National Library of Medicine): PMID=29358297
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Link to original document through DOI: 10.1128/AAC.02245-17 (may require a subscription)
Rogiers O, Holtappels M, Siala W, Lamkanfi M, Van Bambeke F, Lagrou K, Van Dijck P, Kucharíková S
Anidulafungin increases the antibacterial activity of tigecycline in polymicrobial Candida albicans/Staphylococcus aureus biofilms on intraperitoneally implanted foreign bodies
Journal of Antimicrobial Chemotherapy (2018) 73:2806-2814
Original paper - Journal impact factor (in 2017): 5.217
Abstract
Link to PubMed (US National Library of Medicine): PMID=30010876
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Link to original document through DOI: 10.1093/jac/dky246 (may require a subscription)
Siala W, Rodriguez-Villalobos H, Fernandes P, Tulkens PM, Van Bambeke F
Activity of combinations of antistaphylococcal antibiotics with fusidic acid against staphylococcal biofilms in in vitro static and dynamic models
Antimicrobial Agents and Chemotherapy (2018) 62: e00598-18 (12 printed pages)
Original paper - Journal impact factor (in 2016-2017): 4.302
Abstract
Link to PubMed (US National Library of Medicine): PMID=29712650
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Link to original document through DOI: 10.1128/AAC.00598-18 (may require a subscription)
Somers A, Spinewine A, Spriet I, Steurbaut S, Tulkens P, Hecq JD, Willems L, Robays H, Dhoore M, Yaras H, Vanden Bremt I, Haelterman H
Development of clinical pharmacy in Belgian hospitals through pilot projects funded by the government
Acta Clinica Belgica (2018) Apr 30:1-7 (Epub ahead of print)
Original paper - Journal impact factor (in 2017-2018): 0.916
Abstract
Link to PubMed (US National Library of Medicine): PMID=29708056
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Link to original document through DOI: 10.1080/17843286.2018.1462877 (may require a subscription)
Swain J, El Khoury M, Kempf J, Briée F, Van Der Smissen P, Décout JL, Mingeot-Leclercq MP
Effect of cardiolipin on the antimicrobial activity of a new amphiphilic aminoglycoside derivative on Pseudomonas aeruginosa.
PLoS One (Public Llibrary of Science) (2018) 13: e0201752 (16 printed pages)
Original paper - Journal impact factor (in 2017): 2.806
Abstract
Link to PubMed (US National Library of Medicine): PMID=30125281
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Link to original document through DOI: 10.1371/journal.pone.0201752
Verstraeten SL, Albert M, Paquot A, Muccioli GG, Tyteca D, Mingeot-Leclercq MP
Membrane cholesterol delays cellular apoptosis induced by ginsenoside Rh2, a steroid saponin
Toxicology and Applied Pharmacology (2018) 18;352:59-67
Original paper - Journal impact factor (in 2016-2017): 3.791
Abstract
Link to PubMed (US National Library of Medicine): PMID=29782965
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Link to original document through DOI: 10.1016/j.taap.2018.05.014 (may require a subscription)
Zimmermann L, Kempf J, Briée F, Swain J, Mingeot-Leclercq MP, Décout JL
Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines
European Journal of Medicinal Chemistry (2018) 157:1512-1525
Original paper - Journal impact factor (in 2017-2018): 4.816
Abstract
Link to PubMed (US National Library of Medicine): PMID=30282323
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Link to original document through DOI: 10.1016/j.ejmech.2018.08.022 (may require a subscription)

2017

Anantharajah A, Buyck JM, Sundin C, Tulkens PM, Mingeot-Leclercq MP, Van Bambeke F
Salicylidene acylhydrazides and hydroxyquinolines act as inhibitors of type three secretion systems in Pseudomonas aeruginosa by distinct mechanisms
Antimicrobial Agents and Chemotherapy (2017) 61:e02566-16 (17 printed pages)
Original paper - Journal impact factor (in 2016): 4.415
Abstract
Link to PubMed (US National Library of Medicine): PMID=28396545
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Link to original document through DOI: 10.1128/AAC.02566-16 (may require a subscription)
Buyck JM, Luyckx C, Muccioli GG, Krause KM, Nichols WW, Tulkens PM, Van Bambeke F
Pharmacodynamics of ceftazidime/avibactam against extracellular and intracellular forms of Pseudomonas aeruginosa
Journal of Antimicrobial Chemotherapy (2017) 72:1400-1409
Original paper - Journal impact factor (in 2016): 4.916
Abstract
Link to PubMed (US National Library of Medicine): PMID=28137941
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Link to original document through DOI: 10.1093/jac/dkw587 (may require a subscription)
Catteau L, Reichmann NT, Olson J, Pinho MG, Nizet V, Van Bambeke F, Quetin-Leclercq J
Synergy between ursolic and oleanolic acids from Vitellaria paradoxa leaf extract and beta-lactams against methicillin-resistant Staphylococcus aureus: in Vitro and in Vivo Activity and underlying mechanisms
Molecules (2017) 22:2245 (17 printed pages)
Original paper - Journal impact factor: 2.861 (in 2016-2017)
Abstract
Link to PubMed (US National Library of Medicine): PMID=29258194
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Link to original document through DOI: 10.3390/molecules22122245
Chalhoub H, Pletzer D, Weingart H, Braun Y, Tunney MM, Elborn JS, Rodriguez-Villalobos H, Plésiat P, Kahl BC, Denis O, Winterhalter M, Tulkens PM, Van Bambeke F
Mechanisms of intrinsic resistance and acquired susceptibility of Pseudomonas aeruginosa isolated from cystic fibrosis patients to temocillin, a revived antibiotic
Scientific Reports (2017) 7:40208 (14 printed pages)
Original paper - Journal impact factor: 5.228 (in 2016)
Abstract
Link to PubMed (US National Library of Medicine): PMID=28091521
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Link to original document through DOI: 10.1038/srep40208
Defraine V, Verstraete L, Van Bambeke F, Anantharajah A, Townsend EM, Ramage G, Corbau R, Marchand A, Chaltin P, Fauvart M, Michiels J
Antibacterial activity of 1-((2,4-dichlorophenethyl)amino)-3-phenoxypropan-2-ol against antibiotic-resistant strains of diverse bacterial pathogens, biofilms and in pre-clinical infection models
Frontiers in Microbiology (2017) 8:2585 (10 printed pages)
Original paper - Journal impact factor (in 2016-2017): 4.076
Abstract
Link to PubMed (US National Library of Medicine): PMID=29312259
Reprint (with Supplementary Materia) (PDF) -
Link to original document through DOI: 10.3389/fmicb.2017.02585
Delattre IK, Taccone FS, Jacobs F, Hites M, Dugernier T, Spapen H, Laterre PF, Wallemacq PE, Van Bambeke F, Tulkens PM
Optimizing beta-lactams treatment in critically-ill patients using pharmacokinetics/pharmacodynamics targets: are first conventional doses effective?
Expert Review of Anti-Infective Therapy (2017) 15:677-688.
Review and Expert Opinion - Journal impact factor (in 2016/2017): 3.139
Abstract
Link to PubMed (US National Library of Medicine): PMID=28571493
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1080/14787210.2017.1338139
Dos Santos AG, Bayiha JC, Dufour G, Cataldo D, Evrard B, Silva LC, Deleu M, Mingeot-Leclercq MP
Changes in membrane biophysical properties induced by the Budesonide/Hydroxypropyl-ß-cyclodextrin complex.
Biochimica Biophysica Acta - Biomembranes (2017) 1859:1930-1940
Original paper - Journal impact factor (in 2016): 3.498
Abstract
Link to PubMed (US National Library of Medicine): PMID=28642042
Reprint [with Supplementary Material] (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1016/j.bbamem.2017.06.010 (may require a subscription)
Dos Santos AG, Marquês JT, Carreira AC, Castro IR, Viana AS, Mingeot-Leclercq MP, de Almeida RFM, Silva LC.
The molecular mechanism of Nystatin action is dependent on the membrane biophysical properties and lipid composition.
Physical Chemistry Chemical Physics (2017) 19:30078-30088
Original paper - Journal impact factor (in 2016-2017): 4.123
Abstract
Link to PubMed (US National Library of Medicine): PMID=29098221
Reprint [with Supplementary Material] (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1039/c7cp05353c (may require a subscription)
El Khoury M, Swain J, Sautrey G, Zimmermann L, Van Der Smissen P, Décout JL, Mingeot-Leclercq MP
Targeting bacterial cardiolipin enriched microdomains: an antimicrobial strategy used by amphiphilic aminoglycoside antibiotics.
Scientific Reports (2017) 7:10697 (12 printed pages)
Original paper - Journal impact factor: 5.228 (in 2016)
Abstract
Link to PubMed (US National Library of Medicine): PMID=28878347
Reprint (PDF) -
Supplementary Material: movie #1 (.avi) - movie #2 (.avi)
Link to original document through DOI: 10.1038/s41598-017-10543-3
Houhoula D, Papaparaskevas J, Zatsou K, Nikolaras N, Malkawi HI, Mingeot-Leclercq MP, Konteles S, Koussisis S, Tsakris A, Charvalos E
Magnetic nanoparticle-enhanced PCR for the detection and identification of Staphylococcus aureus and Salmonella enteritidis.
New Microbiologica (2017) 40:165-169,
Original paper - Journal impact factor (in 2016-2017): 1.568
Asbtract
Link to PubMed (US National Library of Medicine): PMID=28513808
Reprint (PDF) -
Le TB, Beaufay C, Nghiem DT, Mingeot-Leclercq MP, Quetin-Leclercq J
In vitro anti-leishmanial activity of essential oils extracted from vietnamese plants
Molecules (2017) 27;22:E1071 (12 printed pages)
Original paper - Journal impact factor: 2.861
Abstract
Link to PubMed (US National Library of Medicine): PMID=28654013
Reprint [with Supplementary Material] (PDF) -
Link to original document through DOI: 10.3390/molecules22071071
Léonard C, Conrard L, Guthmann M, Pollet H, Carquin M, Vermylen C, Gailly P, Van Der Smissen P, Mingeot-Leclercq MP, Tyteca D
Contribution of plasma membrane lipid domains to red blood cell (re)shaping
Scientific Reports (2017) 7:4264 (16 printed pages)
Original paper - Journal impact factor: 5.228 (in 2016)
Abstract
Link to PubMed (US National Library of Medicine): PMID=28655935
Reprint [with Supplementary Material] (PDF) -
Link to original document through DOI: 10.1038/s41598-017-04388-z
Léonard C, Alsteens D, Dumitru A, Mingeot-Leclercq MP, Tyteca D
Lipid domains and membrane (re)shaping: from biophysics to biology.
In: Epand R., Ruysschaert JM. (eds) The Biophysics of Cell Membranes. Springer Series in Biophysics, vol 19. Springer, Singapore
ISBN 978-981-10-6243-8 - ISBN 978-981-10-6244-5 [eBook]
Chapter 5, pp121-177
Reprint of chapter (with cover) (PDF) - UCL only - Copyright owned by the publisher
Reprint of book (full) (PDF) - - UCL only - Copyright owned by the publisher
Link to chapter through DOI: 10.1007/978-981-10-6244-5_5
Link to full book through DOI: 10.1007/978-981-10-6244-5
Mustafa M-H, Khandekar S, Tunney MM, Elborn JS, Kahl BC, Denis O, Plésiat P, Traore H, Tulkens PM, Vanderbist F, Van Bambeke F
Acquired resistance to macrolides in Pseudomonas aeruginosa from cystic fibrosis patients
European Respiratory Journal (2017) 49:1601847 (13 printed pages)
Original paper - Journal impact factor: 10.569 (in 2016/2017)
Abstract
Link to PubMed (US National Library of Medicine): PMID=28526799
Reprint [with Supplementary Material] (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1183/13993003.01847-2016 (may require a subscription)

The Journal published a commentary about this paper:
Chalmers JD: Macrolide resistance in Pseudomonas aeruginosa: implications for practice.
European Respiratory Journal (2017) 49:1700689 (3 printed pages)
PDF (UCL only) - DOI: 10.1183/13993003.00689-2017 (may require a subscription)
Oumar AA, Abdoulaye A, Maiga M, Sidibé Y, Cissoko Y, Konate I, Diarra M, Sangho F, Dembélé JP, Murphy RL, Tulkens PM, Dao S
Adverse Drug Reactions to Antiretroviral Therapy (ART): Prospective Study in HIV Infected Adults in Sikasso (Mali)
Journal of Pharmacovigilance (2017) 5:2 (6 printed pages)
Original paper
Reprint (PDF)
Link to original document through DOI: 10.4172/2329-6887.1000228
Tam VH, Chang KT, Zhou J, Ledesma KR, Phe K, Gao S, Van Bambeke F, Sánchez-Díaz AM, Zamorano L, Oliver A, Cantón R
Determining beta-lactam exposure threshold to suppress resistance development in Gram-negative bacteria
Journal of Antimicrobial Chemotherapy (2017) 72:1421-1428
Original paper - Journal impact factor (in 2016): 4.916
Abstract
Link to PubMed (US National Library of Medicine): PMID=28158470
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1093/jac/dkx001 (may require a subscription)

2016

Anantharajah A, Faure E, Buyck JM, Sundin C, Lindmark T, Mecsas J, Yahr TL, Tulkens PM, Mingeot-Leclercq M-P, Guery B, Van Bambeke F
Inhibition of the injectisome and flagellar type III secretion systems by INP1855 impairs Pseudomonas aeruginosa pathogenicity and inflammasome activation
Journal of Infectious Diseases (2016) 214:1105-1116
Original paper - Journal impact factor (in 2015): 6.344
Abstract
Link to PubMed (US National Library of Medicine): PMID=27412581
Reprint [with supplementary material] (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1093/infdis/jiw295 (may require a subscription)
Anantharajah A, Mingeot-Leclercq MP, Van Bambeke F
Targeting Type Three Secretion System in Pseudomonas aeruginosa
Trends in Pharmacological Sciences (2016) 37:734-749
Review - Journal impact factor (in 2015): 11.539
Abstract
Link to PubMed (US National Library of Medicine): PMID=27344210
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1016/j.tips.2016.05.011 (may require a subscription)
Buyck JM, Lemaire S, Seral C, Anantharajah A, Peyrusson F, Tulkens PM, Van Bambeke F
In vitro Models for the Study of the Intracellular Activity of Antibiotics
In “Bacterial Persistence”, Molecular Biology Laboratory Protocols Series, J. Michiels and M. Fauvart, editors, 2016, p 147-157
Humana Press (Springer), ISBN 978-1-4939-2853-8 ; ISBN 978-1-4939-2854-5 (ebook)
Chapter of book
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Link to full book through DOI: 10.1007/978-1-4939-2854-5 (may require a subscription)
Ceyssens PJ, Van Bambeke F, Mattheus W, Bertrand S, Fux F, Van Bossuyt E, Damée S, Nyssen H-J, De Craeye S, Verhaegen J, The Belgian Streptococcus pneumoniae Study Group, Tulkens PM, Vanhoof R
Molecular analysis of rising fluoroquinolone resistance in Belgian non-invasive Streptococcus pneumoniae isolates (1995-2014)
PLoS One (Public Library of Science) (2016) 11:e0154816 (17 printed pages)
Original paper - Journal impact factor: 3.234 (in 2015)
Abstract
Link to PubMed (US National Library of Medicine): PMID=27227336
Reprint [with Supplementary Material] (PDF) -
Link to original document through DOI: 10.1371/journal.pone.0154816
Chalhoub H, Sáenz Y, Rodriguez-Villalobos H, Denis O, Kahl BC, Tulkens PM, Van Bambeke F
High-level resistance to meropenem in clinical isolates of Pseudomonas aeruginosa in the absence of carbapenemases: role of active efflux and porin alterations
International Journal of Antimicrobial Agents (2016) 48:740-743.
Original paper - Journal impact factor (in 2015) : 4.097
Abstract
Link to PubMed (US National Library of Medicine): PMID=28128097
Reprint [with Supplementary Material] (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1016/j.ijantimicag.2016.09.012 (may require a subscription)
Denamur S, Boland L, Beyaert M, Verstraeten SL, Fillet M, Tulkens PM, Bontemps F, Mingeot-Leclercq MP
Subcellular mechanisms involved in apoptosis induced by aminoglycoside antibiotics: Insights on p53, proteasome and endoplasmic reticulum
Toxicology and Applied Pharmacology (2016) 309:24-36.
Original paper - Journal impact factor: 3.847 (in 2015)
Abstract
Link to PubMed (US National Library of Medicine): PMID=27568863
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1016/j.taap.2016.08.020 (may require a subscription)
Lorent JH, Léonard C, Abouzi M, Akabi F, Quetin-Leclercq J, Mingeot-Leclercq MP
Alpha-hederin induces apoptosis, membrane permeabilization and morphologic changes in two cancer cell lines through a cholesterol-dependent mechanism
Planta Medica (2016) 82:1532-1539.
Original paper - Journal impact factor (in 2015): 1.990
Abstract
Link to PubMed (US National Library of Medicine): PMID=27574896
Reprint [with supplementary material] (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1055/s-0042-114780 (may require a subscription)
Mingeot-Leclercq MP, Décout JL
Bacterial lipid membranes as promising targets to fight antimicrobial resistance, molecular foundations and illustration through the renewal
of aminoglycoside antibiotics and emergence of amphiphilic aminoglycosides
MedChemComm (Medicinal Chemical Communications) (2016) 7:586-611
Review - Journal impact factor; 2.495 (in 2015)
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1039/c5md00503e (may require a subscription)
Mustafa MH, Chalhoub H, Denis O, Deplano A, Vergison A, Rodriguez-Villalobos H, Tunney MM, Elborn JS, Kahl BC, Traore H, Vanderbist F, Tulkens PM, Van Bambeke F
Antimicrobial susceptibility of Pseudomonas aeruginosa isolated from cystic fibrosis patients through Northern Europe
Antimicrobial Agents and Chemotherapy (2016) 60:6735-6741
Original paper - Journal impact factor (in 2015) : 4.415
Abstract
Link to PubMed (US National Library of Medicine): PMID= 27572406
Reprint [with supplementary material] (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1128/AAC.01046-16 (may require a subscription)
Riou M, Avrain L, Carbonnelle S, El Garch F, Pirnay JP, De Vos D, Plésiat P, Tulkens PM, Van Bambeke F
Increase of efflux-mediated resistance in Pseudomonas aeruginosa during antibiotic treatment in patients suffering from nosocomial pneumonia
International Journal of Antimicrobial Agents (2016) 47:77–83
Original paper - Journal impact factor: 4.296 (in 2014)
Abstract
Link to PubMed (US National Library of Medicine): PMID=26691019
Reprint [with Supplementary Material] (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1016/j.ijantimicag.2015.11.004 (may require a subscription)
Sautrey G, El Khoury M, Dos Giros A, Zimmermann L, Deleu M, Lins L, Decout JL, Mingeot-Leclercq MP.
Negatively-charged lipids as potential target for new amphiphilic aminoglycoside antibiotics: a biophysical study
Journal of Biological Chemistry (2016) 291:13864-13874
Original paper - Journal impact factor (in 2015): 4.573
Abstract
Link to PubMed (US National Library of Medicine): PMID=27189936
Reprint [with Supplementary Material] (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1074/jbc.M115.665364 (may require a subscription)
Siala W, Kucharíková S, Braem A, Vleugels J, Tulkens PM, Mingeot-Leclercq MP, Van Dijck P, Van Bambeke F
The antifungal caspofungin increases fluoroquinolone activity against Staphylococcus aureus biofilms by inhibiting N-acetylglucosamine transferase
Nature Communications (2016) 7:13286 (15 printed pages)
Original paper - Journal impact factor (in 2015): 11.329
Abstract
Link to PubMed (US National Library of Medicine): PMID=27808087
Reprint [with supplementary material] (PDF)
Link to original document through DOI: 10.1038/ncomms13286
Siala W, Van Bambeke F, Taresco V, Piozzi A, Francolini I
Synergistic activity between an antimicrobial polyacrylamide and daptomycin vs. Staphylococcus aureus biofilm
Pathogens and Disease (2016) 74:ftw042 (8 printed pages)
Original paper - Journal impact factor (in 2015): 2.403
Abstract
Link to PubMed (US National Library of Medicine): PMID=27154750
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1093/femspd/ftw042 (may require a subscription)
Van Bambeke F, Tulkens PM
Colistin and a new paradigm in drug development
Clinical Infectious Diseases (2016) 62:559-560.
Comment on "Updated United States and European dose recommendations for intravenous colistin: How do they perform?" by Nation et al. Clin Infect Dis 2016; 62:552–8.
Clinical Infectious Diseases (2016) 62:559-560
Invited Comment - Journal impact factor: 8.886 (in 2014)
Link to PubMed (US National Library of Medicine): PMID= 26607423
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1093/cid/civ968
Van Bambeke F, Tulkens PM.
The role of solithromycin in the management of bacterial community-acquired pneumonia
Expert Review on Anti-infective Therapy (2016) 14:311-324
Review paper - Journal impact factor (in 2015): 3.461
Abstract
Link to PubMed (US National Library of Medicine): PMID=26848612
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1586/14787210.2016.1138857
Vandevelde NM, Tulkens PM, Van Bambeke F
Modulating antibiotic activity towards respiratory bacterial pathogens by comedications: a multi-target approach
Drug Discovery Today (2016) 21:1114-1129
Keynote Review - Journal impact factor (in 2015): 6.691
Abstract
Link to PubMed (US National Library of Medicine): PMID=27094105
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1016/j.drudis.2016.04.001
Zimmermann L, Das I, Désiré J, Sautrey G, Barros R S V, El Khoury M, Mingeot-Leclercq MP, Decout JL
New broad-spectrum antibacterial amphiphilic aminoglycosides active against resistant bacteria: from neamine derivatives to smaller neosamine analogues
Journal of Medicinal Chemistry (2016) 59:9350-9369
Original paper - Journal impact factor (in 2015): 5.589
Abstract
Link to PubMed (US National Library of Medicine): PMID=27690420
Reprint [with supplementary material] (PDF) - UCL only - Copyright owned by the publisher
SMILES in CSV format [right-click to save as .csv file]
Link to original document through DOI: 10.1021/acs.jmedchem.6b00818

2015

Anantharajah A., Buyck J.M., Faure E., Glupczynski Y., Rodriguez-Villalobos H., De Vos D., Pirnay J-P., Bilocq F. Guery B., Tulkens P.M., Mingeot-Leclercq M-P., Van Bambeke F.
Correlation between cytotoxicity induced by Pseudomonas aeruginosa clinical isolates from acute infections and IL-1-beta secretion in a model of human THP-1 monocytes
FEMS Pathogens and Disease (2015) 73:ftv049.
Original paper - Journal impact factor: 2.403 (in 2014)
Abstract
Link to PubMed (US National Library of Medicine): PMID= 26203053
Reprint [with Supplementary Material] (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1093/femspd/ftv049 (may require a subscription)
Buyck JM, Peyrusson F, Tulkens PM, Van Bambeke F
RX-P873, a novel protein synthesis inhibitor, accumulates in human THP-1 monocytes and is active against intracellular infections by Gram-positive
(Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa) bacteria
Antimicrobial Agents and Chemotherapy (2015) 59:4750-4758
Original paper - Journal impact factor: 4.476 (in 2014)
Abstract
Link to PubMed (US National Library of Medicine): PMID=26014952
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1128/AAC.00428-15 (may require a subscription)
Buyck JM, Tulkens PM, Van Bambeke F
Activity of antibiotic combinations towards resistant strains of Pseudomonas aeruginosa in a model of infected THP-1 monocytes.
Antimicrobial Agents and Chemotherapy (2015) 59:258-268
Original paper - Journal impact factor: 4.476 (in 2014)
Abstract
Link to PubMed (US National Library of Medicine): PMID=25348528
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1128/AAC.04011-14 (may require a subscription)
Catteau L, Van Bambeke F, Quetin-Leclercq J
Preliminary evidences of the direct and indirect antimicrobial activity of 12 plants used in traditional medicine in Africa
Phytochemistry Reviews (2015) 14:975–991
Original paper - Journal impact factor: 2.407 (in 2014)
Abstract
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1007/s11101-015-9437-x (may require a subscription)
Chalhoub H, Tunney M, Elborn JS, Vergison A, Denis O, Plésiat P, Kahl BC, Van Bambeke F, Tulkens PM
Avibactam confers susceptibility to a large proportion of ceftazidime-resistant Pseudomonas aeruginosa isolates recovered from cystic fibrosis patients
Journal of Antimicrobial Chemotherapy (2015) 70:1596-8
Original paper (Research Letter) - Journal impact factor: 5.313 (in 2014)
No abstract available
Link to PubMed (US National Library of Medicine): PMID=25587996
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1093/jac/dku551 (may require a subscription)
Claeys C, Dufrasne M, De Vriese C, Nève J, Tulkens PM, Spinewine A
Transmission d’information au pharmacien d’officine après hospitalisation du patient : élaboration d’une feuille de transfert, évaluation prospective de son effet et enquête sur les besoins d’information des pharmaciens
Journal de Pharmacie de Belgique (2015) 97:42-54
Original paper
Abstract (in English and in French)
Link to PubMed (US National Library of Medicine): PMID=26571796 (English)
Reprint (PDF) (French) - UCL only - Copyright owned by the publisher
Claeys C, Dufrasne M, De Vriese C, Nève J, Tulkens PM, Spinewine A
Informatieoverdracht naar de officina-apotheker na ziekenhuisopname: ontwikkeling van een transferblad, prospectieve evaluatie van het effectervan en onderzoek naar de informatienoden van apothekers
Farmaceutisch Tijdschrift voor België (2015) 95:42-54
Original paper (Dutch version of the previous paper)
Abstract (in English and in Dutch)
Link to PubMed (US National Library of Medicine): PMID=26571796 (English)
Reprint (PDF) (Dutch) - UCL only - Copyright owned by the publisher
Flanagan S, McKee EE, Das D, Tulkens PM, Hosako H, Fiedler-Kelly J, Passarell J, Radovsky A, Prokocimer P
Evaluation of the potential of tedizolid and linezolid to affect mitochondrial function using nonclinical and pharmacokinetic assessments
Antimicrobial Agents and Chemotherapy (2015) 59:178-185
Original paper - Journal impact factor: 4.476 (in 2014)
Abstract
Link to PubMed (US National Library of Medicine): PMID=25331703
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1128/AAC.03684-14 (may require a subscription
Frippiat F, Musuamba PT, Seidel L, Albert A, Denooz R, Charlier C, Van Bambeke F, Wallemacq P, Descy J, Lambermont B, Layios N, Damas P, Moutschen M
Modelled target attainment after meropenem infusion in patients with severe nosocomial pneumonia: the PROMESSE study
Journal of Antimicrobial Chemotherapy (2015) 70:207-216
Original paper - Journal impact factor: 5.313 (in 2014)
Abstract
Link to PubMed (US National Library of Medicine): PMID=25216821
Reprint [with Supplementary Material] (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1093/jac/dku354 (may require a subscription)
Laterre PF, Wittebole X, Van de Velde S, Muller AE, Mouton JW, Carryn S, Tulkens PM, Dugernier T
Temocillin 6 g daily in critically-ill patients: continuous infusion versus thrice daily administration
Journal of Antimicrobial Chemotherapy (2015) 70:891–898
Original paper - Journal impact factor: 5.313 (in 2014)
Abstract
Link to PubMed (US National Library of Medicine): PMID=25433006
Reprint [with Supplementary Material] (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1093/jac/dku465/ (may require a subscription)
Ngougni Pokem P, Miranda Bastos AC, Tulkens PM, Wallemacq P, Van Bambeke F, Capron A
Validation of a HPLC-MS/MS assay for the determination of total and unbound concentration of temocillin in human serum
Clinical Biochemistry (2015) 48:542–545
Original paper - Journal impact factor: 2.275 (in 2014)
Abstract
Link to PubMed (US National Library of Medicine): PMID=25712752
Reprint [with Supplementary Material] (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1016/j.clinbiochem.2015.02.006 (may require a subscription)
Oumar AA, Maiga M, Dembele JP, Djibril N, Sangho F, Konate I, Kone Y , Guida L, Tulkens PM, Dao S
Adverse neurological events due to antiretroviral therapy in Mali
International Journal of Research in Pharmacology & Pharmacotherapeutics (2015) 4:455-459
Original paper - No impact factor
Abstract
Reprint (PDF)
Peyrusson F, Butler D, Tulkens PM, Van Bambeke F
Cellular pharmacokinetics and intracellular activity of the novel peptide deformylase inhibitor GSK1322322 against Staphylococcus aureus laboratory and clinical strains with various resistance phenotypes. Studies with human THP-1 monocytes and J774 murine macrophages
Antimicrobial Agents and Chemotherapy (2015) 59:5747-5760
Original paper - Journal impact factor: 4.476 (in 2014)
Abstract
Link to PubMed (US National Library of Medicine): PMID=26169402
Reprint [with Supplementary Material] (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1128/AAC.00827-15 (may require a subscription)
Theuretzbacher U, Ambrose PG, MacGowan AP, Andes DR, Sörgel F, Derendorf H, Mouton JW, Drusano GL, Tulkens PM, Dudley MN, Cars O, Nation RL
In memoriam William A. Craig
Antimicrobial Agents and Chemotherapy (2015) 59:2971
Editorial - Journal impact factor: Impact factor: 4.476 (in 2014)
Link to PubMed (US National Library of Medicine): PMID=25896702
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Link to original document through DOI: 10.1128/AAC.00849-15 (may require a subscription)
Theuretzbacher U, Van Bambeke F, Cantón R, Giske GC, Mouton JW, Nation RL, Paul M, Turnidge JD, Kahlmeter G
Reviving old antibiotics
Journal of Antimicrobial Chemotherapy (2015) 70:2177–2181
Leading article - Journal impact factor: 5.313 (in 2014)
Abstract
Link to PubMed (US National Library of Medicine): PMID=26063727
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1093/jac/dkv157 (may require a subscription)
Van Bambeke F
Delafloxacin, a non-zwitterionic fluoroquinolone in Phase III of clinical development: Evaluation of its pharmacology, pharmacokinetics, pharmacodynamics, and clinical efficacy
Future Microbiology: Drug Evaluation review (2015) 10:1111–1123
Review - Journal impact factor: Impact factor: 4.275 (in 2014)
Abstract
Link to PubMed (US National Library of Medicine): PMID=26119479
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.2217/FMB.15.39 (may require a subscription)
Van Bambeke F
Lipoglycopeptide antibacterial agents in Gram-positive infections: A comparative review
Drugs (2015) 75:2073-2095
Review paper - Journal impact factor: 4.343 (in 2014)
Abstract
Link to PubMed (US National Library of Medicine): PMID=26603874
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1007/s40265-015-0505-8 (may require a subscription)
Vandecasteele SJ, Miranda Bastos AC, Capron A, Spinewine A, Tulkens PM, Van Bambeke F
Thrice weekly temocillin administered after each dialysis session is appropriate for the treatment of serious Gram-negative infections in haemodialysis patients.
International Journal of Antimicrobial Agents (2015) 46:660-665
Original paper - Journal impact factor: 4.296 (in 2014)
Abstract
Link to PubMed (US National Library of Medicine): PMID=26603304
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1016/j.ijantimicag.2015.09.005 (may require a subscription)
Vandevelde NM, Tulkens PM, Muccioli GG, Van Bambeke F
Modulation of the activity of moxifloxacin and solithromycin in an in vitro pharmacodynamic model of S. pneumoniae naive and induced biofilms
Journal of Antimicrobial Chemotherapy (2015) 70:1713-1726
Original paper - Journal impact factor: 5.313 (in 2014)
Abstract
Link to PubMed (US National Library of Medicine): PMID=25712316
Reprint [with Supplementary Material] (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1093/jac/dkv032 (may require a subscription)

2014

Das D, Tulkens PM, Mehra P, Fang E, Prokocimer P
Tedizolid phosphate for the management of acute bacterial skin and skin structure infections: Safety summary
Clinical Infectious Diseases (2014) 58 (Suppl 1):S51–S57
Original paper - Journal impact factor: 9.416(in 2013)
Abstract
Link to PubMed (US National Library of Medicine): PMID=24343833
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI:10.1093/cid/cit618 (may require a subscription)
Imöhl M, Reinert RR, Tulkens PM, van der Linden M
Penicillin susceptibility breakpoints for Streptococcus pneumoniae and their effect on susceptibility categorisation in Germany (1997-2013)
European Journal of Clinical Microbiololgy & Infectious Diseases (2014) 33:2035–2040
Original paper - Journal impact factor: 2.544 (in 2013)
Abstract
Link to Pubmed (US National Library of Medicine): PMID=24930041
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1007/s10096-014-2174-z (may require a subscription)
Lemaire S, Mingeot-Leclercq MP, Tulkens PM, Van Bambeke F
Study of macrophage functions in murine J774 cells and human activated THP-1 cells exposed to oritavancin, a lipoglycopeptide with high cellular accumulation
Antimicrobial Agents and Chemotherapy (2014) 58:2059-2066
Original paper - Journal impact factor: 4.451 (in 2013)
Abstract
Link to Pubmed (US National Library of Medicine): PMID= 24449768
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1128/AAC.02475-13 (may require a subscription)
Lorent J, Lins L, Domenech O, Quetin-Leclercq J, Brasseur R, Mingeot-Leclercq MP
Domain formation and permeabilization induced by the saponin alpha-Hederin and its aglycone hederagenin in a cholesterol-containing bilayer
Langmuir (2014) 30:4556-4569
Original paper - Journal impact factor: 4.384 (in 2013)
Abstract
Link to Pubmed (US National Library of Medicine): PMID= 24690040
Reprint (PDF) - UCL only - Copyright owned by the publisher - video
Link to original document through DOI: 10.1021/la4049902 (may require a subscription)
Lorent JH, Quetin-Leclercq J, Mingeot-Leclercq MP
The amphiphilic nature of saponins and their effects on artificial and biological membranes and potential consequences for red blood and cancer cells
Organic & Biomolecular Chemistry (2014) 12:8803-8822
Review - Journal impact factor: 3.487 (in 2013)
Abstract
Link to Pubmed (US National Library of Medicine): PMID=25295776
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1039/c4ob01652a (may require a subscription)
Marquez B, Pourcelle V, Vallet CM, Mingeot-Leclercq MP, Tulkens PM, Marchand-Bruynaert J, Van Bambeke F
Pharmacological characterization of 7-(4-(piperazin-1-yl)) ciprofloxacin derivatives: antibacterial activity, cellular accumulation, susceptibility to efflux transporters, and intracellular activity
Pharmaceutical Research (2014) 31:1290–1301
Original paper - Journal impact factor: 3.952 (in 2013)
Abstract
Link to Pubmed (US National Library of Medicine): PMID= 24306327
Reprint [with supplementary material] (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1007/s11095-013-1250-x (may require a subscription)
Miranda Bastos AC, Vandecasteele SJ, Tulkens PM, Spinewine A, Van Bambeke F
Development and validation of a High Performance Liquid Chromatography Assay for the Determination of Temocillin in Serum of Haemodialysis Patients
Journal of Pharmaceutical and Biomedical Analysis (2014) 90:192–197
Original paper - Journal impact factor: 2.829 (in 2013)
Abstract
Link to Pubmed (US National Library of Medicine): PMID= 24389461
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1016/j.jpba.2013.12.002 (may require a subscription)
Sautrey G, Zimmermann L, Deleu M, Delbar A, Souza Machado L, Jeannot K, Van Bambeke F, Buyck JM, Decout J-L, Mingeot-Leclercq M-P
New amphiphilic neamine derivatives active against resistant Pseudomonas aeruginosa and their interactions with lipopolysaccharides
Antmicrobial Agents and Chemotherapy (2014) 58:4420-4430
Original paper - Journal impact factor: 4.451 (in 2013)
Abstract
Link to Pubmed (US National Library of Medicine): PMID= 24867965
Reprint [with supplementary material] (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1128/AAC.02536-13 (may require a subscription)
Siala W, Mingeot-Leclercq M-P, Tulkens PM, Hallin M, Denis O,Van Bambeke F
Antibiotic activity against biofilms from Staphylococcus aureus clinical isolates: factors determining the activity of the investigational fluoroquinolone delafloxacin in comparison with daptomycin and vancomycin
Antimicrobial Agents and Chemotherapy (2014) 58:6385-6398
Original paper - Journal impact factor: 4.451 (in 2013)
Abstract
Link to Pubmed (US National Library of Medicine): PMID=25114142
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Link to original document through DOI: 10.1128/AAC.03482-14 (may require a subscription)
Van Bambeke F
Macrolides and Ketolides
In: Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics (Chapter 11), A. Vinks, H Derendorf & JW Mouton, editors, 2014, p 257-278
Springer, ISBN 978-0-387-75612-7 - ISBN 978-0-387-75613-4 (eBook)
Chapter of book
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Link to full book through DOI: 10.1007/978-0-387-75613-4
Van Bambeke F
Renaissance of antibiotics against difficult infections: Focus on oritavancin and new ketolides and quinolones
Annals of Medicine (2014) 46(7):512-29.
Review - Journal impact factor: 4.733 (in 2013)
Abstract
Link to Pubmed (US National Library of Medicine): PMID= 25058176
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Link to original document through DOI: 10.3109/07853890.2014.935.470 (may require a subscription)
Vandevelde NM, Tulkens PM, Van Bambeke F
Antibiotic activity against naive and induced Streptococcus pneumoniae biofilms in an in vitro pharmacodynamic model
Antimicrobial Agents and Chemotherapy (2014) 58:1348-1358
Original paper - Journal impact factor: 4.451 (in 2013)
Abstract
Link to Pubmed (US National Library of Medicine): PMID= 24342635
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Link to original document through DOI: 10.1128/AAC.01858-13 (may require a subscription)
Vandevelde NM, Tulkens PM, Diaz Iglesias Y, Verhaegen J, Rodriguez-Villalobos H, Philippart I, Cadrobbi J, Coppens N, Boel A, Van Vaerenbergh K, Francart H, Vanhoof R, Liistro G, Jordens P, d’Odemont J-P, Valcke Y, Verschuren F, Van Bambeke F
Characterization of a collection of Streptococcus pneumoniae isolates from patients suffering from acute exacerbations of chronic bronchitis: in vitro susceptibility to antibiotics and biofilm formation in relation with antibiotic efflux and serotypes/serogroups.
International Journal of Antimicrobial Agents (2014) 44:209–217
Original paper - Journal impact factor: 4.259 (in 2013)
Abstract
Link to Pubmed (US National Library of Medicine): PMID= 25123808
Reprint [with supplementary material] (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1016/j.ijantimicag.2014.05.016 (may require a subscription)

2013

Ampe E, Delaere B, Hecq JD, Tulkens PM, Glupczynski Y
Implementation of a protocol for administration of vancomycin by continuous infusion: pharmacokinetic, pharmacodynamic, and toxicological aspects.
International Journal of Antimicrobial Agents (2013) 41:439-446
Original paper - Journal impact factor: 4.415 (in 2012)
Abstract
Link to PubMed (US National Library of Medicine): PMID=23523733
Reprint (with Supplementary Material) PDF (UCL only Copyright owned by the publisher)
Link to original document through DOI:10.1016/j.ijantimicag.2013.01.009 (may require a subscription)
Avrain L, Mertens P, Van Bambeke F
RND efflux pumps in P. aeruginosa: an underestimated resistance mechanism
Clinical Laboratory International [Cli-online] (2013) April-May 26-28
Educational paper
Reprint (PDF)
Link to original document: http://www.cli-online.com/ (free subscription)
Bauer J, Siala W, Tulkens PM, Van Bambeke F
A combined pharmacodynamic quantitative and qualitative model reveals the potent activity of Daptomycin and Delafloxacin against Staphylococcus
aureus biofilms
Antimicrobial Agents and Chemotherapy (2013) 57:2726-2737
Original paper - Journal impact factor: 4.565 (in 2012)
Abstract
Link to PubMed (US National Library of Medicine): PMID=23571532
Reprint (with Supplementary Material) PDF (UCL only Copyright owned by the publisher) - videos: MSSA - MRSA
Link to original document through DOI:10.1128/AAC.00181-13 (may require a subscription)
Buyck JM, Tulkens PM, Van Bambeke F
Pharmacodynamic evaluation of the intracellular activity of antibiotics towards Pseudomonas aeruginosa PAO1 in a model of THP-1 human monocytes
Antimicrobial Agents and Chemotherapy (2013) 57:2310-2318.
Original paper - Journal impact factor: 4.565 (in 2012)
Abstract
Link to PubMed (US National Library of Medicine): PMID= 23478951
Reprint [with supplementary material] (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI:10.1128/AAC.02609-12 (may require a subscription)
Buyle FM, Decruyenaere J, De Waele J, Tulkens PM, Van Audenrode T, Depuydt P, Claeys G, Robays H, Vogelaers D
A survey of beta-lactam antibiotics and vancomycin dosing strategies in intensive care units and general wards in Belgian hospitals
European Journal of Clinical Microbiology and Infectious Diseases (2013) 32:763-768
Original paper - Journal impact factor: 3.024 (in 2012)
Abstract
Link to PubMed (US National Library of Medicine): PMID=23271675
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI:10.1007/s10096-012-1803-7 (may require a subscription)
Caceres NE, Aerts M, Marquez B, Mingeot-Leclercq MP, Tulkens PM, Devreese B, Van Bambeke F
Analysis of the membrane proteome of ciprofloxacin-resistant macrophages by stable isotope labeling with amino acids in cell culture (SILAC)
PloS ONE (Public Library of Science) (2013) 8(3):e58285.
Original paper - Journal impact factor: 3.730 (in 2012)
Abstract
Link to PubMed (US National Library of Medicine):PMID=23505477
Reprint [with part of Supplementary Material] (PDF) - Table S1 - Table S2
Link to original document through DOI:10.1371/journal.pone.0058285
Catalano A, Carocci A, Defrenza I, Muraglia M, Carrieri C, Van Bambeke F, Filomena Corbo A, Franchini C
2-Aminobenzothiazole derivatives: Search for new antifungal agents
European Journal of Medicinal Chemistry (2013) 64C:357-364
Original paper - Journal impact factor: 3.499 (in 2012)
Abstract
Link to PubMed (US National Library of Medicine):PMID=23644218
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI:10.1016/j.ejmech.2013.03.064
D'Auria L, Deleu M, Dufour S, Mingeot-Leclercq MP, Tyteca D
Surfactins modulate the lateral organization of fluorescent membrane polar lipids: A new tool to study drug:membrane interaction and assessment of the role of cholesterol and drug acyl chain length.
Biochimica et Biophysica Acta (2013) 1828:2064–2073
Original paper - Journal impact factor: 3.399 (in 2012)
Abstract
Link to PubMed (US National Library of Medicine):PMID=23685123
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI:10.1016/j.bbamem.2013.05.006
Deleu M, Lorent J, Lins L, Brasseur R, Braun N, El Kirat K, Nylander T, Dufrêne YF, Mingeot-Leclercq MP.
Effects of surfactin on membrane models displaying lipid phase separation.
Biochimica et Biophysica Acta (Biomembranes) (2013) 1828:801-15
Original paper - Journal impact factor: 3.399 (in 2012)
Abstract
Link to PubMed (US National Library of Medicine):PMID=23159483
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI:10.1016/j.bbamem.2012.11.007 (may require a subscription)
Garcia LG, Lemaire S, Kahl BC, Becker K, Proctor RA, Denis O, Tulkens PM, Van Bambeke F
Antibiotic activity against Small Colony Variants of Staphylococcus aureus: Review of in vitro, animal, and clinical data
Journal of Antimicrobial Chemotherapy (2013) 68:1455-1464
Review - Journal impact factor: 5.338 (in 2012)
Abstract
Link to PubMed (US National Library of Medicine): PMID=23485724
Reprint [with Supplementary Material] (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI:10.1093/jac/dkt072 (may require a subscription)
Lorent J, Le Duff CS, Quetin-Leclercq J, Mingeot-Leclercq MP
Induction of highly curved structures in relation to membrane permeabilization and budding by the triterpenoid saponins, alpha- and delta-hederin..
Journal of Biological Chemistry (2013) 288:14000-140017
Original paper - Journal impact factor: 4.651(in 2012)
Abstract
Link to PubMed (US National Library of Medicine):PMID=23530040
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI: 10.1074/jbc.M112.407635.
Melard A, Garcia LG, Das D, Rozenberg R, Tulkens PM, Van Bambeke F, Lemaire S
Activity of ceftaroline against extracellular (broth) and intracellular (THP 1 monocytes) forms of methicillin-resistant Staphylococcus aureus: comparison with vancomycin, linezolid and daptomycin.
Journal of Antimicrobial Chemotherapy (2013) 68: 648–658
Abstract
Original paper - Journal impact factor: 5.338 (in 2012)
Link to PubMed (US National Library of Medicine): PMID=23188792
Reprint [with supplementary material] (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI:10.1093/jac/dks442 (may require a subscription)
Raverdy V, Ampe E, Hecq JD, Tulkens PM
Stability and compatibility of vancomycin for administration by continuous infusion.
Journal of Antimicrobial Chemotherapy (2013) 68:1179-1182.
Abstract
Original paper (Brief Report) - Journal impact factor: 5.338 (in 2012)
Link to PubMed (US National Library of Medicine): PMID=23302579
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI:10.1093/jac/dks510 (may require a subscription)
Zimmermann L, Bussière A, Ouberai M, Baussanne I, Jolivalt C, Mingeot-Leclercq MP, Décout JL.
Tuning the Antibacterial Activity of Amphiphilic Neamine Derivatives and Comparison to Paromamine Homologues.
Journal of Medicinal Chemistry (2013) 56:7691-7705
Abstract
Original paper - Journal impact factor: 5.614 (in 2012)
Link to PubMed (US National Library of Medicine): PMID=24083676
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI:10.1093/10.1021/jm401148j (may require a subscription) .

2012

Baquir B, Lemaire S, Van Bambeke F, Tulkens PM, Lin L, Spellberg B
Macrophage killing of bacterial and fungal pathogens is not inhibited by intense intracellular accumulation of the lipoglycopeptide antibiotic oritavancin
Clinical Infectious Diseases (2012) 54 (Suppl 3) S229-S232
Original paper - Journal impact factor: 9.154 (in 2011)
Abstract
Link to PubMed (US National Library of Medicine):PMID=22431853
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI:10.1093/cid/cir921 (may require a subscription)
Buyck JM, Guénard S, Plésiat P, Tulkens PM, Van Bambeke F.
Role of MexAB-OprM in intrinsic resistance of Pseudomonas aeruginosa to temocillin and impact on the susceptibility of strains isolated from patients suffering from cystic fibrosis
Journal of Antimicrobial Chemotherapy (2012) 67:771-775.
Original paper (Research Letter) - Journal impact factor: 5.068 (in 2011)
No abstract available
Link to PubMed (US National Library of Medicine):PMID=22218683
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI:10.1093/jac/dkr543 (may require a subscription)
Buyck JM, Plésiat P, Traore H, Vanderbist F, Tulkens PM, Van Bambeke F
Increased susceptibility of Pseudomonas aeruginosa to macrolides and ketolides in eukaryotic cell culture media and biological fluids (serum,
bronchoalveolar lavage) by decreased expression of OprM (efflux impairment) and increased outer membrane permeability
Clinical Infectious Diseases (2012) 55:534-542
Original paper - Journal impact factor: 9.154 (in 2011)
Abstract
Link to PubMed (US National Library of Medicine):PMID=22573850
Reprint [with supplementary materail] (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI:10.1093/cid/cis473 (may require a subscription)
Claeys C, Nève J, Tulkens PM, Spinewine A.
Content validity and inter-rater reliability of an instrument to characterize unintentional medication discrepancies.
Drugs & Aging (2012) 29:577-91.
Original paper - Journal impact factor: 2.671 (in 2011)
Abstract
Link to PubMed (US National Library of Medicine):PMID=22715864
Reprint (PDF) UCL only - Copyright owned by the publisher
Link to original document through DOI:10.2165/11631980-000000000-00000 (may require a subscription)
Garcia LG, Lemaire S, Kahl BC, Becker K, Proctor RA, Denis O, Tulkens PM, Van Bambeke F
Pharmacodynamic evaluation of the activity of antibiotics against hemin- and menadione-dependent small-colony variants of Staphylococcus aureus in models of extracellular (broth) and intracellular (THP-1 monocytes) infections.
Antimicrobial Agents and Chemotherapy (2012) 56:3700-3711
Original paper - Journal impact factor: 4.841 (in 2011)
Abstract
Link to PubMed (US National Library of Medicine):PMID=22564838
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI:10.1128/AAC.00285-12 (may require a subscription)
Garcia LG, Lemaire S, Kahl B, Becker K, Proctor RA, Tulkens PM, Van Bambeke F
Intracellular forms of menadione-dependent Small-Colony Variants of methicillin-resistant Staphylococcus aureus are hypersusceptible to beta-lactams in a model of THP-1 cells due to cooperation between vacuolar acidic pH and oxidant species
Journal of Antimicrobial Chemotherapy (2012) 67:2873-2881
Original paper - Journal impact factor: 5.068 (in 2011)
Abstract
Link to PubMed (US National Library of Medicine):PMID=23002174
Reprint [with supplementary material] (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI:10.1093/jac/dks325 (may require a subscription)
Garcia LG, Lemaire S, Kahl B, Becker L, Proctor R, Tulkens PM, Van Bambeke F
Influence of the protein kinase C activator, phorbol myristate acetate (PMA), on the intracellular activity of antibiotics against hemin and menadione auxotrophic Small-Colony Variant (SCV) mutants of Staphylococcus aureus and their wild-type parental strain in human THP-1 cells
Antimicrobial Agents and Chemotherapy (2012) 56:6166-6174
Original paper - Journal impact factor: 4.841 (in 2011)
Abstract
Link to PubMed (US National Library of Medicine):PMID=22985883
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI:10.1128/AAC.01031-12 (may require a subscription)
Imbuluzqueta E, Lemaire S, Gamazo C, Elizondo E, Ventosa N, Veciana J, Van Bambeke F, Blanco-Prieto MJ
Cellular pharmacokinetics and intracellular activity against Listeria monocytogenes and Staphylococcus aureus of chemically modified and nanoencapsulated gentamicin
Abstract
Link to PubMed (US National Library of Medicine):PMID=22615297
Journal of Antimicrobial Chemotherapy (2012) 67:2158-2164
Original paper - Journal impact factor: 5.068 (in 2011)
Reprint [with supplementary material] (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI:10.1093/jac/dks172 (may require a subscription)
Jackowski O, Bussière A, Vanhaverbeke C, Baussanne I, Peyrin E, Mingeot-Leclercq MP, Décout JL
Major increases of the reactivity and selectivity in aminoglycoside O-alkylation due to the presence of fluoride ions
Tetrahedron (2012) 68:737-746
Original paper - Journal impact factor: 3.025 (in 2011)
Abstract
Link to PubMed (US National Library of Medicine):in process
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI:10.1016/j.tet.2011.10.102 (may require a subscription)
Kovács E, Savopol T, Iordache MM, Saplacan L, Sobaru I, Istrate C, Mingeot-Leclercq MP, Moisescu MG
Interaction of gentamicin polycation with model and cell membranes
Bioelectrochemistry (2012) 87:230–235
Original paper - Journal impact factor: 3.759 (in 2011)
Abstract
Link to PubMed (US National Library of Medicine):PMID=22522030
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI:10.1016/j.bioelechem.2012.03.001 (may require a subscription)
Lismond A, Carbonnelle S, Verhaegen J, Schatt P, De Bel A, Jordens P, Jacobs F, Dediste A, Verschuren F, Huang D, Tulkens PM, Glupczynski Y, Van Bambeke F
Antimicrobial susceptibility of Streptococcus pneumoniae isolates from vaccinated and non-vaccinated patients with a clinically-confirmed diagnosis of community-acquired pneumonia (CAP) in Belgium
International Journal of Antimicrobial Agents (2012) 39:208– 216
Original paper - Journal impact factor: 4.128 (in 2011)
Abstract
Link to PubMed (US National Library of Medicine):PMID=22245497
Reprint [with supplementary material] (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI:10.1016/j.ijantimicag.2011.11.011 (may require a subscription)
Mingeot-Leclercq MP, Tulkens PM, Denamur S, Vaara T, Vaara M
Novel polymyxin derivatives are less cytotoxic than polymyxin B to renal proximal tubular cells
Peptides (2012) 35:248–252
Original paper - Journal impact factor: 2.434 (in 2011)
Abstract
Link to PubMed (US National Library of Medicine):PMID=22504013
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI:10.1016/j.peptides.2012.03.033 (may require a subscription)
Oumar AA, Diallo K, Dembélé JP, Samaké L, Sidibé I, Togo B, Sylla M, Tounkara A, Dao S, Tulkens PM.
Adverse drug reactions to antiretroviral therapy: prospective study in children in Sikasso (Mali).
The Journal of Pediatric Pharmacology and Therapeutics (2012) 17:382-388.
Original paper (no impact factor)
Abstract
Link to PubMed (US National Library of Medicine):PMID=23411444
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI:10.5863/1551-6776-17.4.382
Tulkens PM, Arvis P, Kruesmann, F.
Moxifloxacin safety: an analysis of 14 years of clinical data
Drugs in Research and Development (2012) 12:71-100
Original paper - Journal impact factor: 1.787 (in 2010)
Link to PubMed (US National Library of Medicine):PMID=22715866
Reprint [with supplementary material] (PDF) - Open access - Copyright owned by the publisher
Link to original document through DOI:10.2165/11634300-000000000-00000
Tulkens PM
Review der Sicherheitsdaten zu Moxifloxacin
Infection (2012) 40 (Supplement): 61-63
Symposium Proceeding - Journal impact factor: 2.659 (in 2011)
Reprint (PDF) - UCL only Copyright owned by the publisher
Van Herendael B, Jeurissen A, Tulkens PM, Vlieghe E, Verbrugghe W, Jorens WG, Ieven M
Continuous infusion of antibiotics in the critically ill: the new holy grail for beta-lactams and vancomycin?
Annals of Intensive Care (2012) 2:22 (12 printed pages)
Review
Abstract
Link to PubMed (US National Library of Medicine):PMID=22747633
Reprint (PDF) - Open access - Copyright owned by the publisher
Link to original document through DOI:10.1186/2110-5820-2-22

2011

Andrade RJ, Tulkens PM
Hepatic safety of antibiotics used in primary care
Journal of Antimicrobial Chemotherapy (2011) 66:1431-1446.
Review - Journal impact factor: 4.659 (in 2010)
Abstract
Link to PubMed (US National Library of Medicine): PMID=21586591
Reprint (PDF) - Open access - Copyright owned by the publisher
Link to original document through DOI:10.1093/jac/dkr159 (open access)
Bush K, Courvalin P, Dantas G, Davies J, Eisenstein B, Huovinen P, Jacoby GA, Kishony R, Kreiswirth BN, Kutter E, Lerne SAr, Levy S, Lewis K, Lomovskaya O,
Miller JH, Mobashery S, Piddock LJV, Projan S, Thomas CM, Tomasz A, Tulkens PM, Walsh TR, Watson JD, Witkowski J, Witte W, Wrigh Gt, Yeh P, Zgurskaya HI
Tackling antibiotic resistance
Nature Reviews Microbiology (2011) 9:894-896. doi: 10.1038/nrmicro2693
Essay - Journal impact factor (in 2010): 20.686
Abstract
Link to PubMed (US National Library of Medicine): PMID=22048738
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI:10.1038/nrmicro2693 (may require a subscription)
Denamur S, Tyteca D, Marchand-Brynaert J, Van Bambeke F, Tulkens PM, Courtoy PJ, Mingeot-Leclercq MP
Role of oxidative stress in lysosomal membrane permeabilization and apoptosis induced by gentamicin, an aminoglycoside antibiotic.
Free Radical Biology & Medicine (2011) 51:1656-1665
Original paper - Journal impact factor: 5.707 (in 2010)
Abstract
Link to PubMed (US National Library of Medicine): PMID=21835240
Reprint (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI:10.1016/j.freeradbiomed.2011.07.015 (may require a subscription)
Lemaire S, Kosowska-Shick K, Appelbaum PC, Glupczynski Y, Van Bambeke F, Tulkens PM
Activity of moxifloxacin against intracellular community-acquired methicillin-resistant Staphylococcus aureus: comparison with clindamycin, linezolid and co-trimoxazole and attempt at defining an intracellular susceptibility breakpoint.
Journal of Antimicrobial Chemotherapy (2011) 66:596-607
Original paper - Journal impact factor: 4.659 (in 2010)
Abstract
Link to PubMed (US National Library of Medicine): PMID=21186193
Reprint (PDF) - Open access - Copyright owned by the publisher
Link to original document through DOI:10.1093/jac/dkr159 (may require a subscription)
Lemaire S, Tulkens PM, Van Bambeke F.
Contrasting effect of acidic pH on the extracellular and intracellular activity of anti-Gram-positive fluoroquinolones (moxifloxacin and delafloxacin) against Staphylococcus aureus.
Antimicrobial Agents and Chemotherapy (2011) 55:649-58.
Original paper - Journal impact factor: 4.672 (in 2010)
Abstract
Link to PubMed (US National Library of Medicine): PMID=21135179
Reprint [with supplementary material] (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI:10.1128/AAC.01201-10 (may require a subscription)
Lemaire S, Van Bambeke F, Pierard D, Appelbaum PC, Tulkens PM
Activity of CEM-102 (fusidic acid) towards extracellular and intracellular Staphylococcus aureus: Influence of pH and comparison with linezolid and clindamycin.
Clinical Infectious Diseases (2011) 52 Suppl 7:S493-503.
Original paper (in Supplement section) - Journal impact factor: 8.186 (in 2010)
Abstract
Link to PubMed (US National Library of Medicine): PMID=21546626
Reprint [with supplementary material] (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI:10.1093/cid/cir165 (may require a subscription
Lemaire S, Van Bambeke F, Tulkens PM
Activity of finafloxacin, a novel fluoroquinolone with increased activity at acid pH, towards extracellular and intracellular Staphylococcus aureus, Listeria monocytogenes, and Legionella pneumophila
International Journal of Antimicrobial Agents (2011) 38:52-59.
Original paper - Journal impact factor: 3.787 (in 2010)
Abstract
Link to PubMed (US National Library of Medicine): PMID=21596526
Reprint [with supplementary material] (PDF) - UCL only - Copyright owned by the publisher
Link to original document through DOI:10.1016/j.ijantimicag.2011.03.002 (may require a subscription)
Lismond A, Carbonnelle S, Tulkens PM, Van Bambeke F
Efflux of novel quinolones in contemporary Streptococcus pneumoniae isolates from community-acquired pneumonia
Journal of Antimicrobial Chemotherapy (2011) 66:948-951
Original paper (Research Letter) - Journal impact factor: 4.659 (in 2010)
Abstract
Link to PubMed (US National Library of Medicine): PMID=21393137
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Link to original document through DOI:10.1093/jac/dkr004 (may require a subscription)
Marquez B, Van Bambeke F.
ABC multidrug transporters: Target for modulation of drug pharmacokinetics and drug-drug interactions.
Current Drug Targets (2011) 12:600-620
Review paper - Journal impact factor 4.187 (in 2009; paper submitted in 2008)
Abstract
Link to PubMed (US National Library of Medicine): PMID=21039335
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Whole Issue (PDF) - UCL only - Copyright owned by the publisher
Marquez B, Ameye G, Vallet CM, Tulkens PM, Poirel HA, Van Bambeke F
Characterization of Abcc4 gene amplification in stepwise-selected mouse J774 macrophages resistant to the topoisomerase II inhibitor ciprofloxacin
PLoS ONE (Public Library of Science) 6:e28368
Original paper - Journal impact factor (in 2010): 4.411
Abstract
Link to PubMed (US National Library of Medicine): PMID=22162766
Reprint [with supplementary material] (PDF) - Open access - Copyright owned by the publisher
Link to original document through DOI:10.1371/journal.pone.0028368.1016 (open access)
Ouberai M, El Garch F, Bussiere A, Riou M, Alsteens D, Lins L, Baussanne I, Dufrêne YF, Brasseur R, Decout JL, Mingeot-Leclercq MP.
The Pseudomonas aeruginosa membranes: A target for a new amphiphilic aminoglycoside derivative?
Biochimica Biophysica Acta - Biomembranes (2011) 1808:1716-1727
Original paper - Journal impact factor: 4.647 (in 2010)
Abstract
Link to PubMed (US National Library of Medicine): PMID=21291859
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Link to original document through DOI:10.1016/j.bbamem.2011.01.014 (may require a subscription)
Rolin C, Hecq, JD, Tulkens P, Vanbeckbergen D, Jamart J, Galanti L
Long-term stability of temocillin in dextrose 5% and in sodium chloride 0.9% polyolefin bags at 5 +/- 3°C after freeze-thaw treatment
Annales Pharmaceutiques Françaises (2011) 69:296-301
Original paper - Journal impact factor: not available
Abstract
Link to PubMed (US National Library of Medicine): PMID=22115132
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Link to original document through DOI:10.1016/j.pharma.2011.09.004 (may require a subscription)
Sandberg A, Lemaire S, Van Bambeke F, Tulkens PM, Hughes D, von Eiff C, Frimodt-Møller, N
Intra- and extracellular activity of dicloxacillin and linezolid against a clinical Staphylococcus aureus strain with small-colony variant phenotype in an in vitro (THP-1 macrophages) and an in vivo mouse peritonitis model
Antimicrobial Agents and Chemottherapy (2011) 55:1443-1452
Original paper - Journal impact factor: 4.672 (in 2010)
Abstract
Link to PubMed (US National Library of Medicine): PMID=21282430
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Link to original document through DOI:10.1128/AAC.00205-10 (may require a subscription)
Vallet CM, Marquez B, Ngabirano E, Lemaire S, Mingeot-Leclercq MP, Tulkens PM, Van Bambeke F
Cellular accumulation of fluoroquinolones is not predictive of their intracellular activity: studies with gemifloxacin, moxifloxacin, and ciprofloxacin in a pharmacokinetic/pharmacodynamic model of uninfected and infected macrophages.
International journal of Antimicrobial Agents (2011) 38:249-256.
Original paper - Journal impact factor: 3.787 (in 2010)
Abstract
Link to PubMed (US National Library of Medicine): PMID=21764262
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Link to original document through DOI:10.1016/j.ijantimicag.2011.05.011 (may require a subscription)
Vallet CM, Marquez B, Nhiri N, Anantharajah A, Mingeot-Leclercq M-P, Tulkens PM, Lallemand J-Y, Jacquet E, Van Bambeke F
Modulation of the expression of ABC transporters in murine (J774) macrophages exposed to large concentrations of the fluoroquinolone antibiotic moxifloxacin
Toxicology (2011) 290:179-187
Original paper - Journal impact factor (in 2010): 3.65
Abstract
Link to PubMed (US National Library of Medicine): PMID=21946100
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Link to original document through DOI:10.1016/j.tox.2011.09.003 (may require a subscription)
Van Bambeke F
ABC transporters: role in modulation of drug pharmacokinetics and in physiopathology and therapeutic perspectives (Editorial)
Current Drug Targets (2011) 12:598-599
Editorial - Journal impact factor 4.187 (in 2008; submission early 2009)
Abstract
Link to PubMed (US National Library of Medicine): PMID=21039339
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2010

Baudoux P, Lemaire S, Denis O, Tulkens PM, Van Bambeke F, Glupczynski Y
Activity of quinupristin-dalfopristin against extracellular and intracellular Staphylococcus aureus with various resistance phenotypes
Journal of Antimicrobial Chemotherapy (2010) 65:1228-1236
Original paper - Journal impact factor: 4.352 (in 2009)
Abstract
Link to PubMed (US National Library of Medicine): PMID=20378672
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Link to original document through DOI:10.1093/jac/dkq110 (may require a subscription)
Baussanne I, Bussière A, Halder S, Ganem-Elbaz C, Ouberai M, Riou M, Paris JM, Ennifar E, Mingeot-Leclercq MP, Décout JL.
Synthesis and antimicrobial evaluation of amphiphilic neamine derivatives.
Journal of Medicinal Chemistry (2010) 14:119-127
Original paper - Journal impact factor (in 2008 [last known]): 4.898
Abstract
Link to PubMed (US National Library of Medicine): PMID=20000576
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Link to original document through DOI:10.1021/jm900615h (may require a subscription)
Becker JP, Van Bambeke F, Tulkens PM, Prévost M.
Dynamics and structural changes induced by ATP binding in SAV1866, a bacterial ABC exporter.
Journal of Physical Chemistry B (2010) 114:15948-15957
Original paper - Journal impact factor: 4.189 (in 2009)
Abstract
Link to PubMed (US National Library of Medicine): PMID=21069970
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Link to original document through DOI:10.1021/jp1038392 (may require a subscription)
Berthoin K, Le Duff CS, Marchand-Brynaert J, Carryn S, Tulkens PM
Stability of meropenem and doripenem solutions for administration by continuous infusion
Journal of Antimicrobial Chemotherapy (2010) 65:1073-1075
Original paper (Research Letter) - Journal impact factor: 4.352 (in 2009)
Link to PubMed (US National Library of Medicine): PMID=20176578
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Link to original document through DOI:10.1093/jac/dkq044 (may require a subscription)
Bernal P, Lemaire S, Pinho MG, Mobashery S, Hinds J, Taylor PW
Insertion of epicatechin gallate into the cytoplasmic membrane of methicillin-resistant Staphylococcus aureus disrupts penicillin binding protein (PBP) 2a-mediated ß-lactam resistance by delocalizing PBP2
Journal of Biological Chemistry (2010) 285:24055-24065
Original paper - Journal impact factor: 5.328 (in 2009)
Link to PubMed (US National Library of Medicine): PMID=20516078
Reprint with supplemental material (PDF) - Free Text - Copyright owned by the publisher
Link to original document through DOI:10.1074/jbc.M110.114793 (may require a subscription)
Brinch KS, Tulkens PM, Van Bambeke F, Frimodt-Møller N, Høiby N, Kristensen HH
Intracellular activity of the peptide antibiotic NZ2114: studies with Staphylococcus aureus and human THP-1 monocytes, and comparison with daptomycin and vancomycin
Journal of Antimicrobial Chemotherapy (2010) 65:1720-1724.
Original paper (Brief report) - Journal impact factor: 4.3652 (in 2009)
Link to PubMed (US National Library of Medicine): PMID=20534628
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Link to original document through DOI:10.1093/jac/dkq159 (may require a subscription)
Carryn S, Couwenbergh B, Tulkens PM
Long-term Stability of Temocillin in Elastomeric Pumps for Outpatient Antibiotic Therapy (OPAT) in Cystic Fibrosis (CF) Patients.
Journal of Antimicrobial Chemotherapy (2010) 65:2045-2046
Original paper (Research Letter) - Journal impact factor: 4.352 (in 2009)
Abstract
Link to PubMed (US National Library of Medicine): PMID=20576638
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Link to original document through DOI:10.1093/jac/dkq229 (may require a subscription)
Domenech O, Dufrêne Y, Van Bambeke F, Tulkens PM, Mingeot-Leclercq MP
Interactions of oritavancin, a new semi-synthetic lipoglycopeptide, with lipids extracted from Staphylococcus aureus.
Biochimica et Biophysica Acta - Biomembranes (2010) 1798:1876-1885
Original paper - Journal impact factor: 3.998 (in 2009)
Abstract
Link to PubMed (US National Library of Medicine): PMID=20599683
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Link to original document through DOI:10.1016/j.bbamem.2010.06.011 (may require a subscription)
El Garch F, Lismond A, Piddock LJV, Courvalin P, Tulkens PM, Van Bambeke F
Fluoroquinolones induce the expression of patA and patB which encode ABC efflux pumps in Streptococcus pneumoniae
Journal of Antimicrobial Chemotherapy (2010) 65:2076-82
Original paper - Journal impact factor: 4.352 (in 2009)
Abstract
Link to PubMed (US National Library of Medicine): PMID= 20709735
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Link to original document through DOI: 10.1093/jac/dkq287 (may require a subscription)
Gordon C, Van Bambeke F
Azithromycin
In: Kucers's the use of antibiotics: a clinical review of antibacterial, antifungal, antiparasitic and antiviral drugs
6th Edition, volume 1, pages 801-818, 2010, Edward Arnold (Publishers) Ltd.
Introduction
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Langan C, Van Bambeke F
Clarithromycin
In: Kucers's the use of antibiotics: a clinical review of antibacterial, antifungal, antiparasitic and antiviral drugs
6th Edition, volume 1, pages 779-800, 2010, Edward Arnold (Publishers) Ltd.
Introduction
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Lemaire S, Tulkens PM, Van Bambeke F
Cellular pharmacokinetics of the novel biaryloxazolidinone radezolid in phagocytic cells: studies with macrophages and polymorphonuclear neutrophils.
Antimicrobial Agents and Chemotherapy (2010) 54:2540-2548
Original paper - Journal impact factor: 4.716 (in 2008)
Abstract
Link to PubMed (US National Library of Medicine): PMID=20385873
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Link to original document through DOI:10.1128/AAC.01723-09 (may require a subscription)
Lemaire S, Kosowska-Shick K, Appelbaum PC, Verween G, Tulkens PM, Van Bambeke F
Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila.
Antimicrobial Agents and Chemotherapy (2010) 54:2549-2559
Original paper - Journal impact factor: 4.716 (in 2008)
Abstract
Link to PubMed (US National Library of Medicine): PMID=20385852
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Link to original document through DOI:10.1128/AAC.01724-09 (may require a subscription)
Oumar AA, Jnaoui K, Yombi JC, Kabamba BM, Ruelle J, Tulkens PM, Wallemacq P, Goubau P.
L'infection par le virus de l'immunodéficience humaine (VIH) et son traitement au Mali
Louvain Médical (2010) 129: 116-122
Educational paper
Abstract
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Riou M, Carbonnelle S, Avrain L, Mesaros N, Pirnay JP, Bilocq F, De Vos D, Simon A, Pierard D, Jacobs F, Dediste A, Tulkens PM, Van Bambeke F, Glupczynski Y
In vivo development of antimicrobial resistance in Pseudomonas aeruginosa strains isolated from lower respiratory tract of intensive care unit patients with nosocomial pneumonia and receiving antipseudomonal therapy
International Journal of Antimicrobial Agents
Original paper - Journal impact factor: 3.032 (in 2009)
International Journal of Antimicrobial Agents (2010) 36:513-522
Abstract
Link to PubMed (US National Library of Medicine): PMID=20926262
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Link to original document through DOI:10.1016/j.ijantimicag.2010.08.005 (may require a subscription)
Sandberg A, Jensen KS, Baudoux P, Van Bambeke F, Tulkens PM, Frimodt-Møller N
Intra- and extracellular activity of dicloxacillin against Staphylococcus aureus in vivo and in vitro.
Antimicrobial Agents and Chemotherapy (2010) 54:2391-2400
Original paper - Journal impact factor: 4.716 (in 2008)
Abstract
Link to PubMed (US National Library of Medicine): PMID=20308386
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Link to original document through DOI:10.1128/AAC.01400-09 (may require a subscription)
Sandberg A, Jensen KS, Baudoux P, Van Bambeke F, Tulkens PM, Frimodt-Møller N
Intra- and extracellular activity of linezolid against Staphylococcus aureus in vivo and in vitro
Journal of Antimicrobial Chemotherapy (2010) 65:962-973
Original paper - Journal impact factor: 4.352 (in 2009)
Abstract
Link to PubMed (US National Library of Medicine): PMID=20211859
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Link to original document through DOI:10.1093/jac/dkq052 (may require a subscription)
Staes E, Absil PA, Lins L, Brasseur R, Deleu M, Lecouturier N, Fievez V, des Rieux A, Mingeot-Leclercq MP, Raussens V, Préat V.
Acylated and unacylated ghrelin binding to membranes and to ghrelin receptor: towards a better understanding of the underlying mechanisms.
Biochimica Biophysica Acta - Biomembranes. (2010) 1798::2102-13.
Original paper - Journal impact factor: 3.998 (in 2009)
Abstract
Link to PubMed (US National Library of Medicine): PMID=20637180
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Link to original document through DOI:10.1016/j.bbamem.2010.07.002 (may require a subscription)
Van Bambeke F, Pagès J-M, Lee VJ
Inhibitors of bacterial efflux pumps as adjuvants in antibacterial therapy and diagnostic tools for detection of resistance by efflux
In: Frontiers in Anti-Infective Drug Discovery (2010) vol. 1, 138-175,
Atta-ur-Rahman & M. Iqbal Choudhary (Eds.), Bentham Science Publishers.
Chapter of book
Abstract
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Van Bambeke F, Glupczynski, Y, Mingeot-Leclercq, MP, Tulkens PM
Mechanisms of Action.
In: Infectious Diseases (3d edition; J. Cohen, W. Powderly & S. Opal, eds), chapter 130, pp 1288-1307, Elsevier/Mosby, 2010 (ISBN 978-0-323-04579-7)
Chapter of book
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Available on line at http://www.expertconsultbook.com (requires a subscription)
Van Bambeke F
Erythromycin
In: Kucers's the use of antibiotics: a clinical review of antibacterial, antifungal, antiparasitic and antiviral drugs
6th Edition, volume 1, pages 751-769, 2010, Edward Arnold (Publishers) Ltd.
Introduction
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Van Bambeke F
Roxithromycin
In: Kucers's the use of antibiotics: a clinical review of antibacterial, antifungal, antiparasitic and antiviral drugs
6th Edition, volume 1, pages 770-778, 2010, Edward Arnold (Publishers) Ltd.
Introduction
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Van Bambeke F
Josamycin and rosaramicin
In: Kucers's the use of antibiotics: a clinical review of antibacterial, antifungal, antiparasitic and antiviral drugs
6th Edition, volume 1, pages 819-824, 2010, Edward Arnold (Publishers) Ltd.
Introduction
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2009

Becker JP, Depret G, Van Bambeke F, Tulkens PM, Prevost M
Molecular models of human P-glycoprotein in two different catalytic states
BMC Structural Biology (2009) 9:3
Original paper - Journal impact factor: 2.000 (in 2008)
Abstract
Link to PubMed (US National Library of Medicine): PMID=19159494
Reprint (PDF) - Open access
Link to original document through DOI:10.1186/1472-6807-9-3 (open access)
Berthoin K, Ampe E, Tulkens PM, Carryn S
Correlation between free and total vancomycin serum concentrations in patients treated for Gram-positive infections.
International Journal of Antimicrobial Agents (2009) 34:555-60.
Original paper - Journal impact factor: 3.067 (in 2008)
Abstract
Link to PubMed (US National Library of Medicine): PMID=19782538
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Link to original document through DOI:10.1016/j.ijantimicag.2009.08.005 (may require a subscription)
Brinch KS, Sandberg A, Baudoux P, Van Bambeke F, Tulkens PM, Frimodt-Møller N, Høiby N, Kristensen HH
Plectasin shows intracellular activity against Staphylococcus aureus in human THP-1 monocytes and in the mouse peritonitis model.
Antimicrobial Agents and Chemotherapy (2009) 53:4801-4808
Original paper - Journal impact factor: 4.716 (in 2008)
Abstract
Link to PubMed (US National Library of Medicine): PMID=19738011
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Link to original document through DOI:10.1128/AAC.00685-09 (may require a subscription)
Domenech O, Francius G, Tulkens PM, Van Bambeke F, Dufrene Y, Mingeot-Leclercq MP
Interactions of oritavancin, a new lipoglycopeptide derived from vancomycin, with phospholipid bilayers: effect on membrane permeability and nanoscale lipid membrane organization.
Biochimica et Biophysica Acta - Biomembranes (2009) 1788:1832-1840
Original paper - Journal impact factor: 4.180 (in 2008)
Abstract
Link to PubMed (US National Library of Medicine): PMID=19450541
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Link to original document through DOI:10.1016/j.bbamem.2009.05.003 (may require a subscription)
Feron JM, Legrand D, Pestiaux D, Tulkens PM
Prescription d’antibiotiques en médecine générale en Belgique et en France: entre déterminants collectifs et responsabilité individuelle
Pathologie Biologie (Paris) (2009) 57:61-64. .
Review - Journal impact factor: 0.960 (in 2008)
Abstract
Link to PubMed (US National Library of Medicine): PMID=18848403
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Link to original document through DOI:10.1016/j.patbio.2008.07.002 (may require a subscription)
Franchini C, Muraglia M, Corbo F, Florio MA, Di Mola A, Rosato A, Matucci R, Nesi M, van Bambeke F, Vitali C.
Synthesis and biological evaluation of 2-mercapto-1,3-benzothiazole derivatives with potential antimicrobial activity
Archiv der Pharmazie - Chemistry in Life Sciences (Weinheim) (2009) 342:605-613
Original paper - Journal impact factor: 1.429 (in 2008)
Abstract
Link to PubMed (US National Library of Medicine): PMID=19753564
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Link to original document through DOI:10.1002/ardp.200900092 (may require a subscription)
Lemaire S, Glupczynski Y, Duval V, Joris B, Tulkens PM, Van Bambeke F
Activity of ceftobiprole and other cephalosporins against extracellular and intracellular (THP-1 macrophages, keratinocytes) forms of Methicillin-Sensitive (MSSA) and Methicillin-Resistant Staphylococcus aureus (MRSA).
Antimicrobial Agents and Chemotherapy (2009) 53:2289-2297
Original paper - Journal impact factor (in 2008): 4.716
Abstract
Link to PubMed (US National Library of Medicine): PMID=19289525
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Link to original document through DOI:10.1128/AAC.01135-08 (may require a subscription)
Lemaire S, Van Bambeke F, Tulkens PM.
Cellular accumulation and pharmacodynamic evaluation of the Intracellular activity of CEM-101, a novel fluoroketolide, towards Staphylococcus aureus, Listeria monocytogenes, and Legionella pneumophila in human THP-1 macrophages.
Antimicrobial Agents and Chemotherapy (2009) 53:3734-3743
Original paper - Journal impact factor: 4.716 (in 2008)
Abstract
Link to PubMed (US National Library of Medicine): PMID=19564365
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Link to original document through DOI:10.1128/AAC.00203-09 (may require a subscription)
Lemaire S, Van Bambeke F, Appelbaum P.C., Tulkens PM
Cellular pharmacokinetics and intracellular activity of torezolid (TR-700): studies with human macrophage (THP-1) and endothelial (HUVEC) cell lines.
Journal of Antimicrobial Chemotherapy (2009) 64:1035-1043
Original paper - Journal impact factor: 4.238 (in 2008)
Abstract
Link to PubMed (US National Library of Medicine): PMID=19759040
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Link to original document through DOI:10.1093/jac/dkp267 (may require a subscription)
Lemaire S, Tulkens PM, Van Bambeke F.
Therapeutic options for intracellular MRSA: Current views and perspectives
In: Methicillin-Resistant Staphylococcus Aureus (MRSA): Etiology, At-Risk Populations and Treatment (C.L. Kolendi, ed.), chapter 2, pp 55-74
ISBN: 978-1-60741-398-1
Chapter of book
Provisional reprint (PDF)
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Livermore DM, Tulkens PM
Temocillin revived
Journal of Antimicrobial Chemotherapy (2009) 63:243-245
Review - Journal impact factor: 4.238 (in 2008)
Abstract
Link to PubMed (US National Library of Medicine): PMID=19095679
Reprint (PDF) - Open access - Copyright owned by the publisher
Link to original document through DOI:10.1093/jac/dkn511 (free access)
Marquez B, Caceres NE, Mingeot-Leclercq MP, Tulkens PM, Van Bambeke F.
Identification of the efflux transporter of the fluoroquinolone antibiotic ciprofloxacin in murine macrophages: studies with ciprofloxacin-resistant cells
Antimcrobial Agents and Chemotherapy (2009) 53: 2410-2416
Original paper - Journal impact factor (in 2008): 4.716
Abstract
Link to PubMed (US National Library of Medicine): PMID=19307362
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Link to original document through DOI:10.1128/AAC.01428-08 (may require a subscription)
Nguyen HA, Denis O, Vergison A, Theunis A, Tulkens PM, Struelens MJ, Van Bambeke F
Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus Small Colony Variant isolated from a cystic fibrosis patient : 1. Pharmacodynamic evaluation and comparison with isogenic normal phenotype and revertant strains.
Antimicrobial Agents and Chemotherapy (2009) 53:1434–1442
Original paper - Journal impact factor (in 2008): 4.716
Abstract
Link to PubMed (US National Library of Medicine): PMID=19188393
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Link to original document through DOI:10.1128/AAC.01145-08 (may require a subscription)
Nguyen HA, Denis O, Vergison A, Tulkens PM, Struelens MJ, Van Bambeke F
Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus Small Colony Variant isolated from a cystic fibrosis patient : 2. Study of antibiotic combinations.
Antimicrobial Agents and Chemotherapy (2009) 53:1443-1449
Original paper - Journal impact factor (in 2008): 4.716
Abstract
Link to PubMed (US National Library of Medicine): PMID=19188397
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Link to original document through DOI:10.1128/AAC.01146-08 (may require a subscription)
Olivier AC, Lemaire S, Van Bambeke F, Tulkens PM, Oldfield E
Role of rsbU and staphyloxanthin in phagocytosis and intracellular growth of Staphylococcus aureus in human macrophages and endothelial cells.
Journal of Infectious Diseases (2009) 200:1367-1370
Original paper - Journal impact factor: 5.375 (in 2008)
Abstract
Link to PubMed (US National Library of Medicine): PMID=19817587
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Link to original document through DOI:10.1086/606012 (may require a subscription)
Tytgat I, Colacino E, Tulkens PM, Poupaert JH, Prévost M, Van Bambeke F
DD-Ligases as a Potential Target for Antibiotics: Past, Present and Future
Current Medicinal Chemistry (2009) 16: 2566-2580
Review - Journal impact factor: 4.823 (in 2008)
Abstract
Link to PubMed (US National Library of Medicine): PMID=19601798
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Tytgat I, Vandevuer S, Ortmans I, Sirockin F, Colacino E, Van Bambeke F, Duez C, Poupaert JH, Tulkens PM, Dejaegere A, Prévost M
Structure-based design of benzoxazoles as new inhibitors for D-alanyl - D-alanine ligase
QSAR and Combinatorial Sciences (2009) 28: 1394-1404
Original paper - Journal impact factor: 2.594 (in 2008)
Abstract
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Link to original document through DOI:10.1002/qsar.200910054 (may require a subscription)
Van Bambeke F, Tulkens PM.
Safety profile of moxifloxacin, a respiratory fluoroquinolone: comparison with other fluoroquinolones and other antibiotic classes
Drug Safety (2009) 32:359-378
Review paper - Journal impact factor (in 2008): 3.597
Abstract
Link to PubMed (US National Library of Medicine): PMID=19419232
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Link to original document through DOI:10.2165/00002018-200932050-00001 (may require a subscription)
Van Bambeke F, Tulkens PM
Pharmacodynamie des antibiotiques dans le LCR : principes et conséquences (facteurs prédictifs d'efficacité
Médecine et maladies infectieuses (2009) 39:483-492
Educational paper
Abstract
Link to PubMed (US National Library of Medicine): PMID=19500928
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link to original document through DOI:10.1016/j.medmal.2009.02.038 (may require a subscription)
Glycopeptides (Dalbavancin, Oritavancin, Teicoplanin, Telavancin, Vancomycin) - Update 2009
Van Bambeke F, Virgincar N, MacGowan A. Glycopeptides (Dalbavancin, Oritavancin, Teicoplanin, Telavancin, Vancomycin) - Update 2009
Antimicrobial Therapy and Vaccines. Vol. II: Antimicrobial Agents (2009) 42pp
V.L. Yu et al. eds
Web edition (Esun Technologies), Pittsburgh, PA (http://www.antimicrobe.org - requires a subscription)
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Van de Velde S, Carryn S, Van Bambeke F, Hill C, Tulkens PM, Sleator RD
Penicillin-binding Proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in beta-lactam sensitivity of Listeria monocytogenes.
Gut Pathogens (2009) 1:23
Original paper - Journal impact factor: not in ISI 2008 list
Abstract
Link to PubMed (US National Library of Medicine): PMID=20003484
Reprint (PDF) - Open access - Copyright owned by the publisher
link to original document through DOI:10.1186/1757-4749-1-23 (free access)
Van de Velde S, Delaive E, Dieu M, Carryn S, Van Bambeke F, Devreese B, Raes M, Tulkens PM.
Isolation and 2D-DIGE proteomic analysis of intracellular and extracellular forms of Listeria monocytogenes.
Proteomics (2009) 9:5484-5496
Original paper - Journal impact factor: 4.585 (in 2008)
Abstract
Link to PubMed (US National Library of Medicine): PMID=19834917
Reprint (PDF) (with Supplementary Material) - UCL only - Copyright owned by the publisher
link to original document through DOI:10.1002/pmic.2009005030 (may require a subscription)

2008

Barcia-Macay M, Mouaden F, Mingeot-Leclercq MP, Tulkens PM, Van Bambeke F
Cellular pharmacokinetics of telavancin, a novel lipoglycopeptide antibiotic, and analysis of lysosomal changes in cultured eukaryotic cells (J774 mouse macrophages; rat embryonic fibroblasts).
Journal of Antimicrobial Chemotherapy (2008) 61:1288-1294
Original paper - Journal impact factor: 4.038 (in 2007)
Abstract
Link to PubMed (US National Library of Medicine): PMID=18375379
Reprint (PDF) (Open access - Copyright owned by the publisher)
Link to original document through DOI: 10.1093/jac/dkn120 (Open access)
Bensikaddour H, Snoussi K, Lins L, Brasseur R, Van Bambeke F, Tulkens PM, Goormaghtigh E, Mingeot-Leclercq MP
Interactions of ciprofloxacin with DPPC and DPPG: Fluorescence anisotropy, ATR-FTIR and 31P NMR spectroscopies and conformational analysis
Biochimica Biophysica Acta (Biomembranes) (2008) 1778:2535-2543
Original paper - Journal impact factor: 3.640 (in 2007)
Abstract
Link to PubMed (US National Library of Medicine): PMID=18809375
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Link to original document through DOI: 10.1016/j.bbamem.2008.08.015 (may require a subscription)
Bensikaddour H, Fa N, Burton I, Deleu M, Lins L, Schanck A, Brasseur R, Dufrêne YF, Goormaghtigh E, Mingeot-Leclercq MP
Characterization of the interactions between fluoroquinolone antibiotics and lipids: a multitechnique approach
Biophysical Journal (2008) 94:3035-3046
Original paper - Journal impact factor: 4.627 (in 2007)
Abstract
Link to PubMed (US National Library of Medicine): PMID=18178657
Reprint (PDF) (Open access - Copyright owned by the publisher)
Link to original document through DOI:10.1529/biophysj.107.114843 (may require a subscription)
Brasseur R, Deleu M, Mingeot-Leclercq MP, Francius G, Dufrêne YF
Probing peptide–membrane interactions using AFM
Surface and Interface Analysis (2008) 40:151–156
Original paper - Journal impact factor: 1.036 (in 2007)
Abstract
Reprint (PDF) (UCL only - Copyright owned by the publisher)
Link to original document through DOI: 10.1002/sia.2682 (may require a subscription)
De Jongh R, Hens R, Basma V, Mouton JW, Tulkens PM, Carryn S
Continuous vs intermittent infusion of temocillin, a directed spectrum penicillin for intensive care patients with nosocomial pneumonia: stability, compatibility, population pharmacokinetic studies and breakpoint selection.
Journal of Antimicrobial Chemotherapy (2008) 61:382-388
Original paper - Journal impact factor: 4.038 (in 2007)
Abstract
Link to PubMed (US National Library of Medicine): PMID=18070831
Reprint (PDF) (with supplementary material - UCL only - Copyright owned by the publisher)
Link to original document through DOI:10.1093/jac/dkm467 (may require a subscription)
Denamur S, Van Bambeke F, Mingeot-Leclercq MP, Tulkens PM
Apoptosis induced by aminoglycosides in LLC-PK1 cells: comparison between neomycin, gentamicin, amikacin, and isepamicin using electroporation.
Antimicrobial Agents and Chemotherapy (2008) 52:2236–2238
Original paper - Journal impact factor (last known): 4.390 (in 2007)
Abstract
Link to PubMed (US National Library of Medicine): PMID=18391041
Reprint (PDF) (with supplementary material - UCL only - Copyright owned by the publisher)
Link to original document through DOI:10.1128/AAC.01680-07 (may require a subscription)
Francius G, Domenech O, Mingeot-Leclercq MP, Dufrêne YF.
Direct observation of Staphylococcus aureus cell wall digestion by lysostaphin
Journal of Bacteriolology (2008) 190:7904-7909
Original paper - Journla impact factor: 4.013 (in 2007)
Abstract
Link to PubMed (US National Library of Medicine): PMID=18835985
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Link to original document through DOI:10.1128/JB.01116-08 (may require a subscription)
Francius G, Dufour S, Deleu M, Paquot M, Mingeot-Leclercq MP, Dufrêne YF.
Nanoscale membrane activity of surfactins: influence of geometry, charge and hydrophobicity.
Biochimica et Biophysica Acta - Biomembranes (2008) 1778:2058-2068.
Original paper - Journla impact factor: 3.815 (in 2007)
Abstract
Link to PubMed (US National Library of Medicine): PMID=18455997
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Link to original document through DOI:10.1016/j.bbamem.2008.03.023 (may require a subscription)
Kent L, Bradley JM, France M, Döring G, Carryn S, Bradbury I, Rendall J, Jones A, Elborn JS.
Temocillin in cystic fibrosis: A retrospective pilot study.
Journal of Cystic Fibrosis (2008) 7:551-554
Original paper - Journal impact factor: not known (new journal)
Abstract
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Link to original document through DOI: 10.1016/j.jcf.2008.06.005 (may require a subscription)
Lemaire S, Fuda C, Van Bambeke F, Tulkens PM, Mobashery S
Restoration of susceptibility of methicillin-resistant Staphylococcus aureus (MRSA) to beta-lactam antibiotics by acidic pH: role of penicillin-binding-protein 2A (PBP 2A)
Journal of Biological Chemistry (2008) 283:12769-12776
Original paper - Jounal impact factor: 5.581 (in 2007)
Abstract
Link to PubMed (US National Library of Medicine): PMID=18337244
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Link to original document through DOI:10.1074/jbc.M800079200 (may require a subscription)
Lemaire S, Kosowska-Shick K, Julian K, Tulkens PM, Van Bambeke F, Appelbaum PC
Activities of antistaphylococcal antibiotics towards the extracellular and intraphagocytic forms of S. aureus isolates from a patient with persistent bacteraemia and endocarditis
Clinical Microbiology and Infection (2008) 14:766-777
Original paper - Journal impact factor: 2.980 (in 2007)
Abstract
Link to PubMed (US National Library of Medicine): PMID=18727801
Reprint (PDF) (with supplementary material - UCL only - Copyright owned by the publisher - free access through
Link to original document through DOI:10.1111/j.1469-0691.2008.02035.x (may require a subscription)
Lemaire S, Olivier A, Van Bambeke F, Tulkens PM, Appelbaum PC, Glupczynski Y.
Restoration of susceptibility of intracellular Methicillin Resistant Staphylococcus aureus (MRSA) to beta-lactams: comparison between strains, cells, and antibiotics
Antimicrobial Agents and Chemotherapy (2008) 52:2997-2805
Original paper - Journal impact factor: 4.390 (in 2007)
Abstract
Link to PubMed (US National Library of Medicine): PMID=18519727
Reprint (PDF) (with supplementary material- UCL only - Copyright owned by the publisher)
Link to original document through DOI:10.1128/AAC.00123-08 (may require a subscription)
Lismond A, Tulkens PM, Mingeot-Leclercq MP, Courvalin P, Van Bambeke, F.
Cooperation between prokaryotic (Lde) and eukaryotic (MRP) efflux transporters in J774 macrophages infected with Listeria monocytogenes. Studies with ciprofloxacin and moxifloxacin.
Antimicrobial Agents and Chemotherapy (2008) 52:3040-3046
Origina paper - Journal impact factor: 4.390 (in 2007)
Abstract
Link to PubMed (US National Library of Medicine): PMID=18573933
Reprint (PDF) (with supplementary material - UCL only - Copyright owned by the publisher)
Link to original document through DOI:10.1128/AAC.00105-08 (may require a subscription)
Mouton JW, Theuretzbacher U, Craig WA, Tulkens PM, Derendorf H, Cars O
Tissue concentrations: do we ever learn?
Journal of Antimicrobial Chemotherapy (2008) 61:235-237.
Review - Journal impact factor: 4.038 (in 2007)
Abstract
Link to PubMed (US National Library of Medicine): PMID=18065413
Reprint (PDF) (free - Copyright owned by the publisher)
Link to original document through DOI:10.1093/jac/dkm476 (free)
Servais H,. Ortiz A, Devuyst O, Denamur S, Tulkens PM, Mingeot-Leclercq M-P
Renal cell apoptosis induced by nephrotoxic drugs: cellular and molecular mechanisms and potential approaches to modulation.
Apoptosis (2008) 13:11-32.
Review - Journal impact factor: 3.043 (in 2007)
Abstract
Link to PubMed (US National Library of Medicine): PMID=17968659
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Link to original document through DOI:10.1007/s10495-007-0151-z (may require a subscription)
Van Bambeke F.
L'ABC des hépatites virales
Journal de Pharmacie de Belgique (2008) 63:15-20
Educational paper
Abstract
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Van Bambeke F, Harms J, Van Laethem Y, Tulkens PM.
Ketolides: pharmacological profile and rational positioning in the treatment of respiratory tract infections
Expert Opinion on Pharmacotherapy (2008) 9:267-283
Review paper - Journal impact factor: 1.703 (in 2007)
Abstract
Link to PubMed (US National Library of Medicine): PMID=18201149
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Link to original document through DOI: 10.1517/14656566.9.2.267 (may require a subscription)
Van Bambeke F, Mingeot-Leclercq MP, Struelens MJ, Tulkens PM.
The bacterial envelope as a target for novel anti-MRSA antibiotics
Trends in Pharmacological Sciences (TIPS) (2008) 29:124-134
Review paper - Journal impact factor: 9.610 (in 2007)
Abstract
Link to PubMed (US National Library of Medicine): PMID=18262289
Reprint (PDF) (UCL only - Copyright owned by the publisher)
Link to original document through DOI:10.1016/j.tips.2007.12.004 (may require a subscription)
Van de Velde S, Nguyen HA, Van Bambeke F, Tulkens PM, Grellet J, Dubois V, Quentin C, Saux, MC.
Contrasting effects of human THP-1 cells differentiation on levofloxacin and moxifloxacin intracellular accumulation and activity against Staphylococcus aureus and Listeria monocytogenes.
Journal of Antimicrobial Chemotherapy (2008) 62:518-521
Original paper (Brief Note) - Journal impact factor: 4.038 (in 2007)
Abstract
Link to PubMed (US National Library of Medicine): PMID=18544595
Reprint (PDF) (UCL only - Copyright owned by the publisher)
Link to original document through DOI:10.1093/jac/dkn232 (may require a subscription)

2007

Avrain L, Garvey M, Mesaros N, Glupczynski Y, Mingeot-Leclercq MP, Piddock LJV, Tulkens PM, Vanhoof R, Van Bambeke F
Selection of quinolone resistance in Streptococcus pneumoniae exposed in vitro to sub-inhibitory drug concentrations.
Journal of Antimicrobial Chemotherapy (2007) 60:965-972
Original paper - Journal impact factor: 3.891(last known)
Abstract
Link to PubMed (US National Library of Medicine): PMID=17693451
Reprint (PDF) (UCL only - Copyright owned by the publisher)
Link to original document through DOI:10.1093/jac/dkm292 (may require a subscription)
Baudoux P, Bles N, Lemaire S, Mingeot-Leclercq MP, Tulkens PM, Van Bambeke F.
Combined effect of pH and concentration on the activities of gentamicin and oxacillin against Staphylococcus aureus in pharmacodynamic models of extracellular and intracellular infections.
Journal of Antimicrobial Chemotherapy (2007) 59:246-53
Original paper - Journal impact factor: 3.886 (last known)
Abstract
Link to PubMed (US National Library of Medicine): PMID=17220162
Reprint (PDF) (UCL only - Copyright owned by the publisher)
Link to original document through DOI:10.1093/jac/dkl489 (may require a subscription)
Brasseur R, Braun N, El Kirat K, Deleu M, Mingeot-Leclercq MP, Dufrêne Y
The biologically important surfactin lipopeptide induces nanoripples in supported lipid bilayers
Langmuir (2007) 23:9769-9772
Original paper - Journal impact factor: 3.902
Abstract
Link to PubMed (US National Library of Medicine): PMID=17696376
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Link to original document through DOI:10.1021/la7014868 (may require a subscription)
Fa N, Lins L, Courtoy PJ, Dufrêne Y, Van Der Smissen P, Brasseur R, Tyteca D, Mingeot-Leclercq MP.
Decrease of elastic moduli of DOPC bilayers induced by a macrolide antibiotic, azithromycin.
Biochimica Biophysica Acta [Biomembranes] (2007) 1768:1830-1838.
Original paper - Journal impact factor: 3.587 (last known)
Abstract
Link to PubMed (US National Library of Medicine): PMID= 17537401
Reprint (PDF) (UCL only - Copyright owned by the publisher)
Link to original document through DOI:10.1016/j.bbamem.2007.04.013 (may require a subscription)
Hernout O, Berthoin K, Delattre I, Tulkens PM, Carryn S, Marchand-Brynaert J
Design and evaluation of analogues of the bacterial cell-wall peptidoglycan motif L-Lys-D-Ala-D-Ala for use in a vancomycin biosensor
Bioorganic & Medicinal Chemistry Letters (2007) 17:5758–5762
Original paper - Journal impact factor: 2.538 (last knwon)
Abstract
Link to PubMed (US National Library of Medicine): PMID=17855088
Reprint (PDF) (UCL only - Copyright owned by the publisher)
Link to original document through DOI:10.1016/j.bmcl.2007.08.055 (may require a subscription)
Lemaire S, Van Bambeke F, Mingeot-Leclercq MP, Glupczynski Y, Tulkens PM
Role of Acidic pH in the Susceptibility of Intraphagocytic Methicillin-Resistant Staphylococcus aureus Strains to
Meropenem and Cloxacillin
Antimicrobial Agents and Chemotherapy (2007) 51:1627-1632.
Original paper - Journal impact factor: 4.153 (in 2006)
Abstract
Link to PubMed (US National Library of Medicine): PMID=17307986
Reprint (PDF) (Free access - Copyright owned by the publisher)
Link to original document through DOI:10.1128/AAC.01192-06 (may require a subscription)
Lemaire S, Van Bambeke F, Mingeot-Leclercq M-P, Tulkens PM.
Modulation of the Cellular Accumulation and Intracellular Activity of Daptomycin towards phagocytized Staphylococcus aureus by the P-glycoprotein (MDR1) Efflux Transporter in human THP-1 macrophages and Madin-Darby canine kidney cells.
Antimicrobial Agents and Chemotherapy (2007) 51:2748-2757
Original paper - Journal impact factor: 4.153 (in 2006)
Abstract
Link to PubMed (US National Library of Medicine): PMID=17548493
Reprint (PDF) (Free access - Copyright owned by the publisher)
Link to original document through DOI:10.1128/AAC.00090-07 (may require a subscription)
Mallet L, Spinewine A, Huang A
The challenge of managing drug interactions in elderly people
Lancet. (2007) 370:185-91.
Review - Journal impact factor: 25.800 (last known)
Abstract
Link to PubMed (US National Library of Medicine): PMID=17630042
Reprint (PDF) (UCL only - Copyright owned by the publisher)
Link to original document through DOI:10.1016/S0140-6736(07)61092-7 (may require a subscription)
Mathot F, Schanck A, Van Bambeke F, Ariën A, Noppe M, Brewster M, Préat V.
Passive diffusion of polymeric surfactants across lipid bilayers.
Journal of Controlled Release (2007) 120:79-87
Original paper - Journal impact factor: 4.012
Abstract
Link to PubMed (US National Library of Medicine): PMID=17524515
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Link to original document through DOI:10.1016/j.jconrel.2007.03.015 (may require a subscription)
Mesaros N, Glupczynski Y, Avrain L, Caceres NE, Tulkens PM, Van Bambeke F.
A combined phenotypic and genotypic method for the detection of Mex efflux pumps in Pseudomonas aeruginosa.
Journal of Antimicrobial Chemotherapy (2007) 59:378-386.
Original paper - Journal impact factor: 3.886 (last known)
Abstract
Link to PubMed (US National Library of Medicine): PMID=17289770
Reprint (PDF) (UCL only - Copyright owned by the publisher)
Link to original document through DOI: 10.1093/jac/dkl504 (may require a subscription)
Mesaros N, Nordmann P, Plésiat P, Roussel-Delvallez M, Van Eldere J, Glupczynski Y, Van Laethem Y, Jacobs F, Lebecque P, Malfroot A, Tulkens PM, Van Bambeke F.
Pseudomonas aeruginosa : resistance and therapeutic options at the turn of the new millennium.
Clinical Microbiology and Infection (2007) 13: 560–578
Review - Journal impact factor: 2.679 (last known)
Abstract
Link to PubMed (US National Library of Medicine): PMID=17266725
Reprint (PDF) (UCL only - Copyright owned by the publisher - free access through )
Link to original document through DOI: 10.1111/j.1469-0691.2007.01681.x (may require a subscription)

versions françaises: Pseudomonas aeruginosa : résistance et options thérapeutiques à l'aube du nouveau millénaire.
- Antibiotiques [Paris] (2007) 9:189-198 -- Tiré-à-part (PDF)
- Louvain-Médical (Bruxelles) -- Tiré-à-part (PDF)
Spinewine A, Swine C, Dhillon S, Lambert P, Nachega J, Wilmotte L, Tulkens PM.
Impact of a collaborative approach on the quality of prescribing for geriatric inpatients. A randomized controlled trial.
Journal of the American Geriatrics Society (2007) 55:658–665
Original paper - Journal impact factor: 3.479 (last known)
Abstract
Link to PubMed (US National Library of Medicine): PMID=17493184
Reprint (PDF) (UCL only - Copyright owned by the publisher)
Link to original document through DOI: 10.1111/j.1532-5415.2007.01132.x (may require a subscription)
Spinewine A, Schmader KE, Barber N, Hughes C, Lapane KL, Swine C, Hanlon JT
Appropriate prescribing in elderly people: how well can it be measured and optimised?
Lancet. (2007) 370:173-84.
Review - Journal impcat factor: 25.800 (last known)
Abstract
Link to PubMed (US National Library of Medicine): PMID=17630041
Reprint (PDF) (UCL only - Copyright owned by the publisher)
Link to original document through DOI:10.1016/S0140-6736(07)61091-5 (may require a subscription)
Van Bambeke F, Reinert RR, AppelbaumPC, Tulkens PM, Peetermans WE
Multidrug-Resistant Streptococcus pneumoniae infections: current and future therapeutic options.
Drugs (2007) 67:2355-2382 Review - Journal impact factor: 4.472 (last known)
Abstract
Link to PubMed (US National Library of Medicine): PMID=17983256
Reprint (PDF) (UCL only - Copyright owned by the publisher)
Supplementary material: PDF

2006

Ampe E, Spinewine A, Tulkens PM.
Klinische Farmacie, een positieve ontwikkeling op de weg naar een betere patiëntenzorg in de Belgische ziekenhuizen.
Tijdschrift voor Geneeskunde (2006) 62:1273-1284
Educational paper
Abstract
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Ampe E, Spinewine A, Wilmotte L, Hecq JD, et Tulkens PM
La Pharmacie clinique: un développement récent de l'activité des pharmaciens pour une prise en charge optimisée des patients du point de vue médicamenteux.
Louvain Médical (2006) 125:275-290
Educational paper
Abstract
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Barcia-Macay M, Seral C, Mingeot-Leclercq MP, Tulkens PM, Van Bambeke F.
Pharmacodynamic evaluation of the intracellular activity of antibiotics against Staphylococcus aureus in a model of THP-1 macrophages.
Antimicrobial Agents and Chemotherapy (2006) 50:841-851
Original paper - Journal impact factor: 4.246 (last known)
Abstract
Link to PubMed (US National Library of Medicine): PMID=16495241
Reprint (PDF file) (Free access - Copyright owned by the publisher)
Link to original document through DOI: 10.1128/AAC.50.3.841-851.2006 (may require a subscription)
Barcia-Macay M, Lemaire S, Mingeot-Leclercq MP, Tulkens PM, Van Bambeke F.
Evaluation of the Extracellular and Intracellular Activities (human THP-1 macrophages) of Telavancin vs. Vancomycin against Methicillin-susceptible, Methicillin-resistant, Vancomycin-intermediate and Vancomycin-resistant Staphylococcus aureus
Journal of Antimicrobial Chemotherapy (2006) 58:1177–1184
Original paper - Journal impact factor: 3.886 (last known)
Abstract
Link to PubMed (US National Library of Medicine): PMID=17062609
Reprint (PDF file) (Open Access - available for non-commercial use)
Link to original document through DOI: 10.1093/jac/dkl424 (Open Access - available for non-commercial use)
Charvalos E, Tzatzarakis MN, Van Bambeke F, Tulkens PM, Tsatsakis AM, Tzanakakis GN, Mingeot-Leclercq MP.
Water-soluble amphotericin B-polyvinylpyrrolidone complexes with maintained antifungal activity against Candida spp. and Aspergillus spp. and reduced haemolytic and cytotoxic effects.
Journal of Antimicrobial Chemotherapy (2006) 57:236-244
Original paper - Journal impact factor: 3.611 (last known)
Abstract
Link to PubMed (US National Library of Medicine): PMID=16361329
Reprint (PDF file) (UCL only - Copyright owned by the publisher)
Link to original document through DOI: 10.1093/jac/dki455 (may require a subscription)
Fa N, Ronkart S, Schanck A, Deleu M, Gaigneaux A, Goormaghtigh E, Mingeot-Leclercq MP.
Effect of the antibiotic azithromycin on thermotropic behavior of DOPC or DPPC bilayers.
Chem Phys Lipids (2006) 144:108-16.
Original paper - Journal impact factor: 2.351 (last known)
Abstract
Link to PubMed (US National Library of Medicine): PMID=17007828
Reprint (PDF file) (UCL only - Copyright owned by the publisher)
Link to original document through DOI: 10.1016/j.chemphyslip.2006.08.002 (may require a subscription)
Michot JM, Heremans MF, Caceres NE, Mingeot-Leclercq MP, Tulkens PM, Van Bambeke F
Cellular accumulation and activity of quinolones in ciprofloxacin-resistant J774 macrophages.
Antimicrobial Agents and Chemotherapy (2006) 50:1689-1695
Original paper - Journal impact factor: 4.246 (last known)
Asbtract
Link to PubMed (US National Library of Medicine): PMID=16641436
Reprint (PDF file) (UCL only - Copyright owned by the publisher)
Link to original document through DOI: 10.1128/AAC.50.5.1689-1695.2006 (may require a subscription)
Servais H, Jossin Y, Van Bambeke F, Tulkens PM, Mingeot-Leclercq MP
Gentamicin causes apoptosis at low concentrations in renal LLC-PK1 cells subjected to electroporation
Antimicrobial Agents and Chemotherapy (2006) 50:1213-1221
Original paper - Journal impact factor: 4.246 (last known)
Asbtract
Link to PubMed (US National Library of Medicine): PMID=1656983
Reprint (PDF file) (UCL only - Copyright owned by the publisher)
Link to original document through DOI: 10.1128/AAC.50.4.1213-1221.2006 (may require a subscription)
Spinewine A, Dhillon S, Mallet L, Tulkens PM, Wilmotte L, Swine C.
Implementation of ward-based clinical pharmacy services in Belgium - Description of the impact on a geriatric unit.
Annals of Pharmacotherapy (2006) 40:720-728
Original paper - Journal impact factor (last known): 1.739
Asbtract
Link to PubMed (US National Library of Medicine): PMID=16569792
Reprint (PDF file) (UCL only - Copyright owned by the publisher)
Link to original document through DOI:10.1345/aph.1G515 (may require a subscription)
Van Bambeke F.
Glycopeptides and glycodepsipeptides in clinical developement: a comparative of their antibacterial spectrum, pharmacokinetics and clinical efficacy.
Current Opinion in Investigational Drugs (2006) 7:740-749
Review - Journal impact factor: new Journal (no impact factor known in 2006)
Abstract
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Van Bambeke F, Barcia-Macay M, Lemaire S, Tulkens PM
Cellular pharmacokinetics and pharmacodynamics of antibiotics: current views and perspectives
Current Opinion in Drug Discovery & Development (2006) 9:218-230
Review - Journal impact factor: 3.698 (last known)
Abstract
Link to PubMed (US National Library of Medicine): PMID=16566292
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Van Bambeke F, Pagès J-M, Lee VJ
Inhibitors of bacterial efflux pumps as adjuvants in antibiotic treatments and diagnostic tools for detection of resistance by efflux.
Recent Patents on Anti-Infective Drug Discovery (2006) 1:157-175.
Review paper - New Journal (no impact factor known in 2006)
Abstract
Indexed in Chemical Abstracts
Reprint (PDF file) (UCL only - Copyright owned by the publisher)
Vandevuer S, Van Bambeke F, Tulkens PM, Prévost M
Predicting the three-dimensional structure of human P-glycoprotein in absence of ATP by computational techniques embodying cross-linking data: insight into the mechanism of ligand migration and binding sites.
Proteins (Proteins-structure function and bioinformatics) (2006) 63:466-478
Original paper - Journal impact factor: 4.429 (last known)
Abstract
Link to PubMed (US National Library of Medicine): PMID=16463278
Reprint (PDF file) (UCL only - Copyright owned by the publisher)
Link to original document through DOI: 10.1002/prot.20892 (may require a subscription)
Supporting information: Protein DataBank file 617 Kb (pdb file; can be opened with Viewer Lite of Accelrys/SciFinder)

2005

Berquand A, Fa N, Dufrêne YF, Mingeot-Leclercq M-P
Interaction of the macrolide antibiotic azithromycin with lipid bilayers: effect on membrane organization, fluidity, and permeability.
Pharmaceutical Research (2005) 22:465-475
Original paper - Journal impact factor: 2.940 (in 2004)
Abstract
Link to PubMed (US National Library of Medicine): PMID=15835753
Reprint (PDF file) (UCL only - Copyright owned by the publisher)
Link to original document through DOI: 10.1007/s11095-004-1885-8 (may require a subscription)
Block S, Gerkens P, Peulen O, Jolois O, Mingeot-Leclercq M-P, De Paux-Gillet M-CL, Quetin-Leclercq J
Induction of apoptosis in human promyelocytic leukemia cells by a natural trachylobane diterpene.
Anticancer Research (2005) 25:363-368
Original paper - Journal impact factor: 1.395 (in 2004)
Abstract
Link to PubMed (US National Library of Medicine): PMID=15816559
Reprint (PDF file) (UCL only - Copyright owned by the publisher)
Chanteux H, Van Bambeke F, Mingeot-Leclercq M-P, Tulkens PM
Accumulation and oriented transport of ampicillin in Caco-2 cells from its pivaloyloxymethyl ester prodrug (PIVA).
Antimicrobial Agents and Chemotherapy (2005)49:1279-88.
Original paper - Journal impact factor: 4.246 (last known)
Abstract
Link to PubMed (US National Library of Medicine): PMID=15589222
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Link to original document through DOI: 10.1128/AAC.49.4.1279-1288.2005 (may require a subscription)
Lemaire S, Van Bambeke F, Mingeot-Leclercq MP, Tulkens PM
Activity of 3 beta-lactams (ertapenem, meropenem, and ampicillin) against intraphagocytic L. monocytogenes and S. aureus
Journal of Antimicrobial Chemotherapy (2005) 55:897–904
Original paper - Journal impact factor: 3.611 (last known)
Abstract
Link to PubMed (US National Library of Medicine): PMID=15860552
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Link to original document through DOI: 10.1093/jac/dki094 (may require a subscription)
Mesaros N, Van Bambeke F, Avrain L, Glupczynski G, Vanhoof R, Tulkens PM
Actieve efflux van antibiotica en bacteriële resistentie: actualisatie en implicaties
Tijdschrift voor Geneeskunde (2005) 61:1407-1417
Educational paper
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Mesaros N, Van Bambeke F, Avrain L, Glupczynski Y, Vanhoof R, Plesiat P, Tulkens PM
L'efflux actif des antibiotiques et la résistance bactérienne: état de la question et implications
La Lettre de l'Infectiologue (2005) 20:117-126
Educational paper
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Mesaros N, Van Bambeke F, Glupczynski Y, Vanhoof R, Tulkens PM
L'efflux actif des antibiotiques et la résistance bactérienne: état de la question et implications microbiologiques et cliniques
Louvain Médical (2005) 124:308-320
Educational paper
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Michot JM, Seral C, Van Bambeke F, Mingeot-Leclercq MP, Tulkens PM.
Influence of efflux transporters on the accumulation and efflux of four quinolones (ciprofloxacin, levofloxacin, garenoxacin, and moxifloxacin) in J774 macrophages.
Antimicrobial Agents and Chemotherapy (2005) 49:2429-2437
Original paper - Journal impact factor: 4.246 (last known)
Abstract
Link to PubMed (US National Library of Medicine): PMID=15917543
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Link to original document through DOI:10.1128/AAC.49.6.2429-2437.2005 (may require a subscription)
Mulazimoglu L, Tulkens PM, Van Bambeke F
Macrolides
In: Antimicrobial Therapy and Vaccines. Vol. II: Antimicrobial Agents, 2005. V.L. Yu, G. Edwards, P.S. McKinnon, C. Peloquin, & G.D. Morse, editors. Esun Technologies, Pittsburgh, PA. pp. 243-283.
Chapter of book.
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Piret J, Schank A, Delfosse S, Van Bambeke F, Kishore BK, Tulkens PM, Mingeot-Leclercq M-P
Modulation of the in vitro activity of lysosomal phospholipase A1 by membrane lipids.
Chemistry and Physics of Lipids (2005) 133:1-15
Original paper - Journal impact factor: 2.164 (last known)
Abstract
Link to PubMed (US National Library of Medicine): PMID=15589222
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Link to original document through DOI: 10.1016/j.chemphyslip.2004.08.002 (may require a subscription)
Seral C, Barcia-Macay M, Mingeot-Leclercq MP, Tulkens PM, Van Bambeke F
Comparative activity of quinolones (ciprofloxacin, levofloxacin, moxifloxacin, and garenoxacin) against extracellular and intracellular infection by Listeria monocytogenes and Staphylococcus aureus in J774 macrophages.
Journal of Antimicrobial Chemotherapy (2005) 55:511-517
Original paper - Journal impact factor: 3.080 (last known)
Abstract
Link to PubMed (US National Library of Medicine): PMID=15731197
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Link to original document through DOI: doi:10.1093/jac/dki059 (may require a subscription)
Servais H, Mingeot-Leclercq MP, and Tulkens PM
Antibiotic-induced nephrotoxicity
In: Toxicology of the Kidney (Target Organ Toxicology Series), 2004, chap. 16, pp 635-685, J.B. Tarloff & L.H. Lash, eds., CRC Press, Boca Raton, Fla., ISBN 0-415-24864-7
chapter of book
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Servais H, Van Der Smissen P, Thirion G, Van der Essen G, Van Bambeke F, Tulkens PM, Mingeot-Leclercq MP
Gentamicin-induced apoptosis in LLC-PK1 cells: involvement of lysosomes and mitochondria
Toxicology and Applied Pharmacolology (2005) 15:321-333
Original paper - Journal impact factor: 2.993 (last known)
Abstract
Link to PubMed (US National Library of Medicine): PMID=15731197
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Link to original document through DOI: 10.1016/j.taap.2004.11.024 (may require a subscription)
Spinewine A, Swine C, Dhillon S, Franklin DB, Tulkens PM, Wilmotte L, Lorant V
Appropriateness of use of medicines in elderly inpatients: qualitative study
British Medical Journal (2005) 331:935-940
Original paper - Journal impact factor: 7.038 (last known)
Abstract
Link to PubMed (US National Library of Medicine): PMID=16093254
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Link to original document through DOI: 10.1136/bmj.38551.410012.06 (may require a subscription)
Van Bambeke F, Michot JM, Van Eldere J, Tulkens PM
Quinolones in 2005: an update
Clinical Microbiology and Infection (2005) 11:256-280 - Erratum published: 11:513, 2005
Review paper - Journal impact factor: 2.238 (last known)
Abstract
Link to PubMed (US National Library of Medicine): PMID=15760423
Reprint (PDF file) - Erratum (PDF-File) (UCL only - Copyright owned by the publisher - free access through
Link to original document through DOI: doi:10.1111/j.1469-0691.2005.01131.x -- Erratum: doi: 10.1111/j.1469-0691.2005.01192.x
(may require a subscription)
Van Bambeke F, Saffran J, Mingeot-Leclercq MP, Tulkens PM
Mixed lipid storage disorder induced in macrophages and fibroblasts by oritavancin (LY333328), a new glycopeptide antibiotic with exceptional cellular accumulation.
Antimicrobial Agents and Chemotherapy (2005) 49:1695-1700.
Original paper - Journal impact factor: 4.246 (last known)
Abstract
Link to PubMed (US National Library of Medicine): PMID=15855483
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Link to original document through DOI: doi:10.1128/AAC.49.5.1695-1700.2005 (may require a subscription)

2004

Bauraind I, Lopez-Lozano J-M, Beyaert A, Marchal J-L, Yane F, Goossens H, Tulkens PM, Verbist L
Association between antibiotic sales and public campaigns for their appropriate use.
JAMA-Journal of the American Medical Association (2004) 24:2468-2470
Original paper - Journal impact factor: 21.455 (last known)
Abstract
Link to PubMed (US National Library of Medicine): PMID=15562124
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Ben Abdelaziz HB, Lemaire S, Carryn S, Van Bambeke F, Mingeot-Leclercq M-P, Tulkens PM
Inhibition of TNF-alpha production in THP-1 macrophages by glatiramer acetate does not alter their susceptibility to infection by Listeria monocytogenes and does not impair the efficacy of ampicillin or moxifloxacin against intracellular bacteria.
Journal of Antimicrobial Chemotherapy (2004) 54:288-289
Original paper - Journal impact factor: 3.080 (last known)
Abstract
Link to PubMed (US National Library of Medicine): PMID=15190038
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Link to original document through DOI: 10.1093/jac/dkh288 (may require a subscription)
Berquand A, Mingeot-Leclercq M-P, Dufrêne YF
Real-time imaging of drug-membrane interactions by atomic force microscopy.
Biochimica et Biophysica Acta (Biomembranes) (2004) 1664:198-205
Original paper - Journal impact factor: 3.243 (in 2003) - Contributing unit(s): FACM (see key)
Abstract
Link to PubMed (US National Library of Medicine): PMID=15328052
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Link to original document through DOI: 10.1016/j.bbamem.2004.05.010 (may require a subscription)
Carryn S, Van de Velde S, Van Bambeke F, Mingeot-Leclercq M-P, Tulkens PM
Impairment of growth of listeria monocytogenes in THP-1 macrophages by granulocyte macrophage colony-stimulating factor : release of tumor necrosis factor-a and nitric oxide.
The Journal of Infectious Diseases (2004) 189:2101-2109
Original paper - Journal impact factor: 4.857 (last known)
Abstract
Link to PubMed (US National Library of Medicine): PMID=15143479
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De Clercq E, Tulkens P
Anti-infectives.
Current Opinion in Pharmacology (2004) 4:429-430
Review paper - - Journal impact factor: 4.593 (last known)
Link to PubMed (US National Library of Medicine): PMID=15351345
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Link to original document through DOI: 10.1016/j.coph.2004.08.002 (may require a subscription)
Michot J-M, Van Bambeke F, Mingeot-Leclercq M-P, Tulkens PM
Active efflux of ciprofloxacin from J774 macrophages through an MRP-like transporter.
Antimicrobial Agents and Chemotherapy (2004) 48:2673-2682
Original paper - Journal impact factor: 4.246 (last known)
Abstract
Link to PubMed (US National Library of Medicine): PMID=15215125
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Link to original document through DOI: 10.1128/AAC.48.7.2673-2682.2004 (may require a subscription)
Nassogne M-C, Lizarraga C, N'Kuli F, Van Bambeke F, Van Binst R, Wallemacq P, Tulkens PM, Mingeot-Leclercq M-P, Courtoy PJ
Cocaine induces a mixed lysosomal lipidosis in cultured fibroblasts, by inactivation of acid sphingomyelinase and inhibition of phospholipase A1.
Toxicology and Applied Pharmacology (2004) 194:101-110
Original paper - Journal impact factor: 2.993 (last known)
Abstract
Link to PubMed (US National Library of Medicine): PMID=14736491
Link to original document through DOI: 10.1016/j.taap.2003.09.026 (may require a subscription)
Spinewine A, Schoevaerdts D, Choteau B, Doyen C, Swine C
Le traitement de la douleur chez la personne agée.
Association des Soins Palliatifs en Province de Namur (2004) 11:17-24
Original paper
Van Bambeke F
Glycopeptides in clinical development: pharmacological profile and clinical perspectives.
Current Opinion in Pharmacology (2004) 4:471-478
Review paper - - Journal impact factor: 4.593 (last known)
Abstract
Link to PubMed (US National Library of Medicine): PMID=15351351
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Link to original document through DOI: 10.1016/j.coph.2004.04.006 (may require a subscription)
Van Bambeke F, Carryn S, Seral C, Chanteux H, Tyteca D, Mingeot-Leclercq M-P, Tulkens PM
Cellular pharmacokinetics and pharmacodynamics of the glycopeptide antibiotic oritavancin (LY333328) in a model of J774 mouse macrophages.
Antimicrobial Agents and Chemotherapy (2004) 48:2853-2860
Original paper - Journal impact factor: 4.246 (last known)
Abstract
Link to PubMed (US National Library of Medicine): PMID=15273091
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Link to original document through DOI: 10.1128/AAC.48.8.2853-2860.2004 (may require a subscription)
Van Bambeke F, Van Laethem Y, Courvalin P, Tulkens PM
Glycopeptide antibiotics: from conventional molecules to new derivatives.
Drugs (2004) 64:913-936
Review paper - Journal impact factor: 5.368 (last known)
Abstract
Link to PubMed (US National Library of Medicine): PMID=15101783
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2003

Baririan N, Chanteux H, Viaene E, Servais H, Tulkens PM
Stability and compatibility of cefepime in comparison with ceftazidime for administration by continuous infusion for ambulatory treatment of cystic fibrosis patients and for administration in intensive care units (abridged title).
Journal of Antimicrobial Chemotherapy (2003) 51:651-658
Original paper - Journal impact factor: 3.329 (in 2002)
Abstract
Link to PubMed (US National Library of Medicine): PMID=12615867
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Link to original document through DOI: 10.1093/jac/dkg134 (may require a subscription)
Carryn S, Chanteux H, Seral C, Mingeot-Leclercq M-P, Van Bambeke F, Tulkens PM
Intracellular pharmacodynamics of antibiotics.
Infectious Disease Clinics of North America (2003) 17:615-634
Review paper - Journal impact factor: 1.781 (in 2002)
Abstract
Link to PubMed (US National Library of Medicine): PMID=14711080
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Link to original document through DOI: 10.1016/SO891-5520(03)00066-7 (may require a subscription)
Carryn S, Van Bambeke F, Mingeot-Leclercq MP, Tulkens PM
Activity of beta-lactams (ampicillin, meropenem), gentamicin, azithromycin and moxifloxacin against intracellular Listeria monocytogenes in a 24h THP-1 human macrophage model.
Journal of Antimicrobial Chemotherapy (2003) 51:1051-1052
Letter to the Editor or short commentary - Journal impact factor: 3.329 (in 2002)
Abstract
Link to PubMed (US National Library of Medicine): PMID=12654747
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Link to original document through DOI: 10.1093/jac/dkg189 (may require a subscription)
Chanteux H, Mingeot-Leclercq M-P, Sonveaux E, Van Bambeke F, Tulkens PM
Intracellular accumulation and activity of ampicillin used as free drug and as its phthalimidomethyl or pivaloyloxymethyl ester (pivampicillin) against Listeria monocytogenes in J774 macrophages.
Journal of Antimicrobial Chemotherapy (2003) 52:610-615
Original paper - Journal impact factor: 3.329 (in 2002)
Abstract
Link to PubMed (US National Library of Medicine): PMID=12972457
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Link to original document through DOI: 10.1093/jac/dkg431 (may require a subscription)
Chanteux H, Paternotte I, Mingeot-Leclercq M-P, Brasseur R, Sonveaux E, Tulkens PM
Cell handling, membrane-binding properties, and membrane-penetration modeling approaches of pivampicillin and phthalimidomethylampicillin, two basics esters of ampicillin, in comparison with chloroquine and azithromycin.
Pharmaceutical Research (2003) 20:624-631
Original paper - Journal impact factor: 2.354 (in 2002)
Abstract
Link to PubMed (US National Library of Medicine): PMID=12739771
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Dom G, Shaw-Jackson C, Matis C, Bouffioux O, Picard JJ, Prochiantz A, Mingeot-Leclercq MP, Brasseur R, Rezsohazy R
Cellular uptake of antennapedia penetratin peptides is a two-step process in which phase transfer precedes a tryptophan-dependent translocation.
Nucleic Acids Research (2003) 31:556-561
Original paper - Journal impact factor: 7.051 (in 2002)
Abstract
Link to PubMed (US National Library of Medicine): PMID=12527762
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Link to original document through DOI: 10.1093/nar/gkg160 (may require a subscription)
Mingeot-Leclercq MP, Lins L, Bensliman M, Thomas A, Van Bambeke F, Peuvot J, Schank A, Brasseur R
Piracetam inhibits the lipid-destabilising effect of the amyloid peptide A beta C-terminal fragment.
Biochimica et Biophysica Acta (Biomembranes) (2003) 1609:28-38
Original paper - Journal impact factor: 3.011 (in 2002)
Abstract
Link to PubMed (US National Library of Medicine): PMID=12507755
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Link to original document through DOI: 10.1016/s0005-2736(02)00654-5 (may require a subscription)
Seral C, Carryn S, Tulkens PM, Van Bambeke F
Influence of P-glycoprotein and MRP efflux pump inhibitors on the intracellular activity of azithromycin and ciprofloxacin in macrophages infected by Listeria monocytogenes or Staphylococcus aureus.
Journal of Antimicrobial Chemotherapy (2003) 51:1167-1173
Original paper - Journal impact factor: 3.329 (in 2002)
Abstract
Link to PubMed (US National Library of Medicine): PMID=12697643
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Link to original document through DOI: 10.1093/jac/dkg223 (may require a subscription)
Seral C, Michot JM, Chanteux H, Mingeot-Leclercq MP, Tulkens PM, Van Bambeke F
Influence of P-glycoprotein inhibitors on accumulation of macrolides in J774 murine macrophages.
Antimicrobial Agents and Chemotherapy (2003) 47:1047-1051
Original paper - Journal impact factor: 4.215 (in 2002)
Abstract
Link to PubMed (US National Library of Medicine): PMID=12604540
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Link to original document through DOI: 10.1128/AAC.47.3.1047-1051.2003 (may require a subscription)
Seral C, Van Bambeke F, Tulkens PM
Quantitative analysis of gentamicin, azithromycin, telithromycin, ciprofloxacin, moxifloxacin and oritavancin (LY333328) activities against intracellular Staphylococcus aureus in mouse J774 macrophages.
Antimicrobial Agents and Chemotherapy (2003) 47:2283-2292
Original paper - Journal impact factor: 4.215 (in 2002)
Abstract
Link to PubMed (US National Library of Medicine): PMID=12821480
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Link to original document through DOI: 10.1128/aac.47.7.2283-2292.2003 (may require a subscription)
Spinewine A
La pharmacie clinique, une nouvelle orientation pharmaceutique au service des patients: réalisations à l'étranger et possibilités en Belgique.
Louvain Médical (2003) 122:127-139
Educational paper
Abstract
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Spinewine A, Mallet L
Pharmaceutical care in the aged: illustration of the process in patients hospitalized in Canada.
Journal de Pharmacie de Belgique (2003) 58:21-27
Original paper
Abstract
Link to PubMed (US National Library of Medicine): PMID=12722541
Spinewine A, Mallet L
Effet de la simvastatine sur la mortalité et la morbidité chez 20 536 patients à risque élevé de mortalité cardio-vasculaire.
Pharmactuel (2003) 36:10-13
Educational paper
Abstract
Tyteca D, Schank A, Dufrene YF, Deleu M, Courtoy PJ, Tulkens PM, Mingeot-Leclercq M-P
The macrolide antibiotic azithromycin ineracts with lipids and affects membrane organization and fluidity: studies on Langmuir-Blodgett monolayers, liposomes and J774 macrophages.
Journal of Membrane Biology (2003) 192:203-215
Original paper - Journal impact factor: 2.440 (in 2002)
Abstract
Link to PubMed (US National Library of Medicine): PMID=12820665
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Van Bambeke F, Glupczynski Y, Plésiat P, Pechère JC, Tulkens PM
Antibiotic efflux pumps in prokaryotic cells : occurence, impact on resistance and strategies for the future of antimicrobial therapy.
Journal of Antimicrobial Chemotherapy (2003) 51:1055-1065
Review paper - Journal impact factor: 3.329 (in 2002)
Abstract
Link to PubMed (US National Library of Medicine): PMID=12697642
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Link to original document through DOI: 10.1093/jac/dkg224 (may require a subscription)
Van Bambeke F, Lambert DM, Mingeot-Leclercq M-P, Tulkens PM
Mechanims of action.
In: Infectious Diseases 2, Cohen Jonathan ed., Mosby, 1717-1732 (2003) ISBN 978-0323024075
Chapter of book/Proceeding
Van Bambeke F, Michot JM, Tulkens PM
Antibiotic efflux pumps in eukaryotic cells: occurence and impact on antibiotic cellular pharmacokinetics, pharmacodynamics and toxicodynamics.
Journal of Antimicrobial Chemotherapy (2003) 51:1067-1077
Review paper - Journal impact factor: 3.329 (in 2002)
Abstract
Link to PubMed (US National Library of Medicine): PMID=12697641
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Link to original document through DOI: 10.1093/jac/dkg225 (may require a subscription)

2002

Carryn S, Van Bambeke F, Mingeot-Leclercq MP, Tulkens PM
Comparative intracellular (THP-1 Macrophage) and extracellular activities of beta-lactams, azithromycin, gentamicin, and fluoroquinolones against Listeria monocytogenes at clinically relevant concentrations.
Antimicrobial Agents and Chemotherapy (2002) 46:2095-2103
Original paper - Journal impact factor: 4.562 (in 2001)
Abstract
Link to PubMed (US National Library of Medicine): PMID=12069960
Reprint (PDF file) (UCL only - Copyright owned by the publisher)
Link to original document through DOI: 10.1128/AAC.46.7.2095-2103.2002 (may require a subscription)
Mingeot-Leclercq MP, Lins L, Bensliman M, Van Bambeke F, Van Der Smissen P, Peuvot J, Schank A, Brasseur R
Membrane destabilisation induced by beta-amyloid peptide 29-42: importance of the amino-terminus.
Chemistry and Physics of Lipids (2002) 120:57-74
Original paper - Journal impact factor: 2.164 (in 2001)
Abstract
Link to PubMed (US National Library of Medicine): PMID=12426076
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Spinewine A, Dean B
Measuring the impact of medicines information services on patient care: methodological considerations.
Pharmacy World & Science (2002) 24:177-181
Review paper - Journal impact factor: 0.633 (in 2001)
Abstract
Link to PubMed (US National Library of Medicine): PMID=12426961
Spinewine A, Dhillon S
Clinical pharmacy practice: implications for pharmacy education in Belgium.
Pharmacy Education (2002) 2:75-81
Original paper - Journal impact factor: new journal no impact factor known in 2002.
Abstract
Tyteca D, Van Der Smissen P, Mettlen M, Van Bambeke F, Tulkens PM, Mingeot-Leclercq MP, Courtoy PJ
Azithromycin, a lysosomotropic antibiotic, has distinct effects on fluid-phase and receptor-mediated endocytosis, but does not impair phagocytosis in J774 macrophages.
Experimental Cell Research (2002) 281:86-100
Original paper - Journal impact factor: 5.096 (in 2001)
Abstract
Link to PubMed (US National Library of Medicine): PMID=12441132
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Van Bambeke F, Tulkens P
Médicaments anti-infectieux dans les pathologies infectieuses du SNC.
In: Neuro-infectiologie, C. Sindic ed., Doin Editions, 355-388 (2002)
Chapter of book
Reprint (PDF file) (UCL only - Copyright owned by the publisher)
Viaene E, Chanteux H, Servais H, Mingeot-Leclercq MP, Tulkens PM
Comparative stability studies of antipseudomonal beta-lactams for potential administration through portable elastomeric pumps (home therapy for cystic fibrosis patients) and motor-operated syringes (intensive care units).
Antimicrobial Agents and Chemotherapy (2002) 46:2327-2332
Original paper - Journal impact factor: 4.562 (in 2001)
Abstract
Link to PubMed (US National Library of Medicine): PMID=12121900
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2001

Gholizadeh Y, Prévost M, Van Bambeke F, Casadewall B, Tulkens PM, Courvalin P
Sequencing the ddl gene and modeling of the mutated D-alanine:D-alanine ligase in glycopeptide-dependent strains of Enterococcus faecium.
Protein Science (2001) 10:836-844
Original paper - Journal impact factor: 3.869 (in 2000)
Abstract
Link to PubMed (US National Library of Medicine): PMID=11274474
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Mingeot-Leclercq MP, Gallet X, Flore C, Van Bambeke F, Peuvot J, Brasseur R
Experimental and conformational analyses of interactions between butenafine and lipids.
Antimicrobial Agents and Chemotherapy (2001) 45:3347-3354
Original paper - Journal impact factor: 3.954 (in 2000)
Abstract
Link to PubMed (US National Library of Medicine): PMID=11709307
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Paternotte I, Fan HJ, Scrève P, Claesen M, Tulkens PM, Sonveaux E
Syntheses and hydrolysis of basic and dibasic ampicillin esters tailored for intracellular accumulation.
Bioorganic & Medicinal Chemistry (2001) 9:493-502
Original paper - Journal impact factor: 1.799 (in 2000)
Abstract
Link to PubMed (US National Library of Medicine): PMID=11249141
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Servais H, Tulkens PM
Stability and compatibility of ceftazidime administered by continuous infusion to intensive care patients.
Antimicrobial Agents and Chemotherapy (2001) 45:2643-2647
Original paper - Journal impact factor: 3.954 (in 2000)
Abstract
Link to PubMed (US National Library of Medicine): PMID=11502544
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Tyteca D, Van der Smissen P, Van Bambeke F, Leys K, Tulkens PM, Courtoy PJ, Mingeot-Leclercq MP
Azithromycin, a lysosomotropic antibiotic, impairs fluid-phase pinocytosis in cultured fibroblasts.
European Journal of Cell Biology (2001) 80:466-478
Original paper - Journal impact factor: 2.801 (in 2000)
Abstract
Link to PubMed (US National Library of Medicine): PMID=11499789
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Van Bambeke F, Tulkens PM
Macrolides: pharmacokinetics and pharmacodynamics.
International Journal of Antimicrobial Agents (2001) 18:S17-S23
Review paper - Journal impact factor: 1.141 (in 2000)
Abstract
Link to PubMed (US National Library of Medicine): PMID=11574190
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Van Bambeke F, Verhaegen J, Tulkens PM
Erythromycine, autres macrolides et kétolides: usages cliniques actuels et perspectives.
La Lettre de l'Infectiologue (2001) 16:318-328
Educational paper
Abstract
Van Bambeke F, Verhaegen J, Tyteca D, Auckenthaler R, Tulkens PM
Erythromycine en de huidige neomacroliden: klinisch gebruik en perspectieven.
Tijdscrift voor Geneeskunde (2001) 57:382-395
Educational paper
Abstract
Van Bambeke F, Verhaegen J, Tyteca D, Auckenthaler R, Tulkens PM
Erythromycine et néomacrolides actuels, usages cliniques et perspectives.
Médecine & Hygiène (2001) 59:2316-2323
Educational paper
Abstract

2000

El Mouedden M, Laurent G, Mingeot-Leclercq M-P, Tulkens PM
Gentamicin-induced apoptosis in renal cell lines and embryonic rat fibroblasts.
Toxicological Sciences (2000) 56:229-239
Original paper - Journal impact factor: 1.778 (in 1999)
Abstract
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El Mouedden M, Laurent G, Mingeot-Leclercq MP, Taper HS, Cumps J, Tulkens PM
Apoptosis in renal proximal tubules of rats treated with low doses of aminoglycosides.
Antimicrobial Agents and Chemotherapy (2000) 44:665-675
Original paper - Journal impact factor: 3.969 (in 1999)
Abstract
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Prévost M, Van Belle D, Tulkens PM, Courvalin P, Van Bambeke F
Modeling of Enterococcus faecalis D-alanine:D-alanine ligase: structure based study of the active site in the wild-type enzyme and in glycopeptide-dependent mutant.
Journal of Molecular Microbiology and Biotechnology (2000) 2:321-330
Original paper - Journal impact factor: 2.438 (in 2002; new journal with no impact factor known in 2000).
Abstract
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Tulkens PM
New strategies to avoid development of microbial resistance.
In: Ochsner Clinic Symposium on Resistance and the Use and Misuse of Antimicrobial Therapy, G.A. Pankey and G.D. Campbell Jr ed., A.M.M. & Co., Inc., Newtown, PA, 44-52 (2000)
Chapter of book/Proceeding
Van Bambeke F, Courvalin P
Coût biologique de la résistance aux antibiotiques: vancomycine-dépendance, le prix ultime bactérien ?.
La Lettre de l'Infectiologue (2000) 15:285-294
Educational paper
Abstract
Van Bambeke F, Balzi E, Tulkens PM
Antibiotic efflux pumps.
Biochemical Pharmacology (2000) 60:457-470
Review paper - Journal impact factor: 2.755 (in 1999)
Abstract
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Van Bambeke F, Kerkhofs A, Schanck A, Remacle C, Sonveaux E, Tulkens PM, Mingeot-Leclercq MP
Biophysical studies and intracellular destabilization of pH-sensitive liposomes.
Lipids (2000) 35:213-223
Original paper - Journal impact factor: 2.040 (in 1999)
Abstract
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Van Bambeke F, Verhaegen J, Tyteca D, Auckenthaler R, Tulkens PM
Erythromycine et némacrolides actuels: usages cliniques et perspectives.
Louvain Médical (2000) 119:259-286
Educational paper
Abstract
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publications since 1963 through 2000

Original papers (full papers in peer reviewed journals)
Reviews, Books, Chapter of books, Proceedings
Doctoral Theses
Master Degree Dissertations
Educational papers (in professional journals)
Abstracts (from oral or poster presentations at scientific meetings)