1. J Antimicrob Chemother. 2010 Sep;65(9):2045-6. Epub 2010 Jun 24.

Long-term stability of temocillin in elastomeric pumps for outpatient antibiotic 
therapy in cystic fibrosis patients.

Carryn S, Couwenbergh N, Tulkens PM.
Unité de pharmacologie cellulaire et moléculaire, Louvain Drug ResearchInstitute, 
Université catholique de Louvain, B-1200 Bruxelles, Belgium.

No abstract available.

Authors' conclusions:

Temocillin remainz stable in elastomeric
devices commonly used for outpatient antibiotic therapy (OPAT) when stored (up to
4 weeks) and handled as for home-based therapy. By application
of a principle of precaution, we would, however, recommend
to users: (i) not to store the pumps for more than 3 weeks at
4°C; (ii) to install a temperature-monitoring device in the
refrigerator where the pumps are stored; and (iii) to strictly
limit the storage to 24 h once out of the refrigerator. OPAT
with temocillin performed under these conditions may be both
helpful and safe for cystic fibrosis patients when Burkolderia cepacia infection is suspected
or proven.

PMID: 20576638 [PubMed - in process]