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51th Interscience Conference on Antimicrobial
Agents and Chemotherapy (ICAAC)
Chicago, IL, 17-20 September 2011
- Inhibitors
of Type Three Secretion System (TTSS) protect against Pseudomonas aeruginosa
cellular toxicity by inhibiting the transcription of TTSS
J. Buyck, G. de Laminne de Bex, P.M. Tulkens, F. Van Bambeke
Poster A2-057 - Session "Pharmacokinetic/Pharmacodynamic (PK/PD)
of New Antibacterial Agents"9/17 - /2011 11:30:00 AM
- Increased
susceptibility of Pseudomonas aeruginosa to macrolides in biologically-relevant
media by modulation of outer membrane permeability and of efflux pump
expression
J. Buyck, P.M. Tulkens, F. Van Bambeke
Poster E-139 - Session "Miscellaneous" - 9/17/2011 11:30:00
AM
- Comparative
assessment of antibacterial and cytotoxic effects of colistin, colistin
methanesulfonate and polymyxin B using Pseudomonas aeruginosa,
macrophages and renal cells, and liposomes
D. Das, J. Buyck, F. Van Bambeke, J. Lorent, M.-P. Mingeot-Leclercq,
P. Gobin,* W. Couet,* P.M. Tulkens
* INSERM - ERI 23, Poitiers, France
Poster Number F2-170 - Session "Innovative Drug Discovery and Drug
Development Technologies" - 9/17/2011 11:30:00 AM
- Novel
polymyxin derivatives are less cytotoxic than polymyxin B in a model
of LLC-PK1 renal cell line
M.-P. Mingeot-Leclercq, P.M. Tulkens, T. Vaara,* M. Vaara*,**
* Northern Antibiotics Ltd, Helsinki, Finland; ** Helsinki
University Hospital, Helsinki, Finland
Poster F1-748 - Session "New Peptides, Lipopeptides and Peptidomimetics"
- 9/18/2011 11:15:00 AM
- Role
of MexAB-OprM in intrinsic resistance of Pseudomonas aeruginosa
to temocillin
J. Buyck1, P. Plésiat,* P.M. Tulkens, F. Van Bambeke
* Laboratoire de Bactériologie, Hôpital
Jean Minjoz, Besançon, France
Poster C1-618 - Session "Mechanisms of Action and Mechanisms of
Resistance in Gram-Negatives" - 9/18/2011 11:15:00 AM
- A
maturing and mature staphylococcal biofilm model for screening of antibiotic
activity
J. Bauer, P.M. Tulkens, F. Van Bambeke
Poster E-134 - Session "Staphylococcus" - 9/19/2011 11:15:00
AM
- Interferon-gamma
potentiates the intracellular activity of rifampin towards intracellular
Staphylococcus aureus in human THP-1 macrophages
S. Lemaire, P. M. Tulkens, F. Van Bambeke
Poster A1-1750 - Session "Penetration of Anti-Infective Agents
and PK/PD Modeling Issues" - 9/20/2011 9:00:00 AM
- Influence
of phorbol myristate acetate on cellular accumulation and intracellular
activity of antibiotics against against hemin- and menadione-dependent
small-colony variants of Staphylococcus aureus in human THP-1
cells
L. Garcia, B. C. Kahl,* K. Becker,* R.A. Proctor,** S. Lemaire, P.M.
Tulkens, F. Van Bambeke
* University Clinics Muenster, Muenster, Germany; **
University of Winconsin Medical School, Madison, WI
Poster A1-1751 - Session "Penetration of Anti-Infective Agents
and PK/PD Modeling Issues" - 9/20/2011 9:00:00 AM
- Effect
of menadione supplementation on the intracellular growth of a menadione-dependent
small-colony variant of S. aureus in a model of THP-1 macrophages:
consequences for antibiotic intracellular activity
L. Garcia, B. C. Kahl,* K. Becker,* R.A. Proctor,** S. Lemaire, P.M.
Tulkens, F. Van Bambeke
* University Clinics Muenster, Muenster, Germany; **
University of Winconsin Medical School, Madison, WI
Poster A1-1752 - Session "Penetration of Anti-Infective Agents
and PK/PD Modeling Issues" - 9/20/2011 9:00:00 AM
- Activity
of antibiotic combinations towards intracellular Pseudomonas aeruginosa
in a model of THP-1 macrophages
J. Buyck, P.M. Tulkens, F. Van Bambeke
Poster A1-1753 - Session "Penetration of Anti-Infective Agents
and PK/PD Modeling Issues" - 9/20/2011 9:00:00 AM
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21th European Congress of Clinical Microbiology and Infectious Diseases
(ECCMID)
& 27th International Congress
of Chemotherapy (ICC)
Milan,
Italy, 7-10 May 2011
See also conferences
(2011) for the plenary lecture given during this meeting
- Comparative
analysis of the potential of polymyxin B and gentamicin to cause apoptosis
and necrosis in cultured renal LLC-PK1 cells: concentration-dependent
studies with incubated and electroporated cells
M-P. Mingeot-Leclercq, P.M. Tulkens
Oral presentation O78 (Session: "Antimicrobial pharmacology: from
bench to bedside" -- Saturday, 7 May 2011)
- Exposure
of Pseudomonas aeruginosa to sub-MIC concentrations of chlorhexidine
leads to increased resistance, marked phenotypic changes, overexpression
of MexG, and cross-resistance to antipseudomonal antibiotics
Q. Tan, T. Nguyen, F. Bilocq, D. De Vos*,**, J. Pirnay**,
P. Cornelis,* F. Van Bambeke, P.M. Tulkens
* Bio-ingenieur Wetenschappen, Vrije Universiteit Brussel
& Vlaamse Instituut voor Biotechnologie, Brussels, Belgium; ** Queen
Astrid Military Hospital, Brussels, Belgium
Oral presentation O291 (Session: Clinical and microbiological
update on antibiotic-resistant P. aeruginosa; Monday, 9 May 2011)
- Comparison
of chromogenic and selective media for the detection of Staphylococcus
aureus and Pseudomonas aeruginosa in respiratory samples
from cystic fibrosis patients
A. Nobre Machado*, C. Nonhoff*, S. Roisin*,
A. Vergison*, F. Van Bambeke, N. Legros*, G. Hay*, P. Buidin* C. Thiroux*,
O. Denis*
* Université libre de Bruxelles, Brussels, Belgium
Oral presentation 0297(Session: Clinical and
microbiological update on antibiotic-resistant P. aeruginosa;
Monday, 9 May 2011)
- Differential
recognition of quinolones by efflux pumps in Gram-positive (Staphylococcus
aureus, Streptococcus pneumoniae) and Gram-negative (Pseudomonas
aeruginosa) bacteria
C. Vallet, J. Buyck, F. El Garch,* P.M. Tulkens, F. Van Bambeke
* Laboratoire de microbiologie, Cliniques universitaire
UCL de Mont-Godinne, Yvoir, Belgium
Poster P725 (Session: "Porins and efflux pumps are
good friends" -- Saturday, 7 May 2011)
- Intracellular
activity of fusidic acid against clinical isolates of Staphylococcus
aureus of increasing MIC
S. Lemaire, D. Piérard,* F. Van Bambeke, P.M. Tulkens
* Universitair Ziekenhuis Brussel & Vrije Universiteit Brussel,
Brussels, Belgium
Poster P780 (Session: "Antimicrobial pharmacodynamics" --
Saturday, 7 May 2011)
- Activity
of 9 antibiotics against intracellular forms of S. pneumoniae
S. Lemaire, P.M. Tulkens, F. Van Bambeke
Poster P781 (Session "Antimicrobial pharmacodynamics" -- Saturday,
7 May 2011)
- Population pharmacokinetics
of temocillin in Intensive Care patients and Monte Carlo simulations
to evaluate resistance breakpoints.
A.E. Muller,* P.F. Laterre,* T. Dugernier,** X. Wittebole,** N. Couwenbergh,
P.M. Tulkens, S. Carryn, J.W.Mouton***
* Cliniques universitaires St-Luc, Brussels, Belgium;
** Clinique St Pierre, Ottignies, Belgium, *** Radboud University Nijmegen
Medical Centre, Nijmegen, The Netherlands.
Poster P807 (Session "Antimicrobial pharmacokinetics"
-- Saturday, 7 May 2011)
- Activity
of finafloxacin, a fluroquinolone with enhanced activity at acid pH,
against intracellular Legionella pneumophila: comparison with
azithromycin, clarithromycin, telithromycin, ciprofloxacin and moxifloxacin
S. Lemaire, P.M. Tulkens, F. Van Bambeke
Poster P1139 (Session: "New antimicrobials in vitro activity"
-- Sunday 8 May 2011
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49th
Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
San
Francisco, CA, September 12-15, 2009
Note:
for the plenary lecture ("Meet the Expert" session) given at
this Conference, visit http://www.facm.ucl.ac.be/facm-conferences.htm
- Susceptibility
of Pseudomonas aeruginosa to biocides among clinical isolates
collected from Intensive Care units patients with nosocomial
pneumonia in 5 Belgian teaching hospitals during the 2004-2008 period.
M. Riou, S. Carbonnelle, D. De Vos,* A. Simon, F. Van Bambeke, P. M.
Tulkens
*Vrije Universiteit Brussel & Queen Astrid Military
Hospital, Brussels, Belgium.
Poster Session 072 (Acinetobacter and Pseudomonas: Two Friends) - Presentation
Number: C2-628 - Session Day / Time: 9/13/2009 11:15:00 AM
- Oritavancin
kills S. aureus by increasing membrane permeability without causing
extensive cell lysis: comparative studies with vancomycin, daptomycin,
and lysostaphin
P. Baudoux, H. A. Nguyen, O. Domenech, M. P. Mingeot-Leclercq, F. Van
Bambeke, P. M. Tulkens
Poster Session 155 (Antibiotic Resistance in Staphylococcus aureus)
- Presentation Number: C1-1354 - Session Day / Time: 9/14/2009 11:15:00
AM
- Contrasting
effect of acidic pH on the bactericidal activities of CEM-102 (fusidic
acid) vs. linezolid and clindamycin towards Staphylococcus aureus
S. Lemaire, F. Van Bambeke, P.M. Tulkens
Poster Session 226 (PK/PD Investigational Antibacterials) - Presentation
Number: A1-1928 - Session Day / Time: 9/15/2009 9:00:00 AM
- Torezolid
(TR-700), a novel methyltetrazolyl-oxazolidinone, accumulates markedly
within human THP-1 macrophages and shows activity towards intraphagocytic
Legionella pneumophila: comparison with linezolid
S. Lemaire, F. Van Bambeke, P.M. Tulkens
Poster Session 226 (PK/PD Investigational Antibacterials) - Presentation
Number: A1-1934 - Session Day / Time: 9/15/2009 9:00:00 AM
- Accumulation
and intracellular activity of radezolid, a new oxazolidinone, in non-phagocytic
cells
S. Lemaire, K. Kosowska-Shick,* P.C. Appelbaum,* J. Pirnay,** G. Verween,**
G. Verbeken,** D. De Vos,** P.M. Tulkens, F. Van Bambeke
* Hersey Medical Center, Hershey, PA; ** Queen Astrid
Military Hospital, Brussels, Belgium.
Poster Session 226 (PK/PD Investigational Antibacterials)
- Presentation Number: A1-1936 - Session Day / Time: 9/15/2009 9:00:00
AM
- Radezolid,
a new oxazolidinone, is active against intraphagocytic Staphylococcus
aureus with various resistance phenotypes in a model of THP-1 human
macrophages
S. Lemaire, K. Kosowska-Shick,* P.C. Appelbaum,* P.M. Tulkens, F. Van
Bambeke
* Hershey Medical Center, Hershey, PA.
Poster Session 226 (PK/PD Investigational Antibacterials)
- Presentation Number: A1-1937 - Session Day / Time: 9/15/2009 9:00:00
AM
- Cellular
accumulation and intracellular activity of finafloxacin (FNX), a novel
fluoroquinolone (FQ) with enhanced activity at acid pH, against S.
aureus and L. pneumophila: comparison with ciprofloxacin
and moxifloxacin
S. Lemaire, F. Van Bambeke, P.M. Tulkens
Poster Session 226 (PK/PD Investigational Antibacterials) - Presentation
Number: A1-1940 - Session Day / Time: 9/15/2009 9:00:00 AM
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19th
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)
Helsinki,
Finland, 16-19 May 2009
Note:
for the plenary lectures given at this Conference, visit http://www.facm.ucl.ac.be/facm-conferences.htm
- Competition
between ciprofloxacin and antiviral agents (adefovir, saquinavir, ritonavir)
for efflux transporters in J774 macrophages
L.
Garcia, B. Marquez, S. Carryn, M.P. Mingeot-Leclercq, P.M. Tulkens,
F. Van Bambeke
oral presentation
(Pharmacokinetics/pharmacodynamics: clinical relevance - 023)
-
Determination of pharmacokinetic/pharmacodynamic index for patients
treated with high-dose vancomycin by continuous infusion
E. Ampe, P.M. Tulkens, B. Delaere,*J.D. Hecq,* Y. Glupczynski*
oral presentation (Pharmacokinetics/pharmacodynamics:
clinical relevance - 026)
* Clinique
universitaire UCL de Mont-Godinne, Yvoir, Belgium
-
The
novel oxazolidinone radezolid (RX-1741) accumulates in THP-1 macrophages:
comparative studies with linezolid and azithromycin
S. Lemaire, P.M. Tulkens, F. van Bambeke
oral presentation (Pharmacokinetics/pharmacodynamics: clinical relevance
- 029)
-
Radezolid
(RX-1741), a novel oxazolidinone, is active against intracellular
S. aureus, L. monocytogenes and L. pneumophila
phagocytosed by human THP-1 macrophages
S. Lemaire, PM. Tulkens, F. Van Bambeke
oral presentation (Pharmacokinetics/pharmacodynamics: clinical relevance
- 030)
- Inducibility
of PatA/PatB efflux pumps by fluoroquinolones in Streptococcus pneumoniae
F. El Garch, A. Lismond, F. Van Bambeke, P.M. Tulkens
oral presentation (Streptococci: mechanisms of resistance and epidemiology
- 0495)
-
Role
of rsbU and staphyloxanthin in intracellular growth of Staphylococcus
aureus in human phagocytic cells (THP-1 macrophages)
A. Olivier, S. Lemaire, F. Van Bambeke, P.M. Tulkens, E. Oldfield*
poster (Pathogenesis of infections caused by Gram-positive
bacteria - P735)
* Department of Chemistry and Center for Biophysics and Computational
Biology, University of Illinois, Urbana, IL
- MIC
distribution and efflux of 4 respiratory fluoroquinolones (gemifloxacin,
garenoxacin, moxifloxacin, levofloxacin) towards S. pneumoniae
isolated from patients with confirmed CAP in a country with large fluoroquinolone
use (Belgium)
A. Lismond, S. Carbonnelle, F. Van Bambeke, P.M. Tulkens
poster (Antimicrobial resistance in Gram-positive bacteria - P1068
-
TR-700,
a novel methyltetrazolyl-oxazolidinone, accumulates extensively within
human macrophages cells and shows activity towards intraphagocytic
linezolid-sensitive and linezolid-resistant S. aureus
S. Lemaire, K. Kosowska-Shick,* P. Appelbaum,* F. Van Bambeke, P.M.
Tulkens
poster (New antimicrobials against Gram-positives -
P1092)
* Hershey Medical Center, Hershey, PA
- Comparative
activities of the novel ketolide CEM-101 and telithromycin towards towards
Streptococcus pneumoniae resistant to macrolides from patients
with confirmed community-acquired pneumonia
A. Lismond, F. Van Bambeke, P.M. Tulkens
poster (New antimicrobials against Gram-positives - P1099)
- Prevalence
and epidemiology of antibiotic resistance in Pseudomonas aeruginosa
isolated from low respiratory tract of patients hospitalized in intensive
care units from 5 Belgian hospitals, 2004-2008
M. Riou, S. Carbonnelle, L. Avrain, Y. Glupczynski,1
D. Devos,2 J.-P. Pirnay,2
A. Simon,3 D. Pierard,4
F. Jacobs,5 A. Dediste,6
F. Van Bambeke, P.M. Tulkens
poster (Resistance in Pseudomonas spp - P1502)
1Laboratoire de microbiologie, Clinique universitaire
UCL de Mont-Godinne, Yvoir, Belgium; 2 Queen Astrid Military Hospital,
Brussels, Belgium; 3 Cliniques universitaires St-Luc, Brussels, Belgium;
4 Universitair Zikenhuis Brussel, Brussels, Belgium; 5 Hôpital
Erasme, Brussels, Belgium; 6 Centre hospitalo-universitaire St-Pierre,
Brussels, Belgium
-
Quantitative
comparison of aminoglycoside nephrotoxicity in rats for effective
screening and evaluation of new derivatives, and dosing rationales
that minimise toxicity
C.F. Kostrub,* R. Diokno,* J.B. Aggen,* G.H. Miller,* J.K. Judice,*
P.M. Tulkens
poster (Pharmacokinetics & pharmacodynamics of aminoglycosides
& lipoglycopeptides) Tuesday , 19 May 2009 12:30-13:30
* Achaogen, South San Francisco, CA
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18th
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)
Barcelona,
Spain, 19-22 April 2008
Note:
for the plenary lectures given at this Conference, visit http://www.facm.ucl.ac.be/facm-conferences.htm
- Presence
of extended-spectrum beta-lactamase-producing Enterobacteriaceae in
the faecal flora of patients from general practice
C. Meex,* P. Melin,* J.D. Docquier,* T. Kabasele,* P. Huynen,* P.M.
Tulkens, D. Giet,* P. De Mol*
* Université de Liège (Laboratoire de microbiologie
et Département de médecine générale), Liège,
Belgium)
Poster 631 - Saturday, April 19, 2008, 15:30 - 16:30
- Intracellular
activity of antibiotics against Staphylococcus aureus internalised human
skin keratinocytes: comparison with THP-1 macrophages
S. Lemaire, F. Van Bambeke, J.P. Pirnay,* G. Verween,* P. De Corte,*
D. De Vos,* P.M. Tulkens
* Queen Astrid Military Hospital, Brussels, Belgium
Oral session O143 Sunday, April 20, 09:00 - 09:12 (Lecture Hall 116)
- Temocillin
protein binding is concentration-dependent and not restricted to albumin
S. Carryn, J.W. Mouton,* N. Couwenbergh, P.M. Tulkens
* Casinius Wilhelmina Ziekenhuis, Nijmegen, The Netherlands
Oral session O146 Sunday, April 20, 9:36 - 09:48 (Lecture Hall 116)
- MDR1
(P-glycoprotein) and MRP1 (multidrug resistance-related protein 1) eukaryotic
efflux transporters do not affect the cellular accumulation and intracellular
activity of tigecycline towards intraphagocytic Staphylococcus aureus
S. Lemaire, F. Van Bambeke, M.P. Mingeot-Leclercq, P.M. Tulkens
Oral session O147 Sunday, April 20, 09:48 - 10:00 (Lecture Hall 116)
- Temocillin
6g daily in critically ill patients: continuous infusion vs. conventional
administration
P.F. Laterre,* T. Dugernier,** X. Wittebole,* N. Couwenbergh, P.M. Tulkens,
S. Carryn
* Cliniques universitaires Saint-Luc, Brussels; ** Clinique
Saint-Pierre, Ottignies; Belgium
Oral session O150, Sunday, April 20, 10:24 - 10:36(Lecture Hall 116)
- Activity
of antibiotic combinations towards intracellular small colony variants
of Staphylococcus aureus in a model of THP-1 macrophages
H.A. Nguyen, O. Denis,* A. Vergison,** P.M. Tulkens, M.J. Struelens,*
F. Van Bambeke
* Département
de microbiologie, **Département de maladies infectieuses pédiatriques;
Université libre de Bruxelles, Brussels, Belgium
Poster session P1059, Sunday, April 20
- Identification
of a Staphylococcus aureus strain with increased intracellular
growth and reduced intracellular susceptibility to gentamicin
A. Olivier, F. Van Bambeke, M.P. Mingeot-Leclercq, P.M. Tulkens
Poster session P1060, Sunday, April 20
- Intracellular
activity of antibiotics against a stable small colony variant of Staphylococcus
aureus isolated from a CF patient in model Calu-3 human airway epithelial
cells
H.A. Nguyen, O. Denis,* A. Vergison,** P.M. Tulkens, M.J. Struelens,
F. Van Bambeke
* Département de microbiologie, **Département de maladies
infectieuses pédiatriques; Université libre de Bruxelles,
Brussels, Belgium
Poster session P1058, Sunday April 20
- Guidelines
observance by general practitioners for respiratory tract infections:
a quantitative study using the "Small Samples Approach" for
in-depth, case-based analysis in French-speaking Belgium
J.M. Feron,* D. Legrand,* P.M. Tulkens
* Centre académique de médecine générale,
Université catholique de Louvain, Brussels, Belgium
Oral session O249, Sunday, April 20, 16:36 - 16:48 (Lecture Hall 115)
- Epidemiological
survey of resistance to beta-lactams (AMX, CFX, CRO), macrolides (CLR,
TEL), and fluoroquinolones (LVX, MXF) in a Belgian collection of community-acquired
pneumonia isolates of Streptococcus pneumoniae
A. Lismond, F. Van Bambeke, S. Carbonnelle, F. Jacobs,1
M.J. Struelens,2 J. Gigi,3
A. Simon,3 Y. Van Laethem,4
A. Dediste,4 D. Pierard,5
A. De Bel,5 P.M. Tulkens
1Service
des maladies infectieuses et 2Laboratoire de microbiologie, Hôpital
Erasme, Bruxelles; 3Laboratoire de microbiologie, Cliniques universitaires
Saint-Luc, Bruxelles; 4Service des maladies infectieuses et 5Laboratoire
de microbiologie, CHU St-Pierre, Bruxelles; 6Laboratorium voor microbiologie,
Universitair Zikenhuis Brussel, Brussel; Belgique
Poster session P1747, Monday, April 21
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27ème
Réunion Interdisciplinaire de Chimiothérapie Anti-Infectieuse
(RICAI)
Paris, France, 6-7 décembre 2007
- Evaluation
de l'usage des antibiotiques en médecine générale
en Belgique francophone: détermination des raisons de la surprescription
apparente et de la non-observance des recommandations de bonne pratique
(Présentation orale; no. 235)
J.M. Feron,* D. Legrand,* N. Kacenelenbogen,** A. Freyens,*** P.M. Tulkens
* Centre académique de médecine générale,
Université catholique de Louvain; * Département universitaire
de médecine générale, Université libre de
Bruxelles, Bruxelles; * Département universitaire de médecine
générale, Université de Liège, Liège;
Belgique
- Comparative
intracellular activity of 11 antistaphylococcal antibiotics against
a stable, thymidine-dependent small colony variant (SCV) and a normal
phenotype isolate from a cystic fibrosis patient
H.A. Nguyen, O. Denis,* A. Vergison,**, P.M. Tulkens, M. Struelens,*,
F. Van Bambeke
Poster no. 325 - This
poster has received the AORIC
(Association pour l'Organisation des Réunions Interdisciplinaires
de Chimiothérapie anti-infectieuse) prize
* Département de microbiologie, **Département
de maladies infectieuses pédiatriques; Université libre
de Bruxelles, Bruxelles, Belgique
- Intracellular
activity of moxifloxacin against European, American and Asian clinical
isolates of community-acquired methicillin-resistant S. aureus (CA-MRSA)
S. Lemaire, F. Van Bambeke, Y. Glupczynski,* P.M. Tulkens
Poster no. 487
*Laboratoire
de microbiologie, Clinique universitaire UCL de Mont-Godinne, Yvoir,
Belgique
- Synthesis
and evaluation of vancomycin target analogues as potential biosensors
for on-line therapeutic monitoring
I. Delattre, O. Hernout, J. Marchand-Brynaert,* K. Berthoin, P.M. Tulkens,
S. Carryn**
Poster no. 502
*Unité de chimie organique et médicinale,
Université catholique de Louvain, Louvain-La-Neuve; **Eumedica
sa, Manage; Belgique
- Apoptosis
induced by aminoglycosides in cultured cells: comparison between gentamicin
and amikacin using incubated and electroporated cells
Poster no. 503
S. Denamur, F. Van Bambeke, M.P. Mingeot-Leclercq, P.M.
Tulkens
- Epidemiological
survey of antibiotic resistance in a Belgian collection of CAP isolates
of Streptococcus pneumoniae
Poster no. 557
A. Lismond, F. Van Bambeke, S. Carbonelle, F. Jacobs,1
M. Struelens,2 J. Gigi,3
A. Simon,3 Y. Van Laethem,4
A. Dediste,5 D. Pierard,6
P.M. Tulkens
1Service des maladies infectieuses et 2Laboratoire de
microbiologie, Hôpital Erasme, Bruxelles; 3Laboratoire de microbiologie,
Cliniques universitaires Saint-Luc, Bruxelles; 4Service des maladies
infectieuses et 5Laboratoire de microbiologie, CHU St-Pierre, Bruxelles;
6Laboratorium voor microbiologie, Universitair Zikenhuis Brussel, Brussel;
Belgique
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47th
Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
Chicago,
Ill., September 17-20, 2007
- Ciprofloxacin
selects for PatA/PatB over-expression in a wild-type and PmrA-overproducer
S. pneumoniae exposed to half-MIC concentrations -- (Poster
C1/110)
L. Avrain, M. Garvey,* Y. Glupczynski,** N. Mesaros, M. P. Mingeot-Leclercq,
L. J. V. Piddock,* P. M. Tulkens, R. Vanhoof,*** F. Van Bambeke
*University of Birmingham, Birmingham, United Kingdom;
** Cliniques universitaires de Mont-Godinne, Yvoir, Belgium; *** Institut
Pasteur, Brussels, Belgium
- Competition
between ciprofloxacin and non-steroidal anti-inflammatory drugs for
efflux transporters in J774 macrophages -- (Poster A1141)
F. Huyghe, M.P. Mingeot-Leclercq, B. Marquez-Garrido, P. M. Tulkens,
F. Van Bambeke
- Insufficient
activity of most common antistaphylococcal antibiotics towards intraphagocytic
forms of S. aureus isolates from a patient with persistent bactereriemia:
a cause for treatment failure ? -- (Poster
A1439)
S. Lemaire, L. M. Koeth, H. Labischinski,** K. Kosowska-Shick,***
F. Van Bambeke, P. M. Tulkens, P. Appelbaum***
* Laboratory Specialists, Westlake, OH, ** Combinature
Biopharm AG, Berlin, Germany, ***Hershey Med. Ctr., Hershey, PA.
- Intraphagocytic
activities of ceftobiprole vs. conventional cephalosporins against
methicillin-sensitive (MSSA) and methicillin-eesistant S. aureus
(MRSA) -- (Poster A1438)
S. Lemaire, F. Van Bambeke, Y. Glupczynski,* P. M. Tulkens
* Cliniques universitaires de Mont-Godinne, Yvoir, Belgium.
- Comparative
intracellular activity of ten antistaphylococcal antibiotics against
a stable Small Colony Variant (SCV) of S. aureus in a model of
human THP-1 macrophages -- (Poster
A1437)
H. A. Nguyen, O. Denis,* A. Vergison,** P. M. Tulkens, M. Struelens,*
F. Van Bambeke
* Université libre de Bruxelles (Hôpital
Erasme), Brussels, Belgium; ** Université libre de Bruxelles
(Hôpital universitaire des enfants Reine Fabiola), Brussels, Belgium
- Phoenix
is overcalling the resistance of Enterobacteriaceae to temocillin
-- (Poster D24)
A. Simon (1), K. Camps (2),
H. De Beenhouwer (3), B. Glibert
(4), F. Meunier
(5), A. Trouve (6), V. Vael
(7), P.M. Tulkens, S. Carryn (8)
(1) Cliniques universitaires St-Luc, Brussels; (2) ZNA
Stuyvenberg, Antwerp; (3) OLVZ Aalst, Aalst; (4) AZ Zusters van Barmhartigheid,
Ronse; (5) CH de Jolimont, La Louvière; (6) WZVGO Knokke-Heist;
(7) ZNA J. Palfijn, Antwerp; (8) Belpharma SA, Brussels and Université
catholique de Louvain, Brussels
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17th European Congress
of Clinical Microbiology and Infectious Diseases (ECCMID) & 27th International
Congress of Chemotherapy
Munich, Germany, 31 March - 3 April 2007
- Extracellular
and intracellular activities of Quinupristin-Dalfopristin (Synercid)
against S. aureus, with different resistant phenotypes (MSSA,
MRSA, VISA).
P. Baudoux, Y. Glupczynski,* P.M.Tulkens, F. Van Bambeke. - Tuesday,
April 03, 2007 - Poster 2058
* Laboratoire de microbiologie, Cliniques universitaires
de Mont-Godinne, Yvoir
- Ciprofloxacin
and doxorubicin are substrates of different Multidrug Resistance-related
Proteins efflux transporters in J774 macrophages
F. Clesse, M.-P. Mingeot-Leclercq, P.M. Tulkens, F. Van Bambeke - Tuesday,
April 03, 2007 - Poster 2067
- Intracellular
activity of daptomycin against methicillin-sensitive, methicillin-resistant,
and vancomycin-intermediate S. aureus
S. Lemaire, F. Van Bambeke, and P.M. Tulkens - Sunday, April 01,
2007 - Poster 829
- Inhibitors
and activator of the P-glycoprotein efflux pump modulate the accumulation
of daptomycin in THP-1 macrophages and its intracellular activity towards
S. aureus.
S. Lemaire, F. Van Bambeke, and P.M. Tulkens - Tuesday, April 03,
2007 10:18-10:30 (oral session) presentation O429
- Comparative
activity of moxifloxacin, linezolid, cloxacillin, clindamycin, trimethoprim-sulfamethoxazole,
and ciprofloxacin against intracellular Methicillin-sensitive and Community-Acquired
Methicillin-Resistant S. aureus.
S. Lemaire, F. Van Bambeke, P.M. Tulkens and Y. Glupczynski.* - Sunday,
April 01, 2007 - Poster 703
* Laboratoire de microbiologie, Cliniques universitaires
de Mont-Godinne, Yvoir
- Prevalence
of Mex-mediated resistance in P. eruginosa isolates from patients
with ventilator-associated pneumonia in 4 Belgian hospitals.
N. Mesaros, Y. Glupczynski,* D. Pierard,** A. Dediste,*** Y. Van Laethem,***
F. Jacobs,**** M. Struelens,**** D. De Vos,***** J.-P. Pirnay,*****
F. Van Bambeke, P.M. Tulkens - Monday, April 02, 2007 - Poster 1358
* Laboratoire de microbiologie, Cliniques universitaires de Mont-Godinne,
Yvoir ; ** Dients voor MIcrobologie, AZ-VUB, Brussels; *** CHU St-Pierre,
Brussels; **** Erasme Hospital, Brussels; **** Queen Astrid Military
Hospital, Brussels
- Aminoglycoside-induced
apoptosis in cultured renal (LLC-PK1) and non-renal (J774 macrophages)
cells: comparison between gentamicin and amikacin
S. Denamur, F. Van Bambeke, M.-P. Mingeot-Leclercq, P.M. Tulkens - Tuesday,
April 03, 2007 10:06-10:18 (oral session) presentation O428
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26ème
Réunion Interdisciplinaire de Chimiothérapie Anti-Infectieuse
(RICAI)
Paris, France, December 7-8th, 2006
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FEBS Special
Meeting - European Lipidomics Initiative: New concepts in lipidology:
from lipidomics to disease
Noordwijkerhout, The Netherlands, October 21 - 25, 2006
- Characterization
at nanometric scale of the interactions between fluoroquinolones (ciprofloxacin)
and membrane lipids
H. Bensikaddour, N. Fa, M. Deleu,* A. Schanck,** Y. Dufrene,*** M.-P.
Mingeot-Leclercq
* Unité de chimie biologique industrielle, Faculté universitaire
des Sciences agronomiques de Gembloux, Gembloux, Belgium; ** Unité de
chimie structurale et des mécanismes réactionnels, Université catholique
de Louvain, Louvain-La-Neuve, Belgium; *** Unité de chimie des interfaces,
Université catholique de Louvain, Louvain-la-Neuve, Belgium
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46th Interscience
Conference on Antimicrobial Agents and Chemotherapy
San Francisco,
CA, September 27-30, 2006
Note:
for the plenary lectures given at this Conference, visit http://www.facm.ucl.ac.be/facm-conferences.htm
- Mechanisms
of resistance in S. pneumoniae exposed to half MICs of ciprofloxacin
and moxifloxacin.
L. Avrain, N. Mesaros, Y. Glupczynski*, F. Van Bambeke, R. Vanhoof**,
and P.M. Tulkens
* Laboratoire de Microbiologie, Cliniques universitaires
Mont-Godinne, Yvoir, Belgium; ** Eenheid voor antibiotica onderzoek,
Pasteur Instituut, Brussels, Belgium
Poster C1-0041
- Telavancin
is more bactericidal than vancomycin against both extracellular and
intracellular (THP-1 macrophages) Staphylococcus aureus with
different resistance phenotypes.
M. Barcia-Macay, S. Lemaire, M.-P. Mingeot-Leclercq, P.M. Tulkens, and
F. Van Bambeke
Poster A-0642
- Bactericidal
activity of ceragenin CSA-13 against intracellular MSSA, hospital-acquired
(HA) and Community-acquired (CA) MRSA, and VISA in THP-1 macrophages:
relation to cellular toxicity ?
S. Lemaire, T. Bogdanovitch,* S. Chavez-Bueno,** P.D. Savage,*** F.
Van Bambeke, P. Appelbaum,* and P.M. Tulkens
* Hershey Medical Center, Hershey, PA; ** University
of Texas Southwestern Medical Center, Dallas, TX; ***Brigham Young University,
Provo, UT
Poster A-0633
- Intracellular
MRSA, VISA and VRSA are sensitive to cloxacillin and meropenem.
S. Lemaire, F. Van Bambeke, Y. Glupczynski,* P. C. Appelbaum,** and
P.M. Tulkens
* Laboratoire de Microbiologie, Cliniques universitaires
de Mont-Godinne, Yvoir, Belgium; ** Hershey Medical Center, Hershey,
PA
Poster A-0634
- Synergy
between bacterial Lde and macrophage MRP efflux pumps markedly reduces
the activity of ciprofloxacin but not that of moxifloxacin against intracellular
Listeria monocytogenes.
A. Lismond, P. Courvalin,* M.-P. Mingeot-Leclercq, P.M. Tulkens, F.
Van Bambeke
* Unité des Agents Antibactériens, Institut
Pasteur, Paris, France
Poster A-1108
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12th
International Symposium on Staphylococci & Staphylococcal Infections
Maastricht, The Netherlands, 3-6 September 2006
- Contrasting
effect of acid pH on the extracellular and intracellular activities
of gentamicin and oxacillin against Staphylococcus aureus.
P. Baudoux, N. Bles, S. Lemaire, M.-P. Mingeot-Leclercq, P. M. Tulkens,
F. Van Bambeke
Poster no. P-002
- Intracellular
activity of antibiotics against methicillin-sensitive, hospital-acquired
methicillin-resistant, and vancomycin-intermediate Staphylococcus
aureus (MSSA, HA-MRSA, and VISA) in human macrophages (THP-1.
S. Lemaire, P. Baudoux, M. Barcia-Macay, F. Van Bambeke, Y. Glupczynski,*
P.M. Tulkens
* Laboratoire de Microbiologie, Cliniques universitaires
de Mont-Godinne, Yvoir, Belgium
Poster no. P-004
- Intracellular
infection of THP-1 human macrophages by Staphylococcus aureus
and role of haemolysins.
A. Olivier, S. Lemaire, M.P. Mingeot-Leclercq, F. Van Bambeke, P.M.
Tulkens.
Poster no. P-021
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International
Burkholderia cepacia Working Group
Ghent, Belgium, April 20-23, 2006
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16th European
Congress of Clinical Microbiology and Infectious Diseases
Nice, France, April 1-4th, 2006
- Pharmacokinetics
of Temocillin in Intensive Care Patients and Monte Carlo Simulations
to Evaluate Breakpoints
J.W. Mouton *, R. DeJongh **, V. Basma, P.M. Tulkens, S. Carryn
Poster P-1515
* Casinius Whilhelmina Ziekenhuis, Nijmegen, The Netherlands;
** Zuid-Oost-Limburg Ziekenhuis, Genk, Belgium
- Pharmacodynamic
evaluation of the bactericidal activity of telavancin (TLV) against
extracellular and intracellular MSSA and MRSA
M. Barcia-Macay, M.P. Mingeot-Leclercq, P.M. Tulkens, F. Van Bambeke
oral presentation O356
- Meropenem
and cloxacillin are active against MRSA clinical isolates (including
VISA) in acidic broth and in THP-1 macrophages.
S. Lemaire, F. Van Bambeke, P.M. Tulkens, M.P. Mingeot-Leclercq, J.
Coyette,* Y. Glupczynski**
Poster P1534
* Université de Liège, Liége, Belgium;
** Cliniques
universitaires de Mont-Godinne, Yvoir, Belgium
- Detection
of mexA and mexX efflux genes in P. aeruginosa: correlation between
QC-RT-PCR and Real-Time PCR.
N. Mesaros, Y. Glupczynski,* D. Pierard,** A. Dediste,***
Y. Van Laethem,*** P.M. Tulkens, M.P. Mingeot-Leclercq, F. Van Bambeke
Poster P1751
*
Cliniques universitaires de Mont-Godinne, Yvoir, Belgium; ** AZ-Vrije
Universiteit Brussel, Brussels, Belgium; *** CHU Saint-Pierre, Brussels,
Belgium
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45th Interscience
Conference on Antimicrobial Agents and Chemotherapy
Washington, DC, December 16-19th, 2005
Note:
for the plenary lectures given at this Conference, visit http://www.facm.ucl.ac.be/facm-conferences.htm
- Telavancin
accumulates in cultured macrophages and is active against intracellular
S. aureus
M. Barcia-Macay, M.P. Mingeot-Leclercq, P.M. Tulkens, and F. Van Bambeke
Poster A-1831
- Carbapenems
are Active against Intracellular MRSA
S. Lemaire, F. Van Bambeke, M.-P. Mingeot-Leclercq, Y. Glupczynski,*
and P.M. Tulkens
* Laboratoire de microbiologie, Cliniques universitaires
de Mont-Godinne, Yvoir, Belgium
Poster A-1832
- Genotypic
method is more reliable than phenotypic characterization to detect Mex
efflux pumps in clinical Isolates of Pseudomonas aeruginosa
N. Mesaros, N. Caceres, F. Van Bambeke, Y. Glupczynski,* M.P. Mingeot-Leclercq,
and P.M. Tulkens
* Laboratoire de microbiologie, Cliniques universitaires
de Mont-Godinne, Yvoir, Belgium
Poster D-1699
- Gentamicin
causes apoptosis at low concentrations in LLC-PK1 cells subjected to
electroporation.
H. Servais, Y. Jossin,* F. Van Bambeke, M.P. Mingeot-Leclercq, and P.M.
Tulkens
* Unité de neurobiologie du développement,
Université catholique de Louvain, Brussels, Belgium
Poster A-1836
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7th European
Congress of Chemotherapy and Infectious Diseases
Florence, Italy, October 19-22, 2005
- Comparative
in vitro activity of temocillin, meropenem, ceftazidime and piperacillin/tazobactam
against panel strains and clinical isolates of Burkholderia cepacia
complex from 9 different genomovars.
S. Carryn, PM Tulkens and P. Vandamme*
*Laboratorium voor Microbiologie, Universiteit Gent,
Ghent, Belgium
Poster PS10-271 - Journal of Chemotherapy (2005), 17 (suppl. 3) : 94.
- Induction
of fluoroquinolone efflux in Streptococcus pneumoniae by subinhibitory
ciprofloxacin concentrations
L. Avrain, N. Mesaros, R. Vanhoof,* F. Van Bambeke, and P.M. Tulkens.
* Antibiotica resistentie en nosocomiale infecties, Instituut
Pasteur, Brussels, Belgium
Poster PS2-071 - Journal of Chemotherapy (2005), 17 (suppl. 3) : 3
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Lipids, Liposomes,
and Biomembranes 2005
Vancouver, BC, Canada, July 27-30th, 2005
- Probing
fluoroquinolone-biomembrane interactions on the nanoscale
Nathalie Fa, Ingrid Burton,* Magali Deleu,** Robert
Brasseur,*** Yves Dufrêne,* Marie-Paule Mingeot-Leclercq
* Unité de chimie des interfaces, Université
catholique de Louvain, Louvain-la-Neuve; ** Unité de Chimie Biologique
Industrielle, Faculté Universitaire des Sciences Agronomiques
de Gembloux, Gembloux; *** Centre de Biophysique Moléculaire
Numérique, Faculté Universitaire des Sciences Agronomiques
de Gembloux, Gembloux.
Poster
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15th
European Conference on Clinical Microbiology and Infectious Diseases (ECCMID)
Copenhagen, Denmark, April 2-5, 2005
- Learning appropriate use of antibiotics
(PK/PD and guidelines :a CD-rom course for healthcare professionals
and students
E. Ampe, Y. Glupczynski*, P.M. Tulkens, and F. Van Bambeke
* Laboratoire de Microbiologie, Cliniques universitaires
UCL, Mont-Godinne
Poster P878 - Clinical Microbiology and Infection (2005): 11 Suppl.
2, 295.
Note: Persons interested in obtaining a copy of the course may send
an E-mail to tulkens@facm.ucl.ac.be
- Ciprofloxacin (CIP) accumulation
and intracellular activity against L. monocytogenes are reduced
in ciprofloxacin-resistant macrophages due to increased efflux
M. Heremans, M.P. Mingeot-Leclercq, P.M. Tulkens, and F. Van Bambeke
Poster P1100 - Clinical Microbiology and Infection (2005): 11 Suppl.
2, 344.
- Phenotypic and genotypic detection
of Mex efflux pumps in P. aeruginosa
N. Mesaros, N. Caceres, F. Van Bambeke, M.P. Mingeot-Leclercq and
P.M. Tulkens
Poster P1731- Clinical Microbiology and Infection (2005): 11 Suppl.
2, 568-569.
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Association
of Biomolecular Resources Facilities Annual meeting
Savannah, Georgia, February 5-8, 2005.
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Biophysical
Society 49th Annual Meeting
Long Beach, Cal., 12-16 February, 2005
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Annual
meeting of the Belgian Society for Microbiology
Brussels, December 3d, 2004
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24ème
Réunion Interdisciplinaire de Chimiothérapie Anti-Infectieuse
(RICAI) and 6th European Congress of Chemotherapy,
Paris, France, December 2d-3d, 2004
- A versatile method
to quantify the expression level of mexAB-oprM AND mexXY-oprM
genes in P. aeruginosa
N. Mesaros, N. Caceres, F. Van Bambeke, M.P. Mingeot-Leclercq, and P.M.
Tulkens
Poster 564/91P
- Continuous versus intermittent infusion
of temocillin in Intensive Care patients
V. Basma, R. de Jongh*, F. Van Bambeke, M.P. Mingeot-Leclercq, and P.M.
Tulkens
* Zuid Oost-Limburg Ziekenhuis, Genk, Belgium
Poster 660/96P
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44th Interscience Conference on Antimicrobial Agents
and Chemotherapy (ICAAC)
Washington, DC, 30 october - 2 november 2004
- Ciprofloxacin-resistant
J774 mouse macrophages show a reduction in the accumulation of quinolones
through increased activity of an MRP-like transporter
M. Heremans, J.M. Michot, M.P. Mingeot-Leclercq,
P.M. Tulkens, F. Van Bambeke
Oral presentation (abstract no. 1304)
- Beta-lactams
are bactericidal against intracellular forms of S. aureus in a
24-h human macrophages model (THP-1 cells)
Maritza Barcia-Macay, Cristina Seral, Marie-Paule Mingeot-Leclercq,
Paul M. Tulkens, Françoise Van Bambeke.
Poster A1488
- Synthesis and activity of penicillin G hydroxamic
acid derivatives against S. aureus, S. pneumoniae, and intraphagocytic
L. monocytogenes.
Leah Efron, Françoise Van Bambeke, Catherine Berhin, Youri Glupczynski*,
Paul M. Tulkens, and Etienne Sonveaux**.
(* Laboratoire de microbiologie, Clinique Universitaire de l'UCL
à Mont-Godinne, Yvoir; ** Unité de Chimie Pharmaceutiques)
Poster F333
- Contrasting effects of ertapenem (ETP) against intracellular
L. monocytogenes and S. aureus in a model of THP-1 macrophages
S. Lemaire, F. Van Bambeke, M.P. Mingeot-Leclercq, P.M. Tulkens.
Poster A1487
- Involvement
of mitochondrial pathway and Bax in gentamicin-induced apoptosis in
renal LLC-PK1 cells.
H. Servais, E.
Delbecq, G. Van der Essen, G. Thirion, F. Van Bambeke, P.M. Tulkens
and M.P. Mingeot-Leclercq
Poster A 1491
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3rd Portuguese-Spanish Biophysics Congress
Lisbon, Portugal, October 29th - November 1st 2004
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Groupe
d'Etude des Interactions Molécules - Membranes (GEIMM) - 2004
Dinard, France, 21-24 septembre 2004
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15th
International Symposium on Problems of Listeriosis (ISOPOL)
Uppsala,
Sweden, September 12-15th, 2004
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World
Conference on Magic Bullets (Celebrating Paul Ehrlich's 150th birthday)
Nuremberg, Germany, September 9th-11th, 2004
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14th European Congress of Clinical Microbiology and
Infectious Diseases (14th ECCMID)
Prague, Czech Republic, Mai 1st-May 4th, 2004
- Antibiotic activity of new penams (6-APA)
and cephems (7-ACA) with bulky T-shaped side-chains.
L. Efron, Th. Happaerts, E. Sonveaux, H. Chanteux, C. Berhin,Y.
Glupczynski, F. Van Bambeke, P.M. Tulkens.
Poster P544
- Comparison of ertapenem, ampicillin, and meropenem
against the intracellular forms of Listeria monocytogenes in human THP-1
macrophages.
S. Lemaire, S. Van de Velde, S. Carryn, F. Van Bambeke, M.-P.
Mingeot-Leclercq, P.M. Tulkens.
Poster P1045
- In-vitro antifungal activity, cytotoxicity and cellular
accumulation of new water-soluble amphotericin B (AMB) polyvinylpyrrolidone
(PVP) formulations.
E. Charvalos, M.N. Tzatzarakis, F. Van Bambeke, P.M. Tulkens, A.M. Tsatsakis,
M.-P. Mingeot-Leclercq
Poster P1785
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43d Interscience Conference on Antimicrobial Agents
and Chemotherapy (ICAAC)
Chicago, IL, 14-17 september 2003
- Oritavancin accumulates to high levels
in the lysosomes of macrophages by endocytosis
F. Van Bambeke, H. Chanteux, D. Tyteca, M.P. Mingeot-Leclercq,
P.M. Tulkens
Poster 1169 A
- Comparative Activity of 12 Antibiotics Used at Clinically-meaningful
Extracellular Concentration Against Staphylococcus aureus in Broth and
in Human THP-1 Macrophages
M. Barcia-Macay, C. Seral, M.P. Mingeot-Leclercq, P.M. Tulkens, F. Van
Bambeke
Poster 1174 A
- Influence of Inhibitors of Efflux Pumps on the Accumulationof
Quinolones in a model of Calu-3 Human Airway Epithelial Cells
C. Seral, E. Viaene, F. Van Bambeke, M.P. Mingeot-Leclercq and P.M.
Tulkens
Poster 1175 A
- Activity of Garenoxacin (BMS284756) and Levofloxacin
Against Intracellular Staphylococcus aureus or Listeria monocytogenes
in J774 Macrophages
C. Seral, P.M. Tulkens and F. Van Bambeke
Poster 1176 A
- Two Years
of National Public Campaigns to Promote Appropriate Use of Antibiotics
in the Community In BelgiumI. Bauraind, H. Goossens, E.
Hendrickx, F. Yane, B. Seys, J.-L. Marchal, P.M. Tulkens, L. Verbist,
J.-M. Lopez-Lozano, A. Beyaert.
Poster 1362A
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forthcoming or last meetings | 2012 | 2011
| 2010 | 2009 | 2008
| 2007 | 2006 | 2005
| 2004 | 2003
