Quick links
At a glance:
 
 
 

&&

Useful links:
See also
11

U
aa





Our laboratory focuses its activities on the study of drugs (with special emphasis on anti-infective drugs) in a broad context.

The Team
consists of approx. 20 scientists, 4 technicians, 1 half-time secretary, and students


Research activities include:
  • Laboratory Research examines the interactions between antiinfective agents (mainly antibiotics) and eucaryotic cells within a context of cellular and molecular pharmacology and toxicology. Disciplines and methodologies used span from Biophysics and Cellular and Molecular Biology to Morphology and Animal Trials.  New, original molecules are either designed and synthesized or screened from natural sources
    .
  • Clinical Research aims at improving the use of antibiotics in the hospital set-up, based usually but not exclusively on pharmacodynamic considerations and starting from original experimental research in this area.  

    Note: Clinical Pharmacy, launched in 2001, is now organized as the Centre for Clinical Pharmacy (with a research group part of the Louvain Drug Research Institute)

Educational activities are undertaken within the context of the the Information Center on Infective Pathology and Anti-infective Chemotherapy, the Séminaire de Pathologie Infectieuse, the Belgian Antibiotic Policy Coordination Committee, the Belgian Society of Infectiology and Clinical Microbiology, and the International society for Antiinfective Pharmacology.

Contract-based research and educational activities are undertaken in each of these areas.



Science and Education
Contact and Relations


Main Themes of research

  1. Laboratory research

  2. Clinical research

    • Clinical evaluation of the new therapeutics approaches (aminoglycosides, beta-lactams, vancomycin) (under construction)

  3. Clinical Pharmacy (launched in 2001)
    This activity has now evolved on its own, while maintaining strong links with our researcxh group
    Please, visit the WEB site of the
    Centre for Clinical Pharmacy (CFCL)



Expertise (available for contract-based activities) 
  • Laboratory  research
    • in vitro studies of drug-membrane interactions (biophysical and biochemical studies)
    • in vitro (cellular models) of antibiotic activity in intracellular infections (cellular pharmacokinetics and pharmacodynamics)
    • in vitro (cellular and a-cellular models) and in vivo (animal models) evaluation of antibiotic safety
    • rational design and synthesis of new antimicrobials
    • phenotypic and genotypic methods for the search of resistance by efflux in human pathogens

  • Clinical trials and assessment of benefit/risk ratio of antibiotics: 
    • pharmacodynamics and toxicodynamics-based new approaches for antibiotic dosing
    • new drug trials
    • litterature and database analysis (for registration and regulatory affairs purposes)

  • Educational activities
    • workshop and conferences on pharmacodynamics, resistance and appropriate choice of antiinfective agents
    • interactive sessions about the appropriate use of drugs for medical and pharmaceutical audiences
    • private courses for Industry


Publications (asbtracts and full text available for the most recents)
  • list of all papers by categories 
  • original contributions, reviews, books, chapter of books, proceedings, PhD and Master degree dissertations, educational papers, published abstracts 
  • indexed search 
  • by author, year, journal, type of publication, keywords


Educational activities


Contacts:


Address and  access:

Location:

The Unit is located on the campus of the Health Sciences Sector (Secteur des Sciences de la Santé) of the Catholic University of Louvain (Université catholique de Louvain) in Brussels (Woluwé Saint-Lambert; approx. 10km [7 mi.] from the city center). Access: Directions and Access Maps (car - train and subway - plane) - Find us on Google maps (will open a new tab)

Team (Last update: November 16, 2014) -- see photo of most of the members of the lab during our last social activities (visiting Bruges on July 4, 2007; Pairi Daiza on July 8, 2013) and on Christmas parties (2007; 2008; 2009; 2010; 2011; 2012-2013 ; 2013)
 

Phone numbers: if calling from

  • within the Health Science Sector (Faculties and Cliniques universitaires St-Luc at Woluwé-St-Lambert): dial 4 and then only the last 4 digits (ex.: 4-7370)
  • from the University main campus (Louvain-la-Neuve) or the campuses of St-Gilles and Mons: dial 774 and the last 4 digits (ex.: 774-7370)
  • from anywhere else in Belgium: dial 02 followed by the 7 digits number shown hereunder (thus 9 digits in total; ex.: 02-7647370)
  • from outside Belgium: dial your International Access Code (IAC) followed by 32 (Belgium), 2 (Brussels) and the the 7 digits number shown hereunder (thus 10 digits in total after your IAC)
    (example: IAC-32-2-7647370)
E-mails: as from July 2007, the University uses the <first_name.last_name@uclouvain.be> addressing system, which is in use for all addresses created since then. However, all former addresses using <name@facm.ucl.ac.be> as shown hereunder and which were created before July 2007 are still working and can be used.
Click here (http://www.uclouvain.be/en-repertoire-personnel.html) if you wish to get e-mail adresses using the new adressing system.

Scientific Staff

Senior investigators (click on the name to get a C.V.)

 
 
 
  • Professor (invited) Paul M. Tulkens (MD, PhD), founder of the Unit
    764.73.71 (University switchboard) -
    direct line: from Belgium: 02-762.21.36 - from abroad: dial your international access code and then 3227622136
    <tulkens@facm.ucl.ac.be
    >

Junior Investigators

Eugénie Basseres, France (PhD)
764.72.37

<eugenie.basseres@uclouvain.be>
research topic: Impact of antibiotic resistance and bacterial virulence on biofilm formation in P. aeruginosa
general theme: Antibiotic efflux and permeability resistance mechanisms | Antibiotic activity against biofilms
support:
Fonds de la Recherche Scientifique (F.R.S.-FNRS)
Isabelle Delattre, Belgium (PhD)
764.73.71
<isabelle.delattre@uclouvain.be>

research topic: Therapeutic monitoring for stratified and dose adjusted treatment (in collaboration Prof. P. Wallemacq; LTAP, IREC )
general theme:
Clinical evaluation of new approaches in antibiotic dosing and Clinical Pharmacy
support: FP7 programm of European Union

Micheline El Khoury, Lebanon (PhD)
764.73.56
<micheline.elkhoury@uclouvain.be>

research topic: mode of action of novel antibiotics acting on bacterial membranes
general theme:
drug-membrane interactions
support: Fonds de la Recherche Scientifique (F.R.S.-FNRS)
Shaunak Khandekar, India (PhD)
764.72.37
<shaunak.khandekar@uclouvain.be>
research topic: factors affecting poor response to antibiotics in intracellular infections
general theme: Chemotherapy of intracellular infection
support: Interuniversity attraction poles (Program MICRODEV)
Wafi Siala, Tunisie (PhD)
764.72.37
<wafi.siala@uclouvain.be>
research topic: activity of antibiotics and biocides against biofilms of S. aureus
general theme: Antibiotic activity against biofilms
support: Région bruxelloise/Brusselse Gewest (Prospective Research for Brussels)
Yolanda Saenz Dominguez, Spain (PhD)
764.72.25

research topic: Impact of antibiotic resistance and bacterial virulence on biofilm formation in P. aeruginosa
general theme: Antibiotic efflux and permeability resistance mechanisms | Antibiotic activity against biofilms
Ahalieyah Anantharajah, Pharm, France
(PhD in Pharmaceutical Sciences)
764.73.76
<ahalieyah.anantharajah@uclouvain.be>

research topic: new therapeutic strategies against intracellular Pseudomonas
general theme: Antibiotic efflux and permeability resistance mechanisms
and Chemotherapy of intracellular infection
support: Fonds de la Recherche Scientifique (F.R.S.-FNRS)

Ana Bastos, Pharm, Portugal
(PhD in Pharmaceutical Sciences)
764.73.75
<ana.bastos@uclouvain.be>

research topic: development of clinical pharmacy approaches (opimization of beta-lactam mode of administration)
general theme:
Clinical evaluation of new approaches in antibiotic dosing and Clinical Pharmacy
support:
Université catholique de Louvain
Hussein Chalhoub, MSc, Lebanon
(PhD in Pharmaceutical Sciences)
764.73.75
<hussein.chalhoub@uclouvain.be>
research topic: temocillin and Pseudomonas aeruginosa : study of intrinsic and acquired resistance mechanisms
general theme: Antibiotic efflux and permeability resistance mechanisms
support: Fonds pour la Recherche dans l'Industrie et l'Agriculture (FRIA)
Andreia Giro dos Santos, Portugal
764.73.75
<andreia.giro@uclouvain.be>

research topic: interaction of budenosine-cyclodextrine complex with membranes
general theme:
drug-membrane interactions
support: Région wallonne

Catherine Léonard, Bio-Igr, Belgium
(PhD in Pharmaceutical Sciences)
764.73.56
<catherine.leonard@student.uclouvain.be>

research topic: interaction of ginsenosides with membrane lipids and consequences for the activity of transmembrane proteins
general theme:
drug-membrane interactions
support: Fonds pour la Recherche dans l'Industrie et l'Agriculture (FRIA)

Tamara Milosevic, Pharm, Serbia
(PhD in Pharmaceutical Sciences)
764.73.71
<tamara.milosevic@uclouvain.be>

research topic: cellular pharmacokinetics and toxicity of oxazolidinones
general theme: Cellular toxicity induced by antibiotics and other drugs
support: Université catholique de Louvain

Hariri Mustafa, Igr & MSc, Malaysia
(PhD in Pharmaceutical Sciences)

764.73.56
<muhammad.mustafa@uclouvain.be>
research topic: synergistic antibiotic combinations in cystic fibrosis patients
general theme:
Antibiotic efflux and permeability resistance mechanisms and Antibiotic activity against biofilms
support:
Innoviris in connection with SMB
Frédéric Peyrusson, MSc, Pharm, France
(PhD in Pharmaceutical Sciences)

764.73.76
<frederic.peyrusson@uclouvain.be>
research topic: Factors determining intracellular persistence of Gram-positive bacteria
general theme: Chemotherapy of intracellular infection
support: Université catholique de Louvain
Marie Albert, Belgium
764.72.37
<m.albert@student.uclouvain.be>
research topic: interaction of ginsenosides with membrane lipids and consequences for the activity of transmembrane proteins
general theme:
drug-membrane interactions
Student in experimental biomedical sciences
Jules César Bayiha, Cameroon
764.72.25
< jules.bayiha@student.uclouvain.be>

research topic: interaction of budenosine-cyclodextrine complex with membranes
general theme:
drug-membrane interactions
Student in toxicology
Aurélien Flament, France
764.72.25
< aurelien.flament@student.uclouvain.be>

research topic: mode of action of novel antibiotics acting on bacterial membranes
general theme:
drug-membrane interactions
Student in pharmacy

Gwenn Huys, Belgium
764.72.37
<gwenn.huys@student.uclouvain.be>
research topic: activity of new antimirobial agents against intracellular bacteria
general theme:
Chemotherapy of intracellular infection
Student in pharmacy
Perrin Ngougni Poken, Cameroon
764.73.75
<perrin.ngougni@student.uclouvain.be>
research topic: development of clinical pharmacy approaches (opimization of beta-lactam mode of administration)
general theme:
Clinical evaluation of new approaches in antibiotic dosing and Clinical Pharmacy
Student in pharmacy
Sergio Ruiz, Spain
764.73.70
research topic: cellular pharmacokinetics and toxicity of oxazolidinones
general theme: Cellular toxicity induced by antibiotics and other drugs
bachelor in chemistry
Félicien Vellut, Belgium
764.72.37

research topic: interaction of ginsenosides with membrane lipids and consequences for the activity of transmembrane proteins
general theme:
drug-membrane interactions
bachelor in medical biology

 

Technical and Administrative Staff

Marie-Claire Cambier (full-time 1st Head Technician)
764.73.75
<cambier@facm.ucl.ac.be>
main techniques: cell culture, microbiology
support: Université catholique de Louvain
Julie Maron (half-time technician)
764.73.76

<julie.maron@uclouvain.be>
main techniques: biophysics, microbiology
support: Fonds de la Recherche Scientifique Médicale (FRSM)

Virginie Mohymont (full-time technician)
764.73.70
<virginie.mohymont@facm.ucl.ac.be>

main activities: secretarial and administrative tasks; microbiology, biochemistry and molecular biology
support: Université catholique de Louvain

Pierre Muller (full-time technician)
764.73.76
<pi.muller@uclouvain.be>

main activities: HPLC, microbiology, molecular biology
support: FP7 program of European Union
Katia Santos Saial (full technician)
764.73.76
<katia.santossaial@uclouvain.be>
main activities: microbiology, biochemistry
support: Fonds de la Recherche Scientifique Médicale (FRSM)
Vasileios Yfantis (full technician)
764.73.70
<vasileios.yfantis@uclouvain.be>

main activities: microbiology, biochemistry and molecular biology
support: Université catholique de Louvain


Former Staff Members, Post-doctoral fellows,Visiting Scientists, Doctoral fellows, Non-doctoral fellows, and Students

by chronological order of joining the laboratory and with the following information by order: Name, degree when joining the Unit, Country/State, period of stay, position(s) held, main and/or final degree earned if any, source(s) of financing

Former staff members

Post-doctoral fellows

Visiting scientits

Doctoral fellows

Non-doctoral fellows

Students

Former Technical and Administrative Staff

by chronological order of leaving the laboratory

  Francine Andries Epse Renoird
(1st Head Technician)
main activities: biochemistry, electron microscopy, training of new fellows, accounting

started: 1970
left: 2006

  Olga Meert (1st Technician) main activities: general maintenance

started: 1991
left:
2007

  Jonathan Gesels (technician) main activities: serotyping by molecular biology techniques started: 2009
left:
2010
  Martial Vergauwen (technician)

main techniques: biophysics, biochemistry, cell fractionation

started: 2004
left:
2011
  Charlotte Misson (technician) main techniques: biochemistry, microbiology started: 2006
left:
2011
  Nathalie Couwenbergh (technician) main techniques: HPLC, microbiology, molecular biology started: 2007
left: 2012
  Ozlem Misir ( technician) main techniques: biophysics, biochemistry

started: 2010
left: 2012



Financing


Special Events

(by chronological order since 1997)