Université catholique de Louvain (UCL-Bruxelles)
Louvain Drug Research Institute
Cellular and Molecular Pharmacology

Seminar "Pharmacokinetics-Pharmacodynamics of Antibiotics"
Séminaire "Pharmacocinétique-Pharmacodynamie des Antibiotiques"

(Paul M. Tulkens - Organized by the "Société Tunisienne de Pathologies infectieuses" and the "Laboratoire de recherche « Microorganismes et pathologies humaines « LR 03SP03 »", Université de Sfax, Tunisia (2-3 November 2017)

Lectures at this Seminar were given in French. Presentations are either in French (marked FR), in English (marked EN), or sometimes mixed (some in FR, some in EN...).

• 1. Introduction générale (FR)
  

  Theories and Principles

• 2-1. Microbiologie: propriétés à considérer (FR)
• 2-2. Concepts généraux de pharmacocinétique (FR)
• 2-3A. Concepts généraux de pharmaodynamie (FR)
• 2-3B: Pharmacodynamie: méthodes (FR)
• 2-3C: Pharmacodynamie: données réelles (FR)
• 2-4A: Résistance: pourquoi et mécanismes (FR)
• 2-4B: Résistance et PK/PD (FR)

  Applications

• 3-A: beta-lactams [including continous infusion] (EN)
• 3-B: aminoglycosides (EN)
• 3-C: vancomycin [continous infusion] (EN)
• 3-D: fluoroquinolones [including Mutant Prevention Concentration] (EN)
  

  Advanced topics

• 4. PK-PD analysis and modelling (EN)
• 5. EUCAST: concentrations critiques (FR)
• 6. Associations d'antibiotiques (FR) / Biofilms (EN)
• 7. Mutant Prevention Concentration: a case analysis (linezolid) (EN)
• 8. Inhibitors of beta-lactamase/Inhibiteurs de beta-lactamase (titles are in FR but texts are in EN)
  

All of the above in a single ZIP file ( !! about 30 Mbytes)

Pharmacokinetics-Pharmacodynamics of Antibiotics: an Integrated 2-days Course

(F. Van Bambeke & P.M. Tulkens - Hanoi University of Pharmacy, Hanoi, Vietnam - 18-19 April 2011 - withe the support of Wallonie-Bruxelles International [see "cooperation"])

• 0-Introduction
• 1-Microbiology
• 2-Pharmacokinetics
• 3A-Pharmacodynamics: concepts
• 3B-Pharmacodynamics: methods
• 3C-Pharmacodynamics: actual data
• 4A-Resistance: mechanims
• 4B-Resistance and PK/PD
• 5A-Aminoglycosides (updated: 3 October 2011)
• 5B-Beta-lactams by continuous infusion (updated: 3 October 2011)
  
  
• All of the above in a single ZIP file ( !! about 10 Mbytes)

Pharmacokinetics-Pharmacodynamics of Antibiotics

(E. Ampe, F. Van Bambeke & P.M. Tulkens - Course created in 2004 for presentation to the 15th European Conference on Clinical Microbiology and Infectious Diseases (ECCMID), Copenhagen, Denmark, April 2-5, 2005; see poster)

This course, which contains Belgian Guidelines as published in 2005 [section 5], exists only in French (FR) and Dutch (NL)
Please, refer to 2011 (above) for a version in English (without guidelines but new items [aminglycosides and beta-lactams by continuous infusion [section 5])

• 0-Introduction FR - NL
• 1-Microbiology: Basics FR - NL
• 2-Pharmacokinetics FR - NL
• 3A-Pharmacodynamics: Concepts FR - NL
• 3B-Pharmacodynamics: Methods FR - NL
• 3C-Pharmacodynamics: Actual data FR - NL
• 4A-Resistance: Mechanisms FR - NL
• 4B-Resistance and PK/PD FR - NL
• 5A-Guidelines: Principles FR - NL
• 5B-Guidelines: Respiratory tract infections FR - NL
• 5C-Guidelines: Urinary tract infections FR - NL
  
  
• All of the above in a single ZIP file ( !! about 12 Mbytes) FR - NL

Asian PK/PD Educational Workshop

(M.R. Jacobs [Case Western Reserve University, Cleveland, OH], & P.M. Tulkens - Course created in 2003 for presentation to an educational workshop organized by GlaxoSmithKline in Taipeh, Taiwan on 4 January 2003)

• 0-Welcome and General Introduction (PMT)
• 1-Microbial susceptibility (MRJ)
• 2-Pharmacokinetics: concepts (PMT)
• 3-Pharmacokinetics: applications (MRJ)
• 4-Pharmacodynamics: concepts (PMT)
• 5-Pharmacodynamics: animal models (PMT)
• 6-Pharmacodynamics: examples with selected antibiotics (MRJ)
• 7-New approaches in PK/PD (PMT)
• 8-Population-based approaches: Regulatory issues and Population simulations (MRJ)
• 9-PK-PD and resistance (PMT)
• 10-Applications of PK/PD to Respiratory Tract Infections (MRJ)
  
  
• All of the above in a single ZIP file ( !! about 6 Mbytes)