• University Theses (Thèses d'agrégation de l'enseignement supérieur)
  Holders have performed at least 4-10 years of post-doctoral work and have published serveral original and review papers of excellent quality on their research topic. They are considered as experts in their field in a broad sense. Awarding of the title is made by the Rector of University upon recommendation of an ad-hoc committee and after (i) the formal submission of a wtitten Thesis, supported by review papers; ii) the formal defense of the Thesis, together with 3 subsidiary theses (Thèses annexes); (iii) the formal presentation of a Public Lecture on a topic decided on by the Jury.
  
  
• PhD Theses (Thèses de Doctorat)
  Holders have presented an original experimental work supported by the publication of at least two original papers in Scientifc Journals of an impact factor of at least 2. The presentation is made accordign a two steps procedure (i) a private defense for the Jury only; (ii) a public defense and the formal publication of the Thesis.
  
  
• DEA (Diplôme d'Etudes Approfondies)
  Holders are graduated students (i.e. holders of a MSc. degree or equivalent) who have (i) performed a one-year research activity of a defined topic, (ii) have submitted a formal wtitten document (Mémoire), and (iii) have presented their data in front of a Jury. Some of these students may have published original papers in Scientifc Journals
  
  
• Master Degree Dissertations (Mémoires de fins d'études)
  Holders are young graduating students who (i) have performed a one-year research activities as part of their university studies; (ii) have presented their data in front of a Jury. Master Dissertation is compulsory for students registered (i) with the Faculty of Science (all orientations); (ii) in the Faculty of Medicine (orientation: Biomedical Sciences). It may also be presented by students in Pharmacy as part of their activities as "research students"

• Thesis
  • Full text (15 MB)
  • Slides (Public Defense and Public Lesson)
    • Main Thesis: WEB - PDF
      
    • Subsidiary theses (thèses annexes)
      • Inhibiting efflux pumps to restore antibiotic activity against Pseudomonas aeruginosa: WEB - PDF
      • Daptomycin: a new-old antibiotic or how did pharmacodynamics bring back to life a disappointing drug ?: WEB - PDF
      • Cholesterol transporters as new therapeutic targets: WEB - PDF
    • Public Lesson (in French): L'importance de la vie intracellulaire dans les infections bactériennes (PDF - 32 MB)
      
      
• Publications (reviews)
• Glycopeptide antibiotics: from conventional molecules to new derivatives (UCL only; copyright retained by the Publisher)
  Drugs (2004) 64:913-936
  
• Antibiotic efflux pumps in prokaryotic cells : occurence, impact on resistance and strategies for the future of antimicrobial therapy (UCL only; copyright retained by the Publisher)
  Journal of Antimicrobial Chemotherapy (2003) 51:1055-1065
  
• Antibiotic efflux pumps in eukaryotic cells: occurence and impact on antibiotic cellular pharmacokinetics, pharmacodynamics and toxicodynamics (UCL only; copyright retained by the Publisher)
  Journal of Antimicrobial Chemotherapy (2003) 51:1067-1077

Marie-Paule Mingeot-Leclercq (2000)

Biochemical and biophysical studies of the interactions between aminoglycoside antibiotics and lipid layers: a molecular approach to the understanding of the cellular toxicity induced by aminoglycoside antibiotics

• Slides (Public defense)
  
  
• Publications (reviews)
  • Aminoglycosides: activity and resistance (UCL only; copyright retained by the Publisher)
    Antimicrob Agents Chemother (1999) 43:727-737.
  • Aminoglycosides: nephrotoxicity (UCL only; copyright retained by the Publisher)
    Antimicrobial Agents and Chemotherapy (1999) 43:1003-1012.
  • Molecular parameters involved in aminoglycosides nephrotoxicity.
    Journal of Toxicology and Environmental Health (1995) 44:263-300.
  • Molecular description of the interactions of aminoglycoside antibiotics with negatively-charged phospholipids. Theoretical molecular modelling and experimental results.
    Life Science/Advances in Pharmacology (1995) 14:71-98.

• Publications (review):
  • Aminoglycoside-induced phospholipidosis and nephrotoxicity.
    Biochemical Pharmacology (1990) 40:2383-2392.
  • Kidney tissue repair after nephrotoxic injury : biochemical and morphological characterization.
    CRC Critical Review of Toxicolology (1988) 19:147-183.
  • Aminoglycoside nephrotoxicity: cellular and molecular aspects.
    In: ISI Atlas of Science: Pharmacology, Waverly Press, Baltimore, 40-44 (1987)
    

Hayet Bensikaddour (2011)

Interactions between fluroquinolones and lipids: biophysical studies

PhD in Biomedical and Pharmaceutical Sciences (Orientation: Pharmaceutical Sciences)

• Thesis
  • Full text
  • Public Defense (slides)
    
    
• Publications
  • Interactions of ciprofloxacin with DPPC and DPPG: Fluorescence anisotropy, ATR-FTIR and 31P NMR spectroscopies and conformational analysis
    Biochimica Biophysica Acta (Biomembranes) (2008) 1778:2535-2543 (Original paper)
    
  • Characterization of the interactions between fluoroquinolone antibiotics and lipids: a multitechnique approach
    Biophysical Journal (2008) 94:3035-3046 (Original paper)

Pierre Baudoux (2010)

Antibiotic activity against intracellular Staphylococcus aureus

PhD in Sciences (Doctorat en Sciences)

• Publications
  • Activity of quinupristin-dalfopristin against extracellular and intracellular Staphylococcus aureus with various resistance phenotypes
    Journal of Antimicrobial Chemotherapy (2010) 65:1228-1236 (Original paper)
  • Combined effect of pH and concentration on the activities of gentamicin and oxacillin against Staphylococcus aureus in pharmacodynamic models of extracellular and intracellular infections.
    Journal of Antimicrobial Chemotherapy (2007) 59:246-53 (Original paper)

Sébastien Van de Velde (2010)

Intracellular localization of Listeria monocytogenes: impact on its proteome and antibiotic treatments

PhD in Biomedical and Pharmaceutical Sciences (Doctorat en Sciences Biomédicales et Pharmaceutiques)

• Publications
  • Isolation and 2D-DIGE proteomic analysis of intracellular and extracellular forms of Listeria monocytogenes.
    Proteomics (2009) 9:5484-5496 (Original paper)
  • Penicillin-binding Proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in beta-lactam sensitivity of Listeria monocytogenes.
    Gut Pathogens (2009) 1:23 (Original paper)
  • Contrasting effects of human THP-1 cells differentiation on levofloxacin and moxifloxacin intracellular accumulation and activity against Staphylococcus aureus and Listeria monocytogenes.
    Journal of Antimicrobial Chemotherapy (2008) 62:518-52 (Original paper)

Isabelle Tytgat (2008)

Les DD-ligases comme cibles de nouveaux antibiotiques : Caractérisation de l'activité enzymatique et étude d'inhibiteurs originaux

PhD in Sciences (Doctorat en Sciences)

• Publications
  • DD-Ligases as a Potential Target for Antibiotics: Past, Present and Future.
    Current Medicinal Chemistry (2009) 16: 2566-2580 (Review)
  • Structure-based design of benzoxazoles as new inhibitors for D-alanyl - D-alanine ligase
    QSAR and Combinatorial Sciences (2009) 28: 1394-1404 (Original paper)

Aurélie Olivier (2008)

Intracellular fate of Staphylococcus aureus in human phagocytic and non phagocytic cells and role of virulence factors

PhD in Sciences (Doctorat en Sciences)

• Thesis
  • Full text
    
    
• Publications
  • Role of rsbU and staphyloxanthin in phagocytosis and intracellular growth of Staphylococcus aureus in human macrophages and endothelial cells.
    Journal of Infectious Diseases (2009) 200:1367-1370 (Original paper)
  • Restoration of susceptibility of intracellular Methicillin Resistant Staphylococcus aureus (MRSA) to beta-lactams: comparison between strains, cells, and antibiotics
    Antimicrobial Agents and Chemotherapy (2008) 52:2997-2805 (Original paper)

Sandrine Lemaire (2008)

Intracellular Staphylococcus aureus, an emerging link to persistent and relapsing infections: factors influencing the activity of antimicrobials against intracellular S. aureus

PhD in Biomedical and Pharmaceutical Sciences (Doctorat en Sciences Biomédicales et Pharmaceutiques)

• Thesis
  • Full text
  • Public defense: slides
    
    
• Publications
  • Activities of antistaphylococcal antibiotics towards the extracellular and intraphagocytic forms of S. aureus isolates from a patient with persistent bacteraemia and endocarditis
    Clinical Microbioloy and Infection (2008) 14:766-777 (Original paper)
    
  • Restoration of susceptibility of intracellular Methicillin Resistant Staphylococcus aureus (MRSA) to beta-lactams: comparison between strains, cells, and antibiotics
    Antimicrobial Agents and Chemotherapy (2008) 52:2997-2805 (Original paper)
  • Restoration of susceptibility of methicillin-resistant Staphylococcus aureus (MRSA) to beta-lactam antibiotics by acidic pH: role of penicillin-binding-protein 2A (PBP 2A)
    Journal of Biological Chemistry (2008) 283:12769-12776 (Original paper)
  • Role of Acidic pH in the Susceptibility of Intraphagocytic Methicillin-Resistant Staphylococcus aureus Strains to Meropenem and Cloxacillin
    Antimicrobial Agents and Chemotherapy (2007) 51:1627-1632. (Original paper)
  • Modulation of the Cellular Accumulation and Intracellular Activity of Daptomycin towards phagocytized Staphylococcus aureus by the P-glycoprotein (MDR1) Efflux Transporter in human THP-1 macrophages and Madin-Darby canine kidney cells.
    Antimicrobial Agents and Chemotherapy (2007) 51:2748-275 (Original paper)

Jean-Michel Michot (2007)

Double-edged effect of a MRP- like transporter on pharmacokinetics, pharmacodynamics and toxicodynamics of quinolones antibiotics in macrophages:
involvement of a common efflux pathway

PhD in Biomedical and Pharmaceutical Sciences (Doctorat en Sciences Biomédicales et Pharmaceutiques)

• Publications
  • Cellular accumulation and activity of quinolones in ciprofloxacin-resistant J774 macrophages.
    Antimicrobial Agents and Chemotherapy (2006) 50:1689-1695 (Original paper)
  • Quinolones in 2005: an update
    Clinical Microbiology and Infection (2005) 11:256-280 (Review)
  • Influence of efflux transporters on the accumulation and efflux of four quinolones (ciprofloxacin, levofloxacin, garenoxacin, and moxifloxacin) in J774 macrophages.
    Antimicrobial Agents and Chemotherapy (2005) 49:2429-2437 (Original paper)
  • Active efflux of ciprofloxacin from J774 macrophages through an MRP-like transporter.
    Antimicrobial Agents and Chemotherapy (2004) 48:2673-2682 (Original paper)
  • Antibiotic efflux pumps in eukaryotic cells: occurence and impact on antibiotic cellular pharmacokinetics, pharmacodynamics and toxicodynamics.
    Journal of Antimicrobial Chemotherapy (2003) 51:1067-1077 (Review)

Maritza Barcia-Macay (2007)

Activity of antibiotics against extracellular and intracellular forms of Staphylococcus aureus : Pharmacodynamic studies in vitro using a model of human THP-1 macrophages

PhD in Biomedical and Pharmaceutical Sciences (Doctorat en Sciences Biomédicales et Pharmaceutiques)

• Thesis
  • Full text
  • Public defense: slides
    
    
• Publications
  • Cellular pharmacokinetics of telavancin, a novel lipoglycopeptide antibiotic, and analysis of lysosomal changes in cultured eukaryotic cells (J774 mouse macrophages; rat embryonic fibroblasts).
    Journal of Antimicrobial Chemotherapy (2008) 61:1288-1294 (Original paper)
  • Evaluation of the Extracellular and Intracellular Activities (human THP-1 macrophages) of Telavancin vs. Vancomycin against Methicillin-susceptible, Methicillin-resistant, Vancomycin-intermediate and Vancomycin-resistant Staphylococcus aureus
    Journal of Antimicrobial Chemotherapy (2006) 58:1177–1184 (Original paper)
  • Pharmacodynamic evaluation of the intracellular activity of antibiotics against Staphylococcus aureus in a model of THP-1 macrophages.
    Antimicrobial Agents and Chemotherapy (2006) 50:841-8 (Original paper)

Anne Spinewine (2006)

Appropriate use of medicines in care of the elderly: factors uderlying inapproriateness, and impact of the clinical pharmacist

PhD in Pharmaceutical Sciences (Doctorat en Sciences Pharmaceutiques)

• Thesis
  • Full text (2.6 MB)
  • Public defense: slides (1.5 MB)
    
    
• Publications
  • Implementation of ward-based clinical pharmacy services in Belgium - Description of the impact on a geriatric unit.
    Annals of Pharmacotherapy (2006) 40:720-728
  • Appropriateness of use of medicines in elderly inpatients: qualitative study
    British Medical Journal (2005) 331:935-940
  • La pharmacie clinique, une nouvelle orientation pharmaceutique au service des patients: réalisations à l'étranger et possibilités en Belgique.
    Louvain Médical (2003) 122:127-139

Helène Servais (2006)

Lysosomes, weapons or shield in gentamicin-induced apoptosis?

PhD in Pharmaceutical Sciences (Doctorat en Sciences Pharmaceutiques)

• Thesis
  • Full text: high resolution (16 MB) - low resolution (9MB)
  • Public defense: slides (7 MB)
    
    
• Publications:
  • Antibiotic-induced nephrotoxicity
    In: Toxicology of the Kidney (Target Organ Toxicology Series), 2004, chap. 16, pp 635-685, J.B. Tarloff & L.H. Lash, eds., CRC Press, Boca Raton, Fla. (Review)
  • Gentamicin-induced apoptosis in LLC-PK1 cells: involvement of lysosomes and mitochondria
    Toxicology and Applied Pharmacolology (2005) 15:321-333 (Original paper)
  • Gentamicin causes apoptosis at low concentrations in renal LLC-PK1 cells subjected to electroporation
    Antimicrobial Agents and Chemotherapy (2006) 50:1213-122 (Original paper)

Stéphane Carryn (2003)

Control of intracellular Listeria monocytogenes growth by antibiotics and granulocyte-macrophage colony stimulating factor

PhD in Pharmaceutical Sciences (Doctorat en Sciences Pharmaceutiques)

• Publications
  • Comparative intracellular (THP-1 Macrophage) and extracellular activities of beta-lactams, azithromycin, gentamicin, and fluoroquinolones against Listeria monocytogenes at clinically relevant concentrations
    Antimicrobial Agents and Chemotherapy (2002) 46:2095-2103 Original paper
  • Intracellular pharmacodynamics of antibiotics
    Infectious Disease Clinics of North America (2003) 17:615-634 (Review)
  • Activity of beta-lactams (ampicillin, meropenem), gentamicin, azithromycin and moxifloxacin against intracellular Listeria monocytogenes in a 24h THP-1 human macrophage model
    Journal of Antimicrobial Chemotherapy (2003) 51:1051-1052 (Original paper)
  • Impairment of growth of Listeria monocytogenes in THP-1 macrophages by granulocyte macrophage colony-stimulating factor : release of tumor necrosis factor-a and nitric oxide
    The Journal of Infectious Diseases (2004) 189:2101-2109 (Original paper)

Donatienne Tyteca (2002)

Azithromycin, a pharmacological agent which selectively inhibits some pathways of endocytosis: characterization, interests and mechanism of action

PhD in Pharmaceutical Sciences (Doctorat en Sciences Pharmaceutiques)

• Thesis
  • Full text: high resolution (18 Mb) | low resolution (3.4 Mb)
  • Public defense: Slides (HTML and PDF)
    
    
• Publications:
  • Azithromycin, a lysosomotropic antibiotic, impairs fluid-phase pinocytosis in cultured fibroblasts
    European Journal of Cell Biology (2001) 80:466-478 (Original paper)
  • Azithromycin, a lysosomotropic antibiotic, has distinct effects on fluid-phase and receptor-mediated endocytosis, but does not impair phagocytosis in J774 macrophages
    Experimental Cell Research (2002) 281:86-100 (Original paper)
  • The macrolide antibiotic azithromycin ineracts with lipids and affects membrane organization and fluidity: studies on Langmuir-Blodgett monolayers, liposomes and J774 macrophages
    Journal of Membrane Biology (2003) 192:203-215 (Original paper)

Mohammed El Mouedden (2000)

Mise en évidence et étude de l'apoptose induite par les antibiotiques du groupe des aminoglycosides

PhD in Biomedical Sciences (Doctorat en Sciences Biomédicales - orientation: biologie et pharmacologie cellulaires)

• Thesis
  • slides
    
    
• Publications
  • Apoptosis in renal proximal tubules of rats treated with low doses of aminoglycosides.
    Antimicrobial Agents and Chemotherapy (2000) 44:665-675 (Original paper)
  • Gentamicin-induced apoptosis in renal cell lines and embryonic rat fibroblasts.
    Toxicological Sciences (2000) 56:229-239 (Original paper)

Isabelle Paternotte-Henry (2000)

Conception, synthèse et évaluation de prodrogues esters basiques d'ampicilline en vue d'une action microbicide intracellulaire

PhD in Sciences (Doctorat en Sciences - orientation: chimie)

• Publication
  • Ester prodrugs of ampicillin tailored for intracellular accumulation.
    Bioorg Med Chem Lett (1997) 7:3107-311 (Original paper)

PhD in Sciences (Doctorat en Sciences - orientation: biologie)

• Publications
  • Lysosomal alterations induced in cultured rat fibroblasts by long-term exposure to low concentrations of azithromycin.
    J Antimicrob Chemother (1998) 42:761-767 (Original paper)
  • Hyperactivity of cathepsin B and other lysosomal enzymes in fibroblasts exposed to azithromycin, a dicationic macrolide antibiotic with exceptional tissue accumulation.
    FEBS Lett (1996) 394:307-310 (Original paper)

Modulation de l'infection intracellulaire à Listeria monocytogenes et de l'activité intrinsèque des antibiotiques par l'interféron gamma et l'interleukine 6

PhD in Biomedical Sciences (Docteur en Sciences Biomédicales - orientation: Biologie et pharmacologie cellulaires)

• Publications
  • Modulation of intracellular growth of Listeria monocytogenes in human enterocyte-like Caco-2 cells by interferon-gamma and interleukin-6: role of nitric oxide and cooperation with antibiotics.
    J Infect Dis (1999) 180:1195-1204 (Original paper)
  • Mechanism of the intracellular killing and modulation of antibiotic susceptibility of Listeria monocytogenes in THP-1 macrophages activated by gamma-interferon.
    Antimicrob Agents Chemother (1999) 43:1242-1251(Original paper)

Etudes des surcharges lysosomiales induites par l'azithromycine dans des cellules en culture: effets sur les phospholipides et le cholestérol cellulaires

PhD in Pharmaceutical Sciences (Doctorat en Sciences Pharmaceutiques)

• Publications
  • Interactions of macrolide antibiotics (erythromycin A, roxithromycin, erythromycylamine and azithromycin) with phospholipids: computer-aided conformational analysis and studies on acellular and cell culture models.
    Toxicol Applied Pharmacol (1999) 156:129-140 (Original paper)
  • Interaction of the macrolide azithromycin with phospholipids. II. Biophysical and computer-aided conformational studies.
    Eur J Pharmacol (1996) 314:215-22 (Original paper)
  • Interaction of the macrolide azithromycin with phospholipids. I. Inhibition of lysosomal phospholipase A1 activity.
    Eur J Pharmacol (1996) 314:203-214. (Original paper)

Influence des antibiotiques du groupe des aminoglycosides sur les propriétés membranaires: études sur liposomes

PhD in Pharmaceutical Sciences (Doctorat en Sciences Pharmaceutiques)

• Publications
  • Aminoglycoside antibiotics prevent the formation of non bilayer structures in negatively-charged membranes. Comparative studies using fusogenic [bis-(beta-diethylaminoethylether)hexestrol] and aggregating (spermine) agents.
    Chem Phys Lipids (1996) 79:123-135. (Original paper)
  • Aminoglycoside antibiotics induce aggregation but not fusion of negatively-charged liposomes.
    Eur J Pharmacol (1995) 289:321-333. (Original paper)
  • Alterations in membrane permeability induced by aminoglycoside antibiotics: studies on liposomes and cultured cells.
    Eur J Pharmacol (1993) 247:155-168. (Original paper)

Conception de modèles quantitatifs d'infection intracellulaire pour l'étude de l'action des antibiotiques

PhD in Biomedical Sciences (Doctorat en Sciences Biomédicales - orientation: biologie et pharmacologie cellulaires)

• Publication
  • Effect of recombinant human gamma interferon on intracellular activities of antibiotics against Listeria monocytogenes in the human macrophage cell line THP-1.
    Antimicrob Agents Chemother (1996) 40:1225-1230. (Original paper)

In vitro models for the study of the regulation of the activity of lysosomal phospholipase A1 by membrane lipids and of its inhibition by aminoglycoside antibiotics

PhD in Sciences (Doctorat en Sciences - orientation: chimie)

• Publication
  • Effect of substrate organization on the activity and on the mechanism of gentamicin-induced inhibition of rat liver lysosomal phospholipase A1.
    Biochem Pharmacol (1992) 43:895-898. (Original paper)

Evaluation systématique et prospective du potentiel toxique de nouveaux aminoglycosides

PhD in Biomedical Sciences (Sciences Biomédicales)

The mechanism of aminoglycoside binding to isolated brush border membrane of proximal tubular cells

PhD in Biomedical Sciences (Doctorat en Sciences Biomédicales - orientation: biologie et pharmacologie cellulaires)

Renal phospholipidosis and phospholipiduria induced by aminoglycoside antibiotics: animal and human studies

PhD in Biomedical Sciences (Doctorat en Sciences Biomédicales: orientation: biologie et pharmacologie cellulaires)

• Publications
  • Urinary phospholipids excretion in neonates treated with amikacin.
    Int J Clin Pharm Res (1994) 14:149-156. (Original paper)
  • Once-a-day administration of amikacin in neonates: assessment of nephrotoxicity and ototoxicity.
    Dev Pharmacol Ther (1993) 20:220-230. (Original paper)

Polyanionic compounds as protectants against aminoglycoside-induced nephrotoxicity

PhD in Biomedical Sciences (Doctorat en Sciences Biomédicales: orientation: biologie et pharmacologie cellulaires)

• Publications
  • Comparative assessment of poly-L-aspartic and poly-L-glutamic acids against gentamicin-induced renal lysosomal phospholipidosis, phospholipiduria and cell proliferation in rats.
    J Pharmacol Exp Ther (1992) 262:424-432 (Original paper)
  • Mechanism of protection afforded by polyaspartic acid against gentamicin-induced phospholipidosis. I. Polyaspartic acid binds gentamicin and displaces it from negatively charged phospholipid layers in vitro.
    J Pharmacol Exp Ther (1990) 255:867-874.(Original paper)
  • Mechanism of protection afforded by polyaspartic acid against gentamicin-induced phospholipidosis. II. Comparative in vitro and in vivo studies with poly-L-aspartic, poly-L-glutamic and poly-D-glutamic acids.
    J Pharmacol Exp Ther (1990) 255:875-885 (Original paper)

Construction, characterization and evaluation of the cellular delivery of diptheria toxin fragment B - associated liposomes containing ribavirin

PhD in Sciences (Doctorat en Sciences - orientation: biologie)

Marie-Paule Mingeot-Leclercq (1988)

Mécanisme moléculaire de la néphrotoxicité induite par les aminoglycosides : études biochimiques et biophysiques

PhD in Pharmaceutical Sciences (Doctorat en Sciences Pharmaceutiques)

• Publications
  • Effect of acidic phospholipids on the activity of lysosomal phospholipases and on their inhibition by aminoglycoside antibiotics. I. Biochemical analysis.
    Biochem Pharmacol (1990) 40:489-497. (Original paper)
  • Effect of acidic phospholipids on the activity of lysosomal phospholipases and on their inhibition by aminoglycoside antibiotics. II. Conformational analysis.
    Biochem Pharmacol (1990) 40:499-506. (Original paper)
  • Ultrastructural, physico-chemical and conformational study of the interactions of gentamicin and bis(beta-diethylaminoethylether)hexestrol with negatively charged phospholipid bilayers.
    Biochem Pharmacol (1989) 38:729-741. (Original paper)
  • Biochemical mechanism of aminoglycoside-induced inhibition of phosphatidylcholine hydrolysis by lysosomal phospholipases.
    Biochem Pharmacol (1988) 37:591-599. (Original paper)

Mise au point de modèles pour l'étude de dérivés lysosomotrophes de beta-lactames

PhD in Sciences (Doctorat en Sciences - orientation: biologie)

• Publications
  • Coupling products of amino acids to penicillin V and cephalothin: synthesis, and susceptibility to carboxypeptidases and lysosomal enzymes.
    J Med Chem (1988) 31:976-983. (Original paper)
  • Influence of conversion of penicillin G into a basic derivative on its accumulation and subcellular localization in cultured macrophages.
    Antimicrob Agents Chemother (1987) 31:410-416. (Original paper)

Interactions entre les aminoglycosides et les structures subcellulaires du cortex renal chez le rat: études biochimiques et morphologiques à doses faibles

PhD in Applied Biomedical Sciences (Doctorat en Sciences Biomédicales Appliquées)

• Publication
  • Impairment of lysosome-pinocytic vesicle fusion in rat kidney proximal tubules after treatment with gentamicin at low doses.
    Toxicol Appl Pharmacol (1986) 86:271-285. (Original paper)

Marie-Béatrice Carlier (1984)

La phospholipidose rénale induite par les aminoglycosides: étude biochimique et morphologique

PhD in Applied Pharmaceutical Sciences  (Doctorat en Sciences Pharmaceutiques Appliquées)

• Publication
  • Inhibition of lysosomal phospholipases by aminoglycoside antibiotics: in vitro comparative studies.
    Antimicrob Agents Chemother (1983) 23:440-449. (Original paper)
  • Mechanism of aminoglycoside-induced lysosomal phospholipidosis: in vitro and in vivo studies with gentamicin and amikacin.
    Biochem Pharmacol (1982) 31:3861-3870 (Original paper)

Implication des hémolysines de S. aureus dans le développement de l'infection intracellulaire dans une lignée de cellules phagocytaires

• Slides

Activité des quinolones vis-à-vis des formes extracellulaires et intracellulaires de Listeria monocytogenes : modulation par les pompes à efflux bactériennes et eucaryotes

• Slides
• Publication (Antimicrob. Agents Chemother.)

Perfusion continue des beta-lactames: 1. Etude de la compatibilité du céfépime en vue de son administration par perfusion continue; 2. Etude clinique comparative de la perfusion continue et de l'administration conventionnelle chez les patients atteints de pneumonie nosocomiale (étude pharmacocinétique, pharmacodynamique et pharmacoéconomique).

• Publication (J. Antimicrob. Chemother.)

Etude de la stabilité et de la compatibilité de la ceftazidime en vue de son administration par perfusion continue chez des patients atteints de pneumopathies nosocomiales

• Publication (Antimicrob. Agents Chemother.)
  

• Poster

Toxicité des fluoroquinolones et des inhibiteurs de topoisomérases I et II dans des cellules exposées de façon chronique aux fluoroquinolones

• Publication (Toxicology)

Rôle des transporteurs multidrogues (MDR) dans l'accumulation cellulaire d'antibiotiques dans les macrophages J774

• Poster
• Publication (Int J.. Antimicrob. Ag.)

L’efflux actif comme mécanisme d’interactions médicamenteuses : Compétition entre Fluoroquinolones et Antiviraux dans un modèle de macrophages J774

• Full text
• Slides
• Oral presentation

Implication des transporteurs ABC dans l’efflux de médicaments au niveau des cellules eucaryotes.

• Poster

• Slides

Apoptose : un marqueur de toxicité des aminoglycosides? Étude comparative sur cellules en culture incubées avec de la gentamicine et de l’amikacine.

• Slides
• Publication

L’efflux actif comme mécanisme d’interactions médicamenteuses : compétition entre fluoroquinolones et AINS pour un même transporteur dans un modèle de macrophages J774

• Slides
• Poster

• Publication (J. Antimicrob. Chemother.)

• Publication (J. Antimicrob. Chemother.)

Accumulation et efflux des fluoroquinolones dans des macrophages J774 sauvages et résistants à la ciprofloxacine

• Slides
• Publication (Antimicrob.Agents Chemother.)

• Full text (PDF)
  
• Publication (J. Antimicrob. Chemother.)

Influence du glatiramer sur l'infection intracellulaire des THP-1 à Listeria monocytogenes et sur l'activité des antibiotiques

• Publication (J. Antimicrob. Chemother.)