Table of Contents
PK / PD (pharmacokinetics / pharmacodynamics) like
magic
The ideal antibiotic ...
Will it always be ideal ?
Main causes of antibiotic failures... Adapted from
Pechère J.C., 1988, 1993, 1998
Pharmacokinetics / pharmacodynamics as a step towards
therapy...
Pharmacokinetics ...
Pharmacodynamics ...
Pharmacokinetics / Pharmacodynamics in drug development
and evaluation of efficacy
PK/PD in drug develop-ment A view from FDA
Are PK/PD important for efficacy / toxicity ?
Pharmacokinetic/ Pharmacodynamics and antibiotic
resistance...
Are PK / PD important in resistance ?
PK/PD parameters: a first sight
PK/PD parameters : a 2d sight
Pharmacokinetics / Pharmacodynamics
PK/PD patterns of antimicrobial activity (1 of
3) (after WA. Craig, 2000)
PK/PD patterns of antimicrobial activity (2 of
3) (after WA. Craig, 2000)
PK/PD patterns of antimicrobial activity (3 of
3) (after WA. Craig, 2000)
PK/PD: role of concentration an example with extracellular
Listeria monocytogenes
Role of extracellular concentration an example
with intracellluar Listeria monocytogenes
Pharmacokinetics / Pharmacodynamics in action ...
Aminoglycosides : obtain a peak !
Aminoglycosides: practical applications for a 30
min infusion
Pharmacokinetics / Pharmacodynamics in action ...
Pharmacokinetics / Pharmacodynamics in action ...
?-lactams : remain at least 50 % of the time above
the MIC...
Typical pharmacokinetics of a model ?-lactam *
? - lactams * in clinical practice:
Pharmacokinetics / Pharmacodynamics in action ...
? - lactams * in clinical practice: giving them
more frequently
? - lactams * in clinical practice : influence
of the schedule on potential breakpoint
Pharmacokinetics / Pharmacodynamics in action ...
PK/PD of fluoroquinolones: role of the 24h-AUC
MIC ciprofloxacin in hospital-acquired pneumonia
AUC / MIC ratio
PPT Slide
PPT Slide
PPT Slide
Pharmacokinetics / Pharmacodynamics in action ...
24h-AUC / MIC as a tool to determine acceptable
sensitivities to fluoroquinolones (p.o.)
The role of the peak for fluoroquinolones ...
Peak concentrations as a tool to determine acceptable
sensitivities to fluoroquinolones (p.o.)
Combining it all …(Peak and 24h-AUC / MIC) as predictors
of efficacy of FQ ...
Pharmacokinetics / Pharmacodynamics in action ...
Pharmacokinetics / Pharmacodynamics in action ...
Where are we ?
Can we simplify it all ?...
Can we simplify it all ?...
AUC24h / MIC and ?-lactams...
Adapting ?-lactam dosages based on AUC24h / MIC
Adapting ciprofloxacin dosage based on AUC24h /
MIC
AUC24h / MIC and aminoglycosides ...
PPT Slide
PK / PD: do they help ?
and let us hope we have a bright future...
Isn’t that all magic ? ... |