1. Erythromycine et néomacrolides actuels: usages cliniques et perspectives.
   Van Bambeke F, Verhaegen J, Tyteca D, Auckenthaler R, Tulkens PM
   Médecine & Hygiène (2001) : in press.
   Educational paper
   
   
2. Erytromycine en de huidige neomacroliden: klinisch gebruik en perspectieven.
   Van Bambeke F, Verhaegen J, Tyteca D, Auckenthaler R, Tulkens PM
   Tijdscrift voor Geneeskunde (2001) : in press.
   Educational paper
   
   
3. Gentamicin-induced apoptosis in renal cell lines and embryonic rat fibroblasts.
   El Mouedden M, Laurent G, Mingeot-Leclercq MP, Tulkens PM
   Tox Sci (2000) 56:229-239.
   Original paper -- Journal impact factor: 1.778 (in 1999)
   Abstract -- Reprint (PDF file - UCL only - copyright owned by the publisher)
   
   
4. Apoptosis in renal proximal tubules of rats treated with low doses of aminoglycosides.
   El Mouedden M, Laurent G, Mingeot-Leclercq MP, Taper HS, Cumps J, Tulkens PM
   Antimicrob Agents Chemother (2000) 44:665-675.
   Original paper -- Journal impact factor: 3.761 (in 1998)
   Abstract -- Reprint (PDF file - UCL only - copyright owned by the publisher)
   
   
5. Synthesis and biological evaluation of ester prodrugs of beta-lactams.
   Paternotte I
   In: PhD Thesis (Thèse présentée en vue de l'obtention du grade de Docteur en Sciences [Chimie], Université catholique de Louvain, Bruxelles), (2000)
   PhD Thesis
   
   
6. Modeling of the Enterococcus faecalis D-alanine:D-alanine ligase: Structure-based study of the active site in the wild-type enzyme and in glycopeptide-dependent mutants.
   Prévost M, Van Belle D, Tulkens PM, Courvalin P, Van Bambeke F
   J Mol Microbiol Biotechnol (2000) 2:321-330.
   Original paper -- Journal impact factor: not known (new journal)
   Abstract
   
   
7. New strategies to avoid developement of microbial resistance.
   Tulkens PM
   In: Ochsner Clinic Sympoisum on resistance and the Use and Misuse of Antimicrobial Therapy, G.A. Pankey & G.D. Campbell ed., A.M.M. & Co, Inc, Newtown, PA, 44-52 (2000)
   Educational paper
   
   
8. Coût biologique de la résistance aux antibiotiques: vancomycine-dépendance, le prix ultime bactérien?.
   Van Bambeke F, Courvalin P
   La Lettre de l'Infectiologue (2000) 15:285-294.
   Educational paper
   Abstract
   
   
9. Antibiotic efflux pumps (Commentary).
   Van Bambeke F, Balzi E, Tulkens PM
   Biochem Pharmacol (2000) 60:457-470.
   Review -- Journal impact factor: 2.755 (in 1999)
   Abstract -- Reprint (PDF file - UCL only - copyright owned by the publisher)
   
   
10. Biophysical studies and intracellular destabilization of pH-sensitive liposomes.
    Van Bambeke F, Kerkhofs A, Schanck A, Remacle C, Sonveaux E, Tulkens PM, Mingeot-Leclercq MP
    Lipids (2000) 35:213-223.
    Original paper -- Journal impact factor: 2.040 (in 1999)
    Abstract
    
    
11. Erythromycine et néomacrolides actuels, usages cliniques et perspectives.
    Van Bambeke F, Verhaege J, Tyteca D, Auckenthaler R, Tulkens PM
    Louvain Med (2000) 119:259-286.
    Educational paper
    Abstract -- Reprint (PDF file - UCL only - copyright owned by the publisher)
    
    
12. Saccharomyces boulardii upgrades cellular adaptation following proximal enterectomy in rats.
    Buts J-P, De Keyser N, Marandi S, Hermans D, Sokal EM, Chae Y-HE, Lambotte L, Chanteux H, Tulkens PM
    Gut (1999) 45:89-96.
    Original paper -- Journal impact factor: 5.111 (in 1998)
    Abstract -- Reprint (PDF file - UCL only - copyright owned by the publisher)
    
    
13. Hyperactivité des enzymes lysosomiales induite par l'azithromycine dans les fibroblastes d'embryon de rats: caractérisation et études mécanistiques.
    Gerbaux-Morlighem C
    In: PhD Thesis (Thèse présentée en vue de l'obtention du grade de Docteur en Sciences [Biologie]), Université Catholique de Louvain, Louvain-La-Neuve, Belgium, pp 120 (1999)
    PhD Thesis
    
    
14. Etude de transporteurs d'efflux de fluoroquinolones dans les cellules eucaryotes: le cas de la ciprofloxacine.
    Michot JM
    In: Mémoire présenté en vue de l'obtention du Diplôme d'Etudes Approfondies (DEA) en Sciences Pharmaceutiques, pp 52 (1999)
    MSc dissertation
    
    
15. Aminoglycosides: nephrotoxicity.
    Mingeot-Leclercq MP, Tulkens PM
    Antimicrob Agents Chemother (1999) 43:1003-1012.
    Review -- Journal impact factor: 3.761 (in 1998)
    Abstract -- Reprint (PDF file - UCL only - copyright owned by the publisher)
    
    
16. Aminoglycosides: activity and resistance.
    Mingeot-Leclercq MP, Glupczynski Y, Tulkens PM
    Antimicrob Agents Chemother (1999) 43:727-737.
    Review -- Journal impact factor: 3.761 (in 1998)
    Abstract -- Reprint (PDF file - UCL only - copyright owned by the publisher)
    
    
17. Interactions of macrolide antibiotics (erythromycin A, roxithromycin, erythromycylamine and azithromycin) with phospholipids: computer-aided conformational analysis and studies on acellular and cell culture models.
    Montenez JP, Van Bambeke F, Piret J, Brasseur R, Tulkens PM, Mingeot-Leclercq MP
    Toxicol Applied Pharmacol (1999) 156:129-140.
    Original paper -- Journal impact factor: 2.654 (in 1998)
    Abstract
    
    
18. Modulation de l'infection intracellulaire à L. monocytogenes et de l'activité intrinsèque des antibiotiques par l'interféron-gamma et l'interleukine-6.
    Ouadrhiri Y
    In: PhD Thesis (Thèse présentée en vue de l'obtention du grade de Docteur en Sciences Biomédicales [orientation: Biologie et Pharmacologie cellulaires]), Université Catholique de Louvain, Bruxelles, Belgium, pp 155 (1999)
    
    
    
19. Mechanism of the intracellular killing and modulation of antibiotic susceptibility of Listeria monocytogenes in THP-1 macrophages activated by gamma-interferon.
    Ouadrhiri Y, Scorneaux B, Sibille Y, Tulkens PM
    Antimicrob Agents Chemother (1999) 43:1242-1251.
    Original paper -- Journal impact factor: 3.761 (in 1998)
    Abstract -- Reprint (PDF file - UCL only - copyright owned by the publisher)
    
    
20. Modulation of intracellular growth of Listeria monocytogenes in human enterocyte-like Caco-2 cells by interferon-gamma and interleukin-6: role of nitric oxide and cooperation with antibiotics.
    Ouadrhiri Y, Sibille Y, Tulkens PM
    J Infect Dis (1999) 180:1195-1204.
    Original paper -- Journal impact factor: 4.966 (in 1998)
    Abstract -- Reprint (PDF file - UCL only - copyright owned by the publisher)
    
    
21. Apoptose induite par la vancomycine et par l'association vancomycine-gentamicine: études sur cellules rénales.
    Tchapkui N
    In: Mémoire présenté en vue de l'obtention du diplôme de licenciée en technologie biomédicale (Université catholique de Louvain, Bruxelles, Belgium), pp 83 (1999)
    MSc dissertation
    
    
22. L'infusion continue, un nouveau concept en antibiothérapie.
    Tulkens PM
    Vaisseaux, Coeur, Poumons (1999) 4:101-103.
    
    
    
23. Pharmacologie et pharmacothérapie anti-infectieuse. 1. Antibiotiques 2. Antifongiques 3. Antiviraux.
    Van Bambeke F, Tulkens PM
    In: Syllabus national belge de pharmacologie, A. Herchuelz ed., Presses Universitaires de Bruxelles, Belgium, pp 232 (1999)
    Book
    
    
24. Optimisation des traitements antibactériens sur base de propriétés pharmacodynamiques des antibiotiques.
    Van Bambeke F, Tulkens PM
    Médisphère (1999) 93:21-24.
    Educational paper
    
    
25. Vancomycin-dependent Enterococcus faecalis clinical isolates and revertant mutants.
    Van Bambeke F, Chauvel M, Reynolds PE, Fraimow HS, Courvalin P
    Antimicrob Agents Chemother (1999) 43:41-47.
    Original paper -- Journal impact factor: 3.761 (in 1998)
    Abstract -- Reprint (PDF file - UCL only - copyright owned by the publisher)
    
    
26. Anti-infective therapy: Mechanisms of action.
    Van Bambeke F, Lambert D, Mingeot-Leclercq MP, Tulkens PM
    In: Infectious Diseases, D. Armstrong and J. Cohen ed., Mosby, London, United Kingdom, 1.1-1.14 (1999)
    Chapter of book / Proceedings
    
    
27. Optimisation des traitements antibactériens sur base des propriétés pharmacodynamiques des antibiotiques.
    Van Bambeke F, Tyteca D, Ouadhriri Y, Tulkens PM
    Louvain Med (1999) 118:43-63.
    Educational paper
    Abstract
    
    
28. Computer-aided prediction of macrolide antibiotic concentrations in human circulating polymorphonuclear leucocytes.
    Bouvier d'Yvoire MJY, Dresco IA, Tulkens PM
    J Antimicrob Chemother (1998) 41:63-68.
    Original paper -- Journal impact factor: 2.563
    Abstract -- Reprint (PDF file - UCL only - copyright owned by the publisher)
    
    
29. Etude de l'accumulation d'antibiotiques (fluoroquinolones et bêta-lactames) dans les polymorphonucléaires humains.
    Burton S
    In: M. Sc. Dissertation (Mémoire présenté pour l'obtention du grade de Licencié en Technologie Biomédicale, Université Catholique de Louvain, Bruxelles, Belgium), pp 104 (1998)
    MSc dissertation
    
    
30. La maladie de Lyme: diagnostic et thérapeutique rationnels.
    Van Bambeke F, Bigaignon G, Ninane J, Tulkens PM
    Louvain Med (1998) 117:375-388.
    Educational paper
    
    
31. Lysosomal alterations induced in cultured rat fibroblasts by long-term exposure to low concentrations of azithromycin.
    Van Bambeke F, Gerbaux C, Michot J-M, Bouvier d'Yvoire M, Montenez JP, Tulkens PM
    J Antimicrob Chemother (1998) 42:761-767.
    Original paper -- Journal impact factor: 2.563
    Abstract -- Reprint (PDF file - UCL only - copyright owned by the publisher)
    
    
32. Aminoglycosides and vancomycin.
    Verpooten GA, Tulkens PM, Bennett WM
    In: Clinical nephrotoxins. Renal injury from drugs and chemicals, M.E. De Broe, G.A. Porter, W.M. Bennett & G.A. Verpooten ed., Kluwer Academic Publishers, The Netherlands, 105-120 (1998)
    Review
    
    
33. Ester prodrugs of ampicillin tailored for intracellular accumulation.
    Fan HJ, Paternotte I, Vermander M, Li K, Beaujean M, Scorneaux B, Dumont P, Tulkens PM, Sonveaux E
    Bioorg Med Chem Lett (1997) 7:3107-3112.
    Original paper -- Journal impact factor: 1.628
    Abstract -- Reprint (PDF file - UCL only - copyright owned by the publisher)
    
    
34. Usages cliniques actuels et raisonables des glycopeptides.
    Nachega J, Van Bambeke F, Vandercam B, Tulkens PM
    Louvain Med (1997) 116:162-174.
    Educational paper
    
    
35. Lysosomal phospholipidosis and apoptosis induced in cultured fibroblasts by aminoglycosides antibiotics and their prevention by poly-L-aspartic.
    El Mouedden M, Laurent G, Tulkens PM
    In: 4th IUBMB Conference (The cell & Death of the Cell), Edinburgh, Scotland, 14-17 (1996)
    Chapter of book / Proceedings
    
    
36. Syntheses of basic prodrugs of beta-lactam antibiotics.
    Fan H-J
    In: PhD Thesis (Thèse présentée en vue de l'obtention du grade de Docteur en Sciences, Université Catholique de Louvain, Louvain-la-Neuve), Université Catholique de Louvain, Belgium, pp 119 (1996)
    PhD Thesis
    
    
37. Etude des altérations lysosomiales induites par l'azithromycine, un antibiotique lysosomotrope: analyse des mécanismes responsables de l'hyperactivité enzymatique.
    Gerbaux C
    In: Mémoire présenté pour l'obtention du Diplôme d'Etudes Approfondies (D.E.A.) en Sciences Biologiques, Université Catholique de Louvain, pp 92 (1996)
    MSc dissertation
    
    
38. Hyperactivity of cathepsin B and other lysosomal enzymes in fibroblasts exposed to azithromycin, a dicationic macrolide antibiotic with exceptional tissue accumulation.
    Gerbaux C, Van Bambeke F, Montenez JP, Piret J, Morlighem G, Tulkens PM
    FEBS Lett (1996) 394:307-310.
    Original paper -- Journal impact factor: 3.750
    Abstract -- Reprint (PDF file - UCL only - copyright owned by the publisher)
    
    
39. Mechanism of the thesaurismosis and altered lysosomal dynamics induced by poly-D-glutamic acid in kidney proximal tubular cells.
    Kishore BK, Fuming L, Maldague P, Tulkens PM, Courtoy PJ
    Lab Invest (1996) 74:1025-1037.
    Original paper -- Journal impact factor: 4.640
    Abstract
    
    
40. Poly-D-glutamic acid induces an acute lysosomal thesaurimosis in proximal tubules and a marked proliferation of interstitium in rat kidney.
    Kishore BK, Maldague P, Tulkens PM, Courtoy PJ
    Lab Invest (1996) 74:1013-1023.
    Original paper -- Journal impact factor: 4.640
    Abstract
    
    
41. Etude des surcharges lysosomiales induites par l'azithromycine dans des cellules en culture: effets sur les phospholipides et le cholestérol cellulaires.
    Montenez JP
    In: PhD Thesis (Thèse présentée en vue de l'obtention du grade de Docteur en Sciences Pharmaceutiques), Université Catholique de Louvain, Belgium, pp 185 (1996)
    PhD Thesis
    
    
42. Interaction of the macrolide azithromycin with phospholipids. II. Biophysical and computer-aided conformational studies.
    Montenez JP, Van Bambeke F, Piret J, Schanck A, Brasseur R, Tulkens PM, Mingeot-Leclercq MP
    Eur J Pharmacol (1996) 314:215-227.
    Original paper -- Journal impact factor: 2.339
    Abstract -- Reprint (PDF file - UCL only - copyright owned by the publisher)
    
    
43. Effect of recombinant human gamma interferon on intracellular activities of antibiotics against Listeria monocytogenes in the human macrophage cell line THP-1.
    Scorneaux B, Ouadrhiri Y, Anzalone G, Tulkens PM
    Antimicrob Agents Chemother (1996) 40:1225-1230.
    Original paper -- Journal impact factor: 3.797
    Abstract -- Reprint (PDF file - UCL only - copyright owned by the publisher)
    
    
44. Intracellular kinetics of antibiotics.
    Tulkens PM
    In: Pathogenesis and Management of Intracellular Bacterial Infections, J.C. Pechère ed., 21-28 (1996)
    Review
    
    
45. Pharmacocinétique et pharmacodynamie intracellulaire des antibiotiques.
    Tulkens PM
    Rev Pneumol Clin (1996) 52:1-4.
    Review
    Abstract
    
    
46. Aminoglycoside antibiotics prevent the formation of non bilayer structures in negatively-charged membranes. Comparative studies using fusogenic [bis-(beta-diethylaminoethylether)hexestrol] and aggregating (spermine) agents.
    Van Bambeke F, Mingeot-Leclercq M-P, Brasseur R, Tulkens PM, Schanck A
    Chem Phys Lipids (1996) 79:123-135.
    Original paper -- Journal impact factor: 2.118
    Abstract
    
    
47. Interaction of the macrolide azithromycin with phospholipids. I. Inhibition of lysosomal phospholipase A1 activity.
    Van Bambeke F, Montenez JP, Piret J, Tulkens PM, Courtoy PJ, Mingeot-Leclercq MP
    Eur J Pharmacol (1996) 314:203-214.
    Original paper -- Journal impact factor: 2.339
    Abstract -- Reprint (PDF file - UCL only - copyright owned by the publisher)
    
    
48. Traitement des infections à Herpes simplex, Varicella zoster et Cytomegalovirus.
    Van Bambeke F, Nachega J, Tulkens PM
    Louvain Med (1996) 115:735-744.
    Educational paper
    
    
49. Activité intracellulaire d'antibiotiques de classes différentes vis-à-vis de Listeria monocytogenes dans les cellules THP-1 (macrophages humains): influence de la différenciation et de l'activation.
    Anzalone G
    In: Mémoire présenté pour l'obtention du diplôme de Licencié en Technologie Biomédicale (Université Catholique de Louvain, Bruxelles), 76pp (1995)
    MSc dissertation
    
    
50. Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin.
    Kotretsou S, Mingeot-Leclercq M-P, Constantinou-Kokotou V, Brasseur R, Georgiadis MP, Tulkens PM
    J Med Chem (1995) 38:4710-4719.
    Original paper -- Journal impact factor: 4.146
    Abstract
    
    
51. Molecular parameters involved in aminoglycosides nephrotoxicity.
    Mingeot-Leclercq M-P, Brasseur R, Schanck A
    J Toxicol Environ Health (1995) 44:263-300.
    Review -- Journal impact factor: 1.498
    Abstract
    
    
52. Molecular description of the interactions of aminoglycoside antibiotics with negatively-charged phospholipids. Theoretical molecular modelling and experimental results.
    Mingeot-Leclercq M-P, Schanck A, Van Bambeke F, Tulkens PM, Lins L, Brasseur R
    Life Science/Advances in Pharmacology (1995) 14:71-98.
    Review -- Journal impact factor: 1.148
    
    
53. Influence des antibiotiques du groupe des aminoglycosides sur les propriétés membranaires: études sur liposomes.
    Van Bambeke F
    In: PhD Thesis (Thèse présentée en vue de l'obtention du grade de Docteur en Sciences Pharmaceutiques), Université Catholique de Louvain, Belgium, 238pp (1995)
    PhD Thesis
    
    
54. Aminoglycoside antibiotics induce aggregation but not fusion of negatively-charged liposomes.
    Van Bambeke F, Tulkens PM, Brasseur R, Mingeot-Leclercq MP
    Eur J Pharmacol (1995) 289:321-333.
    Original paper -- Journal impact factor: 2.637
    
    
55. Accumulation, release and subcellular localization of azithromycin in phagocytic and non-phagocytic cells in culture.
    Carlier MB, Garcia-Luque I, Montenez J-P, Tulkens PM, Piret J
    Int J Tiss React (1994) 16:211-220.
    Original paper
    Abstract
    
    
56. Etude de l'influence de l'azithromycine sur l'activité d'hydrolases lysosomiales impliquées dans le catabolisme de substrats de différentes nature dans des fibroblastes d'embryons de rats en culture.
    Gerbaux C
    In: Mémoire présenté en vue de l'obtention du titre de Licencié en Sciences Biologiques (Orientation Biologie Humaine), Université Catholique de Louvain, Université Catholique de Louvain ed., -124 (1994)
    MSc dissertation
    
    
57. Urinary phospholipids excretion in neonates treated with amikacin.
    Ibrahim S, Langhendries JP, Bernard A, Tulkens PM
    Int J Clin Pharm Res (1994) 14:149-156.
    Original paper
    Abstract
    
    
58. Acute renal failure induced by aminoglycoside antibiotics: pathophysiology, clinical implications and development of protective measures.
    Kishore BK, Maldague P, Laurent G, Mingeot-Leclercq M-P, Ibrahim S, Tulkens PM
    In: Asian Nephrology - Proceedings of Fifth Asian Pacific Congress of Nephrology (1992), Sakhuja V. and Malhotra H.S. ed., Oxford University Press, New Delhi, 401-409 (1994)
    Chapter of book / Proceedings
    
    
59. Increased activities of cathepsin B and other lysosomal hydrolases in fibroblasts and bone tissue cultured in the presence of cysteine proteinases inhibitors.
    Montenez JP, Delaisse JM, Tulkens PM, Kishore BK
    Life Sciences (Pharmacology Letters) (1994) 55:1199-1208.
    Original paper
    Abstract
    
    
60. Leupeptin and E-64, inhibitors of cysteine proteinases, prevent gentamicin-induced lysosomal phospholipidosis in cultured rat fibroblasts.
    Montenez JP, Kishore BK, Maldague P, Tulkens PM
    Toxicol Lett (1994) 73:201-208.
    Original paper
    Abstract
    
    
61. .
    Bryskier AJ, Butzler JP, Neu HC, Tulkens PM
    Macrolides: chemistry, pharmacology and clinical uses, A.J. Bryskier, J.P. Butzler, H.C. Neu and P.M. Tulkens ed., pp 743 (1993)
    Book
    
    
62. Localisation subcellulaire d'antibiotiques dans les macrophages J774 non infectés ou infectés par Salmonella typhi.
    Crasson D
    In: Mémoire de licencié en Sciences Zoologiques (Biologie Cellulaire), Université Catholique de Louvain, Belgium, (1993)
    MSc dissertation
    
    
63. Co-oxydextran as a protectant against gentamicin-induced renal lysosomal phospholipidosis and focal tubular necrosis: Perspectives and limitations.
    Kishore BK, Van Schepdael A, Laurent G, Lambricht P, Claes PJ, Piret J, Tulkens PM, Maldague P
    In: Contributions to Nephrology (Kidney, Proteins and Drugs), C. Bianchi, V. Bocci, F.A. Carone & R. Rabkin ed., Karger, Basel, 213-219 (1993)
    Chapter of book / Proceedings
    Abstract
    
    
64. Once-a-day administration of amikacin in neonates: assessment of nephrotoxicity and ototoxicity.
    Langhendries JP, Battisti O, Bertrand JM, François A, Darimont J, Ibrahim S, Tulkens PM, Bernard A, Scalais E
    Dev Pharmacol Ther (1993) 20:220-230.
    Original paper
    Abstract
    
    
65. Administration en dose unique journalière de l'amikacine: adaptation à la néonatologie pour des enfants traités avant le 3ème jour d'age postnatal.
    Langhendries JP, Battisti O, Betrand JM, François A, Darimont J, Tulkens PM, Bernard A, Buchet JP, Wallemacq PE
    Med Mal Infect (1993) 23 (Sp.):44-54.
    Original paper
    
    
66. In vitro models for the study of the regulation of the activity of lysosomal phospholipase A1 by membrane lipids and of its inhibition by aminoglycoside antibiotics.
    Piret J
    In: PhD Thesis (These presentee en vue de l'obtention du grade de Docteur en Sciences), Universite Catholique de Louvain, Belgium, pp 217 (1993)
    PhD Thesis
    
    
67. Setting up a software for mathematical and statistical analysis of kinetic and binding parameters of Michaelis-Menten equations.
    Piret J
    In: Thèse annexe présentée pour l'obtention du titre de Docteur en Sciences Chimiques. Université Catholique de Louvain & International Institute of Cellular and Molecular Pathology, 32pp (1993)
    PhD Thesis
    
    
68. Conception de modèles quantitatifs d'infection intracellulaire pour l'étude de l'action des antibiotiques.
    Scorneaux B
    In: PhD Thesis (Doctorat en Sciences Biomédicales, orientation Pharmacologie cellulaire), Université Catholique de Louvain, pp283 (1993)
    PhD Thesis
    
    
69. Alterations in membrane permeability induced by aminoglycoside antibiotics: studies on liposomes and cultured cells.
    Van Bambeke F, Mingeot-Leclercq MP, Schanck A, Brasseur R, Tulkens PM
    Eur J Pharmacol (1993) 247:155-168.
    Original paper
    Abstract
    
    
70. Les nouveaux macrolides: de la chimie à la thérapeutique (I).
    Bryskier AJ, Butzler JP, Tulkens PM
    Medisearch (1992) 64:15-29.
    Educational paper
    
    
71. Influnce of the coadministration of poly-L-aspartic acid on the gentamicin-induced renal phospholipidosis, qualitative and quantitative lysosomal alterations and cell turnover in rat kidney cortex.
    Kishore BK, Ibrahim S, Lambricht P, Laurent G, Maldague P, Tulkens PM
    Renal Failure (1992) 14:120.
    Chapter of book / Proceedings
    
    
72. Comparative assessment of poly-L-aspartic and poly-L-glutamic acids against gentamicin-induced renal lysosomal phospholipidosis, phospholipiduria and cell proliferation in rats.
    Kishore BK, Ibrahim S, Lambricht P, Laurent G, Maldague P, Tulkens PM
    J Pharmacol Exp Ther (1992) 262:424-432.
    Original paper
    Abstract
    
    
73. Lysosomal storage disorders and toxicity induced by aminoglycoside antibiotics and polyanionic peptides.
    Kishore BK, Maldague P, Tulkens PM
    In: Endocytosis: From Cell Biology to Health, Disease and Therapy (NATO ASI Series), P. J. Courtoy ed., Springer Verlag, Berlin, 439-446 (1992)
    Chapter of book / Proceedings
    
    
74. Evaluation systématique et prospective du potentiel toxique de nouveaux aminoglycosides.
    Lambricht P
    In: PhD Thesis. Université Catholique de Louvain, Louvain, Belgium, Université Catholique de Louvain, Belgium, p. 168 (1992)
    PhD Thesis
    
    
75. Accessibility of aminoglycosides, isolated and in interaction with phosphatidylinositol, to water: a conformational analysis using the concept of molecular hydrophobicity potential.
    Mingeot-Leclercq MP, Tulkens PM, Brasseur R
    Biochem Pharmacol (1992) 44:1967-1975.
    Original paper
    Abstract
    
    
76. Effect of substrate organization on the activity and on the mechanism of gentamicin-induced inhibition of rat liver lysosomal phospholipase A1.
    Piret J, Kishore BK, Tulkens PM
    Biochem Pharmacol (1992) 43:895-898.
    Original paper
    Abstract
    
    
77. Interactions of aminoglycosides with phosphatidylinositol: a 15N nuclear magnetic resonance study.
    Schanck A, Brasseur R, Mingeot-Leclercq MP, Tulkens PM
    Magn Reson Chem (1992) 30:11-15.
    Original paper
    
    
78. Interactions of aminoglycosides with phospholipids. A deuterium Nuclear Magnetic Resonance study.
    Schanck A, Mingeot-Leclercq MP, Tulkens PM, Carrier D, Smith ICP, Jarrel HC
    Chem Phys Lipids (1992) 62:153-163.
    Original paper
    Abstract
    
    
79. Effect of the schedule of administration of two aminoglycosides, netilmicin and amikacin on urinary phospholipid excretion in humans.
    Ibrahim S, Clerckx-Braun F, Jacqmin Ph, Donnez J, Brulein V, Tulkens PM
    In: Nephrotoxicity: Mechanims, Early Diagnosis and Therapeutic Management., P.H. Bach, N.J. Gregg, M.F. Wilks and L. Delacruz ed., Marcel Dekker, New York, 93-97 (1991)
    Chapter of book / Proceedings
    
    
80. Effect of aminoglycosides and of coadministration of poly-L-aspartic acid on urinary phsopholipids excretion: a comparative Study.
    Ibrahim S, Kishore BK, Lambricht P, Laurent G, Tulkens PM
    In: Nephrotoxicity: Mechanisms, Early Diagnosis and Therapeutic Management, P.H. Bach, N.J. Gregg, M.F. Wilks and L. Delacruzz ed., Marcel Dekker, New York, 105-109 (1991)
    Chapter of book / Proceedings
    
    
81. Morphological evidence of nephrotoxicity of poly-D-glutamic acid in rats.
    Maldague P, Kishore BK, Lambricht P, Ibrahim S, Laurent G, Tulkens PM
    In: Nephrotoxicity: Mechanisms, Early Diagnosis, and Therapeutic Management, P.H. Bach, N.J. Gregg, M.F. Wilks and L. Delacruz ed., Marcel Dekker, Inc. New York., 131-136 (1991)
    Chapter of book / Proceedings
    
    
82. Empiric antimicrobial therapy with a single daily dose of ceftriaxone plus amikacin in febrilegranulocytopenic patients: a pilot study.
    Meunier F, Van der Auwera P, Aoun M, Ibrahim S, Tulkens PM
    J Antimicrob Chemother (1991) 27(C):129-139.
    Chapter of book / Proceedings
    Abstract
    
    
83. Aminoglycosides nephrotoxicity.
    Mingeot-Leclercq MP, Laurent G, Kishore BK, Tulkens PM
    Life Sc Adv (Biochem Pharmacol) (1991) 10:113-141.
    Review
    
    
84. New derivatives of kanamycin B obtained by modifications and substitutions in position 6". II. In vitro and computer-aided toxicological evaluation, with respect to interactions with phosphatidylinositol.
    Mingeot-Leclercq MP, Van Schepdael A, Brasseur R, Busson R, Vanderhaeghe HJ, Claes PJ, Tulkens PM
    J Med Chem (1991) 34:1476-1482.
    Original paper
    Abstract
    
    
85. Distribution of epidermal growth factor in the kidneys of rats exposed to amikacin.
    Toubeau G, Nonclercq D, Zanen J, Lambricht P, Tulkens P, Heuson-Stiennon JA, Laurent G
    Kidney Int (1991) 40:691-699.
    Original paper
    Abstract
    
    
86. Pharmacokinetic and toxicological evaluation of the once-daily regimen versus conventional schedules of netilmicin and amikacin.
    Tulkens PM
    J Antimicrob Chemother (1991) 27:49-61.
    Chapter of book / Proceedings
    Abstract
    
    
87. Intracellular distribution and activity of antibiotics.
    Tulkens PM
    Eur J Clin Microbiol Infect Dis (1991) 10:100-106.
    Review
    Abstract
    
    
88. Target drugs for the treatment of intracellular infections.
    Tulkens PM
    Flem Vet J (1991) Suppl. 1:163-168.
    Chapter of book / Proceedings
    
    
89. Pharmacodynamic parameters and toxicity of netilmicin (6 mg/kg.day) given once daily or in three divided doses to cancer patients with urinary tract infection.
    Van der Auwera P, Meunier F, Ibrahim S, Kaufman L, Derde MP, Tulkens PM
    Antimicrob Agents Chemother (1991) 35:640-647.
    Original paper
    Abstract
    
    
90. Synthesis, antibacterial activity and toxicological evaluation (in vitro and computer-aided) of 1-C-hydroxymethyl kanamycin B and 1-C-hydroxymethyl, 6"chlorokanamycin B.
    Van Schepdael A, Busson R, Vanderhaeghe HJ, Verbist L, Claes PJ, Mingeot-Leclercq MP, Brasseur R, Tulkens PM
    J Med Chem (1991) 34:1483-1492.
    Original paper -- Journal impact factor: ct
    Abstract
    
    
91. New derivatives of kanamycin B obtained by modifications and substitutions in position 6". I. Synthesis and microbiological evaluation.
    Van Schepdael A, Delcourt J, Mulier M, Busson R, Mingeot-Leclercq MP, Tulkens PM, Claes PJ
    J Med Chem (1991) 34:1468-1475.
    Original paper
    Abstract
    
    
92. The mechanism of aminoglycoside binding to isolated brush border membrane of proximal tubular cells.
    Wagner R
    In: PhD Thesis (Thèse présentée en vue de l'obtention du grade de Docteur en Sciences Biomédicales), Université Catholique de Louvain, Belgium, 96 pp (1991)
    PhD Thesis
    
    
93. Protection against gentamicin-induced early renal alterations (phospholipidosis and increased DNA synthesis) by co-administration of poly-L-aspartic acid.
    Beauchamp D, Laurent G, Maldague P, Abid S, Kishore BK, Tulkens PM
    J Pharm Exp Ther (1990) 255:858-866.
    Original paper
    Abstract
    
    
94. Cellular uptake, localization and activity of fluoroquinolones in uninfected and infected macrophages.
    Carlier MB, Scorneaux B, Zenebergh A, Desnottes JF, Tulkens PM
    J Antimicrob Chemother (1990) 26(B):27-39.
    Chapter of book / Proceedings
    Abstract
    
    
95. Renal phospholipidosis and phospholipiduria induced by aminoglycoside antibiotics: animal and human studies.
    Ibrahim S
    In: PhD Thesis (Thèse présentée en vue de l'obtention du grade de Docteur en Sciences Biomédicvales), Université Catholique de Louvain, Belgium, 194 pp (1990)
    PhD Thesis
    
    
96. Safety, pharmacokinetics and efficacy of once-a-day administration of netilmicin and amikacin versus their conventional schedules in patients suffering from pelvic inflammatory disease.
    Ibrahim S, Derde MP, Kaufman L, Clerckx-Braun F, Jacqmin Ph, Brulein V, Donnez J, Tulkens PM
    Renal Failure (1990) 12:199-203.
    Chapter of book / Proceedings
    Abstract
    
    
97. Construction, characterization and evaluation of the cellular delivery of Diphtheria toxin fragment B associated liposomes containing ribavarin.
    Kehoe MJ
    In: PhD Thesis (Thèse présentée en vue de l'obtention du grade de Docteur en Sciences), Université Catholique de Louvain, Belgium, 159 pp (1990)
    PhD Thesis
    
    
98. Polyanionic compounds as protectants against aminoglycoside-induced nephrotoxicity: biochemical and morphological studies.
    Kishore BK
    In: Thèse (Doct. Sc. Biomédicales), Université Catholique de Louvain, Belgium, 303 pp (1990)
    PhD Thesis
    
    
99. Increased levels of protein- and lipid-bound sialic acids in the renal cortex of rats injected with low doses of gentamicin.
    Kishore BK, Ibrahim S, Tulkens PM
    Toxicol Lett (1990) 51:59-65.
    Original paper
    Abstract
    
    
100. Mechanism of protection afforded by polyaspartic acid against gentamicin-induced phospholipidosis. I. Polyaspartic acid binds gentamicin and displaces it from negatively charged phospholipid layers in vitro.
     Kishore BK, Kallay Z, Lambricht P, Laurent G, Tulkens PM
     J Pharmacol Exp Ther (1990) 255:867-874.
     Original paper
     Abstract
     
     
101. Mechanism of protection afforded by polyaspartic acid against gentamicin-induced phospholipidosis. II. Comparative in vitro and in vivo studies with poly-L-aspartic, poly-L-glutamic and poly-D-glutamic acids.
     Kishore BK, Lambricht P, Laurent G, Maldague P, Wagner R, Tulkens PM
     J Pharmacol Exp Ther (1990) 255:875-885.
     Original paper
     Abstract
     
     
102. Inhibition of aminoglycoside-induced nephrotoxicity in rats by polyanionic peptides.
     Kishore KB, Lambricht P, Ibrahim S, Laurent G, Tulkens PM, Maldague P
     In: Contribution to Nephrology (Kidney, Proteins and Drugs), C. Bianchi, Bocci V., Carone F.A., Rabkin, R. ed., Karger, Basel, 191-201 (1990)
     Chapter of book / Proceedings
     
     
103. Aminoglycosides once-a-day in pelvic inflammatory disease.
     Lambricht P, Clerckx-Braun F, Smets M, Leal T, Delmée M, Tulkens PM, Donnez J
     In: Proceed. 2d Intern. Meeting of the European Society for Infectious Diseases in Gynecology and Obstetrics, Guaschino, S. ed., Monduzzi Editore, Bologna, 381-387 (1990)
     Chapter of book / Proceedings
     
     
104. Nephrotoxicity of aminoglycoside antibiotics: molecular and cellular aspects.
     Laurent G
     In: PhD Thesis (Thèse présentée en vue de l'obtention du grade d'agrégé de l'enseignement supérieur), Université Catholique de Louvain, Belgium, 101 pp (1990)
     PhD Thesis
     
     
105. Aminoglycoside-induced phospholipidosis and nephrotoxicity.
     Laurent G, Kishore BK, Tulkens PM
     Biochem Pharmacol (1990) 40:2383-2392.
     Review
     Abstract
     
     
106. Effect of acidic phospholipids on the activity of lysosomal phospholipases and on their inhibition by aminoglycoside antibiotics. I. Biochemical analysis.
     Mingeot-Leclercq MP, Piret J, Brasseur R, Tulkens PM
     Biochem Pharmacol (1990) 40:489-497.
     Original paper
     Abstract
     
     
107. Effect of acidic phospholipids on the activity of lysosomal phospholipases and on their inhibition by aminoglycoside antibiotics. II. Conformational analysis.
     Mingeot-Leclercq MP, Piret J, Tulkens PM, Brasseur R
     Biochem Pharmacol (1990) 40:499-506.
     Original paper
     Abstract
     
     
108. Renal tissue injury and proliferative response after sucessive treatments with anticancer platinum derivatives and tobramycin.
     Nonclercq D, Toubeau G, Tulkens PM, Heuson-Stiennon JA, Laurent G
     Virchows Archiv B (Cell Pathol) (1990) 59:143-158.
     Original paper
     Abstract
     
     
109. Intracellular pharmacokinetics and localization of antibiotics as predictors of their efficacy against intraphagocytic infections.
     Tulkens PM
     Scand J Infect Dis (1990) Suppl. 74:209-217.
     Chapter of book / Proceedings
     Abstract
     
     
110. Accumulation and subcellular distribution of antibiotics in macrophages in relation to activity against intracellular bacteria.
     Tulkens PM
     In: Ciprofloxacin in Pneumology, R.J. Fass ed., Zuckswerdt Verlag, München, 12-22 (1990)
     Chapter of book / Proceedings
     
     
111. The intracellular pharmacokinetics and activity of antibiotics.
     Tulkens PM
     In: Frontiers of Infectious Diseases: New Antibacterial Strategies, H.C. Neu ed., Churchill Livingstone/Longman Group, Edinburgh, 243-259 (1990)
     Review
     
     
112. Efficacy and safety of aminoglycosides once-a-day: experimental and clinical data.
     Tulkens PM
     Scand J Infect Dis (1990) Suppl. 74:249-257.
     Chapter of book / Proceedings
     Abstract
     
     
113. Conformational and biochemical analysis of the interactions between phospholipids and aminoglycoside antibiotics in relation with their toxicity.
     Tulkens PM, Mingeot-Leclercq MP, Laurent G, Brasseur R
     In: Molecular description of biological membrane components by computer-aided conformational analysis, R. Brasseur ed., CRC Press, Inc., Boca Raton, Fla., 63-93 (1990)
     Chapter of book / Proceedings
     
     
114. Renal phospholipidosis in rats after gentamicin and pefloxacin co-administration at low doses.
     Carlier MB, Kaêö,öllay Z, Tulkens PM
     In: Nephrotoxicity: Extrapolation from in vitro to in vivo, and animals to man, P.H. Bach & E.A.Lock ed., Plenum Press, London, 221-225 (1989)
     Chapter of book / Proceedings -- Journal impact factor: ct
     
     
115. Urinary phospholipids patterns after treatment with aminoglycoside antibiotics and cis-platinum.
     Ibrahim S, Kallay Z, Clerckx-Braun F, Donnez J, Tulkens PM, Jacqmin Ph
     In: Nephrotoxicity: Extrapolation from in vitro to in vivo, and animals to man, P.H. Bach & E.A. Lock ed., Plenum Press, London, 177-182 (1989)
     Chapter of book / Proceedings
     
     
116. Effect of netilmicin and amikacin on urinary phospholipid excretion in humans.
     Ibrahim S, Van der Auwera P, Meunier F, Tulkens PM
     Arch Toxicol (1989) Suppl. 13:413-416.
     Chapter of book / Proceedings
     Abstract
     
     
117. Uptake and subcellular distribution of poly-L-aspartic acid, a protectant against aminoglycoside-induced nephrotoxicity, in rat kidney cortex.
     Kallay Z, Tulkens PM
     In: Nephrotoxicity: extrapolation from in vitro to in vivo, and animals to man, P.H. Bach and E.A. Lock ed., Plenum Press, London, United Kindgom, 189-192 (1989)
     Chapter of book / Proceedings
     
     
118. Comparative uptake and lysosomal phospholipidosis induced by gentamicin components C1, C1a, and C2.
     Kallay Z, Carlier MB, Rollmann B, Maldague P, Tulkens PM
     In: Nephrotoxicity: Extrapolation from In Vitro to In Vivo, and Animals to Man, P.H. Bach & E.A. Lock ed., Plenum Press, London, 183-188 (1989)
     Chapter of book / Proceedings
     
     
119. Aminoglycoside nephrotoxicity in obstructive jaundice: possible contribution by concomitantly administered corticosteroids (letter to the Editor).
     Kishore BK
     Am J Med (1989) 87:245-246.
     Letter to Editor / Editorial
     Abstract
     
     
120. Comparative assessment of poly-L-aspartic and poly-L-glutamic acids as protectants against aminoglycoside-induced nephrotoxicity.
     Kishore BK, Tulkens PM
     Arch Toxicol (1989) Suppl. 13:409-412.
     Chapter of book / Proceedings
     
     
121. Clinico-biochemical aspects of guanidine compounds in uraemic toxicity.
     Kishore BK, Kaêö,öllay Z, Tulkens PM
     Int Urol Nephrol (1989) 21:223-232.
     Review
     Abstract
     
     
122. Is malondialdehyde a putative uremic toxin?.
     Kishore KB
     Nepron (1989) 52:286.
     Letter to Editor / Editorial
     Abstract
     
     
123. Ultrastructural, physico-chemical and conformational study of the interactions of gentamicin and bis(beta-diethylaminoethylether)hexestrol with negatively charged phospholipid bilayers.
     Mingeot-Leclercq MP, Schanck A, Ronveaux-Dupal MF, Deleers M, Brasseur R, Ruysschaert JM, Laurent G, Tulkens PM
     Biochem Pharmacol (1989) 38:729-741.
     Original paper
     Abstract
     
     
124. Tissue injury and repair in the rat kidney after exposure to cisplatin and carboplatin.
     Nonclercq D, Toubeau G, Laurent G, Tulkens PM, Heuson-Stiennon JA
     Exp Mol Pathol (1989) 51:123-140.
     Original paper
     Abstract
     
     
125. Nephrotoxic injury and renal tissue repair associated with the administration of the anticancer drugs cisplatin and carboplatin.
     Nonclercq D, Toubeau G, Laurent G, Tulkens PM, Heuson-Stiennon JA
     Micron Microscop Acta (1989) 20:51-58.
     Original paper
     
     
126. Etude expérimentale de la liaison de la gentamicine à des liposomes chargés négativement et à l'acide poly-L-glutamique.
     Piret J
     In: Mémoire présenté en vue de l'obtention du diplôme de Licencié en Sciences Zoologiques. Université de l'état à Mons/Université Catholique de Louvain, (1989)
     MSc dissertation
     
     
127. Nephrotoxicity of aminoglycosides.
     Tulkens PM
     Toxicol Lett (1989) 46:107-123.
     Review
     Abstract
     
     
128. Coupling products of amino acids to penicillin V and cephalothin: synthesis, and susceptibility to carboxypeptidases and lysosomal enzymes.
     Bounkhala Z, Renard C, Baurain R, Marchand-Brynaert J, Ghosez L, Tulkens PM
     J Med Chem (1988) 31:976-983.
     Original paper
     Abstract
     
     
129. In vitro study and conformational analysis of 1-N-aminohydroxybutyryl derivatives of aminoglycosides in correlation with their inhibitory potency towards lysosomal phospholipases.
     Carlier MB, Brasseur R, Ruysschaert JM, Tulkens PM
     Arch Toxicol (1988) Suppl.12:186-189.
     Chapter of book / Proceedings
     
     
130. Interaction of diphtheria toxin (fragment B) with natural membranes.
     Falmagne P, Wattiez R, Cabiaux V, Phalipon A, Kaczorek M, Tulkens PM, Ruysschaert JM
     In: Bacterial Protein Toxins (Zbl. Bakt. Suppl. 17), Fehrenbach ed., G. Fisher Verlag, Stuttgart, 277-285 (1988)
     Chapter of book / Proceedings
     
     
131. Individualisation de la posologie basée sur les paramètres de populations: application aux aminoglycosides.
     Jacqmin Ph, Ponchaut S, Brulein V, Clerckx-Braun F, De Baecker M, Donnez J, Moulin D, Reynaert M, Tulkens PM
     In: Intérêt et Limites de la Pharmacocinétique en Recherche et Développement, J. Bres & G. Panis ed., Sauramps Médical (Diffusion Vigot), Paris, France, 128-137 (1988)
     Chapter of book / Proceedings
     
     
132. Kidney tissue repair after nephrotoxic injury : biochemical and morphological characterization.
     Laurent G, Toubeau G, Heuson-Stiennon JA, Tulkens P, Maldague P
     CRC Crit Rev Toxicol (1988) 19:147-183.
     Review
     Abstract
     
     
133. Tissue injury and proliferative response induced in rat kidney by cis-diamminedichlororo platinum (II).
     Laurent G, Yernaux V, Nonclercq D, Toubeau G, Maldague P, Tulkens PM, Heuson-Stiennon JA
     Virchows Archiv B (Cell Pathol) (1988) 55:129-145.
     Original paper
     Abstract
     
     
134. Mécanisme moléculaire de la néphrotoxicité induite par les aminoglycosides: études biochimiques et biophysiques.
     Mingeot-Leclercq MP
     In: PhD Thesis (Thèse présentée en vue de l'obtention du grade de Docteur en Sciences Pharmaceutiques), Université Catholique de Louvain, pp 141 (1988)
     PhD Thesis
     
     
135. Biochemical mechanism of aminoglycoside-induced inhibition of phosphatidylcholine hydrolysis by lysosomal phospholipases.
     Mingeot-Leclercq MP, Laurent G, Tulkens PM
     Biochem Pharmacol (1988) 37:591-599.
     Original paper
     Abstract
     
     
136. Etude de la capture et de la localisation subcellulaire d'une forme vectorisée d'un antibiotique dans les macrophages.
     Mouilliard Ch
     In: Mémoire présenté pour l'obtention du grade légal de Licencié en Sciences Zoologiques (Université de Mons), Université de l'Etat à Mons, pp 95 (1988)
     MSc dissertation
     
     
137. Light and electron microscopic characterization of the proliferative response induced by tobramycin in rat kidney cortex.
     Nonclercq D, Toubeau G, Laurent G, Maldague P, Tulkens PM, Heuson-Stiennon JA
     Exp Mol Pathol (1988) 48:335-352.
     Original paper
     Abstract
     
     
138. Capture cellulaire et localisation subecellulaire de 4 fluoroquinolones (péfloxacine, ciprofloxacine, ofloxacine, fléroxacine) dans des cellules phagocytaires et non-phagocytaires.
     Scorneaux B
     In: Mémoire présenté en vue de l'obtention du grade de Licencié en Technologie Biomédicale (Université Catholique de Louvain, Bruxelles), Université Catholique de Louvain, pp 125 (1988)
     MSc dissertation
     
     
139. Mode of nephrotoxicity of aminoglycosides, and animal and human experience with once-daily regimen.
     Tulkens PM
     In: Proceedings of The International Symposium on Netilmicin, Y. Ueda ed., Professional Postgraduate Services, K.K., Tokyo, 49-62 (1988)
     Chapter of book / Proceedings
     
     
140. Antibiotic-induced nephrotoxicity.
     Tulkens PM
     In: International Workshop on the Health Significance of Nephrotoxicity, Commission of the European Communities/World Health Organization, 131-167 (1988)
     Review
     
     
141. Safety and efficacy of aminoglycosides once-a-day: experimental data and randomized, controlled evaluation in patients suffering from pelvic inflammatory disease.
     Tulkens PM, Clerckx-Braun F, Donnez J, Ibrahim S, Kaêö,öllay Z, Jacqmin P, Lesne M, Kaufman MP, Gersdorff M
     J Drug Devel (1988) 1:71-82.
     Original paper
     
     
142. Reduction of aminoglycoside-induced renal alterations in rats by coadministration of piperacillin at clinically-relevant doses.
     Carlier MB, Kaêö,öllay Z, Rollmann B, Tulkens PM
     In: Progress in Antimicrobial and Anticancer Chemotherapy, B. Berkarda & H.-P. Kuemmerle ed., Ecomed Verlag, Landsberg/Lech, W. Germany, 873-875 (1987)
     Chapter of book / Proceedings
     
     
143. Cellular uptake and subcellular distribution of roxithromycin and erythromycin in phagocytic cells.
     Carlier MB, Zenebergh A, Tulkens PM
     J Antimicrob Chemother (1987) 20(B):47-56.
     Chapter of book / Proceedings
     Abstract
     
     
144. Handling of two macrolides, erythromycin and roxithromycin (RU 28965) by human and animal macrophages in culture.
     Carlier MB, Zenebergh A, Tulkens PM
     In: Progress in Antimicrobial and Anticancer Chemotherapy, B. Berkarda & H.-P. Kuemmerle ed., Ecomed Verlag, Landsberg/Lech, W. Germany, 569-571 (1987)
     Chapter of book / Proceedings
     
     
145. Synthèse et évaluation d'une forme vectorisée d'un antibiotique pour une nouvelle approche thérapeutique des infections intracellulaires bactériennes.
     Cucurnia P
     In: Mémoire présenté pour l'obtention du grade légal de Licencié en Sciences Zoologiques, Université de l'Etat à Mons, 91 pp (1987)
     MSc dissertation
     
     
146. Contribution à l'étude de la stabilité d'esters en position 2 du groupe des lincosaminides.
     Gallez O
     In: Mémoire présenté pour l'obtention du grade légal de Licencié en Sciences Chimiques, Université de l'Etat à Mons, 110 pp (1987)
     MSc dissertation
     
     
147. Aminoglycoside nephrotoxicity: cellular and molecular aspects.
     Laurent G, Tulkens PM
     In: ISI Atlas of Science: Pharmacology, Waverly Press, Baltimore, 40-44 (1987)
     Review
     
     
148. Influence of conversion of penicillin G into a basic derivative on its accumulation and subcellular localization in cultured macrophages.
     Renard C, Vanderhaeghe HG, Claes PJ, Zenebergh A, Tulkens PM
     Antimicrob Agents Chemother (1987) 31:410-416.
     Original paper
     Abstract
     
     
149. Antibiotics and the kidney: the renal safety of ceftazidime and ceftazidime-aminoglycoside combinations.
     Tulkens PM
     In: Perspectives on Therapeutics in Northern Europe, Theracom Ltd, West Stratton, U.K., 5-6 (1987)
     Educational paper
     
     
150. Mechanisms of the nephrotoxicity of aminoglycosides.
     Tulkens PM
     Current Issues in Medicine (1987) 3:3-4.
     Educational paper
     
     
151. Liaison de la tobramycine à la bordure en brosse isolée de cortex rénal de rat : rôle des phospholipides.
     Wagner R
     In: Mémoire de Licence en Technologie Biomédicale (Université Catholique de Louvain), (1987)
     MSc dissertation
     
     
152. Uptake and intracellular distribution of 2 fluoroquinolones, pefloxacin and ciprofloxacin, in phagocytes.
     Zenebergh A, Carlier MB, Scorneaux B, Tulkens PM
     In: Progress in Antimicrobial and Anticancer Chemotherapy, B. Berkarda & H.-P. Kuemmerle ed., Ecomed Verlag, Landsberg/Lech, W. Germany, 1906-1908 (1987)
     Chapter of book / Proceedings
     
     
153. Reduction of gentamicin nephrotoxicity by the concomitant administration of poly-L-aspartic acid and poly-L-asparagine in rats.
     Beauchamp D, Laurent G, Maldague P, Tulkens PM
     Arch Toxicol (1986) suppl.9:306-309.
     Chapter of book / Proceedings
     Abstract
     
     
154. Effects of gentamicin on the renal uptake of endogenous and exogenous proteins in conscious rats.
     Bernard A, Viau C, Ouled A, Tulkens P, Lauwerys R
     Toxicol Appl Pharm (1986) 84:431-438.
     Original paper
     Abstract
     
     
155. Use of an in vitro model to assess aminoglycoside-phospholipid interactions in relation to their nephrotoxicity.
     Carlier MB, Brasseur R, Laurent G, Mingeot-Leclercq MP, Ruysschaert JM, Tulkens PM
     Fd Chem Toxicol (1986) 24:815-816.
     Chapter of book / Proceedings
     
     
156. Animal study on the nephrotoxic potential of gentamicin-ceftazidime combination treatment at low doses.
     Carlier MB, Laurent G, Beauchamp D, Maldague P, Rollmann B, Tulkens PM
     In: Recent Advances in Chemotherapy, J. Ishigami ed., University of Tokyo Press, Tokyo, 2645-2646 (1986)
     Chapter of book / Proceedings
     
     
157. Effect of hydroxylation of the 2',6' diaminohexose moiety on the intrarenal accumulation of aminoglycoside antibiotics: comparison between kanamycin B, tobramycin, dibekacin and gentamicin.
     Giurgea-Marion L, Tulkens PM
     In: Recent Advances in Chemotherapy, J. Ishigami ed., University of Tokyo Press, Tokyo, 2679-2680 (1986)
     Chapter of book / Proceedings
     
     
158. Impairment of lysosome-pinocytic vesicle fusion in rat kidney proximal tubules after treatment with gentamicin at low doses.
     Giurgea-Marion L, Toubeau G, Laurent G, Heuson-Stiennon J, Tulkens PM
     Toxicol Appl Pharmacol (1986) 86:271-285.
     Original paper
     Abstract
     
     
159. Mise en évidence de l'activité d'une phospholipase C lysosomiale vis-à-vis du phosphatidyl inositol. Etude de son inhibition par les aminoglycosides.
     Lambricht P
     In: Mémoire de Licence en Technologie Biomédicale, Université Catholique de Louvain, pp 87 (1986)
     MSc dissertation
     
     
160. Hydrolysis of Pro-Ala dipeptides by lysosomal hydrolases. Models for the study of lysosomotropic amino acid prodrugs of penicillins.
     Renard C, Michel A, Tulkens PM
     J Med Chem (1986) 29:1291-1293.
     Original paper
     Abstract
     
     
161. Accumulation and subcellular localization of a basic derivative of Penicillin G in J774 macrophages.
     Renard C, Zenebergh A, Vanderhaeghe HJ, Claes PJ, Tulkens PM
     In: Recent Advances in Chemotherapy, J. Ishigami ed., University of Tokyo Press, Tokyo, 331-332 (1986)
     Chapter of book / Proceedings
     
     
162. Dibekacin assay in serum by automated fluorescence polarization immunoassay (Abbott Tdx): comparison with high-performance liquid chromatography, substrate-labelled fluorescent and radioimmunoassay.
     Rollmann B, Van Der Auwera P, Tulkens PM
     J Pharm Biomed Anal (1986) 4:53-61.
     Original paper
     
     
163. Tissue repair in rat kidney cortex after short treatment with aminoglycosides at low doses: a comparative biochemical and morphometric study.
     Toubeau G, Laurent G, Carlier MB, Abid S, Maldague P, Heuson-Stiennon JA, Tulkens PM
     Lab Invest (1986) 54:385-393.
     Original paper
     Abstract
     
     
164. Morphological alterations in distal and collecting tubules of the rat renal cortex after aminoglycoside administration at low doses.
     Toubeau G, Maldague P, Laurent G, Vaamonde CA, Tulkens PM, Heuson-Stiennon JA
     Virchows Arch B (Cell Pathol) (1986) 51:475-485.
     Original paper
     Abstract
     
     
165. Experimental studies on nephrotoxicity of aminoglycosides at low doses: mechanisms and perspectives.
     Tulkens PM
     Am J Med (1986) 80:105-114.
     Review
     Abstract
     
     
166. Interactions of streptomycin and streptomycylamine derivatives with negatively charged lipid layers: correlation between binding, conformation of complexes and inhibition of lysosomal phospholipase activities.
     Brasseur R, Carlier MB, Laurent G, Claes PJ, Vanderhaeghe HJ, Tulkens PM, Ruysschaert JM
     Biochem Pharmacol (1985) 34:1035-1047.
     Original paper
     Abstract
     
     
167. Kidney phospholipidosis and recovery after acute exposure to gentamicin with low and high doses in an infused rat model.
     Giuliano RA, Paulus GJ, Verpooten GA, Pattijn VM, Pollet DE, Nouwen EJ, De Broe ME
     In: Renal Heterogeneity and Target Cell Toxicity, P.H. Bach & E.A. Lock ed., J. Wiley & Sons, Pub., London (U.K.), 323-326 (1985)
     Chapter of book / Proceedings
     
     
168. Interactions entre les aminoglycosides et les structures subcellulaires du cortex rénal chez le rat: études biochimiques et morphologiques à doses faibles.
     Giurgea-Marion L
     In: PhD Thesis (Thèse presentee en vue de l'obtention du grade de Docteur en Biologie Médicale Appliquée), Université Libre de Bruxelles, pp 244 (1985)
     PhD Thesis
     
     
169. Buoyant and functional alterations of lysosomes of proximal tubular cells after treatment with gentamicin : biochemical and morphological studies.
     Giurgea-Marion L, Laurent G, Toubeau G, Heuson-Stiennon J, Beauchamp D, Carlier MB, Tulkens P
     In: Renal Heterogeneity and Target Cell Toxicity, P.H. Bach & E.A. Lock ed., J. Wiley & Sons, Pub., London, 357-360 (1985)
     Chapter of book / Proceedings
     
     
170. The design of antibiotics capable of an intracellular action: aims, potentialities and problems.
     Tulkens PM
     In: Drug Targeting, P. Buri & A. Gumma ed., Elsevier Science Publishers, B.V., Amsterdam, 179-193 (1985)
     Chapter of book / Proceedings
     
     
171. In vitro model and semi-empirical conformational analysis to study and compare the intrinsic nephrotoxicity of aminoglycoside antibiotics.
     Tulkens PM, Laurent G, Carlier MB, Lambricht P, Mingeot-Leclercq MP, Ruysschaert JM
     In: Recent advances in Chemotherapy, J. Ishigami ed., University of Tokyo Press, Tokyo, 2634-2635 (1985)
     Chapter of book / Proceedings
     
     
172. Computer models and structure-activity data for the prediction of aminoglycoside-induced nephrotoxicity.
     Tulkens PM, Ruysschaert JM, Brasseur R, Carlier MB, Laurent G, Claes JP, Vanderhaeghe HJ
     In: Renal Heterogeneity and Target Cell Toxicity, P.H. Bach and E.A. Lock ed., J. Wiley & Sons, Pub., London, 303-313 (1985)
     Chapter of book / Proceedings
     
     
173. Polycationic gentamicin inhibits the tubular reabsorption of plasma proteins according to their electrical charges.
     Viau C, Bernard A, Ouled A, Lauwerys R, Tulkens P
     In: Renal Heterogeneity and Target Cell Toxicity, P.H. Bach & E.A. Lock ed., J. Wiley & Sons, Pub., London, 353-356 (1985)
     Chapter of book / Proceedings
     
     
174. La liaison de la gentamicine aux vésicules lipidiques et son effet inhibiteur sur l'hydrolyse de la phosphatidylcholine: influence de la charge négative portées par la membrane.
     Wagner R
     In: Mémoire d'assistant de laboratoire clinique (Université Catholique de Louvain), (1985)
     MSc dissertation
     
     
175. Liaison de la tobramycine à la bordure en brosse isolée de cortex rénal de rat: rôle des phospholipides.
     Wagner R
     In: Mémoire présenté pour l'obtention du grade de Licencié en Technologie Biomédicale (Université Catholique de Louvain, Bruxelles), 70 pp (1985)
     MSc dissertation
     
     
176. Subcellular localization of clindamycin in J774 macrophages, peritoneal macrophages and fibroblasts compared to two lysosomotropic amines: chloroquine and dimethylaminopropylpenicillinamide.
     Zenebergh A, Renard C, Tulkens PM
     In: Recent Advances in Chemotherapy, J. Ishigami ed., University of Tokyo Press, Tokyo, 732-733 (1985)
     Chapter of book / Proceedings
     
     
177. Interactions of aminoglycoside antibiotics with negatively charged lipid layers: biochemical and conformational studies.
     Brasseur R, Laurent G, Ruysschaert JM, Tulkens P
     Biochem Pharmacol (1984) 33:629-637.
     Original paper
     Abstract
     
     
178. La phospholipidose rénale induite par les aminoglycosides: étude biochimique et morphologique.
     Carlier MB
     In: PhD Thesis (Thèse présentée en vue de l'obtention du grade de Docteur en Applications Pharmaceutiques), Université Catholique de Louvain, 121 pp (1984)
     PhD Thesis
     
     
179. In vitro inhibition of lysosomal phospholipases by aminoglycoside antibiotics: a comparative study.
     Carlier MB, Laurent G, Tulkens P
     Arch Toxicol (1984) 7(suppl.):282-285.
     Chapter of book / Proceedings
     Abstract
     
     
180. Early effects of gentamicin, tobramycin and amikacin on the human kidney.
     De Broe ME, Paulus GJ, Verpooten GA, Roels F, Buyssens N, Wedeen R, Van Hoof F, Tulkens P
     Kidney Int (1984) 25:643-652.
     Original paper
     Abstract
     
     
181. Recovery of cortical phospholipidosis and necrosis after acute gentamicin loading in rats.
     Giuliano RA, Paulus GJ, Verpooten RA, Pattyn V, Pollet DE, Laurent G, Maldague P, Tulkens PM, De Broe ME
     Kidney Int (1984) 26:838-847.
     Original paper
     Abstract
     
     
182. Tubular regeneration in rat kidney cortex during treatment with gentamicin at a low dose..
     Laurent G, Toubeau G, Maldague P, Carlier MB, Heuson-Stiennon J, Tulkens P
     Arch Toxicol (1984) 7(suppl.):459-463.
     Chapter of book / Proceedings
     Abstract
     
     
183. A 2'guanidyl derivative of gentamicin (S86451) with reduced nephrotoxicity : studies at low and medium dose levels in the rat.
     Maldague P, Laurent G, Carlier MB, Tulkens P
     Arch Toxicol (1984) 7(suppl.):455-458.
     Chapter of book / Proceedings
     Abstract
     
     
184. Gentamicin-induced stimulation of DNA synthesis in rat kidney cortex. Comparison between in vivo and in vitro models.
     Porter GA, Laurent G, Maldague P, Tulkens PM
     Toxicol Lett (1984) 23:205-213.
     Original paper
     Abstract
     
     
185. Aminoglycosides nephrotoxicity: recent insights and perspectives.
     Tulkens P
     In: Contributions to Nephrology. Kidney, small molecules and drugs, C. Bianchi, A. Bertelli & G.C. Duarte ed., Karger, A.G., Pub., Basel, 168-181 (1984)
     Chapter of book / Proceedings
     
     
186. Inhibition of lysosomal phospholipases by aminoglycoside antibiotics: in vitro studies.
     Carlier MB, Laurent G, Claes PJ, Vanderhaeghe HJ, Tulkens PM
     In: Proceedings of the 13th International Congress of Chemotherapy, Vienna, K.H. Spitzy & K. Karrer ed., 62-65 (1983)
     Chapter of book / Proceedings
     
     
187. Inhibition of lysosomal phospholipases by aminoglycoside antibiotics: in vitro comparative studies.
     Carlier MB, Laurent G, Claes PJ, Vanderhaeghe HJ, Tulkens PM
     Antimicrob Agents Chemother (1983) 23:440-449.
     Original paper
     Abstract
     
     
188. Early toxicity of aminoglycosides in human kidney: a prospective, comparative study of amikacin, gentamicin, netilmicin and tobramycin.
     De Broe ME, Paulus GJ, Verpooten GA, Giuliano RA, Roels F, Tulkens PM
     In: Proceedings of the 13th International Congress of Chemotherapy, Vienna, K.H. Spitzy & K. Karrer ed., 11-24 (1983)
     Chapter of book / Proceedings
     
     
189. Comparative nephrotoxicity of four aminoglycosides : biochemical and ultrastructural modifications of lysosomes.
     Fillastre JP, Hemet J, Tulkens P, Morin JP, Viotte G, Ollier B, Godin M
     In: Advances in Nephrology, J. Hamburger, J. Crosnier, J.P. Grunfeld & M. Maxwell ed., Year Book Med. Pub., Chicago, Ill, 253-275 (1983)
     Chapter of book / Proceedings
     
     
190. Increased renal DNA synthesis in vivo after administration of low doses of gentamicin to rats.
     Laurent G, Maldague P, Carlier MB, Tulkens P
     Antimicrob Agents Chemother (1983) 24:586-593.
     Original paper
     
     
191. Uptake and distribution of TDM 85530 in mouse macrophages and rat fibroblasts.
     Tatzber F, Lam C, Zenebergh A, Schuster I, Tulkens P
     In: Proceedings of the 13th International Congress of Chemotherapy, Vienna, K.H. Spitzy & K. Karrer ed., 15-19 (1983)
     Chapter of book / Proceedings
     
     
192. Comparative study of the alterations induced in rat kidney by gentamicin, dibekacin, netilmicin, tobramycin and amikacin at low doses.
     Tulkens P, Laurent G, Carlier MB, Toubeau G, Heuson-Stiennon J, Maldague P
     In: Proceedings of the 13th International Congress of Chemotherapy, Vienna, K.H. Spitzy and K. Karrer ed., 30-35 (1983)
     Chapter of book / Proceedings
     
     
193. Lysosomal alterations in aminoglycoside-induced acute renal failure.
     Tulkens PM, De Broe ME, Maldague P, Heuson-Stiennon JA
     In: Acute renal failure: correlations between morphology and function, K. Solez & A. Whelton ed., Marcel Dekker Pub., New York, 299-327 (1983)
     Chapter of book / Proceedings
     
     
194. Gentamicin nephrotoxicity in cadmium, lead and mercury pretreated rats.
     Viau C, Bernard A, Lauwerys RR, Tulkens P, Laurent G, Maldague P
     Toxicology (1983) 27:15-25.
     Original paper
     Abstract
     
     
195. S 86451, a new derivative of gentamicin with reduced nephrotoxicity. Biochemical, morphological and functional studies.
     Wilmotte E, Maldague P, Tulkens P, Baumgartner R, Schmook F, Walzl H, Obenaus H
     Drugs Exp Clin Res (1983) 9:467-477.
     Original paper
     
     
196. Early toxic events in kidney of rat and man following administration of gentamicin at low doses.
     Carlier MB, Paulus G, Maldague P, Giurgea L, Wilmotte E, de Broe ME, Tulkens P
     Arch Toxicol (1982) 5:287-290.
     Chapter of book / Proceedings
     Abstract
     
     
197. Nephrotoxicity of gentamicin in humans..
     De Broe ME, Paulus GJ, Verpooten GA, Roels F, De Prest B, Van Hoof F, Buyssens N
     In: Néphrotoxicité et ototoxicité médicamenteuses/Nephrotoxicity and ototoxicity of drugs, J.P. Fillastre ed., Editions INSERM et Publications de l'Universit{ de Rouen, France, 147-165 (1982)
     Chapter of book / Proceedings
     
     
198. Nephrotoxicity of aminoglycosides : experimental data and clinical implications.
     De Broe ME, Verpooten GA, Giuliano RA, Paulus GJ, Pollet DE, Laurent G, Tulkens PM
     In: Controversial aspects of aminoglycoside therapy, J. Klastersky ed., Europrint 2000, Brussels, 35-45 (1982)
     Chapter of book / Proceedings
     
     
199. Etude comparative de la néphrotoxicité de quatre aminoglycosides: modifications biochimiques et ultrastructurales lysosomiales.
     Fillastre JP, Hemet J, Morin JP, Tulkens P, Viotte G, Olier B, Godin M
     In: Actualités Néphrologiques de l'Hôpital Necker, 91-109 (1982)
     Chapter of book / Proceedings
     
     
200. Mechanism of aminoglycoside-induced lysosomal phospholipidosis: in vitro and in vivo studies with gentamicin and amikacin.
     Laurent G, Carlier MB, Rollman B, Van Hoof F, Tulkens P
     Biochem Pharmacol (1982) 31:3861-3870.
     Original paper
     Abstract
     
     
201. Comparative nephrotoxicity of gentamicin, netilmicin, tobramycin and amikacin in rats.
     Ollier B, Morin JP, Viotte G, Tulkens P, Van Hoof F, Fillastre JP
     In: Current Chemotherapy and Immunotherapy, P. Periti and G. Gialdroni-Grassi ed., Am. Soc. Microbiol. Pub., Washington DC, 839-841 (1982)
     Chapter of book / Proceedings
     
     
202. The lysosomal toxicity of gentamicin: a short review.
     Tulkens P
     In: Néphrotoxicité et ototoxicité médicamenteuses/nephrotoxicity and ototoxicity of drugs, J.P. Fillastre ed., Editions INSERM et Publications de l'Université de Rouen, Rouen, France, 435-443 (1982)
     Chapter of book / Proceedings
     
     
203. Prospective comparative study of the nephrotoxicity of aminoglycosides in human.
     De Broe ME, Paulus G, Verpooten GA, Roels F, Van Hoof F, Tulkens P
     J Antimicrob Chemother (1981) 8(suppl A):111-113.
     Chapter of book / Proceedings
     Abstract
     
     
204. Analytical characterization and purification of plasma membrane from cultured hepatoma cells (HTC cells).
     Sauvage P, Lopez-Saura P, Leroy-Houyet MA, Tulkens P, Trouet A
     Biochim Biophys Acta (1981) 644:41-52.
     Original paper
     Abstract
     
     
205. Intracellular penetration and distribution of antibiotics: the basis for an improved chemotherapy of intracellular infectious.
     Trouet A, Tulkens P
     In: The future of antibiotherapy and antibiotic research, L. Ninet, P.E. Bost, D.H. Bouanchaud, J. Florent ed., Academic Press, London, 337-349 (1981)
     Chapter of book / Proceedings
     
     
206. Lysosomal toxicity of gentamicin in rat kidney and comparisons with amikacin and tobramycin.
     Tulkens P, Carlier MB, Morin JP, Beauwens R, Maldague P, Giurgea L, Van Hoof F
     In: Current Chemotherapy and Immunotherapy, P. Periti and G. Gialdroni-Grassi ed., Am. Soc. Microbiol. Pub., Washington DC, 850-852 (1981)
     Chapter of book / Proceedings
     
     
207. The renal toxicity of aminoglycoside antibiotics: mechanism and comparisons between gentamicin, netilmicin, tobramycin and amikacin..
     Tulkens P, Morin JP, Carlier MB, Van Hoof F, Hallynck Th, Pijck J
     In: Current concepts in microbiology, A. Adam, P. Ers and J. Pijck ed., Elsevier/North Holland Biomed. Press, Amsterdam, 83-103 (1981)
     Chapter of book / Proceedings
     
     
208. Early morphological and biochemical events related to gentamicin nephrotoxicity.
     Morin JP, Van Hoof F, Tulkens P, Fillastre JP
     In: Current chemotherapy and infectious diseases, J.D. Nelson and Carlo Grassi ed., Amer. Soc. Microbiol., Washington DC, 610-612 (1980)
     Chapter of book / Proceedings
     
     
209. Gentamicin-induced nephrotoxicity: a cell biology approach.
     Morin JP, Viotte G, Vandewalle A, Van Hoof F, Tulkens P, Fillastre JP
     Kidney Int (1980) 18:583-590.
     Review
     Abstract
     
     
210. Subcellular localization of infectious agents: pharmacological and pharmacokinetic implications.
     Trouet A, Tulkens P, Schneider Y-J
     In: The host invader interplay, H. Vanden Bossche ed., Janssen Research Foundation, Elsevier/North Holland Biomedical Press, Amsterdam, 31-44 (1980)
     Chapter of book / Proceedings -- Journal impact factor: ct
     
     
211. Comparative toxicity of aminoglycoside antibiotics towards the lysosomes in a cell culture model.
     Tulkens P, Van Hoof F
     Toxicology (1980) 17:195-199.
     Original paper
     Abstract
     
     
212. Membrane recycling (shuttle ?) in endocytosis.
     Tulkens P, Schneider Y-J, Trouet A
     In: Mononuclear phagocytes : functional aspects, R. van Furth ed., M. Nijhoff Pub., The Hague, 613-647 (1980)
     Chapter of book / Proceedings
     
     
213. Gentamicin-induced lysosomal phospholipidosis in cultured rat fibroblasts.
     Aubert-Tulkens G, Van Hoof F, Tulkens P
     Lab Invest (1979) 40:481-491.
     Original paper
     Abstract
     
     
214. Cellular uptake and subcellular distribution of two non-steroidal anti-inflammatory drugs: indomethacin and ketoprofen.
     Blanchard JC, Schneider Y-J, Tulkens P, Trouet A
     Arch Int Pharmacod Ther (1979) 240:4-16.
     Original paper
     Abstract
     
     
215. Nanokapseln: ein neuer lysosomotropischer Trager.
     Couvreur P, Roland M, Speiser P, Trouet A, Tulkens P
     Acta Pharmaceutica Technologica (APV Informations (1979) 7spl:185-188.
     Chapter of book / Proceedings
     
     
216. Cellular toxicity of gentamicin.
     Libert J, Ketelbant-Balasse P, Van Hoof F, Aubert-Tulkens G, Tulkens P
     Am J Ophthalmol (1979) 87:405-411.
     Original paper
     Abstract
     
     
217. Fate of plasma membrane during endocytosis. I. Uptake and processing of anti-plasma membrane and control immunoglobulins by cultured fibroblasts.
     Schneider Y-J, Tulkens P, de Duve C, Trouet A
     J Cell Biol (1979) 82:449-465.
     Original paper
     Abstract
     
     
218. Fate of plasma membrane during endocytosis. II. Evidence for recycling (shuttle) of plasma membrane constituents.
     Schneider Y-J, Tulkens P, de Duve C, Trouet A
     J Cell Biol (1979) 82:466-474.
     Original paper
     Abstract
     
     
219. The role of lysosomes and plasma membrane in the intracellular accumulation of exogenous substances: physiological, pharmacological and toxicological studies in cultured cells.
     Tulkens P
     In: PhD Thesis (Thèse présentée en vue de l'obtention du grade d'Agrégé de l'Enseignement Supérieur), Université Catholique de Louvain, Université Catholique de Louvain, Louvain-la-Neuve, Belgique, pp. 135 (1979)
     PhD Thesis
     
     
220. Cellular pharmacology and toxicology: a tool for the evaluation and design of drugs.
     Tulkens P, Trouet A
     Acta Therapeutica (1979) 5:111-126.
     Chapter of book / Proceedings
     
     
221. Uptake and intracellular distribution of neutral red in cultured fibroblasts.
     Bulychev A, Trouet A, Tulkens P
     Exp Cell Res (1978) 115:343-355.
     Original paper
     Abstract
     
     
222. The intralysosomal pH.
     de Duve C, Okhuma S, Poole B, Tulkens P
     In: Microenvironments and metabolic Compartmentation, Srere, P.A. and Eastabrook, R.W. ed., Academic Press, New York, 371-380 (1978)
     Chapter of book / Proceedings
     
     
223. Analytical fractionation of cultured hepatoma cells (HTC cells).
     Lopez-Saura P, Trouet A, Tulkens P
     Biochim Biophys Acta (1978) 543:430-449.
     Original paper
     Abstract
     
     
224. Uptake and subcellular localization of daunorubicin and adriamycin in cultured fibroblasts.
     Noël G, Peterson C, Trouet A, Tulkens P
     Eur J Cancer (1978) 14:363-368.
     Original paper
     Abstract
     
     
225. Recycling of membranes during endocytosis.
     Schneider Y-J, Tulkens PM, Trouet A
     In: Transport of Macromolecules in Cellular Systems, S.C. Silverstein ed., Dahlem Konferenzen-Berlin, Abakon Verlag-gesell, Berlin W., 181-196 (1978)
     Chapter of book / Proceedings
     
     
226. The uptake and intracellular accumulation of aminoglycoside antibiotics in lysosomes of cultured rat fibroblasts.
     Tulkens P, Trouet A
     Biochem Pharmacol (1978) 27:415-424.
     Original paper
     Abstract
     
     
227. The lysosomal toxicity of aminoglycosides.
     Tulkens P, Aubert-Tulkens G, Van Hoof F, Trouet A
     In: Nephrotoxicity: interaction of drugs with membrane systems : Mitochondria-Lysosomes, J.P. Fillastre ed., Publications de l'Université de Rouen, Rouen, France, and Masson Pub. U.S.A. Inc., New York, N.Y., 231-251 (1978)
     Chapter of book / Proceedings
     
     
228. A shuttle between cell surface and lysosomes during endocytosis.
     Tulkens P, Schneider Y-J, Trouet A
     In: Protein Turnover and Lysosome Function, H. Segal and D. Doyle ed., Academic Press, New York, 719-738 (1978)
     Chapter of book / Proceedings
     
     
229. Nanocapsules: a new type of lysosomotropic carrier.
     Couvreur P, Tulkens P, Roland M, Trouet A, Speiser P
     FEBS Lett (1977) 84:323-326.
     Original paper
     Abstract
     
     
230. Production of rabbit antibodies against active rat cathepsin B.
     Piérart-Gallois M, Trouet A, Tulkens P
     Acta Biol Med Ger (1977) 36:1887-1891.
     Original paper
     Abstract
     
     
231. Recycling of fibroblast plasma membrane antigens internalized during endocytosis.
     Schneider Y-J, Tulkens P, Trouet A
     Biochem Soc Transact (1977) 5:1164-1167.
     Chapter of book / Proceedings
     Abstract
     
     
232. Etude du mécanisme d'endocytose à l'aide d'anticorps spécifiques.
     Schneider Y-J, Tulkens P, Trouet A
     Ann Sci Nat Bot Biol (1977) 18:61-69.
     Chapter of book / Proceedings
     
     
233. The fate of plasma the plasma membrane during endocytosis.
     Tulkens P, Schneider Y-J, Trouet A
     Biochem Soc Transact (1977) 5:1809-1815.
     Review
     Abstract
     
     
234. Studies on the mechanism of endocytosis in fibroblasts with the use of specific antibodies.
     Tulkens P, Schneider Y-J, Trouet A
     In: Intracellular protein catabolism II, V. Turk and N. Marks ed., J. Stefan Institute, Ljubljana and Plenum Press, New York, 73-84 (1977)
     Chapter of book / Proceedings
     
     
235. Flow and shuttle of plasma membrane during endocytosis.
     Tulkens P, Schneider Y-J, Trouet A
     Acta Biol Med Ger (1977) 36:1681-1690.
     Chapter of book / Proceedings
     Abstract
     
     
236. Aminoglycosides and vancomycin.
     Verpooten GA, Tulkens PM, Bennett WM
     In: Clinical nephrotoxins - Renal injury from drugs and chemicals, M.E. Debroe, G.A. Porter, W.M. Bennett & G.A. Verpooten ed., Kluwer Acad. Pub., 105-120 (1977)
     Chapter of book / Proceedings
     
     
237. Lysosomotropic drugs: biological and therapeutical aspects.
     Tulkens P, Trouet A
     In: Membranes and diseases, L. Bolis, J.F. Hoffman and A. Leaf ed., Raven Press, New York, 131-144 (1976)
     Chapter of book / Proceedings
     Abstract
     
     
238. Comparative cell pharmacokinetics of daunorubicin and adriamycin.
     Noël G, Trouet A, Zenebergh A, Tulkens P
     Adriamycin review (1975) 2:99-105.
     Chapter of book / Proceedings
     
     
239. Lysosomotropic agents.
     de Duve C, de Barsy Th, Poole B, Trouet A, Tulkens P, Van Hoof F
     Biochem Pharmacol (1974) 23:2495-2531.
     Review
     Abstract
     
     
240. Uptake and intracellular fate of anti-lysosome and anti-plasma membrane antibodies in cultured rat fibroblasts.
     Trouet A, Tulkens P, Schneider YJ
     In: Enzyme therapy in lysosomal storage diseases, J.M. Tager, C.J.M. Hooghwinkel & W. Th. Daems ed., North Holland Publ. Co., Amsterdam, 187-193 (1974)
     Chapter of book / Proceedings
     
     
241. Effects of anti-lysosome serum on cultured fibroblasts.
     Tulkens P
     In: Methodological developments in biochemistry, E. Reid ed., Longman, London, 327-338 (1974)
     Chapter of book / Proceedings
     
     
242. Analytical fractionation of homogenates from cultured rat embryo fibroblasts.
     Tulkens P, Beaufay H, Trouet A
     J Cell Biol (1974) 63:383-401.
     Original paper
     
     
243. Immunological inhibition of lysosome function.
     Tulkens P, Trouet A, Van Hoof F
     Nature (London) (1970) 228:1282-1285.
     Original paper
     Abstract
     
     
244. Influence of the injection of a sucrose solution on the properties of rat-liver lysosomes.
     Wattiaux R, Wattiaux-De Coninck S, Rutgeerts MJ, Tulkens P
     Nature (London) (1964) 203:757-758.
     Original paper
     
     

Last update: 28/12/2000
Corrections and additions: <tulkens@facm.ucl.ac.be>