Université Catholique de Louvain (UCL-Bruxelles)

1. Michot JM, Van Bambeke F, Mingeot-Leclercq MP, Tulkens PM
   Identification and characterization of ciprofloxacin efflux transporter in murine J774 macrophages.
   In: 40th Interscience Conference on Antimicrobial Agents and Chemotherapy, Toronto, Canada, 662 (2000)
   
   
2. Tyteca D, Van Bambeke F, Tulkens PM, Mingeot-Leclercq MP
   Azithromycin, a lysosomotropic antibiotic, impairs endocytosis in cultured macrophages.
   In: 41st International Conference on the Biochemistry of Lipids, Haale (Saale), Germany, T3/28 (2000)
   
   
3. Uwamahoro MJ, Carryn S, Michot JM, Mingeot-Leclercq MP, Tulkens PM, Van Bambeke F
   Modulation of the cellular accumulation of ciprofloxacin and moxifloxacin in J774 macrophages.
   In: 40th Interscience Conference on Antimicrobial Agents and Chemotherapy, Toronto, Canada, 2268 (2000)
   
   
4. Gerbaux-Morlighem C, Van Bambeke F, Tulkens PM
   Azithromycin increases the activity of cathepsin B, a lysosomal endopeptidase, by inhibiting its degradation in rat embryo fibroblasts.
   In: 39th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, Cal., 1757 (1999)
   
   
5. Gholizadeh Y, Van Bambeke F, Prévost M, Fraimow HS, Chachaty E, Dever LL, Tulkens PM, Courvalin P
   Study of glycopeptide-dependent Enterococcus faecium clinical isolates by sequencing of the ddl gene and computer-aided modeling of the mutated D-Ala:D-Ala ligase.
   In: 39th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, Cal, 1447 (1999)
   
   
6. Prévost M, Van Belle D, Tulkens PM, Courvalin P, Van Bambeke F
   Structure and function of Enterococcus faecalis D-Alanyl:D-Alanine ligase by comparative computer-aided conformational analysis.
   In: 39th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, Cal., 1139 (1999)
   
   
7. Tyteca D, Leys K, Van Bambeke F, Tulkens PM, Mingeot-Leclercq MP
   Macrolide antibiotics (azithromycin and erythromycylamine) perturb the early stages of endocytosis in phagocytic and non-phagocytic cells.
   In: 39th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, Cal., 1756 (1999)
   
   
8. Tyteca D, Van Bambeke F, Tulkens PM, Mingeot-Leclercq MP
   Azithromycin, a lysosomotropic antibiotic, perturbs the early stages of endocytosis in phagocytic and non-phagocytic cells.
   In: European Congress of Cell Biology, Bologna, Italy, D-147 (1999)
   
   
9. El Mouedden M, Laurent G, Mingeot-Leclercq MP, Tulkens PM
   Comparative studies of aminoglycoside-induced apoptosis in rat kidneys: study with gentamicin, netilmicin, amikacin, and isepamicin.
   In: 38th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, CA, A88 (1998)
   
   
10. El Mouedden M, Laurent G, Mingeot-Leclercq MP, Tulkens PM
    Apoptose induite par la gentamicine, un antibiotique lysosomotrope, en relation avec la surcharge lysosomale.
    In: 2eme Congrès Scientifique VML (Vaincre les Maladies Lysosomales), Dijon, France, (1998)
    
    
11. Michot JM, Decottignies A, Tulkens PM, Van Bambeke F
    In search of efflux pumps to fluoroquinolones in macrophages.
    In: 11th Scientific meeting of the Société belge d'Infectiologie et de Microbiologie Clinique/Belgische Vereniging voor Infectiologie en Klinische Microbiologie, Gent, Belgium, ----- (1998)
    
    
12. Michot JM, Gerbaux C, Van Bambeke F, Bouvier d'Yvoire M, Tulkens PM
    Lysosomal alterations induced in cultured cells models by long-term exposure to low, clinically meaningful concentrations of azithromycin.
    In: 38th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, Cal., I052 (1998)
    
    
13. Paternotte I, Burton S, Sonveaux E, Tulkens PM
    Uptake of esters prodrugs of ampicillin (pivampicillin, phthalimidomethylampicillin, S-acetyl-2-thioethylampicillin) in macrophages and PMN with intracellular liberation of ampicillin.
    In: 38th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, Cal., F7 (1998)
    
    
14. Tyteca D, Van Bambeke F, Tulkens PM, Mingeot-Leclercq MP
    Perturbation of membrane traffic induced in cultured cells by azithromycin, a lysosomotropic antibiotic.
    Arch Physiol Biochim (1998) 106:B28
    
    
15. Tyteca D, Van Bambeke F, Tulkens PM, Mingeot-Leclercq MP
    Perturbation of endocytosis induced by azithromycin in a model of cultured cells.
    In: 7th Symposium on Pharmacodynamics of Antimicrobials, International Society of Antiinfective Pharmacology, San Diego, Cal., ------- (1998)
    
    
16. Van Bambeke F, Chauvel M, Reynolds PE, Fraimow HS, Courvalin P
    Study of vancomycin-dependent Enterococcus faecalis clinical isolates and of in vitro revertant mutants.
    In: 38th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, Cal., C086 (1998)
    
    
17. El Mouedden M, Laurent G, Mingeot-Leclercq MP, Tulkens PM
    Understanding the mechanism of aminoglycoside-induced apoptosis and establishing its significance in relation with clinical toxicity of these drugs.
    In: 9th Scientific meeting of the Société Belge d'Infectiologie et de Microbiologie Clinique/Belgische Vereniging voor Infectiologie en Klinische Microbiologie, Verviers, Belgium, 11 (1997)
    
    
18. Kerkhofs A, Mingeot-Leclercq MP, Sonveaux E
    Pénétration intracellulaire d'oligonucléotides et de peptides par encapsulation dans des liposomes.
    In: Semaine scientifique des sciences de la vie, Bruxelles, Belgium, (1997)
    
    
19. Kerkhofs A, Van Bambeke F, Sonveaux E, Tulkens PM, Mingeot-Leclercq MP
    pH-sensitivity, leakage efficiency and endocytosis pathway of pH-sensitive liposomes DOPE/CHEMS AND DOPE/OA.
    In: 7th Forum of pharmaceutical sciences, Blankenberg, Belgium, (1997)
    
    
20. Kerkhofs A, Van Bambeke F, Tulkens PM, Remacle C, Mingeot-Leclercq MP
    Could pH-sensitive liposomes be used as drug delivery systems into cells.
    
    
21. Michot JM, Van Bambeke F, Gerbaux C, Montenez JP, Tulkens PM
    Influence of low doses of azithromycin on lysosomal metabolism in cultured rat embyo fibroblats.
    Arch Physiol Biochem (1997) 105:B11
    
    
22. Montenez JP, Van Bambeke F, Piret J, Brasseur R, Tulkens PM, Mingeot-Leclercq MP
    Comparative studies of lysosomal phospholipidosis induced by four macrolides.
    In: 37th Interscience Conference on Antimicrobial Agents and Chemotherapy, Toronto, Canada, F266 (1997)
    
    
23. 
    pH-sensitive liposomes: pH-sensitivity, leakage efficiency, endocytosis and natural targeting to the acidic compartment.
    In: Liposome Advances. Progress in drug and vaccine delivery. Centre for Drug Delivery Research, London, (1996)
    
    
24. Bouvier d'Yvoire M, Tulkens PM
    Computer-aided prediction of macrolide antibiotics concentrations in human circulating polymorphonuclear leucocytes.
    
    
25. El Mouedden M, Laurent G, Tulkens PM
    Gentamicin causes lysosomal storage disorder (phospholipidosis) and apoptosis in cultured renal cells and rat fibroblasts.
    In: 24th meeting of the Federation of the European Societies of Biochemistry, Barcelona, Spain, ----- (1996)
    
    
26. El Mouedden M, Laurent G, Piret J, Mingeot-Leclercq MP, Tulkens PM
    Correlation between lysosomal phospholipidosis and apoptosis induced by aminoglycosides: in vitro comparative study with gentamicin, netilmicin, and isepamicin.
    In: Programme and abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, La., A86 (1996)
    
    
27. Gerbaux C, Van Bambeke F, Piret J, Morlighem G, Tulkens PM
    Paradoxical increase of the activities of lysosomal enzymes in lysates of rat embryo fibroblasts incubated with azithromycin.
    In: 36th Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, La., A84 (1996)
    
    
28. Kerkhofs A, Van Bambeke F, Sonveaux E, Tulkens PM, Mingeot-Leclercq MP
    pH-sensitive liposomes: pH-sensitivity, leakage efficiency, endocytosis, and natural targeting to the acidic compartments.
    In: Liposome Advances (Progress in drug and vaccine delivery), London, England, A 42 (1996)
    
    
29. Mingeot-Leclercq MP, Montenez JP, Van Bambeke F, Schanck A, Brasseur R, Tulkens PM
    Interaction of cationic lysosomotropic antibiotics with negatively-charged membranes. II. Molecular characterization by biophysical and computer-aided conformational studies.
    In: 24th Meeting of the Federation of European Biochemical Societies, Barcelona, Spain, PS23-48 (1996)
    
    
30. Montenez JP, Van Bambeke F, Mingeot-Leclercq MP, Piret J, Brasseur R, Tulkens PM
    Azithromycin causes an accumulation of lipids in lysosomes of cultured cells: Biochemical mechanism and potential relationship with its long-time retention in cells.
    In: 36th Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, La., A85 (1996)
    
    
31. Scorneaux B, Ouadrhiri Y, Anzalone G, Tulkens PM
    Intracellular activity of azithromycin in relation to its cellular disposition towards bacteria infecting distinct subcellular compartments.
    In: 3d International Conference on the Macrolides, Azalides and streptogramins, Lisbon, Portugal, 4.17 p.42 (1996)
    
    
32. Tyteca D, Belaabidia L, Montenez JP, Van Bambeke F, Mingeot-Leclercq MP, Piret J, Brasseur R, Tulkens PM
    In vitro comparative studies of the interactions of gentamicin and azithromycin with membrane lipids: contribution to the understanding of the molecular mechanism by which they cause a lysosomal phospholipidosis in cultured cells.
    Arch Physiol Biochem (1996) 104:B22
    
    
33. Van Bambeke F, Montenez JP, Mingeot-Leclercq MP, Nachega J, Courtoy PJ, Tulkens PM
    Perturbation of endosome-lysosome fusion induced in cultured cells by two lysosomotropic antibiotics (azithromycin, gentamicin) causing a lysosomal phospholipidosis.
    In: Page-Wood International Symposium on Membrane Traffic in Health and Disease, Cleveland, Ohio, 42 (1996)
    
    
34. Van Bambeke F, Montenez JP, Mingeot-Leclerq MP, Belaabidia L, Tyteca D, Tulkens PM
    Interaction of cationic lysosomotropic antibiotics with negatively-charged membranes. I. Binding, inhibition of lysosomal phospholipase A1 and influence on bilayer aggregation/fusion.
    In: 24th Meeting of the Federation of European Biochemical Societies, Barcelona, Spain, PS23-47 (1996)
    
    
35. Anzalone G, Scorneaux B, Ouadrhiri Y, Tulkens PM
    Effect of human recombinant interferon-gamma on the intracellular activities of antibiotics against L. monocytogenes in a model of THP1 (human macropahges) cell line.
    In: 19th Intern. Congress of Chemotherapy, Montreal, Quebec, Canada/Can. J. Infect. Dis. 6 suppl. C, 4170 (1995)
    
    
36. Bouvier d'Yvoire MJY, Tulkens PM
    Prédiction des concentrations de macrolides dans les polymorphonucléaires humains circulants in vivo.
    In: 15eme Réunion Interdisciplinaire de Chimiothérapie Anti-infectieuse/15th Interdisciplinary Meeting of Anti-infectious Chemotherapy, Paris, France, 372/P24 (1995)
    
    
37. Bruno C, Ibrahim S, Clement de Clety S, Moulin D, Tulkens PM
    Pharmacokinetics of aztreonam in infants after liver transplantation.
    In: Satellite Symposum on Pharmacodynamics of Antimicrobials, International Society of Antiinfective Pharamcology, Québec, Québec, Canda, 5 (1995)
    
    
38. Carreer R, Sibille Y, Tulkens PM
    Oxidant-scavenging activities of ceftazidime and other beta-lactams: evidence for a specific effect toward HCLO.
    In: 19th Intern. Congress of Chemotherapy, Montreal, Quebec, Canada/Can. J. Infect. Dis. 6 suppl. C, O670 (1995)
    
    
39. El Mouedden M, Laurent G, Taper HS, Tulkens PM
    Gentamicin causes apoptosis in renal tubule epithelium of rats treated at low, clinically relevant doses.
    In: 35th Interscience Conference on Antmicrobial Agents and Chemotherapy, San Francisco, Cal., 123 (1995)
    
    
40. El Mouedden M, Laurent G, Taper HS, Piret J, Tulkens PM
    Would lysosomal phospholipidosis cause cell death by apoptosis ?.
    In: 10th European Study Group on Lysosomal Diseases Workshop, Cambridge, U.K., (1995)
    
    
41. Ibrahim S, Tulkens PM
    Phospholipiduria (PLU) for the early detection of aminoglycosides (AG)-induced renal alterations and toxicity: Overview of animal and clinical data.
    Toxicol Lett (1995) 78 Supl.1:41
    
    
42. Ibrahim S, Bruno C, Clement de Clety S, Moulin D, Tulkens PM
    Aztreonam pharmacokinetic parameters in pediatrics after liver transplant.
    In: 19th Intern. Congress of Chemotherapy, Montreal, Quebec, Canada/Can. J. Infect. Dis. 6 suppl. C, 4069 (1995)
    
    
43. Ibrahim S, Van Laethem Y, Hermans P, O'Doherty E, Eestermans GHE, Clumeck N, Tulkens PM
    Renal tolerance of liposomal amikacin in HIV+ patients: a pilot multiple parameters study.
    In: 35th Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco, Cal., A121 (1995)
    
    
44. Leto ML, Byl B, Bruno C, Ibrahim S, Baran D, Tulkens PM, Thys JP
    Serum pharmacokinetic parameters and penetration of aztreonam in sputum of patients with cystic fibrosis.
    In: 5ème réunion scientifique de la Société Belge d'Infectiologie et de Microbiologie Clinique, Leuven, belgium, --- (1995)
    
    
45. Montenez JP, Piret J, Tulkens PM
    Macrolide antibiotics induce a cell overloading with cholesterol from exogenous origin: studies in clutured fibroblasts and comparison between azithromycin, dirithromycin, and erythromycin.
    In: Eurotox 95 (Toxicology from cells to man), Prague, Czech Republic, (1995)
    
    
46. Ouadrhiri Y, Scorneaux B, Sibile Y, Tulkens PM
    Differentiation of macrophages (THP-1 cell line) allows ceftazidime to exert a bactericidal action towards ingested S. aureus.
    In: 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, Cal., 916 (1995)
    
    
47. Piret J, Gerbaux C, Montenez JP, Tulkens PM
    Lysosomal changes induced by neomacrolides in cultured fibroblasts: comparative studies with azithromycin and dirithromycin.
    In: 19th Intern. Congress of Chemotherapy, Montreal, Quebec, Canada/Can J. Infect. Dis. 6 suppl C, 3202 (1995)
    
    
48. Schanck A, Van Bambeke F, Tulkens PM, Mingeot-Leclercq MP
    31P NMR of negatively-charged liposomes interacting with aminoglycosides.
    In: Comptes-rendus du GERM XIV, Anglet-Biarritz, France, 60 (1995)
    
    
49. Scorneaux B, Tulkens PM
    Intracellular bacteria drive cell-associated fluoroquinolones from the cytosol to the infected compartment: importance of the sensitivity of the bacteria to the drug.
    In: 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, Cal., A68 (1995)
    
    
50. Scorneaux B, Tulkens PM
    Uptake, effelux, and subcellular distribution of minocycline and doxycycline in J774 macrophages.
    In: 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, Cal., (1995)
    
    
51. Scorneaux B, Tulkens PM
    Activity of dirithromycine against intracellular pathogens with distinct localizations in a model of J774 macrophages: comparison with erythromycin, roxithromycin and azithromycin.
    In: 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, Cal., (1995)
    
    
52. Scorneaux B, Tulkens PM
    Activities of RP59500 (quinupristin/dalfopristin) and macrolides against Legionella pneumophila in a model of J774 macrophages in relation to their cellular accumulation.
    In: 15eme Réunion Interdisciplinaire de Chimiothérapie Anti-infectieuse/15th Interdisciplinary Meeting of Anti-infectious Chemotherapy, Paris, France, 373/P24 (1995)
    
    
53. Scorneaux B, Anzalone G, Ouadrhiri Y, Sibille Y, Tulkens PM
    Effect of interferon-gamma on the intracellular activity of antibiotics against L. monocytogenes in a model of THP-1 (human macrophages) cell line.
    In: 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, Cal., 108 (1995)
    
    
54. Scorneaux B, Orfila J, Tulkens PM
    Activity of dirithromycin against intracellular pathogens with distinct localization in a model of J774 macrophages: comparison with erythromycin, roxithromycin and azithromycin.
    In: 15eme Réunion Interdisciplinaire de Chimiothérapie Anti-infectieuse/15th Interdisciplinary Meeting of Anti-infectious Chemotherapy, Paris, France, 3/C1 (1995)
    
    
55. Scorneaux B, Ouadrhiri Y, Anzalone G, Tulkens PM
    Contrasting bioavailabilities and/or expression of activity of fluoroquinolones and beta-lactams in Listeria monocytogenes.
    In: 19th Intern. Congress of Chemotherapy, Montreal, Quebec, Canada/Can. J. Infect. Dis. 6 suppl. C, P4170 (1995)
    
    
56. Scorneaux B, Piret J, Montenez JP, Tulkens PM
    Uptake, subcellular distribution and efflux of erythromycylamine in J774 macrophages incubated with dirithromycin: comparison with other macrolides.
    In: 15eme Réunion Interdisciplinaire de Chimiothérapie Anti-infectieuse/15th Interdisciplinary Meeting of Anti-infectious Chemotherapy, Paris, France, 43/C5 (1995)
    
    
57. Van Bambeke F, Mingeot-Leclercq MP, Schanck A, Brasseur R, Tulkens PM
    Aminoglycosides aggregate membranes and prevent phospholipid reorganization: comparative studies with gentamicin, amikacin, and isepamicin and correlation with nephrotoxicity.
    In: 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, Cal., 913 (1995)
    
    
58. Van Bambeke F, Tulkens PM, Schanck A, Mingeot-Leclercq MP
    Aminoglycoside antibiotics cause aggregation of negatively-charged membranes but inhibit the lipid reorganization necessary for their fusion.
    In: 19th Intern. Congress of Chemotherapy, Montreal, Quebec, Canada/Can. J. Infect. Dis. 6 suppl. C., 3009 (1995)
    
    
59. Van Bambeke F, Tulkens PM, Schanck A, Mingeot-Leclercq MP
    Deciphering the toxicological parameters of aminoglycoside nephrotoxicity: a combined biophysical and biochemical study of gentamicin, amikacin and isepamicin in interaction with phosphatidylinositol-containing lipid vesicles.
    In: Satellite symposium on pharmacodynamics of antimicrobials, International Society of Antinfective Pharamcology, Québec, Québec, Canada, 27 (1995)
    
    
60. Bily A, Scorneaux B, Tulkens PM
    Activities of glycopeptide antibiotics (vancomycin, teicoplanin) towards intracellular methicillin-resistant and methicillin-susceptible S. aureus in a model of J774 macrophages in comparison with ciprofloxacin and rifampicin.
    In: 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, Orlando, Fl., E37 (1994)
    
    
61. Gerbaux C, Piret J, Montenez J-P, Tulkens PM
    Azithromycin increases the activities of several lysosomal enzymes when measured in lysates of rat embryo fibroblasts incubated with this antibiotic.
    In: 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, Orlando, Fl., A108 (1994)
    
    
62. Gerbaux C, Piret J, Montenez J-P, Tulkens PM
    Etude d'une nouvelle thésaurismose lysosomiale acquise induite par l'azithromycine: III. Effet paradoxal sur l'activité de la phospholipase A1 et d'autres hydrolases lysosomiales de fibroblastes en culture.
    In: Congrès National sur les Maladies Lysosomales, Saumur, France, 20 (1994)
    
    
63. Gerbaux C, Piret J, Montenez J-P, Carlier M-B, Courtoy PJ, Tulkens PM
    Effects of azithromycin on the activities of several enzymes in rat embryo fibroblasts.
    Arch Int Physiol Biochim (1994) 100:B55
    
    
64. Ibrahim S, Langhendries JP, Bernard A, Tulkens PM
    Increase of phospholipiduria in neonates treated with amikacin.
    In: Future Trends in Chemotherapy, Geneva, Switzerland., 90 (1994)
    
    
65. Lambricht P, Courtoy PJ, Maldague P, Ibrahim S, Tulkens PM, Daniel RR
    Safety of azitromycin and erythromycin in long-term treatments: analysis of phospholipiduria and phospholipidosis in white blood cells.
    In: Future Trends in Chemothery, Geneva, Switzerland., 91 (1994)
    
    
66. Mingeot-Leclercq MP, Depienne L, Van Bambeke F, Montenez JP, Tulkens PM
    Interaction of aminoglycoside and macrolide antibiotics with membranes. Effect on Ca2+ permeability.
    Cell Biol Int Rep (1994) :17/2
    
    
67. Mingeot-Leclercq MP, Kotretsou S, Constantinou-Kokotou S, Georgiadis MP, Brasseur R, Tulkens PM
    Synthesis, microbiological and in vitro toxicological evaluation of amino acid and peptide derivatives in position 6 prime of kanamycin A and netilmicin.
    In: 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, Orlando, Fl., F140 (1994)
    
    
68. Mingeot-Leclercq MP, Van Bambeke F, Schanck A, Depienne L, Montenez JP, Tulkens PM
    Effect of aminoglycoside and macrolide antibiotics on membrane permeability.
    In: FEBS Special Meeting Biological Membranes, Helsinki, Finland, 248 (1994)
    
    
69. Montenez J-P, Carlier M-B, Garcia-Luque I, Piret J, Tulkens PM
    Etude d'une nouvelle thésaurismose lysosomiale acquise induite par l'azithromycine : I. Augmentation des taux cellulaires de phospholipides et de cholestérol estérifié dans des fibroblastes en culture.
    In: 1er Congrès National sur les Maladies lysosomales, Saumur, France., 68 (1994)
    
    
70. Montenez J-P, Carlier MB, Piret J, Garcia-Luque I, Courtoy PJ, Tulkens PM
    Azithromycin induces a lysosomal phospholipidosis in cultured rat embryo fibroblasts.
    Cell Biol Int (1994) 17:15
    
    
71. Montenez JP, Carlier MB, Garcia-Luque I, Tulkens PM
    Azithromycin decreases the buoyant density of lysosomes and increases the lipid phosphorus content of non-phagocytic cells in culture.
    In: 2d International Conference on the Macrolides, Azalides and Streptogramins, Venice, Italy, 210 (1994)
    
    
72. Piret J, Kishore BK, Tulkens PM
    In vitro models for the study of the regulation of the activity of lysosomal phospholipase A1 by membrane lipids.
    Cell Biol Int (1994) 17(2):14
    
    
73. Piret J, Kishore BK, Tulkens PM
    In vitro models for the study of the regulation by membrane lipids of the mode of gentamicin-induced inhibition of lysosomal phospholipase A1.
    Cell Biol Int (1994) 17(2):13
    
    
74. Piret J, Montenez J-P, Tulkens PM
    Etude d'une nouvelle thésaurismose lysosomiale acquise induite par l'azithromycine : II. Inhibition de l'activité de la phospholipase A1 dans un système a-cellulaire et comparaison de mécanisme avec la gentamicine.
    In: 1er Congrès National sur les Maladies Lysosomales, Saumur, France., 64 (1994)
    
    
75. Piret J, Montenez J-P, Tulkens PM
    Azithromycin induces a lysosomal phospholipidosis in cultured rat embryo fibroblasts.
    In: 11th Future Trends in Chemotherapy (Interdisciplinary World Congress on Antimicrobial and Anticancer Drugs), Geneva, Switzerland., 189 (1994)
    
    
76. Piret J, Montenez J-P, Tulkens PM
    Lysosomal alterations induced by azithromycin in cultured rat embryo fibroblasts.
    In: 4th European Congress of Cell Biology, Prague, Czech Republic., 108 (1994)
    
    
77. Piret J, Montenez J-P, Tulkens PM
    Biochemical analysis and mechanism of the phospholipidosis induced by macrolide antibiotics in cultured rat embryo fibroblasts.
    In: 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, Orlando, Fl., A108b (1994)
    
    
78. Scorneaux B, Tulkens PM
    Extracellular and intracellular activities of azithromycin, isepamicin and sparfloxacin alone and in association against Mycobacterium avium complex.
    In: 2d International Conference on the Macrolides, Azalides and Streptogramins, Venice, Italy, 165 (1994)
    
    
79. Scorneaux B, Tulkens PM
    Intracellular infection by L. pneumophila and S. aureus modulates the subcellular distribution of fluoroquinolones but not that of macrolides in a model of J774 macrophages.
    In: 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, Orlando, Fl., E31 (1994)
    
    
80. Scorneaux B, Tulkens PM
    Influence of intracelular infection on the release of macrolides and fluoroquinolones from J774 macrophages.
    In: 2d International Conference on the Macrolides, Azalides and Streptogramins, Venice, Italy, 209 (1994)
    
    
81. Scorneaux B, Tulkens PM
    Comparative intracellular activities of gentamicin, ampicillin, macrolides and fluoroquinolones against virulent L. monocytogenes and S. flexneri and their non-virulent mutants in J774 macrophages.
    In: 2d International Conference on the Macrolides, Azalides and Streptogramins, Venice, Italy, 164 (1994)
    
    
82. Scorneaux B, Tulkens PM
    Quantitative comparison of the activities of different pharmacological classes of antibiotics against extracellular and intracellular forms of susceptible bacteria.
    In: 2d International Conference on the Macrolides, Azalides and Streptogramins, Venice, Italy, 158 (1994)
    
    
83. Scorneaux B, Orfila J, Tulkens PM
    Comparative activities of tretacyclines (tetracycline, oxytetracycline, doxycycline, minocycline) against two types of intracellular pathogens (S. aureus methicillin-sensitive and resistant; Chlamydia spp.) in a model of J774 macrophages.
    In: 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, Orlando, Fl., E35 (1994)
    
    
84. Van Bambeke F, Mingeot-Leclercq MP, Depienne L, Tulkens PM
    Evaluation of the capacity of aminoglycoside antibiotics to induce aggregation or fusion of liposomes, measured by the dequenching of the fluorescence of octadecylrhodamine B chloride (R18).
    Cell Biol Int Rep (1994) :17/2
    
    
85. Van Bambeke F, Mingeot-Leclercq MP, Depienne L, Tulkens PM
    Evaluation of aminoglycoside antibiotics capacity to induce aggregation or fusion of liposomes, by using 3 complementary fluorescence techniques.
    In: FEBS Special Meeting Biological Membranes, Helsinki, Finland, 247 (1994)
    
    
86. Van Bambeke F, Mingeot-Leclercq MP, Depienne L, Tulkens PM
    Aminoglycosides induce aggregation but not fusion of liposomes, as evidenced by biophysical and morphological approaches.
    In: 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, Orlando, Fl., A108a (1994)
    
    
87. Van Bambeke F, Mingeot-Leclercq MP, Schanck A, Brasseur R, Tulkens P
    Aminoglycoside antibiotics induced alterations in membrane permeability of liposomes to increasing molecular weight markers.
    Cell Biol Int Rep (1994) :17/2
    
    
88. Van Laethem Y, Ibrahim S, Dachy B, Dechamps P, Stevens E, Hermans P, Franchioly P, Clumeck N, Sommereijns B, Tulkens PM
    Once-a-day and twice-a-day schedules of amikacin are equally tolerated in Intensive Care Unit patients: a double blind, randomized, prospective study.
    In: 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, Orlando, Fl., M88 (1994)
    
    
89. Van Laethem Y, Ibrahim S, Dechamps P, Stevens E, Hermans P, Kaufman L, Derde MP, Clumeck N, Tulkens PM
    Double-blind, randomized comparison of the renal safety of amikacin once-a-day vs twice-a-day in intensive care unit (ICU) patients.
    In: Future Trends in Chemotherapay, Geneva, Switzerland., 92 (1994)
    
    
90. Crasson D, Scorneaux B, Tulkens PM
    Quantitative comparison of the activities of antibiotics against extracellular and intracellular forms of susceptible bacteria.
    In: 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, La, 767 (1993)
    
    
91. Garcia-Luque I, Carlier MB, Tulkens PM
    Effect of azithromycin on the buoyant density of lysosomes in cultured fibroblasts.
    In: 6th European Congress of Clinical Microbiology and Infectious Diseases, Seville, Spain, 307 (1993)
    
    
92. Langhendries JP, Battisti O, Betrand JM, François A, Darimont J, Ibrahim S, Tulkens PM, Bernard A, Scalais E
    Once-a-day administration of amikacin in neonates: assessment of nephrotoxicity and ototoxicity.
    In: 5th European Congress of Biopharmaceutics and Pharmacokinetics, Brussels, Belgium/Drug Metabolism and Pharmacokinetics., 169 (1993)
    
    
93. Mingeot-Leclercq MP, Van Bambeke F, Brasseur R, Tulkens PM
    Aminoglycoside-induced increase in membrane permeability. II. Studies with cultured cells.
    In: 11th International Biophysics Congress, Budapest, Hungary, C5.32 (1993)
    
    
94. Montenez JP, Carlier B, Garcia-Luque I, Tulkens PM
    Azithromycin decreases the buoyant density of lysosomes and increases the lipid phosphorus content of non-phagocytic cells in culture.
    In: 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, La, 310 (1993)
    
    
95. Piret J, Kishore BK, Tulkens PM
    Influence of the lipid composition of membranes on the mode of inhibition of lysosomal phospholipase A1 activity by gentamicin in vitro.
    In: 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, La, 592 (1993)
    
    
96. Scorneaux B, Tulkens PM
    Influence of intracellular infection on the release of macrolides and fluoroquinolones from J774 Macrophages.
    In: 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, La, 768 (1993)
    
    
97. Scorneaux B, Tulkens PM
    Extracellular (extra) and intracellular (intra) activities of azithromycin, isepamicin, and sparfloxacin alone and in association against Mycobacterium avium complex.
    In: 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, La, 1351 (1993)
    
    
98. Scorneaux B, Carlier MB, Garcia-Luque I, Tulkens PM
    Intracellular activities of macrolides against Mycobacterium avium complex in a model of J774 macrophages.
    In: 6th European Congress of Clinical Microbiology and Infectious Diseases, Sevilla, Spain, 230 (1993)
    
    
99. Tulkens PM
    Penetration, accumulation and intracellular distribution of antibiotics: clinical implications.
    In: 21ème Journées annuelles de la Soci‚t‚ belge de P‚diatrie (Maladies infectieuses chez l'enfant: aspects r‚cents)/21ste Jaarvergadering van de belgische Vereniging voor Kindergeneeskunde (Infectieziekten bij het kind: recente aanwinsten), -- (1993)
    
    
100. Van Bambeke F, Mingeot-Leclercq MP, Tulkens PM
     Alterations in membrane permeability induced by aminoglycoside antibiotics. Studies on liposomes and cells.
     Arch Int Physiol Biochim Biophys (1993) 101:B21
     
     
101. Van Bambeke F, Mingeot-Leclercq MP, Depienne L, Tulkens PM
     Aminoglycoside induced increase of membrane permeability in liposomes and cultured cells.
     In: 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, La, 218B (1993)
     
     
102. Van Bambeke F, Mingeot-Leclercq MP, Depienne L, Schanck A, Tulkens PM
     Aminoglycoside-induced increase in membrane permeability. I. Studies with large unilamellar vesicles.
     In: 11th International Biophysics Congress, Budapest, Hungary, C5.31 (1993)
     
     
103. Willot I, Scorneaux B, Tulkens PM
     Comparative intracellular activity of antibiotics against virulent L. monocytogenes, S. flexneri and their non virulent mutants in a model of J774 macrophages.
     In: 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, La, 769 (1993)
     
     
104. Ibrahim S, Gerard F, Kishore BK, Lambricht P, Wagner R, Tulkens PM
     Aminoglycoside-induced renal alterations: correlation between renal phospholipidosis and phospholipiduria, and modulation by the coadministration of piperacillin.
     Renal Failure (1992) 14:67
     
     
105. Ibrahim S, Gerard F, Kishore BK, Lambricht P, Wagner R, Tulkens PM
     Aminoglycosides (AGs)-induced renal alterations: correlation between renal phospholipidosis (RPL) and phospholipiduria (PLU) and modulation by the coadministration of piperacillin (PIP).
     Renal Failure (1992) 14:116
     
     
106. Kishore BK, Ibrahim S, Lambricht P, Laurent G, Maldague P, Tulkens PM
     Influence of the coadministration of poly-L-aspartic acid on the gentamicin-induced tenal phospholipidosis, qualitative and quantitative lysosomal alterations and cell turn-over.
     Renal Failure (1992) 14:75
     
     
107. Kishore BK, Maldague P, Havaux X, Ibrahim S, Tulkens PM, Courtoy P
     Cytochemical and physicochemical characterization of the acute thesaurismosis induced by poly-D-glutamic acid in rat kidney cortex.
     In: 5th International Congress on Cell Biology, Madrid, Spain, P4.1.122 (1992)
     
     
108. Kishore BK, Maldague P, Laurent G, Lambricht P, Ibrahim S, Tulkens PM
     Acute lysosomal thesaurismosis of proximal tubular cells and proliferation of peritubular cells induced by poly-D-glutamic acid in rat kidney cortex.
     Renal Failure (1992) 14:74
     
     
109. Lambricht P, Derde MP, Kaufman L, Donnez J, Vandercam B, Tulkens PM
     Quantitative analysis of the auditory tolerance of amikacin and isepamicin in 2 cohorts of patients using low and high frequency audiometry.
     In: 32d Interscience Conference on Antimicrobial Agents and Chemotherapy, Anaheim, Cal., 1592 (1992)
     
     
110. Lu F, Kishore BK, Tulkens PM
     Pharmacokinetics and renal uptake of poly-L-aspartic and poly-L-glutamic acids in rats.
     In: 32d Interscience Conference on Antimicrobial Agents and Chemotherapy, Annaheim, Cal., 295 (1992)
     
     
111. Lu F, Kishore BK, Tulkens PM
     A stable model of anesthetised and infused rats for single dose pharmacokinetic studies.
     In: 13th European Workshop on Drug Metabolism (Europ. Society of Biochemical Pharmacology), Bergamo, Italy, (1992)
     
     
112. Montenez JP, Kishore BK, Tulkens PM
     Paradoxical effects of leupeptin on the activity of cathepsin B in vitro and in cultured fibroblasts.
     In: 1st Intern. Union of Biochemistry and Molecular Biology Conference (Biochemistry of Disease), Nagoya, Japan, ------- (1992)
     
     
113. Montenez J-P, Delaisse J-M, Vaes G, Tulkens PM, Kishore BK
     Increased activities of cathepsin B and other lysosomal hydrolases in fibroblasts and bone tissue cultured in the presence of leupeptin.
     In: 5th International Congress on Cell Biology, Madrid, Spain, P-3.6 318 (1992)
     
     
114. Piret J, Dalcq-Aubert A, Kishore BK, Tulkens PM
     Kinetic parameters of native and delipidated rat liver lysosomal phospholipase A1 towards phosphatidylcholine. II. Mathematical modeling and statistical analysis of experimental data.
     Arch Int Physiol Biochim (1992) 100:B62
     
     
115. Piret J, Kishore BK, Tulkens PM
     Kinetic parameters of native and delipidated rat liver lysosomal phospholipase A1 towards phosphatidylcholine I. Experimental design.
     Arch Int Physiol Biochim (1992) 100:B62
     
     
116. Piret J, Kishore BK, Tulkens PM
     Evaluation and validation of in vitro models of inhibition of phospholipid catabolism by aminoglycosides.
     In: 32nd Interscience Conference on Antimicrobial Agents and Chemotherapy, Anaheim, Cal., 294 (1992)
     
     
117. Piret J, Kishore BK, Tulkens PM
     In vitro modulating effect of membrane phospholipids on the activity of lysosomal phosplipase A1: possible relevance to turn-over of membrane phospholipids in vivo.
     In: 5th International Congress on Cell Biology, Madrid, Spain, P-4.3 50 (1992)
     
     
118. Scorneaux B, Tulkens PM
     Activities of macrolides and fluoroquinolones against Legionella pneumophila in a model of J774 macrophages in relation to their cellular accumulation.
     In: 32d Interscience Conference on Antimicrobial Agents and Chemotherapy, Anaheim, Calif., 1701 (1992)
     
     
119. Scorneaux B, Tulkens PM
     Comparison of the intracellular activities of erythromycin and azithromycin against Mycobacterium avium complex in a model of J774 macrophages.
     In: 32d Interscience Conference on Antimicrobial Agents and Chemotherapy, Anaheim, Cal., 1333 (1992)
     
     
120. Scorneaux B, Tulkens PM
     Activities of azithromycin, spafloxacin, gentamicin and ampicillin against a series of facultative and obligatory intracellular parasites in a model of J774 macrophages.
     In: 32d Interscience Conference on Antimicrobial Agents and Chemotherapy, Anaheim, Cal., 1706 (1992)
     
     
121. Tulkens PM, Scorneaux B
     Intracellular activity of new macrolides and azalides.
     In: 1st International Conference on the Macrolides, Azalides and Streptogramins, Santa Fe, New Mexico, 5 (1992)
     
     
122. Wallemacq P, Leal T, Vandercam B, Therasse P, Lambricht P, Tulkens PM
     Analysis of key pharmacokinetic parameters (Vd, t1/2) of isepamicin, a new aminoglycoside, in 2 cohorts of infected patients.
     In: 32d Interscience Conference on Antimicrobial Agents and Chemotherapy, Anaheim, Cal., 210 (1992)
     
     
123. Carlier MB, Lobberding A, Tulkens PM
     Subcellular localization of a phosphorothioate oligonucleotide in eukaryotic cells..
     In: Proceedings of the 17th International Congress of Chemotherapy, Berlin, Germany, (1991)
     
     
124. Carlier MB, Scorneaux B, Tulkens PM
     Accumulation, subcellular distribution and activity of azithromycin compared to roxithromycin and ciprofloxacin in J774 macrophages.
     In: 31st Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, Ill., 510 (1991)
     
     
125. Ibrahim S, Gerard F, Kishore BK, Lambricht P, Wagner R, Tulkens PM
     Aminoglycosides-induced renal alterations: Correlation between renal phospholipidosis and phospholipiduria, and the modulation by co-administration of piperacillin..
     In: Symposium on Acute Renal Failure, Chapel Hill, N. Carolina, 110 (1991)
     
     
126. Ibrahim S, Gerard F, Lambricht P, Kishore BK, Tulkens PM
     Protective effect of piperacillin on netilmicin-induced early renal alterations..
     In: 31st Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, Ill., 331 (1991)
     
     
127. Kishore BK, Maldague P, Havaux X, Tulkens PM, Courtoy P
     Cytochemical characterization of the acute thesaurismosis induced by poly-D-glutamic acid in rat kidney proximal tubular cells.
     Eur Arch Biol (1991) 102:220
     
     
128. Kishore BK, Van Schepdael A, Laurent G, Lambricht P, Piret J, Claes PJ, Tulkens PM
     Effect of co-oxydextran on the early renal alterations induced by gentamicin in rats.
     In: 7th International Symposium on Nephrology (Kidney, Proteins and Drugs), Montecatini Terme, Italy, 64 (1991)
     
     
129. Montenez JP, Kishore BK, Tulkens PM
     Addition of leupeptin, an inhibitor of cysteine proteinases, to the culture medium causes an increase of the activities of cathepsin B and other lysosomal hydrolases in lysates of cultured fibroblasts.
     Arch Int Physiol Biochim (1991) 100:B18
     
     
130. Piret J, Dalcq-Aubert A, Kaufman L, Tulkens PM
     Estimation of binding parameters of single and double Michaelis-Menten equations by nonlinear optimization method.
     In: Symposium on Receptors Signal Transduction and Drug Design, Antwerpen, Belgium, (1991)
     
     
131. Piret J, Kishore BK, Tulkens PM
     Effect of delipidation of rat liver lysosomal phospholipase A1 on its activity towards phosphatidylcholine included in liposomes and on its inhibition by gentamicin.
     In: American Society of Biochemistry and Molecular Biology Symposium (Biological Significance of Lipid Modification of Proteins), Keystone, Colo., (1991)
     
     
132. Piret J, Kishore BK, Tulkens PM
     Effect of composition of lipid vesicles on the activity and on the gentamicin-induced inhibition of rat liver lysosomal phospholipase A1.
     In: Eurotox Congress, Maastricht, The Netherlands, 156 (1991)
     
     
133. Piret J, Kishore BK, Van Schepdael A, Claes PJ, Tulkens PM
     In vitro evaluation of polyanionic dextran and sugar derivatives as protectants against gentamicin-induced lysosomal phospholipidosis.
     In: 1991 Eurotox Congress, Maastricht, The Netherlands, 155 (1991)
     
     
134. Scorneaux B, Orfila J, Tulkens PM
     Comparative activity of sparfloxacin and erythromycin in a model of J774 macrophages infected with Chlamydia pneumoniae.
     In: 31st Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, Ill., 511 (1991)
     
     
135. Tulkens PM
     Targeting and non-targeting of antiinfective drugs for chemotherapy of intracellular infection.
     In: Synthetic polymers as drug carriers. Interactions with blood, A. Baszkin, P. Ferruti, M.A. Marchisio & M.C. Tanzi ed., Eurobiomat Coordination Secretariat, Rudolf-Virchov-Clinic, Berlin, Germany, 175 (1991)
     
     
136. Bodart C, Nonclercq D, Toubeau G, Lambricht P, Tulkens PM, Heuson-Stiennon JA, Laurent G
     Immunocytochemical localization of epidermal growth factor in rat renal tissue after treatment with amikacin.
     J Cell Biol (1990) 111:98a
     
     
137. Busson R, Delcourt J, Claes P, Vanderhaeghe H, Tulkens PM, Mingeot-Leclercq PM
     Chemical modification of kanamycin B in the 6"-position.
     In: Intern. Symposium Carbohydrate Chemistry, Yokoama, Japan, D032 (1990)
     
     
138. Carlier MB, Faraji S, Tulkens PM
     Uptake and subcellular localization of sparfloxacin (AT4140; RP64206) in phagocytic cells.
     In: 30th Interscience Conference Antimicrobial Agents and Chemotherapy, Atlanta, Georgia, 1243 (1990)
     
     
139. Carlier MB, L~êobberding A, Tulkens PM
     Uptake and subcellular localization of a phosphorothioate oligonucleotide in eukaryotic cells.
     In: 30th Interscience Conference Antimicrobial Agents and Chemotherapy, Atlanta, Georgia, 623 (1990)
     
     
140. Claes P, Van Schepdael A, Busson R, Vanderhaeghe H, Tulkens PM, Mingeot-Leclercq PM
     Synthesis of 6"-modified 1-C-CH2OH-kanamycin B analogues.
     In: Intern. Sympium on Carbohydrate Chemistry, Yokoama, Japan, D031 (1990)
     
     
141. Ibrahim S, Lambricht P, Laurent G, Tulkens PM
     Comparative analysis of the renal phospholipidosis and phospholipiduria induced by netilmicin, amikacin and isepamicin in animals and humans.
     In: 30th Interscience Conference Antimicrobial Agents and Chemotherapy, Atlanta, Georgia., 633 (1990)
     
     
142. Kishore BK, Montenez JP, Tulkens PM
     Fibroblast cultures for the study and screening of agents (polyanions and protease inhibitors) for modulating aminoglycoside-induced lysosomal phospholipidosis.
     In: Ann. Meet. Belg. Branch Europ. Tissue Culture Soc. / Contact Group NFWO-FNRS In vitro Cultures, Brussels, Belgium, (1990)
     
     
143. Kishore BK, Piret J, Lambricht P, Tulkens PM
     Leupeptin, an inhibitor of cathepsin B, prevents gentamicin-induced lysosomal phospholipidosis (LPL) in cultured fibroblasts and aides poly-L-glutamic acid to become protectant against LPL.
     In: 30th Interscience Conference on antimicrobial Agents and Chemotherapy, Atlanta, Georgia, 752 (1990)
     
     
144. Kishore BK, Van Schepdael A, Lambricht P, Laurent G, Claes P, Tulkens PM, Maldague P
     Morphological study of the nephrotoxicity of co-oxydextran administered alone or in combination with gentamicin to rats.
     In: Annual meeting of the European Society of Toxicology (EUROTOX'90), Leipzig, Germany, 42 (1990)
     
     
145. Kishore BK, Van Schepdael A, Lambricht P, Laurent G, Claes P, Maldague P, Tulkens PM
     Effect of co-oxydextran on gentamicin-induced lysosomal phospholipidosis and cellular proliferation in rat renal cortex.
     In: Annual meeting of the European Society of Toxicology (EUROTOX'90), Leipzig, Germany, (1990)
     
     
146. Lambricht P, Matsumoto K, Leal T, Wallemacq P, Donnez J, Tulkens PM
     Evaluation of the safety of isepamicin in animal models and in humans.
     In: 9th International Symposium on Future Trends in Chemotherapy, Geneva, Switzerland, 132 (1990)
     
     
147. Leal T, Lambricht P, Donnez J, Tulkens PM, Wallemacq P
     Clinical pharmacokinetics of isepamicin compared to amikacin: a preliminary study in young patients suffering from pelvic inflammatory disease.
     Quimica Clinica (1990) 9:321
     
     
148. Piret J, Kishore KB, Tulkens PM
     Binding of gentamicin to poly-L-glutamic and poly-L-aspartic acids: influence on the protectant effect of these polymers against aminoglycoside-induced nephrotoxicity.
     J Pharm Belg (1990) 45:82
     
     
149. Piret J, Mingeot-Leclercq MP, Delfosse S, Tulkens PM
     Relationship between binding of gentamicin to negatively-charged lipids and inhibition of lysosomal phospholipase A1 towards phosphatidylcholine.
     J Pharm Belg (1990) 45:82
     
     
150. Tulkens P
     Ciblage intracellulaire des antibiotiques.
     Path Biol (1990) 38:312
     
     
151. Tulkens PM
     Le ciblage et le pilotage du médicament vers une structure cellulaire: applications aux médicaments antiinfectieux.
     In: Résumé des Conférences de la Journée Médicale de Charleroi 1990, Société de Médecine de Charleroi, Charleroi, Belg. ed., 15-18 (1990)
     
     
152. Tulkens PM
     Efficacy and safety of aminoglycosides once-a-day (qd): experimental and clinical data.
     In: Pharmacodynamics of Antibiotics-Consequences for Dosing, Stockholm, Sweden, 28 (1990)
     
     
153. Tulkens PM
     Pharmacodynamics and pharmacokinetics of aminoglycosides and beta-lactam antibiotics in relation to prophylaxis.
     In: 1st International Conference on the Prevention of Infection, Nice, France, 69 (1990)
     
     
154. Tulkens PM
     Target drugs for the treatment of intracellular infections.
     In: Intern. Conference Mastitis: Physiology or Pathology, Ghent, Belgium, (1990)
     
     
155. Tulkens PM
     Lysosomal storage disorders and toxicity induced in kidney by aminoglycosides and polyanionic peptides.
     In: 2d European Workshop on Endocytosis (NATO Advanced Research Seminars), Paris, France, (1990)
     
     
156. Tulkens PM
     Intracellular pharmacokinetics and localization of antibiotics as predictors of their efficacy against intraphagocytic infections.
     In: Pharmacodynamics of Antibiotics-Consequences for Dosing, Stockholm, Sweden, 26 (1990)
     
     
157. Tulkens PM, Kishore BK
     Macrophage and fibroblast cell cultures for the assessment of activity and modulation of toxicity of antimicrobials.
     In: 30th Interscience Conference on Antimicrobial Agents and Chemotherapy, Atlanta, Georgia, S-24 (1990)
     
     
158. Tulkens PM, Carlier MB, Scorneaux B, Zenebergh A
     Intracellular penetration and accumulation of antibiotics in relation to effectiveness.
     In: Hospital Infection towards the Year 2000 (2d Intern. Conf. Hospital Infection Society), London, U.K., (1990)
     
     
159. Tulkens PM, Kishore BK, Maldague P, Laurent G
     New insights into the biology of nephrotoxicity.
     In: 3d Annual International Consensus on Supportive Care in Oncology, Brussels, Belgium, S.C. Schimpff and J. Klastersky ed., 195 (1990)
     
     
160. Van Schepdael A, Vanderhaeghe HJ, Busson R, Claes P, Verbist L, Mingeot-Leclercq MP, Tulkens PM
     Synthesis, microbiological and in vitro toxicological evaluation of kanamycin B analogues modified in 6" and in 6" and C1 positions.
     In: 30th Interscience Conference Antimicrobial Agents and Chemotherapy, Atlanta, Georgia, 435 (1990)
     
     
161. Brulein V, Jacqmin Ph, Ibrahim S, Donnez J, Delm{e M, Gersdorff M, Tulkens PM
     Tolerance and efficacy of amikacin once-a-day vs twice-a-day: prospective, controlled study in 40 women suffering from pelvic inflammatory disease.
     In: 4th European Congress of Clinical Microbiology, Nice, France, 42 (1989)
     
     
162. Brulein V, Jacqmin Ph, Ibrahim S, Kaufman L, Derde MP, Donnez J, Tulkens PM
     Evaluation of the safety and efficacy of amikacin once-a-day (qd) in 20 patients suffering from pelvic inflammatory disease.
     Zeits Antimikrob Antineopl Chemoth (1989) suppl. 1:332
     
     
163. Carlier MB, Laurent G, Maldague P, Tulkens PM
     Combined biochemical and morphometrical evaluation of aminoglycoside nephrotoxicity at low, therapeutic doses in the rat.
     In: 1st Conference of the European Society for Analytical Cellular Pathology, Schloss Elmau, West Germany, (1989)
     
     
164. Carlier MB, Scorneaux B, Maquet M, Tulkens PM
     Activity of 4 fluoroquinolones (pefloxacin, ciprofloxacin, BMY40062, and BMY40868) against intracellular S. aureus in J774 macrophages.
     In: 29th Interscience Conference Antimicrobial Agents and Chemotherapy, Houston, Tx., 159 (1989)
     
     
165. Colson I, Orfilla J, Tulkens PM
     Activities of erythromycin and roxithromycin against Chlamydia trachomatis in a model of J774 macrophages in relation with their cellular accumulation.
     In: 29th Interscience Conference Antimicrobial Agents and Chemotherapy, Houston, Tx., 158 (1989)
     
     
166. Delfosse S, Mingeot-Leclercq MP, Piret J, Tulkens PM
     Influence of gangliosides on the activity of lysosomal phospholipases and their inhibition by aminoglycoside antibiotics.
     Arch Int Physiol Biochim (1989) 97:B138
     
     
167. Donnez J, Clerckx-Braun F, Jacqmin Ph, Brulein V, Tulkens PM
     Analysis of the pharmacokinetics, efficacy and safety of once-a-day administration (qd) of 2 aminoglycosides, netilmicin and amikacin, vs their conventional schedules in pelvic inflammatory disease.
     In: 1st World Congress for Infectious Diseases in Obstetrics and Gynaecology, Hawaii, 48/22 (1989)
     
     
168. Ibrahim S, Clerckx-Braun F, Jacqmin Ph, Donnez J, Brulein V, Tulkens PM
     Effect of schedule of aminoglycosides administration on urinary phospholipids excretion.
     In: 4th Intern. Nephrotoxicity Symposium, Guildford, U.K., 23 (1989)
     
     
169. Ibrahim S, Clerckx-Braun F, Jacqmin P, Donnez J, Brulein V, Tulkens PM
     Effect of schedule of aminoglycosides administration on urinary phospholipids excretion..
     Renal Failure (1989) 11:250
     
     
170. Ibrahim S, Derde MP, Kaufman L, Clerckx-Braun F, Jacqmin Ph, Donnez J, Tulkens PM
     Analysis of safety, pharmacokinetics and efficacy of once-a-day administration of netilmicin and amikacin versus their conventional schedules in pelvic inflammatory disease patients..
     Renal Failure (1989) 11:251
     
     
171. Ibrahim S, Derde MP, Kaufman L, Clerckx-Braun F, Jacmin Ph, Donnez J, Tulkens PM
     Analysis of safety, pharmacokinetics and efficacy of once-a-day administration of netilmicin and amikacin versus their conventional schedules in pelvic inflammatory disease patients.
     In: 4th Intern. Nephrotoxicity Symposium, Guilford, U.K., 24 (1989)
     
     
172. Ibrahim S, Donnez J, Clerckx-Braun F, Brulein V, Jacqmin Ph, Kaufman L, Tulkens PM
     Analyse des paramètres d'efficacité, de toxicité et de pharmacocinétique de l'administration uniquotidienne (qd) de 2 aminoglycosides, la nétilmicine et l'amikacine comparée aux schémas conventionnels.
     In: Réunion Interdisciplinaire de Chimiothérapie Antiinfectieuse, Paris, France, Société Française de Microbiologie/Société de Pathologie Infectieuse de Langue Française ed., 51 (15/C2) (1989)
     
     
173. Ibrahim S, Kishore BK, Lambricht P, Laurent G, Tulkens PM
     Effect of aminoglycosides and of coadministration of poly-L-aspartic acid on urinary phospholipids excretion in rats: a comparative study.
     In: 4th Intern. Nephrotoxicity Symposium, Guildford, U.K., 25 (1989)
     
     
174. Ibrahim S, Kishore BK, Laurent G, Tulkens PM
     Effect of aminoglycosides and of coadministration of poly-L-aspartic acid on urinary phospholipids excretion in rats: a comparative study.
     Renal Failure (1989) 11:251
     
     
175. Kishore BK, Ibrahim S, Lambricht P, Laurent G, Maldague P, Tulkens PM
     In vitro and in vivo evaluation of poly-L-aspartic and poly-L-glutamic acids as protectants against aminoglycoside-induced nephrotoxicity: further evidence for a lysosomal site of action.
     In: 29th Interscience Conference Antimicrobial Agents and Chemotherapy, Houston, Tx., 296 (1989)
     
     
176. Kishore BK, Lambricht P, Ibrahim S, Laurent G, Tulkens PM
     Inhibition of aminoglycoside-induced nephrotoxicity in rats by polyanionic peptides. I: in vitro and in vivo biochemical studies.
     Renal Failure (1989) 11:170-171
     
     
177. Kishore BK, Lambricht P, Ibrahim S, Laurent G, Tulkens PM
     Inhibition of aminoglycoside-induced nephrotoxicity in rats by polyanionic peptides. I: in vitro and in vivo biochemical studies.
     In: 6th Intern. Symposium of Nephrology (Kidney, Proteins and Drugs), Montecatini Terme, Italy, 58 (1989)
     
     
178. Kishore KB, Lambricht P, Laurent G, Tulkens PM
     In vitro studies of anionic polypeptides as protectants against aminoglycoside-induced nephrotoxicity.
     In: 5th Intern. Congress of Toxicology, Brighton, England, (1989)
     
     
179. Lambricht P, Kishore BK, Ibrahim S, Wagner R, Maldague P, Laurent G, Tulkens PM
     Evaluation of micronomicin nephrotoxic potential in rats at low and high doses.
     In: 29th Interscience Conference on Antimicrobial Agents and Chemotherapy, Houston, Tx., 299 (1989)
     
     
180. Maldague P, Kishore BK, Lambricht P, Ibrahim S, Laurent G, Tulkens PM
     Morphological evidence of nephrotoxicity of poly-D-glutamic acid in rats.
     Renal Failure (1989) 11:233-234
     
     
181. Maldague P, Kishore BK, Lambricht P, Laurent G, Tulkens PM
     Inhibition of aminoglycoside-induced nephrotoxicity in rats by polyanionic peptides. II: Morphological studies.
     Renal Failure (1989) 11:171
     
     
182. Maldague P, Kishore KB, Lambricht P, Ibrahim S, Laurent G, Tulkens PM
     Morphological evidence of nephrotoxicity of poly-D-glutamic acid in rats.
     In: 4th Intern. Nephrotoxicity Symposium, Guildford, U.K., 03 (1989)
     
     
183. Maldague P, Kishore KB, Lambricht P, Laurent G, Tulkens PM
     Inhibition of aminoglycoside-induced nephrotoxicity in rats by polyanionic peptides. II. Morphological studies.
     In: 6th Intern. Symposium of Nephrology "Kidney, Proteins and Drugs", Montecatini Terme, Italy, 59 (1989)
     
     
184. Mingeot-Leclercq MP, Tulkens PM
     Influence of different negatively-charged phospholipids on the activity of lysosomal phospholipases towards phosphatidylcholine.
     In: 19th Meeting of the Federation of the European Biochemical Societies, Rome, Italy, MO125 (1989)
     
     
185. Mingeot-Leclercq MP, Brasseur R, Wagner R, Piret J, Tulkens PM
     Inhibition of phospholipase A1 activity towards phosphatidylcholine induced by gentamicin: effect of different negatively-charged phospholipids..
     In: 19th Meeting of the Federation of European Biochemical Societies, Rome, Italy, FR167 (1989)
     
     
186. Nonclercq D, Toubeau G, Laurent G, Lambricht P, Tulkens PM, Heuson-Stiennon JA
     Redistribution of epidermal growth factor (EGF) immuno-reactivity in renal tissue after nephrotoxic injury.
     J Cell Biol (1989) 109:306a
     
     
187. Scorneaux B, Tulkens PM
     Comparative activity of erythromycin and 4 new macrolides (roxithromycin, dirithromycin, rokitamycin, midecamycin) against intracellular S. aureus in J774 macrophages.
     In: 29th Interscience Conference on Antimicrobial Agents and Chemotherapy, Houston, Tx., 157 (1989)
     
     
188. Scorneaux B, Pechère JC, Tulkens PM
     pH exerts constrasting effects on cellular uptake and intracellular activity of a fluoroquinolone (pefloxacin) compared to a macrolide (roxithromycin) in a model of S. aureus-infected J774 macroph..
     In: 4th European Congress of Clinical Microbiology, Nice, France, 193 (1989)
     
     
189. Scorneaux B, Zenebergh A, Tulkens PM
     Activity of two macrolides (erythromycin, roxithromycin) that differ by their degree of cellular accumulation, against S. aureus phagocytozed by J774 macrophages.
     In: 16th Intern. Congress of Chemotherapy, Jerusalem, Israel, (1989)
     
     
190. Scorneaux B, Zenebergh A, Tulkens PM
     Contrasting activities of ciprofloxacin, roxithromycin and clindamycin against intracellular S. aureus in J774 macrophages.
     Zeits Antimikrob Antineopl Chemoth (1989) suppl. 1:144
     
     
191. Tulkens PM
     Modulating aminoglycoside nephrotoxicity.
     In: 4th Intern. Nephrotoxicity Symposium, Guildford, U.K., 11 (1989)
     
     
192. Tulkens PM
     Pharmacodynamics and pharmacokinetics of antibiotics: the case of beta-lactams and aminoglycosides.
     In: Annual Meeting of the European Society for Surgery, Brussels, Belgium, (1989)
     
     
193. Tulkens PM
     Intracellular penetration, localization and activity of antibiotics in macrophages.
     Eur Resp Journ (1989) 2 (sppl.8):341
     
     
194. Tulkens PM
     Dosages d'antibiotiques intracellulaires.
     In: A quoi sert le dosage du médicament anti-infectieux ? Applications en clinique, C. Carbon, J.J. Pocidalo et A. Crémieux ed., Arnette, s.a., Paris, 19-20 (1989)
     
     
195. Van der Auwera Ph, Aoun M, Bouguignon AM, Ibrahim S, Tulkens PM, Kaufman L, Derde MP
     Safety and efficacy of netilmicin once-a-day: preliminary results of a prospective randomized study in cancer patients with urinary tract infection.
     In: 16th Intern. Congress of Chemotherapy, Jerusalem, Israel, 195 (1989)
     
     
196. Wagner R, Laurent G, Tulkens PM
     Tobramycin binding to renal brush border membrane is saturable at clinically-relevant concentrations.
     In: 4th European Congress of Clinical Microbiology, Nice, France, 319 (1989)
     
     
197. Böttcher P, Brison J, Moulliard C, Zenebergh A, Tulkens PM
     Synthesis and study of 2-O-esters of the lincosaminide antibiotic pirlimycin and of a pirlimycin-mannosylated albumin conjugate targeted towards lysosomes of macrophages.
     In: 28th Interscience Conference Antimicrobial Agents and Chemotherapy, Los Angeles, Calif., 1013 (1988)
     
     
198. Carlier MB, Tulkens PM
     Uptake and subcellular localization of lomefloxacin (SC 47111) in phagocytic cells in comparison with pefloxacin and fleroxacin.
     In: 28th Interscience Conference Antimicrobial Agents and Chemotherapy, Los Angeles, CA, 52 (1988)
     
     
199. Ibrahim S, Clerckx-Braun F, Brulein V, Jacqmin Ph, Donnez J, Tulkens PM
     Effect of aminoglycosides on urinary excretion of phospholipids in humans treated with amikacin and netilmicin: a comparative study.
     In: 8th International Symposium on Future Trends in Chemotherapy, Pisa, Italy, 119 (1988)
     
     
200. Ibrahim S, Van der Auwera Ph, Bernard A, Kaufman L, Derde MP, Meunier F, Tulkens PM
     Early detection of aminoglycoside-induced renal alterations in patients by measurement of urinary phospholipids excretion.
     In: 28th Interscience Conference Antimicrobial Agents and Chemotherapy, Los Angeles, CA, 294 (1988)
     
     
201. Ibrahim S, Van der Auwera Ph, Meunier F, Tulkens PM
     Effect of netilmicin and amikacin on urinary phospholipids excretion in humans.
     In: EUROTOX'88, Muenchen, 1988, 124 (1988)
     
     
202. Kishore BK, Tulkens PM
     Comparative assessment of poly-L-aspartic and poly-L-glutamic acids as protectants against aminoglycoside-induced nephrotoxicity.
     In: EUROTOX'88, Munchen, September 4-7th, 1988, 40 (1988)
     
     
203. Kishore BK, Kaêö,öllay Z, Tulkens PM
     Poly-L-aspartic acid, a protectant against aminoglycoside-induced nephrotoxicity, binds gentamicin in vitro : possible relevance to in vivo protective action.
     In: 8th International Symposium on Future Trends in Chemotherapy, Pisa, Italy, 121 (1988)
     
     
204. Kishore BK, Mingeot-Leclercq MP, Kaêö,öllay Z, Beauchamp D, Tulkens PM
     Mechanism of the protection afforded by poly-L-aspartic acid against gentamicin-induced nephrotoxicity: poly-L-aspartic acid binds gentamicin in lysosomes.
     In: 28th Interscience Conference Antimicrobial Agents and Chemotherapy, Los Angeles, CA, 293 (1988)
     
     
205. Kishore KB, Ibrahim S, Tulkens PM
     Increased levels of protein- and lipid-bound sialic acids in the renal cortex of rats injected with low doses of aminoglycoside antibiotics.
     In: 14th Congress of the International Union of Biochemistry, Prague, Czechoslovakia, TU:221 (1988)
     
     
206. Lambricht P, Matsumoto K, Kishore BK, Yernaux V, Rollmann B, Vanschepdaal A, Tulkens PM
     Animal and in vitro studies of the early renal alterations induced by HAPA-gentamicin B (isepamicin) in comparison with amikacin and tobramycin.
     In: 8th International Symposium on Future Trends in Chemotherapy, Pisa, Italy, 120 (1988)
     
     
207. Li K, Claessen M, Dumont P, Tulkens PM
     Progrogues lysosomotropes de pénicillines.
     In: 2me Journées Franco-Belges de Pharmacochimie (De la Conception à la Réalisation en Pharmacochimie), 43 (1988)
     
     
208. Matsumoto K, Lambricht P, Kishore BK, Ibrahim S, Rollmann B, Laurent G, Tulkens PM
     In vitro and in vivo evaluation of the early renal alterations induced by HAPA-gentamicin B (isepamicin).
     In: 28th Interscience Conference on Antimicrobial Agents and Chemotherapy, Los Angeles, Calif., 1503 (1988)
     
     
209. Scorneaux B, Carlier MB, Zenebergh A, Tulkens PM
     Uptake of fluoroquinolones in metabolically-inhibited phagocytes and in erythrocytes.
     In: 8th International Symposium on Future Trends in Chemotherapy, Pisa, Italy, 122 (1988)
     
     
210. Tulkens PM, Carlier MB, Scorneaux B, Zenebergh A
     Capture, distribution et activité intracellulaire de la roxithromycine dans les cellules phagocytaires en culture.
     In: Symposium sur les Nouveaux Concepts dans l'Antibiothérapie Ambulatoire, Berne, Suisse, 4 (1988)
     
     
211. Wattiez R, Blondiau F, Falmagne P, Tulkens PM, Cabiaux V, Ruysschaert JM
     Mechanism of the intracellular transport of diphtheria toxin. Fragment B-mediated endocytosis of large unilamellar vesicles containing encapsulated fragment A.
     Arch Int Physiol Biochim (1988) 96:B53
     
     
212. Wattiez R, Falmagne P, Cabiaux V, Defrise-Quertain F, Ruysschaert JM, Tulkens PM
     Liposome-mediated intracytosolic delivery of bioactive molecules: transfer of encapsulated fragment A of diphtheria toxin to cytosol by means of fragment B-associated large unilamellar liposomes.
     In: 28th Interscience Conference Antimicrobial Agents and Chemotherapy, Los Angeles, CA, 322 (1988)
     
     
213. Zenebergh A, Lebaupin C, Tulkens PM
     Binding and subcellular localization of rat monoclonal antibodies raised against bovine polymorphonuclear neutrophils.
     Arch Int Physiol Biochim (1988) 96:B127
     
     
214. Abid S, Carlier MB, Laurent G, Tulkens P, Maldague P
     Comparative regenerative response of rat kidney cortex after treatment with therapeutic doses of aminoglycosides.
     Chemioterapia (1987) 6(Suppl.2):329
     
     
215. Böttcher P, Zenebergh A, Kaekenbeek P, Tulkens PM
     Evidence for receptor-mediated endocytosis of glycoconjugates by bovine mammary gland macrophages.
     Arch Int Physiol Biochim (1987) 95:B54
     
     
216. Carlier MB, Brasseur R, Ruysschaert JM, Tulkens PM
     In vitro study and conformational analysis of 1N-aminobutyryl derivatives of aminoglycosides in correlation with their nephrotoxic potential.
     In: 28th Congress of the European Society of Toxicology, Strasbourg, France, P8 (1987)
     
     
217. Carlier MB, Kaêö,öllay Z, Tulkens PM
     Rat renal phospholipidosis in gentamicin and pefloxacin coadministration at low doses.
     In: 3d Intern. Symposium on Nephrotoxicity, Guildford, U.K., 11 (1987)
     
     
218. Carlier MB, Laurent G, Tulkens PM
     Reduction of aminoglycoside-induced renal alterations in rats by co-administration of piperacillin at clinically relevant doses.
     In: 15th Intern. Congress of Chemotherapy, Istanbul, Turkey, 883 (1987)
     
     
219. Carlier MB, Scorneaux B, Zenebergh A, Tulkens PM
     Uptake and subcellular distribution of 4 quinolones (pefloxacin, ciprofloxacin, ofloxacin, RO-23-6240) in phagocytes.
     In: 27th Interscience Conference Antimicrobial Agents and Chemotherapy, New York, N.Y., 622 (1987)
     
     
220. Carlier MB, Zenebergh A, Tulkens PM
     Handling of two macrolides, erythromicin and roxithromycin (RU 28965) by cultured macrophages.
     In: 15th Intern. Congress of Chemotherapy, Istambul, Turkey, 954 (1987)
     
     
221. Clerckx-Braun F, Donnez J, Ibrahim S, Kaêö,öllay Z, Delmee M, Gersdorff M, Tulkens PM
     Study of the tolerance of netilmicin once a day vs thrice a day (TID) in 28 cases of pelvic inflammatory disease.
     In: 27th Interscience Conference Antimicrobial Agents and Chemotherapy, New York, N.Y., 25 (1987)
     
     
222. Falmagne P, Wattiez R, Tulkens PM, Cabiaux V, Phalipon A, Kaczorek M, Ruysschaert JM
     Mécanisme du transport membranaire du fragment B de la toxine diphtérique. Interactions avec modèles de membrane et membranes naturelles.
     In: Colloque du Centenaire (Société Chimique de Belgique), Société Royale de Chimie, Bruxelles, 1.12 (1987)
     
     
223. Francq-Dufief MP, Laurent G, Toubeau G, Heuson-Stiennon JA, Tulkens PM
     Animal evaluation of the nephrotoxic potential associated with aminoglycoside x vancomycin combinations at low doses.
     In: 27th Interscience Conference Antimicrobial Agents and Chemotherapy, New York, N.Y., 23 (1987)
     
     
224. Ibrahim S, Tulkens P
     Patterns of phospholipids in renal cortex and urine of gentamicin-treated rats.
     Chemioterapia (1987) 6(Suppl.2):330-331
     
     
225. Ibrahim S, Kaêö,öllay Z, Clerckx-Braun F, Donnez J, Tulkens PM
     Urinary phospholipids pattern in humans and animals after treatment with aminoglycoside antibiotics.
     In: 3d Intern. Symposium on Nephrotoxicity, Guildford, U.K., 12 (1987)
     
     
226. Ibrahim S, Kaêö,öllay Z, Clerckx-Braun F, Donnez J, Tulkens PM
     Urinary excretion of phospholipids during aminoglycoside therapy in humans.
     In: 28th Congress of the European Society of Toxicology, Strasbourg, France, P9 (1987)
     
     
227. Kallay Z, Tulkens PM
     Uptake and subcellular distribution of polyaspartic acid (a protectant against aminoglycoside-induced nephrotoxicity) in rat kidney cortex.
     In: 3d Intern. Symposium on Nephrotoxicity, Guildford, U.K., 14 (1987)
     
     
228. Kallay Z, Carlier MB, Rollmann B, Beauchamp D, Tulkens PM
     Renal accumulation and nephrotoxicity of gentamicin subcomponents C1, C1a and C2 after treatment at low doses in rats.
     In: 3d Intern. Symposium on Nephrotoxicity, Guildford, U.K., 13 (1987)
     
     
229. Michel A, Muyshont D, Tulkens PM
     Synthèse peptidique en phase solide: un outil pour l'étude des relations structure-activité des protéines.
     In: Colloque du Centenaire (Société Chimique de Belgique), Société Royale de Chimie, Bruxelles, (1987)
     
     
230. Mingeot-Leclercq MP, Brasseur R, Ruysschaert JM, Schanck A, Deleers M, Tulkens PM
     Conformational and biophysical analysis of the interactions between gentamicin or bis(betadiethylaminoethylether)hexestrol and negatively-charged phospholipid layers.
     In: Structure and Function of Molecules Affecting the Properties of Cellular Membranes, Paris, France, P.19 (1987)
     
     
231. Mingeot-Leclercq MP, Laurent G, Tulkens PM
     Mechanism of inhibition of lysosomal phospholipases by gentamicin, an aminoglycoside antibiotic.
     Arch Int Physiol Biochim (1987) 95:B85
     
     
232. Mingeot-Leclercq MP, Ronvaux-Dupal MF, Deleers M, Schanck A, Tulkens PM
     Changes in the morphology of negatively-charged liposomes induced by gentamicin and bis(beta-diethylaminoethylether)hexestrol.
     In: Structure and function of Molecules Affecting the Properties of Cellular Membranes, Paris, France, P.18 (1987)
     
     
233. Muyshont D, Michel A, Tulkens PM
     Structure-activity relationships studies of diphtheria toxin using synthetic peptides covering region 256-282 of fragment B.
     Arch Int Physiol Biochim (1987) 95:B223
     
     
234. Nonclercq D, Toubeau G, Laurent G, Maldague P, Tulkens PM, Heuson-Stiennon JA
     Etude morphologique des cellules en prolifération dans le cortex rénal de rat traité à la tobramycine.
     Micron Microscop Acta (1987) 18:203-204
     
     
235. Nonclercq D, Yernaux V, Toubeau G, Laurent G, Heuson-Stiennon JA
     Ultrastructural characterization of tubular cells involved in repair of kidney cortex tissue after drug-induced tubular necrosis.
     Biol Cell (1987) 60:14a
     
     
236. Schanck A, Mingeot-Leclercq MP, Tulkens PM
     31P NMR and fluorescence depolarization study of model membranes in the presence of drugs inducing phospholipidosis.
     In: 9th International Biophysics Congress, Jerusalem, Israel, 175 (1987)
     
     
237. Scorneaux B, Carlier MB, Zenebergh A, Tulkens PM
     Uptake and subcellular localization of fluoroquinolones in macrophages.
     Arch Int Physiol Biochim (1987) 95:B237
     
     
238. Tulkens PM
     Mode of nephrotoxicity of aminoglycosides, and animal and human experience of the once-a-day regimen.
     In: International Symposium on Netilmicin, Tokyo, Japan, Professional Postagraduate Services K.K., Tokyo, Japan, 10-11 (1987)
     
     
239. Tulkens PM
     Early alterations induced in rat kidney cortex by aminoglycosides: mechanisms and significance.
     In: 70ème Congrès de Chimie du Canada/70th Canadian Chemical Conference, Québec, Qué., MEB-1-C (1987)
     
     
240. Tulkens PM, Mingeot-Leclercq MP
     Drug-induced lysosomal phospholipidosis: biophysical and biochemical studies with aminoglycoside antibiotics and cationic amphiphiles.
     In: Lipid Storage disorders: biological and medical aspects (NATO Avanced Research Workshop) Toulouse, 50 (1987)
     
     
241. Tulkens PM, Clerckx-Braun F, Donnez J, Ibrahim S, Kaêö,öllay Z, Delm{e M, Giurgea-Marion L
     Efficacy and safety of aminoglycosides once-a-day: animal data and randomized, controlled evaluation in patients suffering from pelvic inflammatory disease.
     In: The impact of novel dosing regimens on the safety and efficacy of aminoglycosides, Sorrento, Italy, 14-15 (1987)
     
     
242. Wattiez R, Falmagne P, Tulkens PM
     Mechanism of the intracellular transport of bacterial toxins. Preparation and properties of an heteroconjugate between fragment B of diphtheria and fragment A of ricin toxins.
     Arch Int Physiol Biochim (1987) 95:B161
     
     
243. Zenebergh A, Boê~ttcher P, Brison J, Tulkens PM
     Comparative uptake and subcellular distribution of 4 closely-related lincosaminides, clindamycin, lincomycin, pirlimycin and glycyl-pirlimycin in phagocytes.
     In: 27th Interscience Conference Antimicrobial Agents and Chemotherapy, New York, N.Y., 1080 (1987)
     
     
244. Zenebergh A, Carlier MB, Scorneaux B, Tulkens PM
     Uptake and intracellular distribution of 2 fluoroquinolones, pefloxacin and ciprofloxacin, in phagocytes.
     In: 15th Intern. Congress of Chemotherapy, Istanbul, Turkey, 184 (1987)
     
     
245. Abid S, Carlier MB, Laurent G, Tulkens PM, Maldague P
     Comparative regenerative response of rat kidney cortex after treatement with therapeutic doses of aminoglycosides.
     In: 5th Mediterranean Congress of Chemotherapy, Cairo, Egypt, P346 (1986)
     
     
246. Carlier MB, Zenebergh A, Tulkens PM
     Accumulation and subcellular localization of two macrolides, erythromycin and roxithromycin (RU28965) in phagocytes.
     In: 26th Interscience Conference Antimicrobial Agents and Chemotherapy, New Orleans, La, 929 (1986)
     
     
247. Ibrahim S, Tulkens PM
     Patterns of phospholipids in renal cortex and urine of gentamicin-treated rats.
     In: 5th Mediterranean Congress of Chemotherapy, Cairo, Egypt, P-342 (1986)
     
     
248. Ibrahim S, Tulkens PM
     Increased urinary excretion and change of patterns of phospholipids in gentamicin-treated rats.
     In: 26th Interscience Conference Antimicrobial Agents and Chemotherapy, New Orleans, La, 27 (1986)
     
     
249. Lambricht P, Laurent G, Tulkens PM
     Characterization of phosphatidylinositol phospholipase C activity in rat liver lysosomes and of its inhibition by aminoglycoside antibiotics.
     Arch Int Physiol Biochim (1986) 94:B19
     
     
250. Laurent G, Beauchamp D, Rollmann B, Abid S, Maldague P, Tulkens PM
     Dose-response relationship of the cell proliferation induced in rat kidney cortex by tobramycin and netilmicin.
     In: 26th Interscience Conference Antimicrobial Agents and Chemotherapy, New Orleans, La., 24 (1986)
     
     
251. Maldague P, Abid S, Carlier MB, Laurent G, Tulkens PM
     Morphometry of the lesions induced by aminoglycosides in rat renal cortex and quantitative analysis of their repair by measure of 3H thymidine incorporation into DNA and labelling index.
     In: VII Symposium International des Sciences Morphologiques, Louvain-en-Woluwe, Belgique, Archives of Biology, 69 (1986)
     
     
252. Maldague P, Carlier MB, Abid S, Tulkens PM
     Early detection and morphometry of the lysosomal phospholipidosis induced by low, therapeutic doses of aminoglycosides.
     In: IXth International Symposium on Drugs Affecting Lipid Metabolism, Florence, Italy, 196 (1986)
     
     
253. Mingeot-Leclercq MP, Laurent G, Schanck A, Ronveaux-Dupal MF, Deleers M, Tulkens PM
     Molecular mechanisms of aminoglycoside-induced lysosomal phospholipidosis.
     In: IXth International Symposium on Drugs Affecting Lipid Metabolism, Florence, Italy, 195 (1986)
     
     
254. Nonclercq D, Toubeau G, Laurent G, Maldague P, Tulkens PM, Heuson-Stiennon JA
     Repair of kidney cortex after tobramycin-induced tubular necrosis : biochemical and ultrastructural characterization of the proliferative response.
     Biol Cell (1986) 57:9a
     
     
255. Vaamonde CA, Laurent G, Beauchamp D, Carlier MB, Ibrahim S, Maldague P, Tulkens PM
     Renal phospholipidosis and cellular response of diabetic and control rats to low, non-toxic doses of gentamicin.
     Kidney Int (1986) 29:311
     
     
256. Abid S, Maldague P, Laurent G, Carlier MB, Beauchamp D, Tulkens PM
     Morphological characterization of the regenerative response in rat kidney cortex during short treatments with aminoglycosides.
     In: 25th Interscience Conference Antimicrobial Agents and Chemotherapy, Minneapolis, Minn, 709 (1985)
     
     
257. Beauchamp D, Laurent G, Maldague P, Tulkens PM
     Reduction of gentamicin nephrotoxicity by concomitant administration of poly-L-aspartic acid and poly-L-asparagine in rats.
     In: 26th Congress of the European Society of Toxicology, Kuopio, Finland, P23 (1985)
     
     
258. Carlier MB, Brasseur R, Laurent G, Mingeot-Leclercq MP, Ruysschaert JM, Tulkens PM
     Use of an in vitro model to assess the aminoglycoside-phospholipid interactions, in relation to their nephrotoxicity.
     In: Intern. Conference on Practical in vitro Toxicology, Reading, Berks., U.K., 6.21 (1985)
     
     
259. Carlier MB, Laurent G, Beauchamp D, Maldague P, Rollmann B, Tulkens PM
     Animal study on the nephrotoxic potential of gentamicin-ceftazidime combination treatment at low doses.
     In: 14th Intern. Congress of Chemotherapy, Kyoto, S24-9 (1985)
     
     
260. Giurgea-Marion L, Tulkens PM
     Effect of hydroxylation of the 2',6'diaminohexose moiety on the intrarenal accumulation of aminoglycoside antibiotics : comparison between kanamycin B, tobramycin, dibekacin and gentamicin.
     In: 14th Intern. Congress of Chemotherapy, Kyoto, P56-107 (1985)
     
     
261. Ibrahim S, Carlier MB, Laurent G, Tulkens PM
     Quantitative analysis of the phospholipid composition of rat kidney cortex after treatment with gentamicin, dibekacin, netilmicin and tobramycin at low doses (10 mg/kg).
     In: 25th Interscience Conference Antimicrobial Agents and Chemotherapy, Minneapolis, Minn, 708 (1985)
     
     
262. Laurent G, Beauchamp D, Carlier MB, Tulkens PM, Loibner H, Stütz P
     Use of fosfomycin salt of an aminoglycoside (S87351) to decrease its toxicity towards rat kidney cortex.
     In: 26th Congress of the European Society of Toxicology, Kuopio, Finland, P22 (1985)
     
     
263. Mingeot-Leclercq MP, Laurent G, Tulkens PM
     The mechanism of gentamicin-induced inhibition of phosphatidylcholine hydrolysis.
     In: 13th Congress of the International Union of Biochemistry, Amsterdam,The Nederlands, TH/443 (1985)
     
     
264. Renard C, Zenebergh A, Vanderhaeghe HJ, Claes PJ, Tulkens PM
     Accumulation and subcellular localization of a basic derivative of Penicillin G in J774 macrophages.
     In: 14th Intern. Congress of Chemotherapy, Kyoto, Japan, P1-5 (1985)
     
     
265. Tulkens PM
     New systems for intracellular delivery of anti-infectious drugs.
     In: 4th European Congress of Clinical Microbiology, Nice, France, 351 (1985)
     
     
266. Tulkens PM, Laurent G, Carlier MB, Mingeot-Leclercq MP, Ruysschaert JM
     In vitro model and semi-empirical conformational analysis to study and to compare the intrinsic nephrotoxicity of aminoglycoside antibiotics.
     In: 14th Intern. Congress of Chemotherapy, Kyoto, S24-4 (1985)
     
     
267. Vaamonde C, Laurent G, Beauchamp D, Carlier MB, Ibrahim S, Maldague P, Tulkens PM
     Renal cortical phospholipidosis in diabetic and control rats evaluated at similar cortical gentamicin accumulation.
     Clin Res (1985) 33:500A
     
     
268. Zenebergh A, Renard C, Tulkens PM
     Uptake and release of clindamycin, lincomycin and pirlimycin by macrophages.
     In: 25th Interscience Conference on Antimicrobial Agents and Chemotherapy, Minneapolis, Minn, 555 (1985)
     
     
269. Zenebergh A, Renard C, Tulkens PM
     Subcellular localization of clindamycin in macrophages, PMN and fibroblasts : failure to demonstrate an intralysosomal sequestration.
     In: 14th Intern. Congress of Chemotherapy, Kyoto, Japan, P11-31 (1985)
     
     
270. Beauchamp D, Laurent G, Ruysschaert JM, Maldague P, Carlier MB, Tulkens PM
     S 87351 potential nephrotoxicity: in vitro study and in vivo evaluation at low doses.
     In: 24th Intersc. Conf. Antimicrob. Agents Chemother., Washington DC, 312 (1984)
     
     
271. Carlier MB, Giurgea-Marion L, Laurent G, Maldague P, Toubeau G, Heuson-Stiennon J, Tulkens PM
     Morphological and functional alteratons of lysosomes of kidney tubular cells during treatment with gentamicin.
     Biol Cell (1984) 52:109A
     
     
272. Giuliano G, Paulus G, Verpooten G, Pattijn V, Pollet D, Laurent G, Tulkens P
     Kidney alterations and recovery after acute loading with gentamicin at low and high doses using a perfused rat model.
     In: 84th Annual Meeting, American Society for Microbiology, St-Louis, Mo., 55 (1984)
     
     
273. Giuliano RA, Pattijn V, Pollet DE, Paulus G, Verpooten GA, De Broe ME, Tulkens P
     The gentamicin-induced alterations in rat kidney cortex are reversible up to threshold in cortical drug level.
     In: IXth Intern. Congress of Nephrology, Los Angeles, Ca, (1984)
     
     
274. Giuliano RA, Paulus GJ, Verpooten GA, Pattijn V, Polled DE, Nouwen EJ, De Broe ME
     Kidney phospholipidosis and recovery after acute exposure to gentamicin with low and high doses in an infused rat model.
     Hum Toxicol (1984) 3:
     
     
275. Giurgea-Marion L, Laurent G, Heuson-Stiennon J, Beauchamp D, Tulkens P
     Buoyant, morphometric and functional alterations of lysosomes from proximal tubular cells during treatment with gentamicin.
     Hum Toxicol (1984) 3:
     
     
276. Giurgea-Marion L, Laurent G, Toubeau G, Heuson-Stiennon J, Tulkens P
     Effect of gentamicin treatment on the functional properties of lysosomes in rat kidney cortex.
     J Cell Biol (1984) 99:364A
     
     
277. Laurent G, Beauchamp D, Maldague P, Giurgea-Marion L, Tulkens PM
     Animal study on the nephrotoxic potential of amikacin x ceftazidime combination at low doses.
     In: 24th Interscience Conference Antimicrobial Agents and Chemother., Washigton, DC, 478 (1984)
     
     
278. Porter GA, Laurent G, Maldague P, Tulkens PM
     Gentamicin-induced stimulation of DNA synthesis in rat kidney cortex: correlation between in vivo and in vitro models..
     In: IXth Intern. Congress of Nephrology, Los Angeles, Ca, (1984)
     
     
279. Toubeau G, Laurent G, Heuson-Stiennon JA, Tulkens P
     Aminoglycoside-induced alterations in distal and collecting tubules of rat kidney cortex.
     Biol Cell (1984) 52:98A
     
     
280. Tulkens P
     Drug-induced phospholipidosis.
     In: 1st Mediterranean Congress of Therapy, Florence, Italy, (1984)
     
     
281. Tulkens P, Brasseur R, Laurent G, Ruysschaert JM, Claes PJ, Vanderhaeghe HJ
     Conformational and biochemical studies of aminoglycoside-phospholipid interactions: a tool for the design of lesser toxic aminoglycosides.
     In: 6th International Symposiuml on Future Trends in Chemotherapy, Pisa, Italy, 197 (1984)
     
     
282. Tulkens P, Ruysschaert JM, Brasseur R, Carlier MB, Laurent G, Claes JP, Vanderhaeghe HJ
     Computer models and structure-activity relationship for the prediction of aminoglycoside nephrotoxicity..
     In: 2nd Meeting on Nephrotoxicity (Nephrotox), Guildford (U.K.), (1984)
     
     
283. Viau C, Bernard A, Tulkens P, Lauwerys R
     Polycationic gentamicin inhibits the tubular readsorption of plasma proteins according to their electric charge.
     Hum Toxicol (1984) 3:
     
     
284. Carlier MB, Ibrahim S, Laurent G, Tulkens P
     Inhibition of lysosomal sphingomyelinase by incubation with negatively-charged phospholipid vesicles (liposomes).
     In: 15th Meeting of the Federation of the European Biochemical Societies, Brussels, S-04FR054 (1983)
     
     
285. Giurgea-Marion L, Laurent G, Tulkens P
     Analysis of kidney lysosomes by isopycnic centrifugation in a zonal rotor.
     In: 15th Meeting of the Federation of the European Biochemical Societies, Brussels, Belgium, S-03MO031 (1983)
     
     
286. Laurent G, Brasseur R, Carlier MB, Ruysschaert JM, Tulkens P
     Molecular approach to the binding of gentamicin and amikacin to lipid bilayers containing phosphatidylinositol: a method to study the mechanism of aminoglycoside-induced phospholipidosis.
     Toxicol Lett (1983) 18(supl.1):133
     
     
287. Laurent G, Brasseur R, Carlier MB, Toubeau G, Maldague P, Heuson-Stiennon J, Tulkens P
     Combined in vitro and in vivo approach to compare the nephrotoxicity of aminoglycosides.
     In: 23d Interscience Conference on Antimicrobial Agents and Chemotherapy, Las Vegas, Na, 590 (1983)
     
     
288. Laurent G, Brasseur R, Ruysschaert JM, Tulkens P
     A combined experimental and mathematical approach to characterize aminoglycoside binding binding to lipid layers.
     In: Meeting on Model Membranes (Belgium F.N.R.S. and Council of Europe), Brugge, (1983)
     
     
289. Laurent G, Maldague P, Carlier MB, Tulkens P
     Evidence of tubular regeneration in rat kidney after short treatment with gentamicin at low doses.
     In: 83d Annual Meeting of the American Society for Microbiology, New Orleans, La, A46 (1983)
     
     
290. Laurent G, Toubeau G, Maldague P, Carlier MB, Heuson-Stiennon J, Tulkens P
     Tubular regeneration in rat kidney after treatment with gentamicin at low doses.
     In: 24th Congress of the European Society of Toxicology, Rome, Italy, (1983)
     
     
291. Maldague P, Laurent G, Carlier MB, Tulkens P
     S 86451, a 2'guanidyl derivative of gentamicin with reduced nephrotoxicity: studies at low and medium doses in the rat.
     In: 24th Congress of the European Society of Toxicology, Rome, 40 (1983)
     
     
292. Rollmann B, Van Der Auwera Ph, Yepsen R, Schwenzer K, Tulkens P
     Dibekacin assay in serum by automated fluorescence polarization immunoassay: comparison with HPLC and substrate labelled fluorescent immunoassay.
     In: 23d Interscience Conference on Antimicrobial Agents and Chemotherapy, Las Vegas, Nevada, 107 (1983)
     
     
293. Toubeau G, Laurent G, Maldague P, Carlier MB, Tulkens P, Heuson-Stiennon J
     Régénération des tubes proximaux du cortex rénal de rat après traitement à la gentamicine.
     Biol Cell (1983) 48:42A
     
     
294. Tulkens P
     Toxicity of aminoglycosides: recent insights and perspectives.
     In: 3d International Symposium on Nephrology (Kidney, Small Proteins and Drugs), Montecatini Terme, Italy, 58 (1983)
     
     
295. Carlier MB, Laurent G, Tulkens P
     Aminoglycoside-induced renal phospholipidosis: in vitro demonstration of lysosomal phospholipases inhibition.
     In: 22d Interscience Conference on Antimicrobial Agents and Chemotherapy, Miami, Fla, 47 (1982)
     
     
296. Tulkens P, De Broe ME, Maldague P, Verpooten G, Scharpe S
     Influence of the dosage schedule on the accumulation and toxicity of gentamicin in rat kidney, at low dose (10 mg/kg).
     In: 82d Annual Meeting of the American Society for Microbiology, Atlanta, Ga, 30 (1982)
     
     
297. Wilmotte E, Maldague P, Tulkens P, Baumgartner R, Schmook F, Walzl H, Obenaus H
     S86451, a new derivative of gentamicin with reduced nephrotoxicity: biochemical, morphological and functional studies.
     In: 5th International Symposium on Future Trends in Chemotherapy, Pisa, Italy, 51 (1982)
     
     
298. Carlier MB, Tulkens P
     Gentamicin induces a loss of activity of acid phospholipase A in rat kidney cortex.
     Arch Int Physiol Biochim (1981) 89:B5-B6
     
     
299. Carlier MB, Paulus G, Maldague P, Giurgea L, Wilmotte E, De Broe ME, Tulkens P
     Early toxic events in kidney of rat and man following administration of gentamicin at low doses.
     In: 22d Congress of the European Society of Toxicology, Dublin, 17-19 August 1981, 46 (1981)
     
     
300. Carlier MB, Trouet A, Tulkens P
     Uptake and intracellular distribution of penicillin V, ampicillin and cephalexin in macrophages.
     In: 81st Annual Meeting of the American Society of Microbiology, Dallas, Tx, A21 (1981)
     
     
301. Morin JP, Ollier B, Viotte G, Tulkens P, Van Hoof F, Fillastre JP
     Comparative nephrotoxicity of gentamicin, netilmicin, tobramycin and amikacin.
     In: 12th Intern.Congress of Chemotherapy, Florence, Italy, 709 (1981)
     
     
302. Paulus G, Verpooten G, Rutsaert R, Tulkens P, Roels F, De Broe ME
     Prospective study of gentamicin nephrotoxicity in the human kidney.
     Kidney Int (1981) 20:432
     
     
303. Paulus G, Wilmotte E, Maldague P, Carlier MB, Verpooten G, Scharpe P, Tulkens P
     Comparative study of the lysosomal alterations induced in kidney of rat and man by aminoglycosides at low doses.
     In: 21st Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, Ill, 543 (1981)
     
     
304. Tulkens P, Carlier MB, Beauwens R, Maldague P, Morin JP, Van Hoof F
     Mechanism of toxicity of gentamicin in rat kidney and comparisons with amikacin and tobramycin.
     In: 12th Intern. Congress of Chemotherapy, Florence, Italy, 1086 (1981)
     
     
305. Verpooten GA, Paulus G, Tulkens P, Van Hoof F, Roels F, De Broe ME
     Nephrotoxicity of aminoglycosides in humans. A prospective and comparative study.
     In: 12th Intern. Congress of Chemotherapy, Florence, July 19-24, 1981, 1093 (1981)
     
     
306. Beauwens R, Rentmeesters M, Van Hoof F, Tulkens P
     Aminoglycoside antibiotics inhibit the normal antidiuretic hormne response.
     Eur J Clin Invest (1980) 10:3
     
     
307. De Broe ME, Verpooten GA, Rutsaert R, Paulus G, Van Hoof F, Tulkens P, Zachee R
     Nephrotoxicity of gentamicin in the human kidney.
     Kidney Int (1980) 18:136
     
     
308. Morin JP, Van Hoof F, Tulkens P
     Biochemical and ultrastructural alterations induced in the lysosomes of rat kidney cortex by two aminoglycoside antibiotics : gentamicin and amikacin.
     Arch Int Physiol Biochim (1980) 88:B93-B94
     
     
309. Tulkens P, Hjelle JT, Morin JP, De Broe ME, Carlier MB, Van Hoof F
     Cellular toxicity of gentamicin in kidney of rat, rabbit and man.
     In: 20th Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, La, 555 (1980)
     
     
310. Tulkens P, Morin JP, Carlier MB, Van Hoof F
     Use of a model of cultured cells for comparative studies of the ellular toxicity of aminoglycosides (gentamicin, tobramycin and amikacin).
     In: Workshop on the Application of Tissue Culture in Toxicology, Soesterberg, The Netherlands, (1980)
     
     
311. Tulkens P, Van Hoof F, Morin JP, Hjelle JT, Carlier MB, De Broe ME, de Barsy Th
     Toxicity of aminoglycoside antibiotics: gentamicin, tobramycin and amikacin in cultured cells and in kidney.
     Toxicol Lett (1980) SI.1:119
     
     
312. Van Hoof F, Morin JP, Tulkens P
     Comparative toxcity of three aminoglycoside antibiotics : gentamicin, amikacin and streptomycin, towards the lysosomes of cultured cells.
     Arch Int Physiol Biochim (1980) 88:B112-B114
     
     
313. Tulkens P, Trouet A
     Recycling of cell surface membrane during endocytosis.
     Adv Exp Med Biol (1979) 114:413-414
     
     
314. Blanchard JC, Schneider Y-J, Tulkens P, Trouet A
     Intracellular distribution of two non-steroidal anti-inflammatory drugs : indomethacin and ketoprofen, in cultured fibroblasts.
     In: 7th International Congress of Pharmacology, Paris, France, (1978)
     
     
315. Tulkens P
     Cellular pharmacology: a tool for the evaluation and development of drugs.
     In: 3rd Intern. Meeting of Pharmaceutical Physicians, Brussels, Belgium, Acta Therapeutica, Pub., 94 (1978)
     
     
316. Tulkens P, Blanchard JC, Schneider Y-J, Trouet A
     Cellular uptake and subcellular distribution of anti-inflammatory drugs: chloroquine, indomethacin and ketoprofen.
     In: Compte-rendus des groupes de contact du F.R.S.M., Bruxelles, Belgique, (1978)
     
     
317. Tulkens P, Schneider Y-J, Trouet A
     Cell surface and lysosome membranes: functional and structural relationships.
     In: Interdisciplinary Training Course: Structure and Functions of Biological Membranes: Molecular Aspect, Comission of the European Communities and Centre de Biophysique Mol{culaire (C.N.R.S., France), A23-A24 (1978)
     
     
318. Piérart-Gallois M, Trouet A, Tulkens P
     Production of rabbit anti-rat cathepsin B antibodies.
     In: 3d Symp. on Intracellular Protein Catabolism, Lubljana, Yougoslavia, Martin Luther Universität, Halle-Wittenberg, Wissenschafliches Beiträge, Halle (Saale), 27 (1977)
     
     
319. Tulkens P, Schneider Y-J, Trouet A
     Flow, recycling and turn-over of plasma membrane constituents during endocytosis.
     In: 3d Symp. on Intracel.Protein Catabolism, Lubljana, Yougoslavia, Martin Luther Universität, Halle-Wittenberg, Wissenschafliche Beiträge, Halle (Saale), 37-39 (1977)
     
     
320. Tulkens P, Schneider Y-J, Trouet A
     A shuttle between cell membrane and lysosomes during endocytosis.
     In: Symposium on Protein Turn-Over and Lysosomal Function, State University of New York at Buffalo, 47-48 (1977)
     
     
321. Bulychev A, Trouet A, Tulkens P
     Accumulation and localization of neutral red in cultured fibroblasts.
     Arch Int Physiol Biochim (1976) 84:1055-1056
     
     
322. Liesse M, Lhoest G, Trouet A, Tulkens P
     Uptake and intracellular localization of morphine in lysosomes and cell sap of cultured fibroblasts.
     Arch Int Physiol Biochim (1976) 84:638-639
     
     
323. Schneider Y-J, Tulkens P, Trouet A
     Uptake and localization of cathepsin D and of antibodies, directed against lysosomes of cathepsin D in cultured fibroblasts.
     Arch Int Physiol Biochim (1976) 84:655-657
     
     
324. Schneider Y-J, Tulkens P, Trouet A
     Studies on the mechanism and regulation of endocytosis in fibroblasts by means of antibodies.
     J Cell Biol (1976) 70:323a
     
     
325. Tulkens P, Schneider Y-J, Trouet A
     Studies on the mechanism and regulation of endocytosis in fibroblasts.
     In: Symposium on Endocytosis and Intracellular Digestion, British Society for Cell Biology, (1976)
     
     
326. Zenebergh A, Loni MC, Tulkens P, Trouet A
     Biochemical characterization of lysosomes and plasma membrane of cultured leukemic L1210 cells.
     Arch Int Physiol Biochim (1976) 84:684-685
     
     
327. Sauvage Ph, Trouet A, Tulkens P
     Purification and antigenic characterization of plasma membrane from hepatoma cells in culture (HTC cells).
     Arch Int Physiol Biochim (1975) 83:995-996
     
     
328. Schneider Y-J, Trouet A, Tulkens P
     Uptake and intracellular fate of antiplasma membrane antibodies in cultured fibroblasts.
     Hoppe Seyler's Z Physiol Chem (1975) 335:84
     
     
329. Schneider Y-J, Trouet A, Tulkens P
     Intracellular fate of plasma membrane antigens during endocytosis.
     Arch Int Physiol Biochim (1975) 83:997-998
     
     
330. Tulkens P, Schneider Y-J, Trouet A
     Studies on endocytosis in fibroblasts with the use of specific antibodies.
     In: 2d Intern. Symposium Intracellular Protein Catabolism, Union of the Chemical Societies of Yugoslavia, Ljubljana ed., 69-70 (1975)
     
     
331. Tulkens P, Van Hoof F, Trouet A
     Lysosome overloading and dysfunction induced by streptomycin in cultured fibroblasts.
     Arch Int Physiol Biochim (1975) 83:1004-1006
     
     
332. Tulkens P, Trouet A
     Uptake and intracellular localization of kanamycin and gentamicin in the lysosomes of cultured fibroblasts.
     Arch Int Physiol Biochim (1974) 82:1018-1019
     
     
333. Lopez-Saura P, Tulkens P, Trouet A
     Characterization of subcellular constituents of hepatoma cultured celles (HTC cells).
     Arch Int Physiol Biochim (1972) 80:977-978
     
     
334. Tulkens P, Trouet A
     Uptake and intracellular localization of streptomycin in the lysosomes of cultured fibroblasts.
     Arch Int Physiol Biochim (1972) 80:623-624
     
     
335. Wattiaux R, Wattiaux-De Coninck S, Tulkens P, Koninckx Ph
     Influence of the injection of some sugar solutions on the properties of rat liver lysosomes.
     In: 2d Meeting of the Federation of the European Societies of Biochemistry, Vienna, Austria, A-181 (1965)
     
     

Last update: 28/12/2000
Corrections and additions: <tulkens@facm.ucl.ac.be>