Early toxic events in kidney of rat and man following administration of gentamicin at low doses.

Carlier MB, Paulus G, Maldague P, Giurgea L, Wilmotte E, de Broe ME, Tulkens P

Kidney cortex of rats and humans treated with low doses of Gentamicin have been examined both morphologically and biochemically. Specific alterations of the lysosomes (loss of activity of phospholipases; accumulation of phospholipid-like material) was detected as early as from 2-4 days of treatment. This finding is consistent with the concept that Gentamicin exerts its toxic action on kidney through lysosomal dysfunction

PMID: 6954911, UI: 82255952