Curriculum vitae of Paul M. Tulkens


		and many others ...

Paul M. Tulkens

MD, 1969 (Ordre des médecins [Belgian Medical Corporation]: no. 6519 Bt - National Institute for Health and Disability Insurance: habilitation no. 1-26519-66-860)
Specialist in Clinical Biology [Biologie clinique], 1975
M Sc. (Biomedical Sciences), 1970
PhD (Agrégé de l'enseignement supérieur), 1979
Founder (1993) and Head (1993-2003) of the Unit of Cellular and Molecular Pharmacology
Founder of the Centre of Clinical Pharmacy (2005)

1969-1991: Research Fellow, Postdoctoral Researcher and Research Associate of the Belgian Fonds de la Recherche Scientifique (F.R.S.-FNRS)
1991-2010: Professor of Pharmacology at the Faculty of Medicine (Department of Pharmaceutical Sciences) of the Université catholique de Louvain (UCL)
1979-2010: Professor of Human Biochemistry and Biochemical Pathology at the Faculty of Medicine (School of Medicine) of the Université de Mons (UMons)
2010-2016: Emeritus Professor and Invited Professor at the Faculties of Medicine and of Pharmacy & Biomedical Sciences of the Health Science Sector of the Université catholique de Louvain (Therapeutic choices including Pharmacoeconomy; Drug Discovery and Development) and member of the Louvain Drug Research Institute (Cellular and Molecular Pharmacology)
2016 to now: Emeritus Professor and member of the Louvain Drug Research Institute (Group Cellular and Molecular Pharmacology)

ORCID (Open Researcher and Contributor Identification): 0000-0002-7121-3623
List of publications (full papers; currently about 280) indexed
- in PubMed (US National Library of Medicine) (free access to abstracts - access to full text depending of publication status and your access rights - click here for free publications in PubMed Central)
- in our web site (access to full texts for UCL only unless indicated otherwise)
- in Google Scholar
- awarded Patents (3)
Posters or oral short communications made at scientific meetings (since 2003)
Invited lectures at scientific meetings and seminars (in English - in French - in Dutch)

Scientific carreer (with the support of the Belgian Fund for Scientific Research [F.N.R.S.] from 1969 through 1989):

1963-1965: Laboratory of Physiological Chemistry of the Facultés Universitaires N.D. de la Paix (now Université de Namur) in Namur, Belgium, as Research Student (Mentors: Profs. R. & S. Wattiaux)
1965-1979: Laboratory of Physiological Chemistry of the Université catholique de Louvain [in the city of Louvain (Leuven, as it is known in Flemish) from 1965 through 1974; in Brussels since 1974) as Research Student, Trainee, Research Fellow and Post-doctoral Researcher (Mentors: Profs C. de Duve, H. Beaufay and A. Trouet)
1979-1993: International Institute of Cellular and Molecular Pathology (now de Duve Institute), Brussels, as Research Associate and Senior Research Associate
(Head of the Cellular and Molecular Toxicology Group since 1981)
1993 up to now: Unit of Cellular and Molecular Pharmacology (Head of Unit up to 2003), Department of Pharmaceutical Sciences of the Faculty of Medicine of the Université catholique de Louvain, Brussels (reorganized in 2009 as the Louvain Drug Research Institute in the "Health Science Sector" of the Université catholique de Louvain).

Main research interest:

Pathophysiology of lysosomes
Endocytosis and of the interactions of drugs and chemicals with membranbes and subcellular organelles
Antibiotic toxicity (molecular, cellular and clinical aspects)
Chemotherapy of intracellular infection
Antibiotic efflux pumps and transporters
Pharmacodynamics and pharmacokinetics of anti-infective drugs (in vitro models and clinical trials)
Discovery and development of new antibiotics.
Promotion of proper antibiotic usage (trough guidelines and public actions)
implementation of Clinical Pharmacy in Belgium

Main scientific achievements:

Cellular biology and toxicology

first experimental example of a mixed "lysosome storage disorder";
first description of the process of membrane flow and recycling during endocytosis ('shuttle');
deciphering the cellular and molecular mechanisms of the toxicity of aminoglycoside antibiotics and of its prevention by polyanions;
discovery and deciphering of the molecular mechanisms of the phospholipidosis induced by macrolide antibiotics;

Antibiotic pharmacodynamics and cellular pharmacokinetics
- design and evaluation of a new schedule of administration of aminoglycosides ('once-a-day'; now widely used in clinical practice)
- pharmacodynamics of macrolides and fluoroquinolones in models of intracellular infection
- characterization of fluoroquinolone and macrolide drug transporters and efflux in macrophages
- establishing the conditions for the use of beta-lactams by continuous infusion in Intensive Care and Cystic Fibrosis Patients

New antibiotic discovery and development
- design and evaluation of new pro-drugs of beta-lactam antibiotics
- discovery of new antibiotics acting against multiresistant bacteria
- preclinical pharmacological assessment of new antibiotics(in vitro models for transport and intracellular activity)
- toxicity and safety assessment of antibiotics (animal and clinical studies)

Promotion of the appropriate usage of antibiotics
- educational activities
- design and analysis of national public campaigns
- participation to national and international committees

Implementation of Clinical Pharmacy in Belgium
- launching of research programme on improved use of drugs (in geriatrics and in infectious diseases)
- creation of the academic environment to support the develpment of clinical pharmacy
- participation to the National Working Group for the implementation of Clinical Pharmacy in Belgium (active in every Belgian acute care hospital since 2013)

Publications and Reviewing:

Author of more than 250 original scientific peer-reviewed papers, reviews, and chapter of books (see above)
.
Reviewer for several Journals in the disciplines of Antimicrobial Chemotherapy and Infectious Diseases, Medicinal Chemistry, Pharmacology, Pharmaceutical Sciences, Internal Medicine, Cell Biology and Biochemistry, Cell Pathology.
Grant reviewer for the Belgian Fonds de la Recherche Scientifique (F.R.S.-FNRS), the French Agence Nationale de la Recherche (ANR), the US National Institutes of Health (National Institute of Allergy and Infectious Diseases [NIAID]), and sevral other national and private funding agencies.

Hnours and Special chairs:

1984: Galien Prize of Pharmacology (for unravelling the toxicity mechanisms of amniglycoside antibiotics) awarded by Le Journal du Médecin.
2006-2010: GSK Chair for Infectious Diseases (jointly with Prof. J. Van Eldere) at the Université catholique de Louvain (UCL) and the Katholieke Universiteit Leuven (KU-Leuven)
(see http://nl.wikipedia.org/wiki/Leerstoel#Lijst_van_leerstoelen-op-naam_aan_de_K.U.Leuven)
2010: Chaire Francqui au titre Belge of the Fondation Francqui/Francqui-Stichting at the Université Libre de Bruxelles (ULB)
(see http://www.facm.ucl.ac.be/facm-conferences-fr.htm#Chaire_Francqui_2010)

Main Committees and Boards:

Editorial Boards (Scientific Journals)

Current

Antimicrobial Agents and Chemotherapy (American Society of Microbiology)

International Journal of Antimicrobial Agents (International Society of Chemotherapy), as Section Editor

Chemotherapy Research and Practice (Hindawi Publishing Corporation)

BioMed Research International - Pharmacology (Hindawi Publishing Corporation)

Infectious Diseases in Clinical Practice (Wolters Kluwer / Lippincot - Williams & Wilkins)

Microbial Drug Resistance (Mary Ann Liebert Publishing)

Open Journal of Pharmacology (Ross Science Publishers)

PeerJ (Open Access publisher of scholarly articles), as Academic Editor

Pharmacy (MDPI - Open Access Publishing)

Past

Biochemical Journal (Biochemical Society; 1979-1986)

International:

Current

International Society of Chemotherapy (ISC) as member of the Working Group "Antimicrobials of the Future"

Past

International Socierty of Anti-Infective Pharmacology (ISAP; President - 1998-2000)

European Union:

European Committee on Antimicrobial Susceptibility Testing (EUCAST)
Member of the Steering Committee (2008-2010) and of the General Committee (since 2003) as representative of the International Society of Chemotherapy (ISC)
European Society of Clinical Microbiology and Infectious Diseases Pharmacokinetic/Pharmacodynamic of Anti-infectives Study Group (EPASG)
Member of the Inauguration Committee (created in 2010) and current member
European Medicines Agency (EMA)
Member of the Scientific Advisory Group for Antibiotics and Infectious Diseases
Initiative Medicines Initiative (IMI)
Member of the Governance Body of DRIVE-AB (Driving reinvestment in R&D for antibiotics and advocating their responsible use)

Belgium:

Current
- Belgian Federal Commission for the Implementation of Clinical Pharmacy in Belgian Hospitals
- Expert at the Belgian (French speaking) Fund for Scientific Research (Fonds de la Recherche Scientifique [F.R.S.-FNRS]
Past
- 1990-2004: Scientific Commission "Pharmaceutical Sciences" (Commission des Sciences Pharmaceutiques) of the National Foundation for Scientific Research (French-speaking; Fonds de la Recherche Scientifique [FRS-FNRS])
- 1990-1999: Scientific Commission "Drug Sciences" (Geneesmiddelen Commissie) of the Foundation for Scientific Research in Flanders (Dutch-speaking; Fonds voor Wetenschappelijke Onderzoek - Vlaanderen [F.W.O.-Vl.])
- 1999-2001: Board of the Belgians Society for Infectious Diseases and Clinical MIcrobiology (Société Belge d'Infectiologie et de Microbiologie Clinique / Belgische Vereniging voor Infectiologie en Klinische Microbiologie [S.B.I.M.C. / B.V.I.K.M.]
- 1998-2002: Belgian Federal Commission on Drug Transparency Committee (Commission de Transparance / Doorzichtigheidscommissie) at the Belgian Federal Ministry of Health
- 1999-2005: Ethical Committee for Phase I studies at Johnson & Johnson Research (Janssen Research Foundation), Beerse, Belgium (Dutch-speaking Ethische Commissie NZ-OG 084)
- 2002: Member of the Site Visit Committee of the Faculties of Pharmacy of Flanders (for the Flemish Interuniversity Council [Vlaamse Interuniversitaire Raad [VLIR])
- 2002-2006: Belgain Federal Commission of Drug Reimbursement (Commission de remboursement des médicaments/Commissie voor Tegemoetkoming van Geneesemiddelen) at the Belgian Ministry of Social Affairs (National Institute for for Sickness and Invalidity [INAMI / RIZIV])
- 2011: Member of the Site Visit Committee of the Faculties of Pharmacy of Flanders (for the Flemish Interuniversity Council [Vlaamse Interuniversitaire Raad [VLIR])
- Belgian Antibiotic Policy Coordination Committee [BAPCOC] (Commission de coordination de la Politique Antibiotique / Commissie voor Antibioticabeleid) at the Belgian Federal Ministry of Health and subcommittee "Public Awardness" (Sensibilisation du public / Sensibilisatrie van het publiek) (see http://www.antibiotiques.org/english)
- Scientific Committee of the Fondation Eugène Yourassowksy

Université catholique de Louvain

1993-2010: co-organizer of the 'Séminaire de Pathologie Infectieuse'
1994-2001: Co-organizer of the 'Séminaires et Conférences du département des Sciences Pharmaceutiques'

Teaching (until 2010 unless indicated otherwise);

at the Faculty of Medicine of the Université catholique de Louvain, Brussels (until 2010)

Graduate level:

Pharmacology and Pharmacotherapy
Medicinal Chemistry and Pharmacology of new Drugs
Drug Discovery, Development and Commercialization (until 2016)
Rational Drug and Therapeutic Choices (incl. Pharmacoeconomy) (until 2016)
Alternative and Unconventional Medicines

Postgraduate level:

Dug Discovery and Development (until 2016)
Infectious Pathology
Cell Biology, Biophysics, and Physiopathology in relation to Drug Design
Molecular Pharmacology
Cellular and Molecular pharmacology
"From pathology to treatment" [in collaboration with the Institut de Chimie Thérapeutique, Facuté de Pharmacie, Université de Lille 2, Lille, France].

at the Faculty of Medicine and Pharmacy of the Université de Mons-Hainaut, Mons (until 2010)

Human Biochemistry and Biochemical Pathology

at the Faculty of Medicine and Pharmacy of the Université d'Abomey-Calavi, Cotonou, Bénin (in 2012-2015)
(as part of a cooperation programme; see courses given)
- General Pharmacology (Pharmacologie générale)
- Special Pharmacology and Pharmacotherapy (Pharmacologie spéciale et Pharmacothérapie)
at the University of Pharmacy, Hanoi, Vietnam (from 2011 to now)
as part of a cooperation programme; see Cooperation)
- Clinical pharmacy (several)
- Pharmacokinetics/Pharmacodynamics of antibiotics (several lectures)
- Appropraite use of drugs and antibiotics (several lectures