Toxicodynamic models for the discovery of cellular alterations induced by macrolides

What do we learn from mathematical models?

K 01

K 10

K 12

K 21

1

2

Ce

C1

C2

dC1/dt = K01. Ce(t) - (K01 + K12) . C1 + K21 . C2

dC2/dt = K12 . C1 - K21 . C2

(Bouvier d’Yvoire)

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