Toxicodynamic models for the discovery of cellular alterations induced by macrolides

Implications in clinical practice?

Long-term therapy with azithromycin

(Van Bambeke et al, 1998)

Prophylaxy of MAC infection

1200 mg once-a-week

max Cc/Ce at steady state ? 30

Therapy of MAC infection

500 mg once-a-day

max Cc/Ce at steady state ? 60

Serum free conc.

Cell conc.

mean serum free conc.

0.03 - 0.1 mg/l

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