Toxicodynamic models for the discovery of cellular alterations induced by macrolides

Lysosomal alterations in cultured cells exposed for short times

to supratherapeutic concentrations of azithromycin (3 days; 10 mg/l)

Morphology:

Biochemistry:

Cathepsin B activity 300%

Phospholipid content 150%

Cholesterol content 120%

(Van Bambeke et al, 1996;

Montenez, 1996;

Gerbaux et al, 1996)

What do we learn from cellular models?

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