Bactericidal activity of FQs against M. bovis

0.01

0.10

1.00

10.00

10

-2

1

[ FQ ] mg/L

Fraction of survivors

10

-4

10

-6

10

-8

10

-10

MPC (10)

1 log

The plateau region correlates with the presence of first-step resistant mutants.

Mutants are not recovered at concentrations above those required for the second sharp drop, …

thereby defining a Mutant Prevention Concentration (MPC).

Previous slide

Next slide

Back to first slide

View graphic version