Mutant-prevention concentration (MPC) (1/3)

Effect of fluoroquinolone concentration on selection of resistant mutants of Mycobacterium bovis BCG and Staphylococcus aureus

Dong YZ, Zhao XL, Domagala J & Drlica-K

Antimicrob. Agents Chemother. 43 : 1756-1758, 1999

• Mycobacterium bovis BCG and Staphylococcus aureus

• increasing concentrations of fluoroquinolones

  • a sharp drop, followed by a plateau and
  • a second sharp drop.

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