Mutant-prevention concentration (MPC) (2/3) ...
Effect of fluoroquinolone concentration on selection of resistant mutants of Mycobacterium bovis BCG and Staphylococcus aureus
Dong YZ, Zhao XL, Domagala J & Drlica-K
Antimicrob. Agents Chemother. 43 : 1756-1758, 1999
The mutant prevention concentration (MPC) is about 10 times larger larger than the MIC99 for most FQ
BUT, a C-8-methoxy group lowers the MPC for N-1-cyclopropyl fluoroquinolones