PK/PD and effectiveness:patterns of antimicrobial activity (after WA. Craig, 2000)

2. Time-dependent killing and prolonged persistent effects (duration related to AUC)

• Seen with glycopeptides, tetracyclines, azithromycin, streptogramins and fluconazole
• Goal of dosing regimen: optimize amount of drug
• AUC/MIC major parameter correlating with efficacy

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