PK/PD and effectiveness:patterns of antimicrobial activity (after WA. Craig, 2000)

1. Time-dependent killing and minimal to moderate persistent effects

• Seen with all beta-lactams, clindamycin, macrolides, oxazolidinones and flucytosine
• Goal of dosing regimen: optimize duration of exposure
• Time above MIC major parameter correlating with efficacy

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