PK/PD and effectiveness:patterns of antimicrobial activity (after WA. Craig, 2000)

3. Concentration-dependent killing and prolonged persistent effects (post-antibiotic effect)

• Seen with aminoglycosides, quinolones, daptomycin, ketolides and amphotericin B
• Goal of dosing regimen: maximize concentrations
• AUC/MIC and Peak/MIC major parameters correlating with efficacy

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