PK/PD : what do we need to do ?

Drug parameter how to be optimal

aminoglycosides pic / MIC > 8

fluoroquinolones 24h-AUC / MIC > 125  peak / MIC > 12

?-lactams t > CMI > 60 % *

glycopeptides t > CMI > 80 %

* more in case of “difficult” organisms (Pseudomonas, e.g.)

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