Peak concentrations as a tool to determine acceptable sensitivities to fluoroquinolones (p.o.)

Drug Dosage Cmax acceptable

(mg/24h) (mg/L) MIC (mg/L)

norfloxacin 800 2.4 * 0.2

ciprofloxacin 500 2.4 * 0.2

ofloxacin 400 3-4.5 *, + 0.2 - 0.4

levofloxacin 500 5-6 *, + 0.4 - 0.8

moxifloxacin 400 4.5 * 0.4

* US prescrib. inf. (adult of 60 kg) of NOROXIN®, CIPRO®, FLOXIN®,

LEVAQUIN®, and AVELOX®

+ first dose to equilibrium

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