Peak concentrations and 24h-AUC / MIC as predictors of efficacy...

acceptable MIC (mg/L)

Drug Dosage AUC/MIC peak / MIC NCCLS

(mg/24h) (24h) Bkpts*

norfloxacin 800 0.1 0.2 < 4

ciprofloxacin 500 0.1 0.2 < 1

ofloxacin 400 0.2-0.4 0.2 - 0.4 < 2

levofloxacin 500 0.4 0.4 - 0.8 < 2

moxifloxacin 400 0.4 0.4 < 2

* US prescrib. inf. (adult of 60 kg) of NOROXIN®, CIPRO®, FLOXIN®, LEVAQUIN®, and AVELOX®

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