Cellular pharmacokinetic properties of AZ

? accumulates in lysosomes of fibroblasts and macrophages (Carlier et al, 1994)

? acidotropic sequestration (de Duve et al, 1974)

H+

B

B

B

BH+

BH+

BH+

H+

H+

Extracellular

fluid

Extralysosomal space

Lysosomes

Previous slide

Next slide

Back to first slide

View graphic version