Pharmacological properties of AZ

? spectrum of activity

? Gram +

? some Gram -

? therapeutic use

? upper and lower respiratory tract infections

? skin infections

? sexually transmitted diseases

? Mycobacterium avium complex in AIDS patients

? pharmacokinetic properties in vivo

? exceptionally high and rapid accumulation in tissues, and

slow release (Foulds et al, 1990)

? consequences

? low serum concentrations

? decrease of the length of treatment

? toxicity ??? Pharmacological properties of AZ

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