PPT Slide

Kanamycin B - 48.5 110 ± 11

6’’-deoxy-6’’-

(N-acetyl- - 24.4 134 ± 7

N-methylamino)

kanamycin B

Drug

Energy of

interaction

(KJ/mol)

Orientation

towards

lipid/water

interface

IC50

(µM)

RATIONAL BASIS FOR SYNTHESIS OF NEW - LESS TOXIC- AMINOGLYCOSIDES

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