RATIONAL BASIS FOR SYNTHESIS OF NEW - LESS TOXIC- AMINOGLYCOSIDES

Aminoglycoside IC50 Calculated Orientation

(µg/ml) interaction towards

(kJ / mol) lipid / water

interface

Isepamicin 125 ± 7 - 23.4

Amikacin 85 ± 4 - 35.7

Kanamycin A 69 ± 11 - 46.8

Kanamycin B 54 ± 4 - 48.5

Previous slide

Next slide

Back to first slide

View graphic version