Effet de Z-VAD.fmk, un inhibiteur des caspases, sur l’apoptose induite par la gentamicine dans les cellules MDCK
gentamicin-treated cellsb
control cells a no Z-VAD.fmk b plus Z-VAD.fmk c
2.9 ± 0.7 22.9 ± 1.9 * 1.4 ± 0.6
a no treatment (cells incubated with Z-VAD.fmk alone for the 2 last days of culture did not
show significant change in apoptotic index).
b cells were treated for 4 days with 2 mM gentamicin only.
c cells were treated for 2 days with 2 mM gentamicin and incubation was then carried on
in the same medium supplemented with 50 µM Z-VAD.fmk for 2 additional days .
* significantly larger than control (p < 0.001).