? in vitro models to reduce the working load of in vivo toxicological studies ?

Cellular

pharmacokinetics

• accumulation

• retention

• binding

Cellular

pharmacodynamics

• effect on metabolism

• functional and

morphological alterations

Pharmacochemistry

• structure - effect

relationships

Definition of

• molecular target

• storage site

Proposals of

strategies to reduce

toxicity

In vitro : What to do for a new drug ?

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