Pharmacodynamic parameters revisited in the light of pharmacokinetics

Is bound concentration of drugs predictive of toxicity ?

• Models to define eucaryotic targets:
  From cellular to molecular pharmacology ?
  

• Models to define the proportion of bound drugs:
  Putting together mathematical and experimental data ?
  

• Models to define the relation “ bound concentration - toxicity “:
  Dose - effect studies ?
  
  Binding versus complexation ?

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