Toxicodynamic models for the understanding ofaminoglycoside nephrotoxicity

What do we learn from animal models?

GM serum concentration (µg/ml)

0 20 40 60

Renal cortical accumulation

Peak

tid

Peak

qd

Uptake

is

saturable !

(Giuliano et al, 1986; Tulkens et al, 1988)

GM

accumulation

(µg/mg)

Phospholipid

content

(% control)

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