Toxicodynamic models for the understanding ofaminoglycoside nephrotoxicity

What do we learn from in vitro, cellular and animal models?

Drug accumulation in lysosomes

Accumulation of phospholipids in the lysosomes

in correlation with

• the drug accumulation

• the ability to bind to acidic phospholipids

inhibit phospholipase activity

Binding at the cell surface and endocytosis

Apoptosis

in correlation with

• the drug accumulation

• the degree of phospholipidosis

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