Pharmacokinetic parameters in relation with efficacy

Dose Cmax MIC for AUC MIC for

(mg) (mg/l) pk/MIC=10 (mg.h/l) AUIC=125

norflo 400 (X2) 1.6 0.2 14 0.1

peflo 400 (X2) 4.6 0.4 108 1.0

cipro 500 (X2) 1.5 0.2 17 0.1

oflo 200 (X2) 3.1 0.4 66 0.4

levoflo 500 8.7 0.8 73 0.4

grepa 600 1.4 0.1 20 0.2

gati 400 4.5 0.4 28 0.2

trova 200 2.3 0.2 25 0.2

moxi 400 2.5 0.2 30 0.2

gemi 600 4 0.4 24 0.2

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