Resistance: do not forget the correct dosing...
“Inadequate dosing of antibiotics is probably an important reason for misuse and subsequent risk of resistance. A recommendation on proper dosing regimens for different infections would be an important part of a comprehensive strategy. The possibility to produce such a dose recommendation based on pharmacokinetic and pharmacodynamic considerations will be further investigated in one of the CPMP working parties…”
European Agency of the Evaluation of Medicinal Products (London)
on Antimicrobial resistance
3 January 1999 EMEA/9880/99