SAR of main pharmacokinetic parameters:how to get a long half life

t 1/2 (h) no. of daily

administrations

oflo 5 - 7 2 x*

peflo 10 2 x*

flero 9 - 13 1 x

grepa 10 - 12 1 x

gati 13 1 x

gemi 8 1 x

trova 10 1 x

moxi 12 1 x

other FQ 3 - 6 2 x

* higher MIC...

N

HN

H

3

C

H

3

C

N

N

N

H

H

H

3

N

+

HN

N

N

CH

2

N

H

3

CO

H

2

N

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