From ofloxacin to levofloxacin...

O

CH

3

-

H

3

C

N

C

O

O

-

O

N

N

F

Ofloxacin is a racemic mixture

N

O

CH

3

H

The active form of ofloxacin is the (-) S isomer

Levofloxacin is the

pure (-) S isomer *

* Eur. pat. 206,283 to Daiichi, 1987

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