Wide spectrum pumps in Pseudomonas

MexAB-OprM

MexCD-OprJ

MexEF-OprN

MexHI-OPrD

MexJK-OprM

MexXY-OprM

?-lac ML TET AG FQ Chl

3. constitutive expression and/or inducible expression

? increase of resistance level higher upon antibiotic exposure

Van Bambeke et al. JAC (2003) 51: 1055-1065

Aeschlimann, Pharmacotherapy (2003) 23:916-924