Optimisation based on pharmacodynamics

High risk of selection of resistance !

Coyle et al. AAC (2001) 45:1654-1659

Quinolone

CIP

LVX

MXF

GAT

Wild-type strain

Efflux resistant strain

MIC

AUC/MIC

Cmax/MIC

MIC

AUC/MIC

Cmax/MIC

0.5

1

0.25

0.25

8

4

0.5

0.5

5.8

15.9

106.8

75.9

0.7

1.6

9.4

7.4

92.8

63.6

213.6

151.8

11.2

6.4

18.8

14.8

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