Optimisation based on pharmacodynamics

Coyle et al. AAC (2001) 45:1654-1659

Quinolone

CIP

LVX

MXF

GAT

Wild-type strain

MIC

AUC/MIC

Cmax/MIC

0.5

1

0.25

0.25

92.8

63.6

213.6

151.8

11.2

6.4

18.8

14.8

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