Pharmacokinetics / Pharmacodynamics in action ...
Aminoglycosides 2d rule of tumb...
give them once-a-day to reduce toxicity
- 1h peaks of 12-18 mg/L for G, T, N
- 1h peaks of 20-30 mg/L for A, I
Increase interval ( ? 36h, ? 48h)
before reducing the unit dose...