Pharmacokinetics / Pharmacodynamics in action ...

Aminoglycosides 1st of the two rules of tumb…

PK / PD “safe” breakpoints for AG

• G, N, T : 2 µg / ml

• A / I : 4 µg / ml

anything with an MIC < 1 will be treatable

efficacy will become a problem important for MIC’s

• > 2 for G, T, N ( up to 6 mg/kg )

• > 4 for A, I ( up to 15 mg/kg )

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