ISAP scientific activities …
Over the last 10 years, a series of key concepts have emerged from our discussions and work:
- dose-effect relationships are not the same for all anti-infectives
- beta-lactams vs aminoglycosides, e.g.
- some anti-infectives are time-dependent, others not
- subinhibitory effects, post-antibiotic effects, cooperation with host defenses modulate the activity of antiinfective drugs
- integration of PK/PD allows to fairly predict success or failure, and even emergence of resistance