Pic / CMI > 10 comme guide pour fixer une limite de sensibilité acceptable aux doses standard de FQ

FQ Dose Cmax

(mg/24h) (mg/L)

norfloxacine 800 2.4 *

péfloxacine 400 4.5 #

ciprofloxacine 500 2.4 *

ofloxacine 400 3-4.5 *, +

lévofloxacine 500 5-6 *, +

moxifloxacine 400 4.5 *

* US prescrib. inf. (adult of 60 kg) of NOROXINŽ, CIPROŽ, FLOXINŽ, TEQUINŽ,

LEVAQUINŽ, and AVELOXŽ; # litterature data

+ first dose to equilibrium

Pt crit. PK/PD

[Cmax / 12] (mg/L)

0.2

0.4

0.3 - 0.4

0.4 - 0.5

0.4