ASC24h/ MIC = 125 comme guide pour fixer une limite de sensibilité acceptable aux doses standard de FQ

FQ Dose ASC24h

(mg/24h) (mg/L x h)

norfloxacine 800 14 *, #

péfloxacine 400 50 #

ciprofloxacine 500 12 *

ofloxacine 400 31 to 66 *, +

lévofloxacine 500 47 *

moxifloxacine 400 48 *

* US prescrib. inf. (adult of 60 kg) of NOROXIN®, CIPRO®, FLOXIN®, LEVAQUIN®,  TEQUIN® and AVELOX®; # litterature data; + first dose to equilibrium

Pt crit. PK/PD [AUC/MIC = 125]

0.1

0.4

0.1

0.2 - 0.4

0.4

0.4

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