PPT Slide

NCCLS PK/PD

S. pneumoniae H. influenzae all organisms Amoxicillin 2 4 2

Amox-clav 2 4 2

Cefuroxime 1 4 1

Cefprozil 2 8 1

Cefixime – 1 0.5

Cefaclor 1 8 0.5

Loracarbef 2 8 0.5

Breakpoint issues: NCCLS vs PK/PD (50 % time coverage) breakpoints of common ?- lactams (µg/ml) *

M. R.Jacobs, 11th ECCMID, 2001

* conventional doses and schedules

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