?-lactam by continuous infusion ?

• Optimized PK/PD-based administration

• Reasonably stable serum concentrations around 20 to 40 mg/L can easily be achieved

BUT….

• Critical issues include

  • the stability of the ?-lactam ring (temperature !!!)
  • physical and chemical compatibility with other drugs administered by continuous infusion (Intensive Care patients, e.g.)

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