Characterization of the transporter(s)

0

5

10

15

0

25

50

75

100

Control

ATP depletion

Time (min)

Residual fraction (%)

ATP depletion increases ciprofloxacin accumulation and decreases ciprofloxacin efflux

(17µg/ml)

Ce = 50 µM

Control

ATP depletion

0.0

2.5

5.0

7.5

10.0

Cc/Ce

2h incubation at 37°C

Michot et al., ICAAC 2000

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