Pharmacodynamics : intracellular MIC ?

Cooperation with cell bactericidal mechanisms

may modulate intracellular activity

Intracellular MIC <<< MIC in broth

in endosomes:

likely

in phagosomes:

likely

pH = 7

pH < 6

in cytosol:

unlikely but...

in phagolysosomes:

very variable

O2. -

NO.

myeloperoxydase

acidity, cationic proteins...

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